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Items: 16


Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice.

Mulder CK, Dong Y, Brugghe HF, Timmermans HA, Tilstra W, Westdijk J, van Riet E, van Steeg H, Hoogerhout P, Eisel UL.

J Alzheimers Dis. 2016;52(3):1111-23. doi: 10.3233/JAD-151136.


A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques.

Hoogerhout P, Kamphuis W, Brugghe HF, Sluijs JA, Timmermans HA, Westdijk J, Zomer G, Boog CJ, Hol EM, van den Dobbelsteen GP.

PLoS One. 2011 Apr 19;6(4):e19110. doi: 10.1371/journal.pone.0019110.


Identification of formaldehyde-induced modifications in proteins: reactions with model peptides.

Metz B, Kersten GF, Hoogerhout P, Brugghe HF, Timmermans HA, de Jong A, Meiring H, ten Hove J, Hennink WE, Crommelin DJ, Jiskoot W.

J Biol Chem. 2004 Feb 20;279(8):6235-43. Epub 2003 Nov 24.


Identification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human CD4 T cells.

van Bleek GM, Poelen MC, van der Most R, Brugghe HF, Timmermans HA, Boog CJ, Hoogerhout P, Otten HG, van Els CA.

J Virol. 2003 Jan;77(2):980-8.


Intraocular T cells of patients with herpes simplex virus (HSV)-induced acute retinal necrosis recognize HSV tegument proteins VP11/12 and VP13/14.

Verjans GM, Dings ME, McLauchlan J, van Der Kooi A, Hoogerhout P, Brugghe HF, Timmermans HA, Baarsma GS, Osterhaus AD.

J Infect Dis. 2000 Sep;182(3):923-7. Epub 2000 Aug 17.


Solid-phase synthesis and application of double-fluorescent-labeled lipopeptides, containing a CTL-epitope from the measles fusion protein.

Hoogerhout P, Stittelaar KJ, Brugghe HF, Timmermans JA, ten Hove GJ, Jiskoot W, Hoekman JH, Roholl PJ.

J Pept Res. 1999 Nov;54(5):436-43.


Epitope specificity of murine and human bactericidal antibodies against PorA P1.7,16 induced with experimental meningococcal group B vaccines.

Rouppe van der Voort EM, Kuipers B, Brugghe HF, van Unen LM, Timmermans HA, Hoogerhout P, Poolman JT.

FEMS Immunol Med Microbiol. 1997 Mar;17(3):139-48.


T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins.

Wiertz EJ, Delvig A, Donders EM, Brugghe HF, van Unen LM, Timmermans HA, Achtman M, Hoogerhout P, Poolman JT.

Infect Immun. 1996 Jan;64(1):298-304.


Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis.

Hoogerhout P, Donders EM, van Gaans-van den Brink JA, Kuipers B, Brugghe HF, van Unen LM, Timmermans HA, ten Hove GJ, de Jong AP, Peeters CC, et al.

Infect Immun. 1995 Sep;63(9):3473-8.


Role of nucleotide excision repair in processing of O4-alkylthymines in human cells.

Klein JC, Bleeker MJ, Roelen HC, Rafferty JA, Margison GP, Brugghe HF, van den Elst H, van der Marel GA, van Boom JH, Kriek E, et al.

J Biol Chem. 1994 Oct 14;269(41):25521-8.


Simultaneous multiple synthesis and selective conjugation of cyclized peptides derived from a surface loop of a meningococcal class 1 outer membrane protein.

Brugghe HF, Timmermans HA, Van Unen LM, Ten Hove GJ, Van de Werken G, Poolman JT, Hoogerhout P.

Int J Pept Protein Res. 1994 Feb;43(2):166-72.


Human HLA class I- and HLA class II-restricted cloned cytotoxic T lymphocytes identify a cluster of epitopes on the measles virus fusion protein.

van Binnendijk RS, Versteeg-van Oosten JP, Poelen MC, Brugghe HF, Hoogerhout P, Osterhaus AD, Uytdehaag FG.

J Virol. 1993 Apr;67(4):2276-84.


Repair and replication of plasmids with site-specific 8-oxodG and 8-AAFdG residues in normal and repair-deficient human cells.

Klein JC, Bleeker MJ, Saris CP, Roelen HC, Brugghe HF, van den Elst H, van der Marel GA, van Boom JH, Westra JG, Kriek E, et al.

Nucleic Acids Res. 1992 Sep 11;20(17):4437-43.


Solid-phase synthesis of DNA fragments containing the modified base 7-hydro-8-oxo-2'-deoxyguanosine.

Roelen HC, Saris CP, Brugghe HF, van den Elst H, Westra JG, van der Marel GA, van Boom JH.

Nucleic Acids Res. 1991 Aug 25;19(16):4361-9.


Use of shuttle vectors to study the molecular processing of defined carcinogen-induced DNA damage: mutagenicity of single O4-ethylthymine adducts in HeLa cells.

Klein JC, Bleeker MJ, Lutgerink JT, van Dijk WJ, Brugghe HF, van den Elst H, van der Marel GA, van Boom JH, Westra JG, Berns AJ, et al.

Nucleic Acids Res. 1990 Jul 25;18(14):4131-7.


Solid-phase synthesis of a cell-wall component of Haemophilus (Actinobacillus) pleuropneumoniae serotype 2.

Veeneman GH, Brugghe HF, van den Elst H, van Boom JH.

Carbohydr Res. 1990 Jan 15;195(2):C1-4. No abstract available.


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