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An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis.

Jönsson F, de Chaisemartin L, Granger V, Gouel-Chéron A, Gillis CM, Zhu Q, Dib F, Nicaise-Roland P, Ganneau C, Hurtado-Nedelec M, Paugam-Burtz C, Necib S, Keita-Meyer H, Le Dorze M, Cholley B, Langeron O, Jacob L, Plaud B, Fischler M, Sauvan C, Guinnepain MT, Montravers P, Aubier M, Bay S, Neukirch C, Tubach F, Longrois D, Chollet-Martin S, Bruhns P.

Sci Transl Med. 2019 Jul 10;11(500). pii: eaat1479. doi: 10.1126/scitranslmed.aat1479.


Basic Structure of Melanoidins Formed in the Maillard Reaction of 3-Deoxyglucosone and γ-Aminobutyric Acid.

Bruhns P, Kanzler C, Degenhardt AG, Koch TJ, Kroh LW.

J Agric Food Chem. 2019 May 8;67(18):5197-5203. doi: 10.1021/acs.jafc.9b00202. Epub 2019 Apr 24.


An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIaV158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages.

Kang TH, Lee CH, Delidakis G, Jung J, Richard-Le Goff O, Lee J, Kim JE, Charab W, Bruhns P, Georgiou G.

Front Immunol. 2019 Mar 27;10:562. doi: 10.3389/fimmu.2019.00562. eCollection 2019.


Intravenous immunoglobulin induces IL-4 in human basophils by signaling through surface-bound IgE.

Galeotti C, Stephen-Victor E, Karnam A, Das M, Gilardin L, Maddur MS, Wymann S, Vonarburg C, Chevailler A, Dimitrov JD, Benveniste O, Bruhns P, Kaveri SV, Bayry J.

J Allergy Clin Immunol. 2019 Aug;144(2):524-535.e8. doi: 10.1016/j.jaci.2018.10.064. Epub 2018 Dec 7.


2-Deoxyglucosone: A New C6-α-Dicarbonyl Compound in the Maillard Reaction of d-Fructose with γ-Aminobutyric Acid.

Bruhns P, Kaufmann M, Koch T, Kroh LW.

J Agric Food Chem. 2018 Nov 7;66(44):11806-11811. doi: 10.1021/acs.jafc.8b03629. Epub 2018 Oct 26.


Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART.

Coindre S, Tchitchek N, Alaoui L, Vaslin B, Bourgeois C, Goujard C, Avettand-Fenoel V, Lecuroux C, Bruhns P, Le Grand R, Beignon AS, Lambotte O, Favier B; ANRS CO6 PRIMO Cohort.

Front Immunol. 2018 Jun 4;9:1217. doi: 10.3389/fimmu.2018.01217. eCollection 2018.


Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction.

Stackowicz J, Balbino B, Todorova B, Godon O, Iannascoli B, Jönsson F, Bruhns P, Reber LL.

Nat Commun. 2018 Jun 13;9(1):2304. doi: 10.1038/s41467-018-04688-6. No abstract available.


Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ; NASA study group, Chollet-Martin S, Longrois D, Gachet C, Bruhns P, Jönsson F.

Sci Immunol. 2018 Apr 13;3(22). pii: eaan5997. doi: 10.1126/sciimmunol.aan5997.


Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.

Gouel-Chéron A, de Chaisemartin L, Jönsson F, Nicaise-Roland P, Granger V, Sabahov A, Guinnepain MT, Chollet-Martin S, Bruhns P, Neukirch C, Longrois D; NASA study group.

Br J Anaesth. 2017 Nov 1;119(5):908-917. doi: 10.1093/bja/aex260.


Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173c. No abstract available.


Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring.

Eyer K, Doineau RCL, Castrillon CE, Briseño-Roa L, Menrath V, Mottet G, England P, Godina A, Brient-Litzler E, Nizak C, Jensen A, Griffiths AD, Bibette J, Bruhns P, Baudry J.

Nat Biotechnol. 2017 Oct;35(10):977-982. doi: 10.1038/nbt.3964. Epub 2017 Sep 11.


Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells.

Kerdiles YM, Almeida FF, Thompson T, Chopin M, Vienne M, Bruhns P, Huntington ND, Raulet DH, Nutt SL, Belz GT, Vivier E.

Immunity. 2017 Aug 15;47(2):199-200. doi: 10.1016/j.immuni.2017.07.026. No abstract available.


Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models.

Lathan R, Simon-Chazottes D, Jouvion G, Godon O, Malissen M, Flamand M, Bruhns P, Panthier JJ.

Sci Rep. 2017 Aug 2;7(1):7096. doi: 10.1038/s41598-017-07543-8.


IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.


Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide.

Reber LL, Gillis CM, Starkl P, Jönsson F, Sibilano R, Marichal T, Gaudenzio N, Bérard M, Rogalla S, Contag CH, Bruhns P, Galli SJ.

J Exp Med. 2017 May 1;214(5):1249-1258. doi: 10.1084/jem.20161238. Epub 2017 Apr 6.


In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

Gillis CM, Zenatti PP, Mancardi DA, Beutier H, Fiette L, Macdonald LE, Murphy AJ, Celli S, Bousso P, Jönsson F, Bruhns P.

J Autoimmun. 2017 Jun;80:95-102. doi: 10.1016/j.jaut.2016.09.009. Epub 2016 Oct 10.


The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.

Desnues B, Macedo AB, Ordoñez-Rueda D, Roussel-Queval A, Malissen B, Bruhns P, Malissen M, Alexopoulou L.

Eur J Immunol. 2016 Dec;46(12):2801-2811. doi: 10.1002/eji.201646573. Epub 2016 Oct 4.


Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.

Gillis CM, Jönsson F, Mancardi DA, Tu N, Beutier H, Van Rooijen N, Macdonald LE, Murphy AJ, Bruhns P.

J Allergy Clin Immunol. 2017 Apr;139(4):1253-1265.e14. doi: 10.1016/j.jaci.2016.06.058. Epub 2016 Aug 24.


Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis.

Balbino B, Sibilano R, Starkl P, Marichal T, Gaudenzio N, Karasuyama H, Bruhns P, Tsai M, Reber LL, Galli SJ.

J Allergy Clin Immunol. 2017 Feb;139(2):584-596.e10. doi: 10.1016/j.jaci.2016.05.047. Epub 2016 Jul 17.


Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites.

Demarta-Gatsi C, Smith L, Thiberge S, Peronet R, Commere PH, Matondo M, Apetoh L, Bruhns P, Ménard R, Mécheri S.

J Exp Med. 2016 Jul 25;213(8):1419-28. doi: 10.1084/jem.20151976. Epub 2016 Jul 18.


Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy.

Bruhns P, Teillaud JL.

Cancer Cell. 2016 Jun 13;29(6):771-773. doi: 10.1016/j.ccell.2016.05.009.


IgG subclasses determine pathways of anaphylaxis in mice.

Beutier H, Gillis CM, Iannascoli B, Godon O, England P, Sibilano R, Reber LL, Galli SJ, Cragg MS, Van Rooijen N, Mancardi DA, Bruhns P, Jönsson F.

J Allergy Clin Immunol. 2017 Jan;139(1):269-280.e7. doi: 10.1016/j.jaci.2016.03.028. Epub 2016 Apr 26.


Human IgG1 antibodies suppress angiogenesis in a target-independent manner.

Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J.

Signal Transduct Target Ther. 2016;1. pii: 15001. Epub 2016 Jan 28.


Molecular Rods Based on Oligo-spiro-thioketals.

Wessig P, Gerngroß M, Freyse D, Bruhns P, Przezdziak M, Schilde U, Kelling A.

J Org Chem. 2016 Feb 5;81(3):1125-36. doi: 10.1021/acs.joc.5b02670. Epub 2016 Jan 25.


Mouse and human FcR effector functions.

Bruhns P, Jönsson F.

Immunol Rev. 2015 Nov;268(1):25-51. doi: 10.1111/imr.12350. Review.


Shaping mycolactone for therapeutic use against inflammatory disorders.

Guenin-Macé L, Baron L, Chany AC, Tresse C, Saint-Auret S, Jönsson F, Le Chevalier F, Bruhns P, Bismuth G, Hidalgo-Lucas S, Bisson JF, Blanchard N, Demangel C.

Sci Transl Med. 2015 May 27;7(289):289ra85. doi: 10.1126/scitranslmed.aab0458.


Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization.

Domínguez-Soto A, de las Casas-Engel M, Bragado R, Medina-Echeverz J, Aragoneses-Fenoll L, Martín-Gayo E, van Rooijen N, Berraondo P, Toribio ML, Moro MA, Cuartero I, Castrillo A, Sancho D, Sánchez-Torres C, Bruhns P, Sánchez-Ramón S, Corbí AL.

J Immunol. 2014 Nov 15;193(10):5181-9. doi: 10.4049/jimmunol.1303375. Epub 2014 Oct 17.


Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.

Ben Mkaddem S, Hayem G, Jönsson F, Rossato E, Boedec E, Boussetta T, El Benna J, Launay P, Goujon JM, Benhamou M, Bruhns P, Monteiro RC.

J Clin Invest. 2014 Sep;124(9):3945-59. doi: 10.1172/JCI74572. Epub 2014 Jul 25.


A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy.

Turini M, Chames P, Bruhns P, Baty D, Kerfelec B.

Oncotarget. 2014 Jul 30;5(14):5304-19.


Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies.

Gillis C, Gouel-Chéron A, Jönsson F, Bruhns P.

Front Immunol. 2014 May 30;5:254. doi: 10.3389/fimmu.2014.00254. eCollection 2014. Review.


The function of Fcγ receptors in dendritic cells and macrophages.

Guilliams M, Bruhns P, Saeys Y, Hammad H, Lambrecht BN.

Nat Rev Immunol. 2014 Feb;14(2):94-108. doi: 10.1038/nri3582. Epub 2014 Jan 21. Review. Erratum in: Nat Rev Immunol. 2014 May;14(5):349.


Neutrophils mediate antibody-induced antitumor effects in mice.

Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P.

Blood. 2013 Oct 31;122(18):3160-4. doi: 10.1182/blood-2013-04-497446. Epub 2013 Aug 26.


Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines.

Hannani D, Locher C, Yamazaki T, Colin-Minard V, Vetizou M, Aymeric L, Viaud S, Sanchez D, Smyth MJ, Bruhns P, Kroemer G, Zitvogel L.

Cell Death Differ. 2014 Jan;21(1):50-8. doi: 10.1038/cdd.2013.60. Epub 2013 Jun 7.


Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions.

Jönsson F, Mancardi DA, Albanesi M, Bruhns P.

J Leukoc Biol. 2013 Oct;94(4):643-56. doi: 10.1189/jlb.1212623. Epub 2013 Mar 26. Review.


The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy.

Mancardi DA, Albanesi M, Jönsson F, Iannascoli B, Van Rooijen N, Kang X, England P, Daëron M, Bruhns P.

Blood. 2013 Feb 28;121(9):1563-73. doi: 10.1182/blood-2012-07-442541. Epub 2013 Jan 4.


Quorum sensing contributes to activated IgM-secreting B cell homeostasis.

Montaudouin C, Anson M, Hao Y, Duncker SV, Fernandez T, Gaudin E, Ehrenstein M, Kerr WG, Colle JH, Bruhns P, Daëron M, Freitas AA.

J Immunol. 2013 Jan 1;190(1):106-14. doi: 10.4049/jimmunol.1200907. Epub 2012 Dec 3.


Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.

Albanesi M, Mancardi DA, Macdonald LE, Iannascoli B, Zitvogel L, Murphy AJ, Daëron M, Leusen JH, Bruhns P.

J Immunol. 2012 Dec 15;189(12):5513-7. doi: 10.4049/jimmunol.1201511. Epub 2012 Nov 12. Erratum in: J Immunol. 2013 Feb 1;190(3):1381. Daëron, Marc [added].


Autonomous phagosomal degradation and antigen presentation in dendritic cells.

Hoffmann E, Kotsias F, Visentin G, Bruhns P, Savina A, Amigorena S.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14556-61. doi: 10.1073/pnas.1203912109. Epub 2012 Aug 20.


Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA.

Fang Y, Larsson L, Bruhns P, Xiang Z.

Allergy. 2012 Oct;67(10):1233-40. doi: 10.1111/j.1398-9995.2012.02878.x.. Epub 2012 Jul 30.


A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.

Ordoñez-Rueda D, Jönsson F, Mancardi DA, Zhao W, Malzac A, Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Méresse S, Duprez E, Bruhns P, Malissen B, Malissen M.

Eur J Immunol. 2012 Sep;42(9):2395-408. doi: 10.1002/eji.201242589.


Properties of mouse and human IgG receptors and their contribution to disease models.

Bruhns P.

Blood. 2012 Jun 14;119(24):5640-9. doi: 10.1182/blood-2012-01-380121. Epub 2012 Apr 25. Review.


Human FcγRIIA induces anaphylactic and allergic reactions.

Jönsson F, Mancardi DA, Zhao W, Kita Y, Iannascoli B, Khun H, van Rooijen N, Shimizu T, Schwartz LB, Daëron M, Bruhns P.

Blood. 2012 Mar 15;119(11):2533-44. doi: 10.1182/blood-2011-07-367334. Epub 2011 Dec 2.


[An unexpected role for neutrophils in anaphylaxis].

Jönsson F, Mancardi DA, Daëron M, Bruhns P.

Med Sci (Paris). 2011 Oct;27(10):823-5. doi: 10.1051/medsci/20112710010. Epub 2011 Oct 21. French. No abstract available.


A strain of Lactobacillus casei inhibits the effector phase of immune inflammation.

Schiffer C, Lalanne AI, Cassard L, Mancardi DA, Malbec O, Bruhns P, Dif F, Daëron M.

J Immunol. 2011 Sep 1;187(5):2646-55. doi: 10.4049/jimmunol.1002415. Epub 2011 Aug 1.


Mouse and human neutrophils induce anaphylaxis.

Jönsson F, Mancardi DA, Kita Y, Karasuyama H, Iannascoli B, Van Rooijen N, Shimizu T, Daëron M, Bruhns P.

J Clin Invest. 2011 Apr;121(4):1484-96. doi: 10.1172/JCI45232. Epub 2011 Mar 23.


Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms.

Araujo LM, Chauvineau A, Zhu R, Diem S, Bourgeois EA, Levescot A, Huerre M, Gombert JM, Bayry J, Daëron M, Bruhns P, Kaveri SV, Herbelin A.

J Immunol. 2011 Mar 15;186(6):3289-93. doi: 10.4049/jimmunol.1003076. Epub 2011 Feb 11.


Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.

Mancardi DA, Jönsson F, Iannascoli B, Khun H, Van Rooijen N, Huerre M, Daëron M, Bruhns P.

J Immunol. 2011 Feb 15;186(4):1899-903. doi: 10.4049/jimmunol.1003642. Epub 2011 Jan 19.


Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.

Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa S, Eberl G.

J Exp Med. 2011 Jan 17;208(1):125-34. doi: 10.1084/jem.20100052. Epub 2010 Dec 20.


Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis.

Syam S, Mero P, Pham T, McIntosh CA, Bruhns P, Booth JW.

J Immunol. 2010 Mar 15;184(6):2966-73. doi: 10.4049/jimmunol.0900016. Epub 2010 Feb 12.


Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis.

Hudrisier D, Clemenceau B, Balor S, Daubeuf S, Magdeleine E, Daëron M, Bruhns P, Vié H.

J Immunol. 2009 Nov 15;183(10):6102-13. doi: 10.4049/jimmunol.0900821. Epub 2009 Oct 19.

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