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Items: 31

1.

Efficacy of Aminomethyl Spectinomycins against Complex Upper Respiratory Tract Bacterial Infections.

Iverson A, Meyer CJ, Vogel P, Waidyarachchi S, Das N, Bruhn DF, Poole A, Butler MM, Bowlin TL, Lee RE, Rosch JW.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02096-18. doi: 10.1128/AAC.02096-18. Print 2019 May.

PMID:
30858215
2.

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives.

Zhang M, Prior AM, Maddox MM, Shen WJ, Hevener KE, Bruhn DF, Lee RB, Singh AP, Reinicke J, Simmons CJ, Hurdle JG, Lee RE, Sun D.

ACS Omega. 2018 Dec 31;3(12):18343-18360. doi: 10.1021/acsomega.8b03174. Epub 2018 Dec 26.

3.

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE.

ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. Epub 2016 Nov 11.

4.

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models.

Robertson GT, Scherman MS, Bruhn DF, Liu J, Hastings C, McNeil MR, Butler MM, Bowlin TL, Lee RB, Lee RE, Lenaerts AJ.

J Antimicrob Chemother. 2017 Mar 1;72(3):770-777. doi: 10.1093/jac/dkw467.

5.

Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives.

Lin H, Bruhn DF, Maddox MM, Singh AP, Lee RE, Sun D.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):4070-6. doi: 10.1016/j.bmcl.2016.06.075. Epub 2016 Jun 27.

6.

Design, synthesis and microbiological evaluation of ampicillin-tetramic acid hybrid antibiotics.

Cherian PT, Deshpande A, Cheramie MN, Bruhn DF, Hurdle JG, Lee RE.

J Antibiot (Tokyo). 2017 Jan;70(1):65-72. doi: 10.1038/ja.2016.52. Epub 2016 May 18.

7.

Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.

Rakesh, Bruhn DF, Scherman MS, Singh AP, Yang L, Liu J, Lenaerts AJ, Lee RE.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):388-391. doi: 10.1016/j.bmcl.2015.12.002. Epub 2015 Dec 7.

8.

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.

Bruhn DF, Wyllie S, Rodríguez-Cortés A, Carrillo AK, Rakesh, Guy RK, Fairlamb AH, Lee RE.

J Antimicrob Chemother. 2016 Apr;71(4):956-63. doi: 10.1093/jac/dkv417. Epub 2015 Dec 18.

9.

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria.

Yao J, Bruhn DF, Frank MW, Lee RE, Rock CO.

J Biol Chem. 2016 Jan 1;291(1):171-81. doi: 10.1074/jbc.M115.699462. Epub 2015 Nov 13.

10.

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.

Bruhn DF, Scherman MS, Liu J, Scherbakov D, Meibohm B, Böttger EC, Lenaerts AJ, Lee RE.

Sci Rep. 2015 Sep 14;5:13985. doi: 10.1038/srep13985.

11.

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE.

Sci Transl Med. 2015 May 20;7(288):288ra75. doi: 10.1126/scitranslmed.3010572.

12.

Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.

Feng L, Maddox MM, Alam MZ, Tsutsumi LS, Narula G, Bruhn DF, Wu X, Sandhaus S, Lee RB, Simmons CJ, Tse-Dinh YC, Hurdle JG, Lee RE, Sun D.

J Med Chem. 2014 Oct 23;57(20):8398-420. doi: 10.1021/jm500853v. Epub 2014 Oct 7.

13.

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.

Rakesh, Bruhn DF, Scherman MS, Woolhiser LK, Madhura DB, Maddox MM, Singh AP, Lee RB, Hurdle JG, McNeil MR, Lenaerts AJ, Meibohm B, Lee RE.

PLoS One. 2014 Feb 5;9(2):e87909. doi: 10.1371/journal.pone.0087909. eCollection 2014.

14.

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ.

Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26.

15.

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents.

Shen L, Maddox MM, Adhikari S, Bruhn DF, Kumar M, Lee RE, Hurdle JG, Lee RE, Sun D.

J Antibiot (Tokyo). 2013 Jun;66(6):319-25. doi: 10.1038/ja.2013.21. Epub 2013 Apr 3.

16.

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.

North EJ, Scherman MS, Bruhn DF, Scarborough JS, Maddox MM, Jones V, Grzegorzewicz A, Yang L, Hess T, Morisseau C, Jackson M, McNeil MR, Lee RE.

Bioorg Med Chem. 2013 May 1;21(9):2587-99. doi: 10.1016/j.bmc.2013.02.028. Epub 2013 Feb 26.

17.

Three mitochondrial DNA polymerases are essential for kinetoplast DNA replication and survival of bloodstream form Trypanosoma brucei.

Bruhn DF, Sammartino MP, Klingbeil MM.

Eukaryot Cell. 2011 Jun;10(6):734-43. doi: 10.1128/EC.05008-11. Epub 2011 Apr 29.

18.

Silencing of a putative inner arm dynein heavy chain results in flagellar immotility in Trypanosoma brucei.

Springer AL, Bruhn DF, Kinzel KW, Rosenthal NF, Zukas R, Klingbeil MM.

Mol Biochem Parasitol. 2011 Jan;175(1):68-75. doi: 10.1016/j.molbiopara.2010.09.005. Epub 2010 Oct 1.

19.

Mitochondrial DNA polymerase POLIB is essential for minicircle DNA replication in African trypanosomes.

Bruhn DF, Mozeleski B, Falkin L, Klingbeil MM.

Mol Microbiol. 2010 Mar;75(6):1414-25. doi: 10.1111/j.1365-2958.2010.07061.x. Epub 2009 Feb 1.

20.

Evaluation of a GFP reporter gene construct for environmental arsenic detection.

Roberto FF, Barnes JM, Bruhn DF.

Talanta. 2002 Aug 16;58(1):181-8.

PMID:
18968744
21.

Surfactin production from potato process effluent by Bacillus subtilis in a chemostat.

Noah KS, Bruhn DF, Bala GA.

Appl Biochem Biotechnol. 2005 Spring;121-124:465-73.

PMID:
15920256
22.

Characterization of surfactin from Bacillus subtilis for application as an agent for enhanced oil recovery.

Schaller KD, Fox SL, Bruhn DF, Noah KS, Bala GA.

Appl Biochem Biotechnol. 2004 Spring;113-116:827-36.

PMID:
15054235
23.

Development of continuous surfactin production from potato process effluent by Bacillus subtilis in an airlift reactor.

Noah KS, Fox SL, Bruhn DF, Thompson DN, Bala GA.

Appl Biochem Biotechnol. 2002 Spring;98-100:803-13.

PMID:
12018303
24.

Attached and unattached bacterial communities in a 120-meter corehole in an acidic, crystalline rock aquifer.

Lehman RM, Roberto FF, Earley D, Bruhn DF, Brink SE, O'Connell SP, Delwiche ME, Colwell FS.

Appl Environ Microbiol. 2001 May;67(5):2095-106.

25.

Evaluation of a fluorescent lectin-based staining technique for some acidophilic mining bacteria.

Fife DJ, Bruhn DF, Miller KS, Stoner DL.

Appl Environ Microbiol. 2000 May;66(5):2208-10.

26.

The arsenical resistance operon of IncN plasmid R46.

Bruhn DF, Li J, Silver S, Roberto F, Rosen BP.

FEMS Microbiol Lett. 1996 Jun 1;139(2-3):149-53.

PMID:
8674982
27.

Characterization of a new bacteriophage which infects bacteria of the genus Acidiphilium.

Ward TE, Bruhn DF, Shean ML, Watkins CS, Bulmer D, Winston V.

J Gen Virol. 1993 Nov;74 ( Pt 11):2419-25.

PMID:
8245857
28.

Selenate reduction by bacteria from a selenium-rich environment.

Maiers DT, Wichlacz PL, Thompson DL, Bruhn DF.

Appl Environ Microbiol. 1988 Oct;54(10):2591-3.

29.

Stillbirth. A humanistic response.

Bruhn DF, Bruhn P.

J Reprod Med. 1984 Feb;29(2):107-12.

PMID:
6708026
30.

ISOTOPIC PLACENTOGRAPHY. AN EVALUATION OF ITS ACCURACY AND SAFETY.

WEINBERG A, SHAPIRO G, BRUHN DF.

Am J Obstet Gynecol. 1963 Sep 15;87:203-9. No abstract available.

PMID:
14077615
31.

Progressive pseudohypertrophic muscular dystrophy complicated by pregnancy. Report of a case.

BRUHN DF, LANSMAN HH, KAVA H, ELMALEH LR.

Obstet Gynecol. 1963 Apr;21:438-40. No abstract available.

PMID:
14016212

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