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Items: 16


Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting.

Adams MR, Moody CT, Sollinger JL, Brudno Y.

Mol Pharm. 2019 Dec 27. doi: 10.1021/acs.molpharmaceut.9b00589. [Epub ahead of print]


Clickable, acid labile immunosuppressive prodrugs for in vivo targeting.

Wang H, Sobral MC, Snyder T, Brudno Y, Gorantla VS, Mooney DJ.

Biomater Sci. 2020 Jan 1;8(1):266-277. doi: 10.1039/c9bm01487j. Epub 2019 Nov 6.


Replenishable drug depot to combat post-resection cancer recurrence.

Brudno Y, Pezone MJ, Snyder TK, Uzun O, Moody CT, Aizenberg M, Mooney DJ.

Biomaterials. 2018 Sep;178:373-382. doi: 10.1016/j.biomaterials.2018.05.005. Epub 2018 May 6.


On-demand drug delivery from local depots.

Brudno Y, Mooney DJ.

J Control Release. 2015 Dec 10;219:8-17. doi: 10.1016/j.jconrel.2015.09.011. Epub 2015 Sep 14. Review.


In vivo targeting through click chemistry.

Brudno Y, Desai RM, Kwee BJ, Joshi NS, Aizenberg M, Mooney DJ.

ChemMedChem. 2015 Apr;10(4):617-20. doi: 10.1002/cmdc.201402527. Epub 2015 Feb 20.


Three-dimensional human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds.

Maione AG, Brudno Y, Stojadinovic O, Park LK, Smith A, Tellechea A, Leal EC, Kearney CJ, Veves A, Tomic-Canic M, Mooney DJ, Garlick JA.

Tissue Eng Part C Methods. 2015 May;21(5):499-508. doi: 10.1089/ten.TEC.2014.0414. Epub 2015 Mar 31.


Refilling drug delivery depots through the blood.

Brudno Y, Silva EA, Kearney CJ, Lewin SA, Miller A, Martinick KD, Aizenberg M, Mooney DJ.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12722-7. doi: 10.1073/pnas.1413027111. Epub 2014 Aug 19.


Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.

Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ.

Biomaterials. 2014 Aug;35(25):6850-6858. doi: 10.1016/j.biomaterials.2014.04.114. Epub 2014 May 23.


Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling.

Shvartsman D, Storrie-White H, Lee K, Kearney C, Brudno Y, Ho N, Cezar C, McCann C, Anderson E, Koullias J, Tapia JC, Vandenburgh H, Lichtman JW, Mooney DJ.

Mol Ther. 2014 Jul;22(7):1243-1253. doi: 10.1038/mt.2014.76. Epub 2014 Apr 28.


Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo.

Shamis Y, Silva EA, Hewitt KJ, Brudno Y, Levenberg S, Mooney DJ, Garlick JA.

PLoS One. 2013 Dec 30;8(12):e83755. doi: 10.1371/journal.pone.0083755. eCollection 2013.


Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors.

Brudno Y, Ennett-Shepard AB, Chen RR, Aizenberg M, Mooney DJ.

Biomaterials. 2013 Dec;34(36):9201-9. doi: 10.1016/j.biomaterials.2013.08.007. Epub 2013 Aug 22.


Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.

Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu XS, Ecker JR, Milos PM, Agarwal S, Rao A.

Nature. 2011 May 19;473(7347):394-7. doi: 10.1038/nature10102. Epub 2011 May 8.


An in vitro translation, selection and amplification system for peptide nucleic acids.

Brudno Y, Birnbaum ME, Kleiner RE, Liu DR.

Nat Chem Biol. 2010 Feb;6(2):148-55. doi: 10.1038/nchembio.280. Epub 2009 Dec 27.


Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.

Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A.

Science. 2009 May 15;324(5929):930-5. doi: 10.1126/science.1170116. Epub 2009 Apr 16.


Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.

Brudno Y, Liu DR.

Chem Biol. 2009 Mar 27;16(3):265-76. doi: 10.1016/j.chembiol.2009.02.004. Review.


DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes.

Kleiner RE, Brudno Y, Birnbaum ME, Liu DR.

J Am Chem Soc. 2008 Apr 9;130(14):4646-59. doi: 10.1021/ja0753997. Epub 2008 Mar 15.

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