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Items: 43

1.

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy.

Vink CA, Counsell JR, Perocheau DP, Karda R, Buckley SMK, Brugman MH, Galla M, Schambach A, McKay TR, Waddington SN, Howe SJ.

Mol Ther. 2017 Aug 2;25(8):1790-1804. doi: 10.1016/j.ymthe.2017.04.028. Epub 2017 May 24.

2.

CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes.

Kooy-Winkelaar YM, Bouwer D, Janssen GM, Thompson A, Brugman MH, Schmitz F, de Ru AH, van Gils T, Bouma G, van Rood JJ, van Veelen PA, Mearin ML, Mulder CJ, Koning F, van Bergen J.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E980-E989. doi: 10.1073/pnas.1620036114. Epub 2017 Jan 3.

3.

Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms.

Wiekmeijer AS, Pike-Overzet K, Brugman MH, van Eggermond MC, Cordes M, de Haas EF, Li Y, Oole E, van IJcken WF, Egeler RM, Meijerink JP, Staal FJ.

Exp Hematol. 2016 Sep;44(9):838-849.e9. doi: 10.1016/j.exphem.2016.06.002. Epub 2016 Jun 11.

PMID:
27302866
4.

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.

Famili F, Brugman MH, Taskesen E, Naber BEA, Fodde R, Staal FJT.

Stem Cell Reports. 2016 May 10;6(5):652-659. doi: 10.1016/j.stemcr.2016.04.009.

5.

The functional relationship between hematopoietic stem cells and developing T lymphocytes.

Staal FJ, Wiekmeijer AS, Brugman MH, Pike-Overzet K.

Ann N Y Acad Sci. 2016 Apr;1370(1):36-44. doi: 10.1111/nyas.12995. Epub 2016 Jan 15. Review.

PMID:
26773328
6.

Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus.

Brugman MH, Wiekmeijer AS, van Eggermond M, Wolvers-Tettero I, Langerak AW, de Haas EF, Bystrykh LV, van Rood JJ, de Haan G, Fibbe WE, Staal FJ.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E6020-7. doi: 10.1073/pnas.1519118112. Epub 2015 Oct 19.

7.

Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.

Wiekmeijer AS, Pike-Overzet K, IJspeert H, Brugman MH, Wolvers-Tettero IL, Lankester AC, Bredius RG, van Dongen JJ, Fibbe WE, Langerak AW, van der Burg M, Staal FJ.

J Allergy Clin Immunol. 2016 Feb;137(2):517-526.e3. doi: 10.1016/j.jaci.2015.08.022. Epub 2015 Oct 4.

PMID:
26441229
8.

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance.

Kohlscheen S, Wintterle S, Schwarzer A, Kamp C, Brugman MH, Breuer DC, Büsche G, Baum C, Modlich U.

PLoS One. 2015 Jul 6;10(7):e0131866. doi: 10.1371/journal.pone.0131866. eCollection 2015.

9.

The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.

Schmitz F, Kooy-Winkelaar Y, Wiekmeijer AS, Brugman MH, Mearin ML, Mulder C, Chuva de Sousa Lopes S, Mummery CL, Staal FJ, van Bergen J, Koning F.

Gut. 2016 Aug;65(8):1269-78. doi: 10.1136/gutjnl-2014-308153. Epub 2015 May 12.

PMID:
25966995
10.

Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.

Wiekmeijer AS, Pike-Overzet K, Brugman MH, Salvatori DC, Egeler RM, Bredius RG, Fibbe WE, Staal FJ.

Biores Open Access. 2014 Jun 1;3(3):110-6. doi: 10.1089/biores.2014.0008.

11.

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis.

Holstege H, Pfeiffer W, Sie D, Hulsman M, Nicholas TJ, Lee CC, Ross T, Lin J, Miller MA, Ylstra B, Meijers-Heijboer H, Brugman MH, Staal FJ, Holstege G, Reinders MJ, Harkins TT, Levy S, Sistermans EA.

Genome Res. 2014 May;24(5):733-42. doi: 10.1101/gr.162131.113. Epub 2014 Apr 23.

12.

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.

Melief SM, Schrama E, Brugman MH, Tiemessen MM, Hoogduijn MJ, Fibbe WE, Roelofs H.

Stem Cells. 2013 Sep;31(9):1980-91. doi: 10.1002/stem.1432.

13.

Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.

Brugman MH, Suerth JD, Rothe M, Suerbaum S, Schambach A, Modlich U, Kustikova O, Baum C.

Hum Gene Ther Methods. 2013 Apr;24(2):68-79. doi: 10.1089/hgtb.2012.175. Epub 2013 Mar 14.

14.

Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents.

Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach A, Manns MP, Baum C, Modlich U, Ott M.

Hepatology. 2013 Jul;58(1):397-408. doi: 10.1002/hep.26204. Epub 2013 May 27.

PMID:
23258554
15.

Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.

Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, Yang M, Li Z, Schambach A, Heinz N, Gerdes S, Roeder I, Ha TC, Steinemann D, Schlegelberger B, Baum C.

Leukemia. 2013 Apr;27(5):1127-38. doi: 10.1038/leu.2012.355. Epub 2012 Dec 5.

PMID:
23212151
16.

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ.

PLoS Biol. 2012;10(11):e1001430. doi: 10.1371/journal.pbio.1001430. Epub 2012 Nov 20.

17.

Comprehensive investigation of parameter choice in viral integration site analysis and its effects on the gene annotations produced.

Huston MW, Brugman MH, Horsman S, Stubbs A, van der Spek P, Wagemaker G.

Hum Gene Ther. 2012 Nov;23(11):1209-19. doi: 10.1089/hum.2011.037. Epub 2012 Sep 27.

PMID:
22909036
18.

Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches.

Roozen PP, Brugman MH, Staal FJ.

Ann N Y Acad Sci. 2012 Aug;1266:78-93. doi: 10.1111/j.1749-6632.2012.06626.x. Review.

PMID:
22901260
19.

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations.

Thol F, Kölking B, Damm F, Reinhardt K, Klusmann JH, Reinhardt D, von Neuhoff N, Brugman MH, Schlegelberger B, Suerbaum S, Krauter J, Ganser A, Heuser M.

Genes Chromosomes Cancer. 2012 Jul;51(7):689-95. doi: 10.1002/gcc.21955. Epub 2012 Mar 27.

PMID:
22454318
20.

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A.

Mol Ther. 2012 May;20(5):1022-32. doi: 10.1038/mt.2011.309. Epub 2012 Feb 14.

21.

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development.

Luis TC, Ichii M, Brugman MH, Kincade P, Staal FJ.

Leukemia. 2012 Mar;26(3):414-21. doi: 10.1038/leu.2011.387. Epub 2011 Dec 15. Review.

22.

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

Luis TC, Naber BA, Roozen PP, Brugman MH, de Haas EF, Ghazvini M, Fibbe WE, van Dongen JJ, Fodde R, Staal FJ.

Cell Stem Cell. 2011 Oct 4;9(4):345-56. doi: 10.1016/j.stem.2011.07.017.

23.

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

Deichmann A, Brugman MH, Bartholomae CC, Schwarzwaelder K, Verstegen MM, Howe SJ, Arens A, Ott MG, Hoelzer D, Seger R, Grez M, Hacein-Bey-Abina S, Cavazzana-Calvo M, Fischer A, Paruzynski A, Gabriel R, Glimm H, Abel U, Cattoglio C, Mavilio F, Cassani B, Aiuti A, Dunbar CE, Baum C, Gaspar HB, Thrasher AJ, von Kalle C, Schmidt M, Wagemaker G.

Mol Ther. 2011 Nov;19(11):2031-9. doi: 10.1038/mt.2011.178. Epub 2011 Aug 23.

24.

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.

Huston MW, van Til NP, Visser TP, Arshad S, Brugman MH, Cattoglio C, Nowrouzi A, Li Y, Schambach A, Schmidt M, Baum C, von Kalle C, Mavilio F, Zhang F, Blundell MP, Thrasher AJ, Verstegen MM, Wagemaker G.

Mol Ther. 2011 Oct;19(10):1867-77. doi: 10.1038/mt.2011.127. Epub 2011 Jul 12.

25.

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery.

Galla M, Schambach A, Falk CS, Maetzig T, Kuehle J, Lange K, Zychlinski D, Heinz N, Brugman MH, Göhring G, Izsvák Z, Ivics Z, Baum C.

Nucleic Acids Res. 2011 Sep 1;39(16):7147-60. doi: 10.1093/nar/gkr384. Epub 2011 May 23. Erratum in: Nucleic Acids Res. 2012 Jan;40(2):939.

26.

Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.

Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Büsche G, Ganser A, Stripecke R.

Gene Ther. 2011 Aug;18(8):750-64. doi: 10.1038/gt.2011.15. Epub 2011 Mar 17.

27.

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.

Heckl D, Wicke DC, Brugman MH, Meyer J, Schambach A, Büsche G, Ballmaier M, Baum C, Modlich U.

Blood. 2011 Apr 7;117(14):3737-47. doi: 10.1182/blood-2010-09-308262. Epub 2011 Feb 2.

28.

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

Warlich E, Kuehle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Schöler HR, Baum C, Schroeder T, Schambach A.

Mol Ther. 2011 Apr;19(4):782-9. doi: 10.1038/mt.2010.314. Epub 2011 Feb 1.

29.

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Maetzig T, Brugman MH, Bartels S, Heinz N, Kustikova OS, Modlich U, Li Z, Galla M, Schiedlmeier B, Schambach A, Baum C.

Blood. 2011 Mar 17;117(11):3053-64. doi: 10.1182/blood-2010-08-303222. Epub 2011 Jan 19.

30.

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

Ng YY, Baert MR, Pike-Overzet K, Rodijk M, Brugman MH, Schambach A, Baum C, Hendriks RW, van Dongen JJ, Staal FJ.

Leukemia. 2010 Sep;24(9):1617-30. doi: 10.1038/leu.2010.140. Epub 2010 Jun 24.

PMID:
20574453
31.

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.

Maetzig T, Galla M, Brugman MH, Loew R, Baum C, Schambach A.

Gene Ther. 2010 Mar;17(3):400-11. doi: 10.1038/gt.2009.129. Epub 2009 Oct 22.

PMID:
19847204
32.

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH, Schambach A, Charrier S, Galy A, Thrasher AJ, Bueren J, Baum C.

Mol Ther. 2009 Nov;17(11):1919-28. doi: 10.1038/mt.2009.179. Epub 2009 Aug 11.

33.

Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.

Kustikova OS, Schiedlmeier B, Brugman MH, Stahlhut M, Bartels S, Li Z, Baum C.

Mol Ther. 2009 Sep;17(9):1537-47. doi: 10.1038/mt.2009.134. Epub 2009 Jun 16.

34.

Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.

Cornils K, Lange C, Schambach A, Brugman MH, Nowak R, Lioznov M, Baum C, Fehse B.

Mol Ther. 2009 Jan;17(1):131-43. doi: 10.1038/mt.2008.238. Epub 2008 Nov 11.

35.

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.

Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike-Overzet K, Chatters SJ, de Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von Kalle C, Gaspar HB, Thrasher AJ.

J Clin Invest. 2008 Sep;118(9):3143-50. doi: 10.1172/JCI35798.

36.

Resistance of mature T cells to oncogene transformation.

Newrzela S, Cornils K, Li Z, Baum C, Brugman MH, Hartmann M, Meyer J, Hartmann S, Hansmann ML, Fehse B, von Laer D.

Blood. 2008 Sep 15;112(6):2278-86. doi: 10.1182/blood-2007-12-128751. Epub 2008 Jun 19.

37.

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z, Maetzig T, Rudolph C, Schlegelberger B, Baum C.

Leukemia. 2008 Aug;22(8):1519-28. doi: 10.1038/leu.2008.118. Epub 2008 May 22.

PMID:
18496560
38.

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.

Schwarzwaelder K, Howe SJ, Schmidt M, Brugman MH, Deichmann A, Glimm H, Schmidt S, Prinz C, Wissler M, King DJ, Zhang F, Parsley KL, Gilmour KC, Sinclair J, Bayford J, Peraj R, Pike-Overzet K, Staal FJ, de Ridder D, Kinnon C, Abel U, Wagemaker G, Gaspar HB, Thrasher AJ, von Kalle C.

J Clin Invest. 2007 Aug;117(8):2241-9.

39.

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.

Deichmann A, Hacein-Bey-Abina S, Schmidt M, Garrigue A, Brugman MH, Hu J, Glimm H, Gyapay G, Prum B, Fraser CC, Fischer N, Schwarzwaelder K, Siegler ML, de Ridder D, Pike-Overzet K, Howe SJ, Thrasher AJ, Wagemaker G, Abel U, Staal FJ, Delabesse E, Villeval JL, Aronow B, Hue C, Prinz C, Wissler M, Klanke C, Weissenbach J, Alexander I, Fischer A, von Kalle C, Cavazzana-Calvo M.

J Clin Invest. 2007 Aug;117(8):2225-32.

40.

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ.

Leukemia. 2007 Apr;21(4):754-63. Epub 2007 Feb 1.

PMID:
17268520
41.

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

Kustikova OS, Geiger H, Li Z, Brugman MH, Chambers SM, Shaw CA, Pike-Overzet K, de Ridder D, Staal FJ, von Keudell G, Cornils K, Nattamai KJ, Modlich U, Wagemaker G, Goodell MA, Fehse B, Baum C.

Blood. 2007 Mar 1;109(5):1897-907. Epub 2006 Nov 21.

42.

Gene therapy: is IL2RG oncogenic in T-cell development?

Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH, Howe SJ, Reinders MJ, Thrasher AJ, Wagemaker G, van Dongen JJ, Staal FJ.

Nature. 2006 Sep 21;443(7109):E5; discussion E6-7.

PMID:
16988660
43.

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.

Weerkamp F, Baert MR, Brugman MH, Dik WA, de Haas EF, Visser TP, de Groot CJ, Wagemaker G, van Dongen JJ, Staal FJ.

Blood. 2006 Apr 15;107(8):3131-7. Epub 2005 Dec 29.

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