Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 225


Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages.

Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS.

Nat Commun. 2020 Apr 6;11(1):1711. doi: 10.1038/s41467-020-15548-7.


United They Stand, Divided They Fall.

Harris IS, Brugge JS.

Cell Metab. 2019 Oct 1;30(4):624-625. doi: 10.1016/j.cmet.2019.09.008.


Role for polo-like kinase 4 in mediation of cytokinesis.

Press MF, Xie B, Davenport S, Zhou Y, Guzman R, Nolan GP, O'Brien N, Palazzolo M, Mak TW, Brugge JS, Slamon DJ.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11309-11318. doi: 10.1073/pnas.1818820116. Epub 2019 May 16.


Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo.

Zoeller JJ, Vagodny A, Taneja K, Tan BY, O'Brien N, Slamon DJ, Sampath D, Leverson JD, Bronson RT, Dillon DA, Brugge JS.

Mol Cancer Ther. 2019 Jun;18(6):1115-1126. doi: 10.1158/1535-7163.MCT-18-0743. Epub 2019 Apr 8.


Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.

Bast RC Jr, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ Jr, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L.

Cancer. 2019 Jun 15;125(12):1963-1972. doi: 10.1002/cncr.32004. Epub 2019 Mar 5.


Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS.

Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21.


Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.

Iavarone C, Zervantonakis IK, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis UA, Hallberg D, Velculescu VE, Leverson JD, Sampath D, Mills GB, Brugge JS.

Mol Cancer Ther. 2019 Mar;18(3):642-655. doi: 10.1158/1535-7163.MCT-18-0413. Epub 2019 Jan 24.


CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.

Walker SJ, Selfors LM, Margolis BL, Brugge JS.

PLoS One. 2018 Nov 15;13(11):e0207470. doi: 10.1371/journal.pone.0207470. eCollection 2018.


Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS.

Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24.


Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.

Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG.

Elife. 2017 Dec 14;6. pii: e27293. doi: 10.7554/eLife.27293.


Identification of cancer genes that are independent of dominant proliferation and lineage programs.

Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11276-E11284. doi: 10.1073/pnas.1714877115. Epub 2017 Dec 11.


Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS.

NPJ Breast Cancer. 2017 Sep 22;3:38. doi: 10.1038/s41523-017-0031-9. eCollection 2017.


Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues.

Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P.

Nano Lett. 2017 Oct 11;17(10):6131-6139. doi: 10.1021/acs.nanolett.7b02716. Epub 2017 Oct 2.


Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS.

Nat Commun. 2017 Aug 28;8(1):365. doi: 10.1038/s41467-017-00263-7.


Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS.

NPJ Breast Cancer. 2017 May 1;3:18. doi: 10.1038/s41523-017-0020-z. eCollection 2017. Erratum in: NPJ Breast Cancer. 2017 Sep 22;3:38.


Metabolic changes promote rejection of oncogenic cells.

Coloff JL, Brugge JS.

Nat Cell Biol. 2017 Apr 27;19(5):414-415. doi: 10.1038/ncb3521.


Moving Closer To Victory.

Muranen T, Brugge JS.

Cold Spring Harb Symp Quant Biol. 2016;81:281-288. doi: 10.1101/sqb.2016.81.031179. Epub 2017 Apr 17. Review. No abstract available.


Starved epithelial cells uptake extracellular matrix for survival.

Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY.

Nat Commun. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989.


ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS.

Cancer Res. 2016 Dec 15;76(24):7168-7180. Epub 2016 Oct 20.


Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.

Clin Cancer Res. 2017 Mar 1;23(5):1263-1273. doi: 10.1158/1078-0432.CCR-16-1237. Epub 2016 Aug 29.


Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.

Iwanicki MP, Chen HY, Iavarone C, Zervantonakis IK, Muranen T, Novak M, Ince TA, Drapkin R, Brugge JS.

JCI Insight. 2016 Jul 7;1(10). pii: 86829. doi: 10.1172/jci.insight.86829.


The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

Stover DG, Coloff JL, Barry WT, Brugge JS, Winer EP, Selfors LM.

Clin Cancer Res. 2016 Dec 15;22(24):6039-6050. Epub 2016 Jun 21.


A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, Singh P, Dhakal S, Harper JW, Brugge JS.

Sci Rep. 2016 Jun 3;6:27114. doi: 10.1038/srep27114.


Coping with the metabolic stress of leaving home.

Coloff JL, Brugge JS.

Cell Res. 2016 Jul;26(7):757-8. doi: 10.1038/cr.2016.61. Epub 2016 May 24.


Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS.

Cell Metab. 2016 May 10;23(5):867-80. doi: 10.1016/j.cmet.2016.03.016. Epub 2016 Apr 28.


Corrigendum: Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2016 Apr 1;30(7):870. doi: 10.1101/gad.280453.116.


Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

Bui DA, Lee W, White AE, Harper JW, Schackmann RC, Overholtzer M, Selfors LM, Brugge JS.

Sci Signal. 2016 Mar 1;9(417):ra23. doi: 10.1126/scisignal.aaa9227.


Cancer: The enemy of my enemy is my friend.

Harris IS, Brugge JS.

Nature. 2015 Nov 12;527(7577):170-1. doi: 10.1038/nature15644. Epub 2015 Oct 21. No abstract available.


Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.

Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB.

Nat Commun. 2015 Jun 17;6:7419. doi: 10.1038/ncomms8419.


Signal transduction in cancer.

Sever R, Brugge JS.

Cold Spring Harb Perspect Med. 2015 Apr 1;5(4). pii: a006098. doi: 10.1101/cshperspect.a006098. Review.


Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

Ng MR, Besser A, Brugge JS, Danuser G.

Elife. 2015 Feb 2;4:e06656. doi: 10.7554/eLife.06656. No abstract available.


Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

Ng MR, Besser A, Brugge JS, Danuser G.

Elife. 2014 Dec 5;3:e03282. doi: 10.7554/eLife.03282. Erratum in: Elife. 2015;4:e06656.


Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis.

Gallegos LL, Brugge JS.

Dev Cell. 2014 Jul 14;30(1):3-4. doi: 10.1016/j.devcel.2014.06.031.


Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.

Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS.

J Clin Invest. 2014 Jun;124(6):2611-25. doi: 10.1172/JCI69815. Epub 2014 Apr 24.


Oncogene-like induction of cellular invasion from centrosome amplification.

Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D.

Nature. 2014 Jun 5;510(7503):167-71. doi: 10.1038/nature13277. Epub 2014 Apr 13.


Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG.

Breast Cancer Res. 2013;15(4):R65.


Chaperone-mediated autophagy degrades mutant p53.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113. Erratum in: Genes Dev. 2013 Sep 1;27(17):1947. Genes Dev. 2016 Apr 1;30(7):870.


PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.

Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS.

Cancer Cell. 2013 Jun 10;23(6):753-67. doi: 10.1016/j.ccr.2013.04.026.


Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.

Albeck JG, Mills GB, Brugge JS.

Mol Cell. 2013 Jan 24;49(2):249-61. doi: 10.1016/j.molcel.2012.11.002. Epub 2012 Dec 6.


Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.

Cancer Cell. 2012 Nov 13;22(5):615-30. doi: 10.1016/j.ccr.2012.09.027.


Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility.

Ng MR, Besser A, Danuser G, Brugge JS.

J Cell Biol. 2012 Oct 29;199(3):545-63. doi: 10.1083/jcb.201207148. Epub 2012 Oct 22.


Into the deep: Refocusing on 3D.

Brugge JS.

Nat Cell Biol. 2012 Apr 2;14(4):332. doi: 10.1038/ncb2470. No abstract available.


Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.

Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG.

Sci Signal. 2012 Mar 6;5(214):ra19. doi: 10.1126/scisignal.2001986.


In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis.

Davidowitz RA, Iwanicki MP, Brugge JS.

J Vis Exp. 2012 Feb 17;(60). pii: 3888. doi: 10.3791/3888.


Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.

Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS.

Cancer Cell. 2012 Feb 14;21(2):227-39. doi: 10.1016/j.ccr.2011.12.024.


Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.

Leung CT, Brugge JS.

Nature. 2012 Feb 8;482(7385):410-3. doi: 10.1038/nature10826.


Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.

Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Brugge JS.

Cancer Discov. 2011 Jul;1(2):144-57. doi: 10.1158/2159-8274.CD-11-0010. Erratum in: Cancer Discov. 2011 Dec;1(7):626. Ince, Tan [corrected to Ince, Tan A].


Extracellular matrix regulation of metabolism and implications for tumorigenesis.

Grassian AR, Coloff JL, Brugge JS.

Cold Spring Harb Symp Quant Biol. 2011;76:313-24. doi: 10.1101/sqb.2011.76.010967. Epub 2011 Nov 21. Review.


Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.

Wang L, Brugge JS, Janes KA.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):E803-12. doi: 10.1073/pnas.1103423108. Epub 2011 Aug 22.


Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS.

Genes Dev. 2011 Aug 15;25(16):1716-33. doi: 10.1101/gad.16771811.

Supplemental Content

Loading ...
Support Center