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Items: 16


Efficiency measures the conversion of agonist binding energy into receptor conformational change.

Nayak TK, Vij R, Bruhova I, Shandilya J, Auerbach A.

J Gen Physiol. 2019 Apr 1;151(4):465-477. doi: 10.1085/jgp.201812215. Epub 2019 Jan 11.


Molecular recognition at cholinergic synapses: acetylcholine versus choline.

Bruhova I, Auerbach A.

J Physiol. 2017 Feb 15;595(4):1253-1261. doi: 10.1113/JP273291. Epub 2016 Dec 12.


Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors.

Nayak TK, Bruhova I, Chakraborty S, Gupta S, Zheng W, Auerbach A.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17660-5. doi: 10.1073/pnas.1414378111. Epub 2014 Nov 24.


Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.

Poulin H, Bruhova I, Timour Q, Theriault O, Beaulieu JM, Frassati D, Chahine M.

Mol Pharmacol. 2014 Oct;86(4):378-89. doi: 10.1124/mol.114.093104. Epub 2014 Jul 15.


Catch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutations.

Purohit P, Bruhova I, Gupta S, Auerbach A.

Biophys J. 2014 Jul 1;107(1):88-99. doi: 10.1016/j.bpj.2014.04.057.


State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.

Tikhonov DB, Bruhova I, Garden DP, Zhorov BS.

Pflugers Arch. 2015 Feb;467(2):253-66. doi: 10.1007/s00424-014-1508-0. Epub 2014 Apr 15.


Energy for wild-type acetylcholine receptor channel gating from different choline derivatives.

Bruhova I, Gregg T, Auerbach A.

Biophys J. 2013 Feb 5;104(3):565-74. doi: 10.1016/j.bpj.2012.11.3833.


Sources of energy for gating by neurotransmitters in acetylcholine receptor channels.

Purohit P, Bruhova I, Auerbach A.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9384-9. doi: 10.1073/pnas.1203633109. Epub 2012 May 30.


Design and control of acetylcholine receptor conformational change.

Jadey SV, Purohit P, Bruhova I, Gregg TM, Auerbach A.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4328-33. doi: 10.1073/pnas.1016617108. Epub 2011 Mar 1.


Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating.

Bruhova I, Auerbach A.

J Biol Chem. 2010 Dec 10;285(50):38898-904. doi: 10.1074/jbc.M110.169110. Epub 2010 Sep 23.


A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data.

Bruhova I, Zhorov BS.

J Gen Physiol. 2010 Mar;135(3):261-74. doi: 10.1085/jgp.200910288.


Access and binding of local anesthetics in the closed sodium channel.

Bruhova I, Tikhonov DB, Zhorov BS.

Mol Pharmacol. 2008 Oct;74(4):1033-45. doi: 10.1124/mol.108.049759. Epub 2008 Jul 24.


Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter.

Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wei AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G.

Mol Pharmacol. 2007 Jun;71(6):1503-11. Epub 2007 Mar 8. Erratum in: Mol Pharmacol. 2007 Sep;72(3):796.


Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine.

Tikhonov DB, Bruhova I, Zhorov BS.

FEBS Lett. 2006 Nov 13;580(26):6027-32. Epub 2006 Oct 24.


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