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Harnessing Gut Microbes for Mental Health: Getting From Here to There.

Bruce-Keller AJ, Salbaum JM, Berthoud HR.

Biol Psychiatry. 2018 Feb 1;83(3):214-223. doi: 10.1016/j.biopsych.2017.08.014. Epub 2017 Aug 30. Review.


Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health.

Knott EJ, Richard AJ, Mynatt RL, Ribnicky D, Stephens JM, Bruce-Keller A.

Sci Rep. 2017 Oct 6;7(1):12770. doi: 10.1038/s41598-017-12846-x.


Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet.

Pepping JK, Vandanmagsar B, Fernandez-Kim SO, Zhang J, Mynatt RL, Bruce-Keller AJ.

PLoS One. 2017 Aug 3;12(8):e0181500. doi: 10.1371/journal.pone.0181500. eCollection 2017.


Understanding heterogeneity in older adults: Latent growth curve modeling of cognitive functioning.

MacAulay RK, Calamia MR, Cohen AS, Daigle K, Foil H, Brouillette R, Bruce-Keller AJ, Keller JN.

J Clin Exp Neuropsychol. 2018 Apr;40(3):292-302. doi: 10.1080/13803395.2017.1342772. Epub 2017 Jul 1.


Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion.

Qualls-Creekmore E, Yu S, Francois M, Hoang J, Huesing C, Bruce-Keller A, Burk D, Berthoud HR, Morrison CD, Münzberg H.

J Neurosci. 2017 Jun 21;37(25):6053-6065. doi: 10.1523/JNEUROSCI.0155-17.2017. Epub 2017 May 24.


Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice.

Bruce-Keller AJ, Fernandez-Kim SO, Townsend RL, Kruger C, Carmouche R, Newman S, Salbaum JM, Berthoud HR.

PLoS One. 2017 Apr 25;12(4):e0175577. doi: 10.1371/journal.pone.0175577. eCollection 2017.


Adipose-specific ablation of Nrf2 transiently delayed high-fat diet-induced obesity by altering glucose, lipid and energy metabolism of male mice.

Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

Am J Transl Res. 2016 Dec 15;8(12):5309-5319. eCollection 2016.


Apolipoprotein E Genotype Linked to Spatial Gait Characteristics: Predictors of Cognitive Dual Task Gait Change.

MacAulay RK, Allaire T, Brouillette R, Foil H, Bruce-Keller AJ, Keller JN.

PLoS One. 2016 Aug 3;11(8):e0156732. doi: 10.1371/journal.pone.0156732. eCollection 2016.


Elevated adiponectin prevents HIV protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice.

Dasuri K, Pepping JK, Fernandez-Kim SO, Gupta S, Keller JN, Scherer PE, Bruce-Keller AJ.

Biochim Biophys Acta. 2016 Jun;1862(6):1228-35. doi: 10.1016/j.bbadis.2016.02.009. Epub 2016 Feb 18.


Reply to: High-Fat Diet-Induced Dysbiosis as a Cause of Neuroinflammation.

Bruce-Keller AJ, Salbaum JM, Luo M, Blanchard E 4th, Taylor CM, Welsh DA, Berthoud HR.

Biol Psychiatry. 2016 Jul 1;80(1):e5-6. doi: 10.1016/j.biopsych.2015.11.006. Epub 2015 Nov 17. No abstract available.


Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain.

Dasuri K, Zhang L, Kim SO, Bruce-Keller AJ, Keller JN.

Biochim Biophys Acta. 2016 Feb;1862(2):274-83. doi: 10.1016/j.bbadis.2015.11.002. Epub 2015 Nov 10.


Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

Jensen BK, Monnerie H, Mannell MV, Gannon PJ, Espinoza CA, Erickson MA, Bruce-Keller AJ, Gelman BB, Briand LA, Pierce RC, Jordan-Sciutto KL, Grinspan JB.

J Neuropathol Exp Neurol. 2015 Nov;74(11):1093-118. doi: 10.1097/NEN.0000000000000255.


Effects of Ghrelin on the Proteolytic Pathways of Alzheimer's Disease Neuronal Cells.

Cecarini V, Bonfili L, Cuccioloni M, Keller JN, Bruce-Keller AJ, Eleuteri AM.

Mol Neurobiol. 2016 Jul;53(5):3168-3178. doi: 10.1007/s12035-015-9227-x. Epub 2015 Jun 2.


Longitudinal assessment of neuropsychological and temporal/spatial gait characteristics of elderly fallers: taking it all in stride.

MacAulay RK, Allaire TD, Brouillette RM, Foil HC, Bruce-Keller AJ, Han H, Johnson WD, Keller JN.

Front Aging Neurosci. 2015 Mar 18;7:34. doi: 10.3389/fnagi.2015.00034. eCollection 2015.


Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity.

Bruce-Keller AJ, Salbaum JM, Luo M, Blanchard E 4th, Taylor CM, Welsh DA, Berthoud HR.

Biol Psychiatry. 2015 Apr 1;77(7):607-15. doi: 10.1016/j.biopsych.2014.07.012. Epub 2014 Jul 18.


A longitudinal study on dual-tasking effects on gait: cognitive change predicts gait variance in the elderly.

MacAulay RK, Brouillette RM, Foil HC, Bruce-Keller AJ, Keller JN.

PLoS One. 2014 Jun 6;9(6):e99436. doi: 10.1371/journal.pone.0099436. eCollection 2014.


Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors.

Pepping JK, Otvos L Jr, Surmacz E, Gupta S, Keller JN, Bruce-Keller AJ.

J Neuroimmune Pharmacol. 2014 Jun;9(3):388-98. doi: 10.1007/s11481-014-9529-1. Epub 2014 Feb 23.


Feasibility, reliability, and validity of a smartphone based application for the assessment of cognitive function in the elderly.

Brouillette RM, Foil H, Fontenot S, Correro A, Allen R, Martin CK, Bruce-Keller AJ, Keller JN.

PLoS One. 2013 Jun 11;8(6):e65925. doi: 10.1371/journal.pone.0065925. Print 2013.


Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice.

Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett TL, Murphy MP, Keller JN.

Biochim Biophys Acta. 2013 Sep;1832(9):1456-62. doi: 10.1016/j.bbadis.2013.01.002. Epub 2013 Jan 9.


Leptin regulates amyloid β production via the γ-secretase complex.

Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP.

Biochim Biophys Acta. 2013 Mar;1832(3):439-44. doi: 10.1016/j.bbadis.2012.12.009. Epub 2012 Dec 26.


NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.

Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E392-404. doi: 10.1152/ajpendo.00398.2012. Epub 2012 Dec 11.


Obesity increases cerebrocortical reactive oxygen species and impairs brain function.

Freeman LR, Zhang L, Nair A, Dasuri K, Francis J, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

Free Radic Biol Med. 2013 Mar;56:226-33. doi: 10.1016/j.freeradbiomed.2012.08.577. Epub 2012 Oct 29.


Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome.

Dasuri K, Ebenezer P, Fernandez-Kim SO, Zhang L, Gao Z, Bruce-Keller AJ, Freeman LR, Keller JN.

Free Radic Res. 2013 Jan;47(1):8-19. doi: 10.3109/10715762.2012.733003. Epub 2012 Oct 16.


Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.

Freeman LR, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

PLoS One. 2012;7(8):e43193. doi: 10.1371/journal.pone.0043193. Epub 2012 Aug 17.


Brain injury caused by HIV protease inhibitors: role of lipodystrophy and insulin resistance.

Gupta S, Knight AG, Losso BY, Ingram DK, Keller JN, Bruce-Keller AJ.

Antiviral Res. 2012 Jul;95(1):19-29. doi: 10.1016/j.antiviral.2012.04.010. Epub 2012 May 9.


Relationship between cognitive domains, physical performance, and gait in elderly and demented subjects.

Bruce-Keller AJ, Brouillette RM, Tudor-Locke C, Foil HC, Gahan WP, Nye DM, Guillory L, Keller JN.

J Alzheimers Dis. 2012;30(4):899-908. doi: 10.3233/JAD-2012-120025.


Saturated long-chain fatty acids activate inflammatory signaling in astrocytes.

Gupta S, Knight AG, Gupta S, Keller JN, Bruce-Keller AJ.

J Neurochem. 2012 Mar;120(6):1060-71. doi: 10.1111/j.1471-4159.2012.07660.x. Epub 2012 Feb 6.


Assessment of cognition, physical performance, and gait in the context of mild cognitive impairment and dementia.

Bruce-Keller AJ, Brouillette RM, Tudor-Locke C, Foil HC, Gahan WP, Correa J, Nye DM, Keller JN.

J Am Geriatr Soc. 2012 Jan;60(1):176-7. doi: 10.1111/j.1532-5415.2011.03762.x. No abstract available.


Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress.

Dasuri K, Zhang L, Ebenezer P, Fernandez-Kim SO, Bruce-Keller AJ, Szweda LI, Keller JN.

Free Radic Biol Med. 2011 Nov 1;51(9):1727-35. doi: 10.1016/j.freeradbiomed.2011.08.001. Epub 2011 Aug 10.


Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.

Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN.

Neurobiol Dis. 2011 Dec;44(3):317-26. doi: 10.1016/j.nbd.2011.07.012. Epub 2011 Jul 28.


Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulation.

Dasuri K, Ebenezer PJ, Uranga RM, Gavilán E, Zhang L, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

J Neurosci Res. 2011 Sep;89(9):1471-7. doi: 10.1002/jnr.22677. Epub 2011 May 23.


Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function.

Zhang L, Ebenezer PJ, Dasuri K, Fernandez-Kim SO, Francis J, Mariappan N, Gao Z, Ye J, Bruce-Keller AJ, Keller JN.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E599-607. doi: 10.1152/ajpendo.00059.2011. Epub 2011 May 17.


Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice.

Pistell PJ, Gupta S, Knight AG, Domingue M, Uranga RM, Ingram DK, Kheterpal I, Ruiz C, Keller JN, Bruce-Keller AJ.

Antiviral Res. 2010 Dec;88(3):334-42. doi: 10.1016/j.antiviral.2010.10.006. Epub 2010 Oct 21.


Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress.

Ebenezer PJ, Weidner AM, LeVine H 3rd, Markesbery WR, Murphy MP, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Gavilán E, Keller JN.

J Alzheimers Dis. 2010;22(3):839-48. doi: 10.3233/JAD-2010-101161.


HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter.

Gupta S, Knight AG, Gupta S, Knapp PE, Hauser KF, Keller JN, Bruce-Keller AJ.

Neurosci Lett. 2010 Nov 26;485(3):233-6. doi: 10.1016/j.neulet.2010.09.019. Epub 2010 Sep 19.


Lessons in the study of Alzheimer's disease: a tribute to Dr. William R. Markesbery.

Bruce-Keller AJ, Keller JN.

Neuromolecular Med. 2011 Mar;13(1):11-4. doi: 10.1007/s12017-010-8127-5. Epub 2010 Jul 17. No abstract available.


High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling.

Morrison CD, Pistell PJ, Ingram DK, Johnson WD, Liu Y, Fernandez-Kim SO, White CL, Purpera MN, Uranga RM, Bruce-Keller AJ, Keller JN.

J Neurochem. 2010 Sep;114(6):1581-9. doi: 10.1111/j.1471-4159.2010.06865.x. Epub 2010 Jul 27.


Intersection between metabolic dysfunction, high fat diet consumption, and brain aging.

Uranga RM, Bruce-Keller AJ, Morrison CD, Fernandez-Kim SO, Ebenezer PJ, Zhang L, Dasuri K, Keller JN.

J Neurochem. 2010 Jul;114(2):344-61. doi: 10.1111/j.1471-4159.2010.06803.x. Epub 2010 May 6. Review.


NOX activity in brain aging: exacerbation by high fat diet.

Bruce-Keller AJ, White CL, Gupta S, Knight AG, Pistell PJ, Ingram DK, Morrison CD, Keller JN.

Free Radic Biol Med. 2010 Jul 1;49(1):22-30. doi: 10.1016/j.freeradbiomed.2010.03.006. Epub 2010 Mar 25.


Increased protein hydrophobicity in response to aging and Alzheimer disease.

Dasuri K, Ebenezer P, Zhang L, Fernandez-Kim SO, Bruce-Keller AJ, Markesbery WR, Keller JN.

Free Radic Biol Med. 2010 May 15;48(10):1330-7. doi: 10.1016/j.freeradbiomed.2010.02.012. Epub 2010 Feb 24.


Cognitive impairment following high fat diet consumption is associated with brain inflammation.

Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ.

J Neuroimmunol. 2010 Feb 26;219(1-2):25-32. doi: 10.1016/j.jneuroim.2009.11.010. Epub 2009 Dec 8.


NOX activity is increased in mild cognitive impairment.

Bruce-Keller AJ, Gupta S, Parrino TE, Knight AG, Ebenezer PJ, Weidner AM, LeVine H 3rd, Keller JN, Markesbery WR.

Antioxid Redox Signal. 2010 Jun 15;12(12):1371-82. doi: 10.1089/ars.2009.2823.


Estrogen receptor alpha inhibits the estrogen-mediated suppression of HIV transcription in astrocytes: implications for estrogen neuroprotection in HIV dementia.

Heron PM, Turchan-Cholewo J, Bruce-Keller AJ, Wilson ME.

AIDS Res Hum Retroviruses. 2009 Nov;25(11):1071-81. doi: 10.1089/aid.2009.0065.


Activation of PERK kinase in neural cells by proteasome inhibitor treatment.

Zhang L, Ebenezer PJ, Dasuri K, Bruce-Keller AJ, Fernandez-Kim SO, Liu Y, Keller JN.

J Neurochem. 2010 Jan;112(1):238-45. doi: 10.1111/j.1471-4159.2009.06448.x. Epub 2009 Oct 24.


Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.

Zhang L, Ebenezer PJ, Dasuri K, Bruce-Keller AJ, Liu Y, Keller JN.

J Neurosci Res. 2009 Nov 1;87(14):3231-8. doi: 10.1002/jnr.22147.


Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.

White CL, Pistell PJ, Purpera MN, Gupta S, Fernandez-Kim SO, Hise TL, Keller JN, Ingram DK, Morrison CD, Bruce-Keller AJ.

Neurobiol Dis. 2009 Jul;35(1):3-13. doi: 10.1016/j.nbd.2009.04.002. Epub 2009 Apr 15.


Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription.

El-Hage N, Bruce-Keller AJ, Yakovleva T, Bazov I, Bakalkin G, Knapp PE, Hauser KF.

PLoS One. 2008;3(12):e4093. doi: 10.1371/journal.pone.0004093. Epub 2008 Dec 31.


Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation.

Turchan-Cholewo J, Dimayuga FO, Gupta S, Keller JN, Knapp PE, Hauser KF, Bruce-Keller AJ.

J Neurochem. 2009 Jan;108(1):202-15. doi: 10.1111/j.1471-4159.2008.05756.x. Epub 2008 Nov 19.


Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction.

Dasuri K, Nguyen A, Zhang L, Fernandez-Kim OS, Bruce-Keller AJ, Blalock BA, Cabo RD, Keller JN.

Free Radic Res. 2009 Jan;43(1):28-36. doi: 10.1080/10715760802534812.


Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN.

J Neurochem. 2009 Feb;108(4):860-6. doi: 10.1111/j.1471-4159.2008.05798.x. Epub 2008 Nov 27.

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