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Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury.

Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM.

Front Cardiovasc Med. 2019 Apr 2;6:31. doi: 10.3389/fcvm.2019.00031. eCollection 2019.


Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells.

Schnack L, Sohrabi Y, Lagache SMM, Kahles F, Bruemmer D, Waltenberger J, Findeisen HM.

Front Immunol. 2019 Jan 23;10:13. doi: 10.3389/fimmu.2019.00013. eCollection 2019.


mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes.

Sohrabi Y, Lagache SMM, Schnack L, Godfrey R, Kahles F, Bruemmer D, Waltenberger J, Findeisen HM.

Front Immunol. 2019 Jan 22;9:3155. doi: 10.3389/fimmu.2018.03155. eCollection 2018.


GLP-1 Receptor Agonist Exendin-4 Attenuates NR4A Orphan Nuclear Receptor NOR1 Expression in Vascular Smooth Muscle Cells.

Takahashi H, Nomiyama T, Terawaki Y, Kawanami T, Hamaguchi Y, Tanaka T, Tanabe M, Bruemmer D, Yanase T.

J Atheroscler Thromb. 2019 Feb 1;26(2):183-197. doi: 10.5551/jat.43414. Epub 2018 Jun 30.


Confirmatory Tests for the Diagnosis of Primary Aldosteronism: A Prospective Diagnostic Accuracy Study.

Song Y, Yang S, He W, Hu J, Cheng Q, Wang Y, Luo T, Ma L, Zhen Q, Zhang S, Mei M, Wang Z, Qing H, Bruemmer D, Peng B, Li Q; Chongqing Primary Aldosteronism Study (CONPASS) Group†.

Hypertension. 2018 Jan;71(1):118-124. doi: 10.1161/HYPERTENSIONAHA.117.10197. Epub 2017 Nov 20.


Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation.

Qing H, Jones KL, Heywood EB, Lu H, Daugherty A, Bruemmer D.

BMC Cardiovasc Disord. 2017 Oct 18;17(1):271. doi: 10.1186/s12872-017-0701-4.


Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes.

Endorf EB, Qing H, Aono J, Terami N, Doyon G, Hyzny E, Jones KL, Findeisen HM, Bruemmer D.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):301-311. doi: 10.1161/ATVBAHA.116.308717. Epub 2016 Dec 8. Erratum in: Arterioscler Thromb Vasc Biol. 2017 May;37(5):e58.


Vascular smooth muscle cell dysfunction in diabetes: nuclear receptors channel to relaxation.

Doyon G, Bruemmer D.

Clin Sci (Lond). 2016 Oct 1;130(20):1837-9. doi: 10.1042/CS20160518.


AP2-NR4A3 transgenic mice display reduced serum epinephrine because of increased catecholamine catabolism in adipose tissue.

Walton RG, Zhu X, Tian L, Heywood EB, Liu J, Hill HS, Liu J, Bruemmer D, Yang Q, Fu Y, Garvey WT.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E69-81. doi: 10.1152/ajpendo.00330.2015. Epub 2016 May 10.


Telomerase Inhibition by Everolimus Suppresses Smooth Muscle Cell Proliferation and Neointima Formation Through Epigenetic Gene Silencing.

Aono J, Ruiz-Rodriguez E, Qing H, Findeisen HM, Jones KL, Heywood EB, Bruemmer D.

JACC Basic Transl Sci. 2016 Jan-Feb;1(1-2):49-60.


Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition.

Qing H, Aono J, Findeisen HM, Jones KL, Heywood EB, Bruemmer D.

J Cell Physiol. 2016 Jun;231(6):1276-82. doi: 10.1002/jcp.25226. Epub 2015 Nov 16.


DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.

Medunjanin S, Daniel JM, Weinert S, Dutzmann J, Burgbacher F, Brecht S, Bruemmer D, Kähne T, Naumann M, Sedding DG, Zuschratter W, Braun-Dullaeus RC.

Cardiovasc Res. 2015 Jun 1;106(3):488-97. doi: 10.1093/cvr/cvv126. Epub 2015 Apr 7.


PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.

Lehrke M, Kahles F, Makowska A, Tilstam PV, Diebold S, Marx J, Stöhr R, Hess K, Endorf EB, Bruemmer D, Marx N, Findeisen HM.

J Mol Cell Cardiol. 2015 Apr;81:23-33. doi: 10.1016/j.yjmcc.2015.01.015. Epub 2015 Jan 30.


Epigenetic regulation of the NR4A orphan nuclear receptor NOR1 by histone acetylation.

Zhao Y, Nomiyama T, Findeisen HM, Qing H, Aono J, Jones KL, Heywood EB, Bruemmer D.

FEBS Lett. 2014 Dec 20;588(24):4825-30. doi: 10.1016/j.febslet.2014.11.017. Epub 2014 Nov 21.


Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.

Kahles F, Findeisen HM, Bruemmer D.

Mol Metab. 2014 Mar 22;3(4):384-93. doi: 10.1016/j.molmet.2014.03.004. eCollection 2014 Jul. Review.


Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis.

Qing H, Liu Y, Zhao Y, Aono J, Jones KL, Heywood EB, Howatt D, Binkley CM, Daugherty A, Liang Y, Bruemmer D.

Stem Cells. 2014 Sep;32(9):2419-29. doi: 10.1002/stem.1747.


Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content.

Garcia-Faroldi G, Melo FR, Bruemmer D, Conneely OM, Pejler G, Lundequist A.

PLoS One. 2014 Feb 20;9(2):e89311. doi: 10.1371/journal.pone.0089311. eCollection 2014.


Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.


Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.

Findeisen HM, Kahles FK, Bruemmer D.

Curr Atheroscler Rep. 2013 May;15(5):319. Review.


Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.

Findeisen HM, Kahles FK, Bruemmer D.

Curr Atheroscler Rep. 2013 Apr;15(4):319. doi: 10.1007/s11883-013-0319-7. Review.


Response to "Lack of evidence to support a beneficial role for glutathione depletion on body weight or glucose intolerance".

Findeisen HM, Bruemmer D.

Obesity (Silver Spring). 2013 Jan;21(1):3-4. doi: 10.1002/oby.20024. No abstract available.


Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.

Tachibana H, Ogawa D, Matsushita Y, Bruemmer D, Wada J, Teshigawara S, Eguchi J, Sato-Horiguchi C, Uchida HA, Shikata K, Makino H.

J Am Soc Nephrol. 2012 Nov;23(11):1835-46. doi: 10.1681/ASN.2012010022. Epub 2012 Oct 18.


Novel mechanisms of abdominal aortic aneurysms.

Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A.

Curr Atheroscler Rep. 2012 Oct;14(5):402-12. doi: 10.1007/s11883-012-0271-y. Review.


Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.

Lu H, Rateri DL, Bruemmer D, Cassis LA, Daugherty A.

Clin Sci (Lond). 2012 Nov;123(9):531-43. doi: 10.1042/CS20120097. Review.


Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.

Zhang X, Thatcher SE, Rateri DL, Bruemmer D, Charnigo R, Daugherty A, Cassis LA.

Circ Res. 2012 May 25;110(11):e73-85. doi: 10.1161/CIRCRESAHA.111.253880. Epub 2012 Apr 26.


Targeting angiogenesis as treatment for obesity.

Bruemmer D.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):161-2. doi: 10.1161/ATVBAHA.111.241992. No abstract available.


Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.

Bruemmer D, Daugherty A, Lu H, Rateri DL.

Ann N Y Acad Sci. 2011 Dec;1245:7-10. doi: 10.1111/j.1749-6632.2011.06332.x. Review.


Regulation of peroxisome proliferator-activated receptor-γ by angiotensin II via transforming growth factor-β1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells.

Subramanian V, Golledge J, Heywood EB, Bruemmer D, Daugherty A.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):397-405. doi: 10.1161/ATVBAHA.111.239897. Epub 2011 Nov 17.


Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity.

Findeisen HM, Gizard F, Zhao Y, Qing H, Jones KL, Cohn D, Heywood EB, Bruemmer D.

Obesity (Silver Spring). 2011 Dec;19(12):2429-32. doi: 10.1038/oby.2011.298. Epub 2011 Sep 29.


Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells.

Gizard F, Zhao Y, Findeisen HM, Qing H, Cohn D, Heywood EB, Jones KL, Nomiyama T, Bruemmer D.

J Biol Chem. 2011 Oct 14;286(41):35485-93. doi: 10.1074/jbc.M111.295840. Epub 2011 Aug 25.


Race-ethnicity as an effect modifier of the association between HbAlc and mortality in U.S. adults without diagnosed diabetes.

Kehl KG, Findeisen HM, Fardo DW, Bruemmer D, Mannino DM, Sanderson WT.

Eur J Endocrinol. 2011 Aug;165(2):275-81. doi: 10.1530/EJE-11-0171. Epub 2011 May 26.


Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis.

Findeisen HM, Pearson KJ, Gizard F, Zhao Y, Qing H, Jones KL, Cohn D, Heywood EB, de Cabo R, Bruemmer D.

PLoS One. 2011 Apr 14;6(4):e18532. doi: 10.1371/journal.pone.0018532.


Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.

Findeisen HM, Gizard F, Zhao Y, Qing H, Heywood EB, Jones KL, Cohn D, Bruemmer D.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):851-60. doi: 10.1161/ATVBAHA.110.221952. Epub 2011 Jan 13.


Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.

Habegger KM, Grant E, Pfluger PT, Perez-Tilve D, Daugherty A, Bruemmer D, Tschöp MH, Hofmann SM.

Front Endocrinol (Lausanne). 2011 Nov 2;2:67. doi: 10.3389/fendo.2011.00067. eCollection 2011.


Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages.

Gizard F, Heywood EB, Findeisen HM, Zhao Y, Jones KL, Cudejko C, Post GR, Staels B, Bruemmer D.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):245-52. doi: 10.1161/ATVBAHA.110.219808. Epub 2010 Nov 24.


Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation.

Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):253-60. doi: 10.1161/ATVBAHA.110.218545. Epub 2010 Nov 18.


Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.

Shridas P, Bailey WM, Gizard F, Oslund RC, Gelb MH, Bruemmer D, Webb NR.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):2014-21. doi: 10.1161/ATVBAHA.110.210237.


Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}.

Subramanian V, Golledge J, Ijaz T, Bruemmer D, Daugherty A.

Circ Res. 2010 Oct 15;107(8):953-8. doi: 10.1161/CIRCRESAHA.110.219089. Epub 2010 Aug 26.


NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology.

Zhao Y, Bruemmer D.

Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1535-41. doi: 10.1161/ATVBAHA.109.191163. Review.


Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke.

Zhang B, Chen L, Swartz KR, Bruemmer D, Eum SY, Huang W, Seelbach M, Choi YJ, Hennig B, Toborek M.

J Neurosci Res. 2010 Oct;88(13):2859-68. doi: 10.1002/jnr.22450.


Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.

Zhao Y, Howatt DA, Gizard F, Nomiyama T, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Daugherty A, Bruemmer D.

Circ Res. 2010 Aug 20;107(4):501-11. doi: 10.1161/CIRCRESAHA.110.222083. Epub 2010 Jun 17.


Intensive glycemic control and cardiovascular disease: an update.

Brown A, Reynolds LR, Bruemmer D.

Nat Rev Cardiol. 2010 Jul;7(7):369-75. doi: 10.1038/nrcardio.2010.35. Epub 2010 Apr 20. Review.


Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells.

Huang W, Rha GB, Chen L, Seelbach MJ, Zhang B, András IE, Bruemmer D, Hennig B, Toborek M.

Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1136-45. doi: 10.1152/ajpheart.01126.2009. Epub 2010 Feb 5.


A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. doi: 10.1038/nchembio.209. Epub 2009 Jul 13.


Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury.

Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D.

Circulation. 2009 Feb 3;119(4):577-86. doi: 10.1161/CIRCULATIONAHA.108.822056. Epub 2009 Jan 19.


NR4A Orphan Nuclear Receptors in Cardiovascular Biology.

Zhao Y, Bruemmer D.

Drug Discov Today Dis Mech. 2009;6(1-4):e43-e48.


The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.

Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D.

Circ Res. 2008 Nov 7;103(10):1155-63. doi: 10.1161/CIRCRESAHA.108.186205. Epub 2008 Sep 25.


Liver X receptors as therapeutic targets in metabolism and atherosclerosis.

Nomiyama T, Bruemmer D.

Curr Atheroscler Rep. 2008 Feb;10(1):88-95. Review.


Phosphorylated troglitazone activates PPARgamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis.

Little PJ, Ballinger ML, Survase S, Osman N, Ogru E, Geytenbeek S, Bruemmer D, Nigro J.

J Cardiovasc Pharmacol. 2008 Mar;51(3):274-9. doi: 10.1097/FJC.0b013e3181626ce7.


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