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Items: 1 to 50 of 217

1.

Subchoroidal Release of VEGF and bFGF Produces Choroidal Neovascularization in Rabbit.

Wong CG, Taban M, Osann K, Ross-Cisneros FN, Bruice TC, Zahn G, You T.

Curr Eye Res. 2017 Feb;42(2):237-243. doi: 10.1080/02713683.2016.1227448. Epub 2016 Oct 17.

PMID:
27749103
2.

Incorporation of positively charged linkages into DNA and RNA backbones: a novel strategy for antigene and antisense agents.

Jain ML, Bruice PY, Szabó IE, Bruice TC.

Chem Rev. 2012 Mar 14;112(3):1284-309. doi: 10.1021/cr1004265. Epub 2011 Nov 11. Review. No abstract available.

PMID:
22074477
3.

Development of potential anticancer agents that target the telomere sequence.

Park M, Bruice TC.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3982-6. doi: 10.1016/j.bmcl.2010.04.089. Epub 2010 May 6.

PMID:
20605447
4.
5.

Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA.

Park M, Bruice TC.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3488-91. doi: 10.1016/j.bmcl.2008.05.030. Epub 2008 May 15.

PMID:
18514514
6.

Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8.

Zhang X, Bruice TC.

Biochemistry. 2008 Jun 24;47(25):6671-7. doi: 10.1021/bi800244s.

PMID:
18512960
7.

Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases.

Zhang X, Bruice TC.

Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5728-32. doi: 10.1073/pnas.0801788105. Epub 2008 Apr 7.

8.

Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents.

Park M, Canzio D, Bruice TC.

Bioorg Med Chem Lett. 2008 Apr 1;18(7):2377-84. doi: 10.1016/j.bmcl.2008.02.063. Epub 2008 Mar 7.

PMID:
18353646
9.
10.
11.

Histone lysine methyltransferase SET7/9: formation of a water channel precedes each methyl transfer.

Zhang X, Bruice TC.

Biochemistry. 2007 Dec 25;46(51):14838-44. Epub 2007 Nov 29.

PMID:
18044969
12.
13.

Catalytic mechanism and product specificity of rubisco large subunit methyltransferase: QM/MM and MD investigations.

Zhang X, Bruice TC.

Biochemistry. 2007 May 8;46(18):5505-14. Epub 2007 Apr 13.

PMID:
17429949
14.

Diels-Alder ribozyme catalysis: a computational approach.

Zhang X, Bruice TC.

J Am Chem Soc. 2007 Jan 31;129(4):1001-7.

PMID:
17243837
15.
16.

Mechanism of methanol oxidation by quinoprotein methanol dehydrogenase.

Zhang X, Reddy SY, Bruice TC.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):745-9. Epub 2007 Jan 10.

17.

Reaction mechanism of guanidinoacetate methyltransferase, concerted or step-wise.

Zhang X, Bruice TC.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16141-6. Epub 2006 Oct 19.

18.

DNA sequence recognition in the minor groove by hairpin microgonotropens.

Kahane AL, Bruice TC.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6255-61. Epub 2006 Oct 10.

PMID:
17035007
19.

Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide incorporating 7-deazaguanine bases.

Jain ML, Bruice TC.

Bioorg Med Chem. 2006 Nov 1;14(21):7333-46. Epub 2006 Aug 30.

PMID:
16945544
20.

Computational approaches: reaction trajectories, structures, and atomic motions. Enzyme reactions and proficiency.

Bruice TC.

Chem Rev. 2006 Aug;106(8):3119-39. Review. No abstract available.

PMID:
16895321
22.
23.

DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.

Correa BJ, Canzio D, Kahane AL, Reddy PM, Bruice TC.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3745-50. Epub 2006 May 8.

PMID:
16682192
24.

The mechanism of M.HhaI DNA C5 cytosine methyltransferase enzyme: a quantum mechanics/molecular mechanics approach.

Zhang X, Bruice TC.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6148-53. Epub 2006 Apr 10.

25.

An investigation of the ionic and solvation patterns of dsDNG versus dsDNA by use of molecular dynamics simulations.

Toporowski JW, Reddy SY, Bruice TC.

Biophys Chem. 2007 Mar;126(1-3):132-9. Epub 2006 Mar 9.

PMID:
16527389
26.

The proficiency of a thermophilic chorismate mutase enzyme is solely through an entropic advantage in the enzyme reaction.

Zhang X, Bruice TC.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18356-60. Epub 2005 Dec 12.

27.

Ribonucleic guanidine demonstrates an unexpected marked preference for complementary DNA rather than RNA.

Park M, Toporowski JW, Bruice TC.

Bioorg Med Chem. 2006 Mar 15;14(6):1743-9. Epub 2005 Nov 8.

PMID:
16288882
28.

Low-frequency normal mode in DNA HhaI methyltransferase and motions of residues involved in the base flipping.

Luo J, Bruice TC.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16194-8. Epub 2005 Oct 19.

29.

Recognition of a 10 base pair sequence of DNA and stereochemical control of the binding affinity of chiral hairpin polyamide-Hoechst 33258 conjugates.

Reddy PM, Toporowski JW, Kahane AL, Bruice TC.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5531-6. Epub 2005 Oct 3.

PMID:
16203135
30.

Covalent intermediates and enzyme proficiency.

Bruice TC, Bruice PY.

J Am Chem Soc. 2005 Sep 14;127(36):12478-9.

PMID:
16144381
31.

A definitive mechanism for chorismate mutase.

Zhang X, Zhang X, Bruice TC.

Biochemistry. 2005 Aug 9;44(31):10443-8.

PMID:
16060652
32.

Binding studies of cationic uridyl ribonucleic guanidine (RNG) to DNA.

Park M, Bruice TC.

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3247-51.

PMID:
15935662
33.
34.

Comparison of positively charged DNG with DNA duplexes: a computational approach.

Toporowski JW, Reddy SY, Bruice TC.

Bioorg Med Chem. 2005 Jun 1;13(11):3691-8.

PMID:
15862998
35.

Focal-point conformational analysis of ethanol, propanol, and isopropanol.

Kahn K, Bruice TC.

Chemphyschem. 2005 Mar;6(3):487-95.

PMID:
15799474
36.

Statistical coevolution analysis and molecular dynamics: identification of amino acid pairs essential for catalysis.

Estabrook RA, Luo J, Purdy MM, Sharma V, Weakliem P, Bruice TC, Reich NO.

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):994-9. Epub 2005 Jan 18.

37.
38.

Mechanisms of ammonia activation and ammonium ion inhibition of quinoprotein methanol dehydrogenase: a computational approach.

Reddy SY, Bruice TC.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15887-92. Epub 2004 Nov 1.

39.

Molecular dynamics studies of ground state and intermediate of the hyperthermophilic indole-3-glycerol phosphate synthase.

Mazumder-Shivakumar D, Bruice TC.

Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14379-84. Epub 2004 Sep 27.

40.

Anticorrelated motions as a driving force in enzyme catalysis: the dehydrogenase reaction.

Luo J, Bruice TC.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13152-6. Epub 2004 Aug 26.

41.
43.

DNG cytidine: synthesis and binding properties of octameric guanidinium-linked deoxycytidine oligomer.

Szabo IE, Bruice TC.

Bioorg Med Chem. 2004 Aug 1;12(15):4233-44.

PMID:
15246099
44.

DNA sequence recognition in the minor groove by hairpin pyrrole polyamide-Hoechst 33258 analogue conjugate.

Reddy PM, Dexter R, Bruice TC.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3803-7.

PMID:
15203166
45.
47.
48.
49.
50.

Conformations and dynamics of Ets-1 ETS domain-DNA complexes.

Reddy SY, Obika S, Bruice TC.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15475-80. Epub 2003 Dec 12.

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