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Items: 47


Modulation of HIF-2α PAS-B domain contributes to physiological responses.

Feng Z, Zou X, Chen Y, Wang H, Duan Y, Bruick RK.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13240-13245. doi: 10.1073/pnas.1810897115. Epub 2018 Dec 6.


A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis.

Souza RF, Bayeh L, Spechler SJ, Tambar UK, Bruick RK.

Curr Opin Pharmacol. 2017 Dec;37:93-99. doi: 10.1016/j.coph.2017.10.004. Epub 2017 Nov 5. Review.


Targeting renal cell carcinoma with a HIF-2 antagonist.

Chen W, Hill H, Christie A, Kim MS, Holloman E, Pavia-Jimenez A, Homayoun F, Ma Y, Patel N, Yell P, Hao G, Yousuf Q, Joyce A, Pedrosa I, Geiger H, Zhang H, Chang J, Gardner KH, Bruick RK, Reeves C, Hwang TH, Courtney K, Frenkel E, Sun X, Zojwalla N, Wong T, Rizzi JP, Wallace EM, Josey JA, Xie Y, Xie XJ, Kapur P, McKay RM, Brugarolas J.

Nature. 2016 Nov 3;539(7627):112-117. doi: 10.1038/nature19796. Epub 2016 Sep 5.


On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.

Cho H, Du X, Rizzi JP, Liberzon E, Chakraborty AA, Gao W, Carvo I, Signoretti S, Bruick RK, Josey JA, Wallace EM, Kaelin WG.

Nature. 2016 Nov 3;539(7627):107-111. doi: 10.1038/nature19795. Epub 2016 Sep 5.


Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD.

Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF.

Gut. 2017 Sep;66(9):1542-1554. doi: 10.1136/gutjnl-2016-312595. Epub 2016 Sep 30.


Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling.

Ding M, Bruick RK, Yu Y.

Nat Cell Biol. 2016 Mar;18(3):319-27. doi: 10.1038/ncb3311. Epub 2016 Feb 8.


Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.

Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK.

J Med Chem. 2015 Aug 13;58(15):5930-41. doi: 10.1021/acs.jmedchem.5b00529. Epub 2015 Jul 30.


F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.

Ruiz JC, Bruick RK.

J Inorg Biochem. 2014 Apr;133:73-7. doi: 10.1016/j.jinorgbio.2014.01.015. Epub 2014 Jan 25. Review.


Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK.

Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24.


Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.

Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK.

J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18.


Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.

Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH.

ACS Chem Biol. 2013 Mar 15;8(3):626-35. doi: 10.1021/cb300604u. Epub 2012 Dec 26.


F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.

Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK.

J Biol Chem. 2013 Jan 4;288(1):552-60. doi: 10.1074/jbc.M112.426171. Epub 2012 Nov 7.


Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.

Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK.

J Biol Chem. 2012 Jul 6;287(28):23710-7. doi: 10.1074/jbc.M112.360404. Epub 2012 May 30.


Protein degradation and iron homeostasis.

Thompson JW, Bruick RK.

Biochim Biophys Acta. 2012 Sep;1823(9):1484-90. doi: 10.1016/j.bbamcr.2012.02.003. Epub 2012 Feb 10. Review.


Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).

Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK.

J Biol Chem. 2012 Mar 2;287(10):7357-65. doi: 10.1074/jbc.M111.308684. Epub 2012 Jan 17.


Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.

Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC.

Cell Metab. 2011 Nov 2;14(5):647-57. doi: 10.1016/j.cmet.2011.08.015.


Conditional HIF-1alpha expression produces a reversible cardiomyopathy.

Bekeredjian R, Walton CB, MacCannell KA, Ecker J, Kruse F, Outten JT, Sutcliffe D, Gerard RD, Bruick RK, Shohet RV.

PLoS One. 2010 Jul 21;5(7):e11693. doi: 10.1371/journal.pone.0011693.


Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk.

Salahudeen AA, Bruick RK.

Ann N Y Acad Sci. 2009 Oct;1177:30-8. doi: 10.1111/j.1749-6632.2009.05038.x. Review.


An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.

Salahudeen AA, Thompson JW, Ruiz JC, Ma HW, Kinch LN, Li Q, Grishin NV, Bruick RK.

Science. 2009 Oct 30;326(5953):722-6. doi: 10.1126/science.1176326. Epub 2009 Sep 17.


Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.

Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-5. doi: 10.1073/pnas.0808092106. Epub 2009 Jan 7.


Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function.

Scheuermann TH, Yang J, Zhang L, Gardner KH, Bruick RK.

Methods Enzymol. 2007;435:3-24.


JMJD6 is a histone arginine demethylase.

Chang B, Chen Y, Zhao Y, Bruick RK.

Science. 2007 Oct 19;318(5849):444-7.


Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

Ozer A, Bruick RK.

Nat Chem Biol. 2007 Mar;3(3):144-53. Review.


Dioxygenases as O2-dependent regulators of the hypoxic response pathway.

Dann CE 3rd, Bruick RK.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):639-47. Epub 2005 Aug 26. Review.


Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.

Yang J, Zhang L, Erbel PJ, Gardner KH, Ding K, Garcia JA, Bruick RK.

J Biol Chem. 2005 Oct 28;280(43):36047-54. Epub 2005 Aug 29.


Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4.

Ozer A, Bruick RK.

Cell Cycle. 2005 Sep;4(9):1153-6. Epub 2005 Sep 19. Review.


Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1.

Hossain CF, Kim YP, Baerson SR, Zhang L, Bruick RK, Mohammed KA, Agarwal AK, Nagle DG, Zhou YD.

Biochem Biophys Res Commun. 2005 Aug 5;333(3):1026-33.


The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

Ozer A, Wu LC, Bruick RK.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7481-6. Epub 2005 May 16.


Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.

Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.

J Biol Chem. 2004 Sep 24;279(39):40337-44. Epub 2004 Jul 22.


Identification and characterization of a novel RNA binding protein that associates with the 5'-untranslated region of the chloroplast psbA mRNA.

Barnes D, Cohen A, Bruick RK, Kantardjieff K, Fowler S, Efuet E, Mayfield SP.

Biochemistry. 2004 Jul 6;43(26):8541-50.


Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W Jr, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP.

Cancer Res. 2004 May 1;64(9):3350-6. No abstract available.


Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7281-6. Epub 2004 Apr 26.


Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.

Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15504-9. Epub 2003 Dec 10.


Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.

Bruick RK.

Genes Dev. 2003 Nov 1;17(21):2614-23. Review. No abstract available.


Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.

Dann CE 3rd, Bruick RK, Deisenhofer J.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15351-6. Epub 2002 Nov 13.


FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK.

Genes Dev. 2002 Jun 15;16(12):1466-71.


Transcription. Oxygen sensing gets a second wind.

Bruick RK, McKnight SL.

Science. 2002 Feb 1;295(5556):807-8. No abstract available.


A conserved family of prolyl-4-hydroxylases that modify HIF.

Bruick RK, McKnight SL.

Science. 2001 Nov 9;294(5545):1337-40. Epub 2001 Oct 11.


Building better vasculature.

Bruick RK, McKnight SL.

Genes Dev. 2001 Oct 1;15(19):2497-502. No abstract available.


A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver.

Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W, Arnot D, Uyeda K.

Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9116-21. Epub 2001 Jul 24.


Light-activated translation of chloroplast mRNAs.

Bruick RK, Mayfield SP.

Trends Plant Sci. 1999 May;4(5):190-195.


A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution.

Bruick RK, Koppitz M, Joyce GF, Orgel LE.

Nucleic Acids Res. 1997 Mar 15;25(6):1309-10.


Template-directed ligation of peptides to oligonucleotides.

Bruick RK, Dawson PE, Kent SB, Usman N, Joyce GF.

Chem Biol. 1996 Jan;3(1):49-56.

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