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Items: 25


Kv7 potassium channels as signal transduction intermediates in the control of microvascular tone.

Byron KL, Brueggemann LI.

Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12419. Review.


PKC-dependent regulation of Kv7.5 channels by the bronchoconstrictor histamine in human airway smooth muscle cells.

Haick JM, Brueggemann LI, Cribbs LL, Denning MF, Schwartz J, Byron KL.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L822-L834. doi: 10.1152/ajplung.00567.2016. Epub 2017 Mar 10.


New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.

Evans AE, Tripathi A, LaPorte HM, Brueggemann LI, Singh AK, Albee LJ, Byron KL, Tarasova NI, Volkman BF, Cho TY, Gaponenko V, Majetschak M.

Int J Mol Sci. 2016 Jun 20;17(5). pii: E971. doi: 10.3390/ijms17060971.


Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.

Mani BK, Robakowski C, Brueggemann LI, Cribbs LL, Tripathi A, Majetschak M, Byron KL.

Mol Pharmacol. 2016 Mar;89(3):323-34. doi: 10.1124/mol.115.101758. Epub 2015 Dec 23.


Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.

Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1659-68. doi: 10.1073/pnas.1417564112. Epub 2015 Mar 16.


Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.

Brueggemann LI, Haick JM, Cribbs LL, Byron KL.

Mol Pharmacol. 2014 Sep;86(3):330-41. doi: 10.1124/mol.114.093799. Epub 2014 Jun 18.


KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.

Brueggemann LI, Haick JM, Neuburg S, Tate S, Randhawa D, Cribbs LL, Byron KL.

Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L476-86. doi: 10.1152/ajplung.00253.2013. Epub 2014 Jan 17.


Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.

Brueggemann LI, Mackie AR, Cribbs LL, Freda J, Tripathi A, Majetschak M, Byron KL.

J Biol Chem. 2014 Jan 24;289(4):2099-111. doi: 10.1074/jbc.M113.527820. Epub 2013 Dec 2.


Social networking among voltage-activated potassium channels.

Brueggemann LI, Gentile S, Byron KL.

Prog Mol Biol Transl Sci. 2013;117:269-302. doi: 10.1016/B978-0-12-386931-9.00010-6. Review.


Vascular KCNQ (Kv7) potassium channels as common signaling intermediates and therapeutic targets in cerebral vasospasm.

Mani BK, O'Dowd J, Kumar L, Brueggemann LI, Ross M, Byron KL.

J Cardiovasc Pharmacol. 2013 Jan;61(1):51-62. doi: 10.1097/FJC.0b013e3182771708.


Exploring arterial smooth muscle Kv7 potassium channel function using patch clamp electrophysiology and pressure myography.

Brueggemann LI, Mani BK, Haick J, Byron KL.

J Vis Exp. 2012 Sep 14;(67):e4263. doi: 10.3791/4263.


Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.

Brueggemann LI, Kakad PP, Love RB, Solway J, Dowell ML, Cribbs LL, Byron KL.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L120-32. doi: 10.1152/ajplung.00194.2011. Epub 2011 Sep 30.


Activation of vascular KCNQ (Kv7) potassium channels reverses spasmogen-induced constrictor responses in rat basilar artery.

Mani BK, Brueggemann LI, Cribbs LL, Byron KL.

Br J Pharmacol. 2011 Sep;164(2):237-49. doi: 10.1111/j.1476-5381.2011.01273.x.


Diclofenac distinguishes among homomeric and heteromeric potassium channels composed of KCNQ4 and KCNQ5 subunits.

Brueggemann LI, Mackie AR, Martin JL, Cribbs LL, Byron KL.

Mol Pharmacol. 2011 Jan;79(1):10-23. doi: 10.1124/mol.110.067496. Epub 2010 Sep 28.


Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles.

Brueggemann LI, Mackie AR, Mani BK, Cribbs LL, Byron KL.

Mol Pharmacol. 2009 Nov;76(5):1053-61. doi: 10.1124/mol.109.057844. Epub 2009 Jul 15.


Labour pains: giving birth to new mechanisms for the regulation of myometrial contractility.

Byron KL, Brueggemann LI.

J Physiol. 2009 May 15;587(Pt 10):2109-10. doi: 10.1113/jphysiol.2009.173641. No abstract available.


Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells.

Mani BK, Brueggemann LI, Cribbs LL, Byron KL.

Cell Calcium. 2009 Apr;45(4):400-11. doi: 10.1016/j.ceca.2009.01.004. Epub 2009 Feb 25.


Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.

Mackie AR, Brueggemann LI, Henderson KK, Shiels AJ, Cribbs LL, Scrogin KE, Byron KL.

J Pharmacol Exp Ther. 2008 May;325(2):475-83. doi: 10.1124/jpet.107.135764. Epub 2008 Feb 13.


Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells.

Brueggemann LI, Moran CJ, Barakat JA, Yeh JZ, Cribbs LL, Byron KL.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1352-63. Epub 2006 Oct 27.


Pharmacological and electrophysiological characterization of store-operated currents and capacitative Ca(2+) entry in vascular smooth muscle cells.

Brueggemann LI, Markun DR, Henderson KK, Cribbs LL, Byron KL.

J Pharmacol Exp Ther. 2006 May;317(2):488-99. Epub 2006 Jan 13.


Evidence against reciprocal regulation of Ca2+ entry by vasopressin in A7r5 rat aortic smooth-muscle cells.

Brueggemann LI, Markun DR, Barakat JA, Chen H, Byron KL.

Biochem J. 2005 May 15;388(Pt 1):237-44.


Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking.

Brueggemann LI, Martin BL, Barakat J, Byron KL, Cribbs LL.

Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H923-35. Epub 2004 Oct 21.


HEK293S cells have functional retinoid processing machinery.

Brueggemann LI, Sullivan JM.

J Gen Physiol. 2002 Jun;119(6):593-612.


All-trans-retinal forms a visible-absorbing pigment with human rod opsin.

Brueggemann LI, Sullivan JM.

Biochemistry. 2001 Apr 10;40(14):4446-53.


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