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Items: 1 to 50 of 99

1.

The gasdermins, a protein family executing cell death and inflammation.

Broz P, Pelegrín P, Shao F.

Nat Rev Immunol. 2019 Nov 5. doi: 10.1038/s41577-019-0228-2. [Epub ahead of print] Review.

PMID:
31690840
2.

An integrative protocol for the structure determination of the mouse ASC-PYD filament.

Mazur A, Broz P, Hiller S.

Methods Enzymol. 2019;625:205-222. doi: 10.1016/bs.mie.2019.04.033. Epub 2019 May 20.

PMID:
31455528
3.

Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation.

Chen KW, Demarco B, Broz P.

Eur J Immunol. 2019 Aug 14. doi: 10.1002/eji.201948254. [Epub ahead of print]

PMID:
31411729
4.

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.

Demarco B, Chen KW, Broz P.

Mol Cell Oncol. 2019 May 7;6(4):1610324. doi: 10.1080/23723556.2019.1610324. eCollection 2019.

PMID:
31211242
5.

Safety and efficacy of outpatient endovenous laser ablation in patients 75 years and older: a propensity score-matched analysis.

Keo HH, Spinedi L, Staub D, Diehm N, Holtz D, Broz P, Uthoff H.

Swiss Med Wkly. 2019 Jun 2;149:w20083. doi: 10.4414/smw.2019.20083. eCollection 2019 May 20.

6.

NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.

Radulovic K, Ayata CK, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, Niess JH.

J Immunol. 2019 Jul 15;203(2):544-556. doi: 10.4049/jimmunol.1800938. Epub 2019 May 31.

PMID:
31152078
7.

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P.

EMBO J. 2019 May 15;38(10). pii: e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22.

PMID:
30902848
8.

Recognition of Intracellular Bacteria by Inflammasomes.

Broz P.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.BAI-0003-2019. Review.

PMID:
30848231
9.

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.

Chen KW, Boucher D, Broz P.

Cell Res. 2019 Mar;29(3):181-182. doi: 10.1038/s41422-018-0138-z. No abstract available.

PMID:
30664729
10.

High-sensitivity Troponins after a Standardized 2-hour Treadmill Run.

Broz P, Rajdl D, Novak J, Hromadka M, Racek J, Trefil L, Zeman V.

J Med Biochem. 2018 Jul 1;37(3):364-372. doi: 10.1515/jomb-2017-0055. eCollection 2018 Jul.

11.

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.

Cerqueira DM, Gomes MTR, Silva ALN, Rungue M, Assis NRG, Guimarães ES, Morais SB, Broz P, Zamboni DS, Oliveira SC.

PLoS Pathog. 2018 Dec 27;14(12):e1007519. doi: 10.1371/journal.ppat.1007519. eCollection 2018 Dec.

12.

A Surface-Induced Asymmetric Program Promotes Tissue Colonization by Pseudomonas aeruginosa.

Laventie BJ, Sangermani M, Estermann F, Manfredi P, Planes R, Hug I, Jaeger T, Meunier E, Broz P, Jenal U.

Cell Host Microbe. 2019 Jan 9;25(1):140-152.e6. doi: 10.1016/j.chom.2018.11.008. Epub 2018 Dec 20.

PMID:
30581112
13.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V.

Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087.

14.

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.

Rühl S, Shkarina K, Demarco B, Heilig R, Santos JC, Broz P.

Science. 2018 Nov 23;362(6417):956-960. doi: 10.1126/science.aar7607.

PMID:
30467171
15.

Global Ion Suppression Limits the Potential of Mass Spectrometry Based Phosphoproteomics.

Dreier RF, Ahrné E, Broz P, Schmidt A.

J Proteome Res. 2019 Jan 4;18(1):493-507. doi: 10.1021/acs.jproteome.8b00812. Epub 2018 Nov 12.

PMID:
30387612
16.

Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida.

Brodmann M, Heilig R, Broz P, Basler M.

Front Cell Infect Microbiol. 2018 Aug 31;8:284. doi: 10.3389/fcimb.2018.00284. eCollection 2018.

17.

Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K.

Sci Immunol. 2018 Aug 24;3(26). pii: eaar6676. doi: 10.1126/sciimmunol.aar6676.

PMID:
30143554
18.

Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.

Santos JC, Broz P.

J Leukoc Biol. 2018 Oct;104(4):729-735. doi: 10.1002/JLB.4MR0118-038R. Epub 2018 Jul 18. Review.

PMID:
30020539
19.

Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament.

Sborgi L, Ude J, Dick MS, Vesin J, Chambon M, Turcatti G, Broz P, Hiller S.

Cell Stress. 2018 Mar 21;2(4):82-90. doi: 10.15698/cst2018.04.131.

20.

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P.

EMBO J. 2018 Mar 15;37(6). pii: e98089. doi: 10.15252/embj.201798089. Epub 2018 Feb 19.

21.

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.

Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O.

Cell Rep. 2017 Dec 26;21(13):3846-3859. doi: 10.1016/j.celrep.2017.12.018.

22.

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice.

Heilig R, Dick MS, Sborgi L, Meunier E, Hiller S, Broz P.

Eur J Immunol. 2018 Apr;48(4):584-592. doi: 10.1002/eji.201747404. Epub 2018 Jan 15.

23.

Mechanisms and Consequences of Inflammasome Activation.

Schroder K, Kanneganti TD, Shao F, Broz P.

J Mol Biol. 2018 Jan 19;430(2):131-132. doi: 10.1016/j.jmb.2017.12.005. Epub 2017 Dec 14. No abstract available.

PMID:
29247654
24.

Detecting Release of Bacterial dsDNA into the Host Cytosol Using Fluorescence Microscopy.

Dreier RF, Santos JC, Broz P.

Methods Mol Biol. 2018;1714:199-213. doi: 10.1007/978-1-4939-7519-8_13.

PMID:
29177864
25.

Function and mechanism of the pyrin inflammasome.

Heilig R, Broz P.

Eur J Immunol. 2018 Feb;48(2):230-238. doi: 10.1002/eji.201746947. Epub 2017 Dec 6. Review.

26.

IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.

Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, Golovliov I, Michal F, Basso P, Djebali S, Provost A, Allatif O, Meunier E, Broz P, Yamamoto M, Py BF, Faudry E, Sjöstedt A, Henry T.

PLoS Pathog. 2017 Oct 2;13(10):e1006630. doi: 10.1371/journal.ppat.1006630. eCollection 2017 Oct.

27.

Inflammasomes in Host Defense and Autoimmunity.

Broz P.

Chimia (Aarau). 2016 Dec 21;70(12):853-855. doi: 10.2533/chimia.2016.853. Review.

PMID:
28661355
28.

Rivaroxaban for thrombosis prophylaxis in endovenous laser ablation with and without phlebectomy.

Uthoff H, Holtz D, Broz P, Staub D, Spinedi L.

J Vasc Surg Venous Lymphat Disord. 2017 Jul;5(4):515-523. doi: 10.1016/j.jvsv.2016.12.002. Epub 2017 Feb 21.

PMID:
28623988
29.

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape.

Brodmann M, Dreier RF, Broz P, Basler M.

Nat Commun. 2017 Jun 16;8:15853. doi: 10.1038/ncomms15853.

30.

Evolutionary Convergence and Divergence in NLR Function and Structure.

Meunier E, Broz P.

Trends Immunol. 2017 Oct;38(10):744-757. doi: 10.1016/j.it.2017.04.005. Epub 2017 May 31. Review.

PMID:
28579324
31.

Genome-wide Expression Profiling (with Focus on the Galectin Network) in Tumor, Transition Zone and Normal Tissue of Head and Neck Cancer: Marked Differences Between Individual Patients and the Site of Specimen Origin.

Zivicova V, Broz P, Fik Z, Mifkova A, Plzak J, Cada Z, Kaltner H, Kucerova JF, Gabius HJ, Smetana K Jr.

Anticancer Res. 2017 May;37(5):2275-2288.

PMID:
28476793
32.

Clinical and duplex ultrasound evaluation of lower extremities varicose veins - a practical guideline.

Spinedi L, Broz P, Engelberger RP, Staub D, Uthoff H.

Vasa. 2017 Aug;46(5):325-336. doi: 10.1024/0301-1526/a000635. Epub 2017 Apr 27. Review.

33.

Corrigendum: ASC filament formation serves as a signal amplification mechanism for inflammasomes.

Dick MS, Sborgi L, Rühl S, Hiller S, Broz P.

Nat Commun. 2017 Mar 17;8:15030. doi: 10.1038/ncomms15030. No abstract available.

34.

Characteristics of Quinolone Resistance in Escherichia coli Isolates from Humans, Animals, and the Environment in the Czech Republic.

Röderova M, Halova D, Papousek I, Dolejska M, Masarikova M, Hanulik V, Pudova V, Broz P, Htoutou-Sedlakova M, Sauer P, Bardon J, Cizek A, Kolar M, Literak I.

Front Microbiol. 2017 Jan 9;7:2147. doi: 10.3389/fmicb.2016.02147. eCollection 2016.

35.

Aneuploidy Detection and mtDNA Quantification in Bovine Embryos with Different Cleavage Onset Using a Next-Generation Sequencing-Based Protocol.

Hornak M, Kubicek D, Broz P, Hulinska P, Hanzalova K, Griffin D, Machatkova M, Rubes J.

Cytogenet Genome Res. 2016;150(1):60-67. doi: 10.1159/000452923. Epub 2016 Dec 2.

PMID:
27907920
36.

Ageing as an Important Risk Factor for Cancer.

Smetana K Jr, Lacina L, Szabo P, Dvořánková B, Brož P, Šedo A.

Anticancer Res. 2016 Oct;36(10):5009-5017. Review.

PMID:
27798859
37.

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O.

Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27.

38.

[Endoluminal Treatment of Varicose Veins: Value of Duplex Ultrasound (Part 2)].

Spinedi L, Aschwanden M, Broz P, Imfeld S, Baldi T, Jaeger K, Staub D, Uthoff H.

Ultraschall Med. 2017 Jan;38(1):14-32. doi: 10.1055/s-0042-113385. Epub 2016 Oct 13. Review. German.

PMID:
27737471
39.

The gasdermin-D pore: Executor of pyroptotic cell death.

Rühl S, Broz P.

Oncotarget. 2016 Sep 6;7(36):57481-57482. doi: 10.18632/oncotarget.11421. No abstract available.

40.

The Ti-Mn system revisited: experimental investigation and thermodynamic modelling.

Khan AU, Brož P, Premović M, Pavlů J, Vřeštál J, Yan X, Maccio D, Saccone A, Giester G, Rogl P.

Phys Chem Chem Phys. 2016 Aug 17;18(33):23326-39. doi: 10.1039/c6cp04542a.

PMID:
27498605
41.

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.

Di Micco A, Frera G, Lugrin J, Jamilloux Y, Hsu ET, Tardivel A, De Gassart A, Zaffalon L, Bujisic B, Siegert S, Quadroni M, Broz P, Henry T, Hrycyna CA, Martinon F.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4671-80. doi: 10.1073/pnas.1602419113. Epub 2016 Jul 26.

42.

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.

Sborgi L, Rühl S, Mulvihill E, Pipercevic J, Heilig R, Stahlberg H, Farady CJ, Müller DJ, Broz P, Hiller S.

EMBO J. 2016 Aug 15;35(16):1766-78. doi: 10.15252/embj.201694696. Epub 2016 Jul 14.

43.

[Well-Tried and New Ones – Update Varicose Vein Treatment 2016].

Uthoff H, Spinedi L, Lattmann T, Broz P, Staub D.

Praxis (Bern 1994). 2016 Jul 6;105(14):813-9. doi: 10.1024/1661-8157/a002405. Review. German.

44.

Influence of pneumatic tube system transport on routinely assessed and spectrophotometric cerebrospinal fluid parameters.

Broz P, Rajdl D, Racek J, Zenkova J, Petrikova V.

Clin Chem Lab Med. 2017 Jan 1;55(1):47-52. doi: 10.1515/cclm-2016-0143.

PMID:
27362961
45.

ASC filament formation serves as a signal amplification mechanism for inflammasomes.

Dick MS, Sborgi L, Rühl S, Hiller S, Broz P.

Nat Commun. 2016 Jun 22;7:11929. doi: 10.1038/ncomms11929.

46.

Ba-filled Ni-Sb-Sn based skutterudites with anomalously high lattice thermal conductivity.

Paschinger W, Rogl G, Grytsiv A, Michor H, Heinrich PR, Müller H, Puchegger S, Klobes B, Hermann RP, Reinecker M, Eisenmenger-Sitter Ch, Broz P, Bauer E, Giester G, Zehetbauer M, Rogl PF.

Dalton Trans. 2016 Jul 5;45(27):11071-100. doi: 10.1039/c6dt01298a.

47.

Inflammasomes: mechanism of assembly, regulation and signalling.

Broz P, Dixit VM.

Nat Rev Immunol. 2016 Jul;16(7):407-20. doi: 10.1038/nri.2016.58. Epub 2016 Jun 13. Review.

PMID:
27291964
48.

Inflammasomes: Intracellular detection of extracellular bacteria.

Broz P.

Cell Res. 2016 Aug;26(8):859-60. doi: 10.1038/cr.2016.67. Epub 2016 Jun 10.

49.

Evaluation of Varicose Veins of the Lower Extremity: the Value of the Duplex Ultrasound (Part 1).

Spinedi L, Broz P, Baldi T, Imfeld S, Staub D, Jaeger K, Aschwanden M, Uthoff H.

Ultraschall Med. 2016 Aug;37(4):348-65. doi: 10.1055/s-0042-104643. Epub 2016 Apr 12. Review. No abstract available.

PMID:
27070126
50.

Immune Response: Intracellular pathogens under attack.

Broz P.

Elife. 2016 Feb 19;5. pii: e14729. doi: 10.7554/eLife.14729.

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