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Hematopoietic stem cell gene therapy for brain metastases using myeloid cell-specific gene promoters.

Andreou T, Rippaus N, Wronski K, Williams J, Taggart D, Cherqui S, Sunderland A, Kartika YD, Egnuni T, Brownlie R, Mathew RK, Holmen SL, Fife C, Droop A, Lorger M.

J Natl Cancer Inst. 2019 Sep 10. pii: djz181. doi: 10.1093/jnci/djz181. [Epub ahead of print]


Immunoproteomic analysis of Lawsonia intracellularis identifies candidate neutralizing antibody targets for use in subunit vaccine development.

Obradovic M, Pasternak JA, Hon Ng S, Allan B, Brownlie R, Wilson HL.

Vet Microbiol. 2019 Aug;235:270-279. doi: 10.1016/j.vetmic.2019.07.014. Epub 2019 Jul 19.


Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors.

Brownlie RJ, Wright D, Zamoyska R, Salmond RJ.

JCI Insight. 2019 Jul 23;5. pii: 127847. doi: 10.1172/jci.insight.127847.


miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.

Łyszkiewicz M, Winter SJ, Witzlau K, Föhse L, Brownlie R, Puchałka J, Verheyden NA, Kunze-Schumacher H, Imelmann E, Blume J, Raha S, Sekiya T, Yoshimura A, Frueh JT, Ullrich E, Huehn J, Weiss S, Gutierrez MG, Prinz I, Zamoyska R, Ziętara N, Krueger A.

PLoS Biol. 2019 Mar 11;17(3):e2006716. doi: 10.1371/journal.pbio.2006716. eCollection 2019 Mar.


US3 Kinase-Mediated Phosphorylation of Tegument Protein VP8 Plays a Critical Role in the Cellular Localization of VP8 and Its Effect on the Lipid Metabolism of Bovine Herpesvirus 1-Infected Cells.

Zhang K, Donovan T, Sucharita S, Brownlie R, Snider M, Tikoo SK, van Drunen Littel-van den Hurk S.

J Virol. 2019 Mar 5;93(6). pii: e02151-18. doi: 10.1128/JVI.02151-18. Print 2019 Mar 15.


The bovine herpesvirus-1 major tegument protein, VP8, interacts with host HSP60 concomitant with deregulation of mitochondrial function.

Afroz S, Brownlie R, Fodje M, van Drunen Littel-van den Hurk S.

Virus Res. 2019 Feb;261:37-49. doi: 10.1016/j.virusres.2018.12.006. Epub 2018 Dec 11.


Nuclear-resident RIG-I senses viral replication inducing antiviral immunity.

Liu G, Lu Y, Thulasi Raman SN, Xu F, Wu Q, Li Z, Brownlie R, Liu Q, Zhou Y.

Nat Commun. 2018 Aug 10;9(1):3199. doi: 10.1038/s41467-018-05745-w.


A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3.

Garg R, Brownlie R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Antiviral Res. 2018 Oct;158:78-87. doi: 10.1016/j.antiviral.2018.07.021. Epub 2018 Jul 30.


Index coronary angiography use in Manitoba, Canada: a population-level descriptive analysis of First Nations and non-First Nations recipients.

Schultz ASH, Dahl L, McGibbon E, Brownlie RJ, Cook C, Elbarouni B, Katz A, Nguyen T, Sawatzky JA, Sinclaire M, Throndson K, Fransoo R.

BMJ Open. 2018 Mar 25;8(3):e020856. doi: 10.1136/bmjopen-2017-020856.


Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.

Brownlie RJ, Zamoyska R, Salmond RJ.

Immunology. 2018 Jul;154(3):377-382. doi: 10.1111/imm.12919. Epub 2018 Apr 16. Review.


Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking.

Taggart D, Andreou T, Scott KJ, Williams J, Rippaus N, Brownlie RJ, Ilett EJ, Salmond RJ, Melcher A, Lorger M.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1540-E1549. doi: 10.1073/pnas.1714089115. Epub 2018 Jan 31.


Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity.

Garg R, Brownlie R, Latimer L, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2017 Dec 18;35(51):7139-7146. doi: 10.1016/j.vaccine.2017.10.095. Epub 2017 Nov 16.


Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.

Brownlie RJ, Garcia C, Ravasz M, Zehn D, Salmond RJ, Zamoyska R.

Nat Commun. 2017 Nov 7;8(1):1343. doi: 10.1038/s41467-017-01427-1.


Induction of interferon and interferon-induced antiviral effector genes following a primary bovine herpesvirus-1 (BHV-1) respiratory infection.

Osman R, Gonzalez-Cano P, Brownlie R, Griebel PJ.

J Gen Virol. 2017 Jul;98(7):1831-1842. doi: 10.1099/jgv.0.000825. Epub 2017 Jul 5.


Local innate responses and protective immunity after intradermal immunization with bovine viral diarrhea virus E2 protein formulated with a combination adjuvant in cattle.

Sadat SMA, Snider M, Garg R, Brownlie R, van Drunen Littel-van den Hurk S.

Vaccine. 2017 Jun 14;35(27):3466-3473. doi: 10.1016/j.vaccine.2017.05.029. Epub 2017 May 17.


Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.

Burn GL, Cornish GH, Potrzebowska K, Samuelsson M, Griffié J, Minoughan S, Yates M, Ashdown G, Pernodet N, Morrison VL, Sanchez-Blanco C, Purvis H, Clarke F, Brownlie RJ, Vyse TJ, Zamoyska R, Owen DM, Svensson LM, Cope AP.

Sci Signal. 2016 Oct 4;9(448):ra99.


Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.

Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R.

J Immunol. 2016 Jul 15;197(2):429-40. doi: 10.4049/jimmunol.1502656. Epub 2016 Jun 10.


S1 domain of the porcine epidemic diarrhea virus spike protein as a vaccine antigen.

Makadiya N, Brownlie R, van den Hurk J, Berube N, Allan B, Gerdts V, Zakhartchouk A.

Virol J. 2016 Apr 1;13:57. doi: 10.1186/s12985-016-0512-8.


Phosphorylation of Bovine Herpesvirus 1 VP8 Plays a Role in Viral DNA Encapsidation and Is Essential for Its Cytoplasmic Localization and Optimal Virion Incorporation.

Zhang K, Brownlie R, Snider M, van Drunen Littel-van den Hurk S.

J Virol. 2016 Apr 14;90(9):4427-4440. doi: 10.1128/JVI.00219-16. Print 2016 May.


VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling.

Afroz S, Brownlie R, Fodje M, van Drunen Littel-van den Hurk S.

J Virol. 2016 Apr 29;90(10):4889-4904. doi: 10.1128/JVI.00017-16. Print 2016 May 15.


Reverse vaccinology as an approach for developing Histophilus somni vaccine candidates.

Madampage CA, Rawlyk N, Crockford G, Wang Y, White AP, Brownlie R, Van Donkersgoed J, Dorin C, Potter A.

Biologicals. 2015 Nov;43(6):444-51. doi: 10.1016/j.biologicals.2015.09.001. Epub 2015 Oct 12.


Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.

Salmond RJ, Brownlie RJ, Meyuhas O, Zamoyska R.

J Immunol. 2015 Nov 15;195(10):4615-22. doi: 10.4049/jimmunol.1501473. Epub 2015 Oct 9.


Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.

Salmond RJ, Brownlie RJ, Zamoyska R.

Cell Cycle. 2015;14(5):705-11. doi: 10.1080/15384101.2015.1007018.


Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1.

Zhang K, Afroz S, Brownlie R, Snider M, van Drunen Littel-van den Hurk S.

J Virol. 2015 Apr;89(8):4598-611. doi: 10.1128/JVI.03180-14. Epub 2015 Feb 11.


The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle.

Snider M, Garg R, Brownlie R, van den Hurk JV, van Drunen Littel-van den Hurk S.

Vaccine. 2014 Nov 28;32(50):6758-64. doi: 10.1016/j.vaccine.2014.10.010. Epub 2014 Oct 25.


The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.

Salmond RJ, Brownlie RJ, Morrison VL, Zamoyska R.

Nat Immunol. 2014 Sep;15(9):875-883. doi: 10.1038/ni.2958. Epub 2014 Aug 10.


Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response.

Lohmann KL, Lopez AM, Manning ST, Marques FJ, Brownlie R, Allen AL, Sangster AE, Mutwiri G, Gerdts V, Potter A, Townsend HG.

Can J Vet Res. 2013 Jul;77(3):161-9.


Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: potential implications for immunotherapy of familial prion diseases.

Madampage CA, Määttänen P, Marciniuk K, Brownlie R, Andrievskaia O, Potter A, Cashman NR, Lee JS, Napper S.

Prion. 2013 Jul-Aug;7(4):301-11. doi: 10.4161/pri.25148. Epub 2013 May 31.


T cell receptor signalling networks: branched, diversified and bounded.

Brownlie RJ, Zamoyska R.

Nat Rev Immunol. 2013 Apr;13(4):257-69. doi: 10.1038/nri3403. Review.


Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

Brownlie RJ, Miosge LA, Vassilakos D, Svensson LM, Cope A, Zamoyska R.

Sci Signal. 2012 Nov 27;5(252):ra87. doi: 10.1126/scisignal.2003365.


Regulation of allograft survival by inhibitory FcγRIIb signaling.

Callaghan CJ, Win TS, Motallebzadeh R, Conlon TM, Chhabra M, Harper I, Sivaganesh S, Bolton EM, Bradley JA, Brownlie RJ, Smith KG, Pettigrew GJ.

J Immunol. 2012 Dec 15;189(12):5694-702. doi: 10.4049/jimmunol.1202084. Epub 2012 Nov 12.


Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.

Garlapati S, Garg R, Brownlie R, Latimer L, Simko E, Hancock RE, Babiuk LA, Gerdts V, Potter A, van Drunen Littel-van den Hurk S.

Vaccine. 2012 Jul 27;30(35):5206-14. doi: 10.1016/j.vaccine.2012.06.011. Epub 2012 Jun 17.


Pathotypic and molecular characterization of a fowl adenovirus associated with inclusion body hepatitis in Saskatchewan chickens.

Dar A, Gomis S, Shirley I, Mutwiri G, Brownlie R, Potter A, Gerdts V, Tikoo SK.

Avian Dis. 2012 Mar;56(1):73-81.


Avian toll-like receptors.

Brownlie R, Allan B.

Cell Tissue Res. 2011 Jan;343(1):121-30. doi: 10.1007/s00441-010-1026-0. Epub 2010 Sep 1. Review.


Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway.

Jackel-Cram C, Qiao L, Xiang Z, Brownlie R, Zhou Y, Babiuk L, Liu Q.

J Gen Virol. 2010 Jun;91(Pt 6):1388-95. doi: 10.1099/vir.0.017418-0. Epub 2010 Feb 3.


LAT polices T cell activation.

Brownlie R, Zamoyska R.

Immunity. 2009 Aug 21;31(2):174-6. doi: 10.1016/j.immuni.2009.08.002.


Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides.

Brownlie R, Zhu J, Allan B, Mutwiri GK, Babiuk LA, Potter A, Griebel P.

Mol Immunol. 2009 Sep;46(15):3163-70. doi: 10.1016/j.molimm.2009.06.002. Epub 2009 Jul 1.


Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8.

Zhu J, van Drunen Littel-van den Hurk S, Brownlie R, Babiuk LA, Potter A, Mutwiri GK.

Mol Immunol. 2009 Feb;46(5):884-92. doi: 10.1016/j.molimm.2008.09.020. Epub 2008 Nov 18.


Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization.

Zhu J, Brownlie R, Liu Q, Babiuk LA, Potter A, Mutwiri GK.

Mol Immunol. 2009 Feb;46(5):978-90. doi: 10.1016/j.molimm.2008.09.024. Epub 2008 Nov 8.


The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice.

Brownlie R, Mayers RM, Pierce JA, Marley AE, Smith DM.

Biochem Soc Trans. 2008 Oct;36(Pt 5):950-4. doi: 10.1042/BST0360950. Review.


Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.

Brownlie RJ, Lawlor KE, Niederer HA, Cutler AJ, Xiang Z, Clatworthy MR, Floto RA, Greaves DR, Lyons PA, Smith KG.

J Exp Med. 2008 Apr 14;205(4):883-95. doi: 10.1084/jem.20072565. Epub 2008 Mar 24.


Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.

Gorman T, Hope DC, Brownlie R, Yu A, Gill D, Löfvenmark J, Wedin M, Mayers RM, Snaith MR, Smith DM.

Diabetes Obes Metab. 2008 Sep;10(10):885-97. Epub 2007 Nov 22.


Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9.

Kindrachuk J, Potter JE, Brownlie R, Ficzycz AD, Griebel PJ, Mookherjee N, Mutwiri GK, Babiuk LA, Napper S.

J Biol Chem. 2007 May 11;282(19):13944-53. Epub 2007 Mar 13.


FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis.

Xiang Z, Cutler AJ, Brownlie RJ, Fairfax K, Lawlor KE, Severinson E, Walker EU, Manz RA, Tarlinton DM, Smith KG.

Nat Immunol. 2007 Apr;8(4):419-29. Epub 2007 Feb 18.


Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system.

Meurens F, Whale J, Brownlie R, Dybvig T, Thompson DR, Gerdts V.

Immunology. 2007 Apr;120(4):544-55. Epub 2007 Jan 22.


Expression of TECK/CCL25 and MEC/CCL28 chemokines and their respective receptors CCR9 and CCR10 in porcine mucosal tissues.

Meurens F, Berri M, Whale J, Dybvig T, Strom S, Thompson D, Brownlie R, Townsend HG, Salmon H, Gerdts V.

Vet Immunol Immunopathol. 2006 Oct 15;113(3-4):313-27. Epub 2006 Jul 12.


Treatment of murine collagen-induced arthritis by the stress protein BiP via interleukin-4-producing regulatory T cells: a novel function for an ancient protein.

Brownlie RJ, Myers LK, Wooley PH, Corrigall VM, Bodman-Smith MD, Panayi GS, Thompson SJ.

Arthritis Rheum. 2006 Mar;54(3):854-63.


Intercellular trafficking of the major tegument protein VP22 of bovine herpesvirus-1 and its application to improve a DNA vaccine.

Zheng CF, Brownlie R, Huang DY, Babiuk LA, van Drunen Littel-van den Hurk S.

Arch Virol. 2006 May;151(5):985-93. Epub 2005 Dec 28.


Characterization of the nuclear localization and nuclear export signals of bovine herpesvirus 1 VP22.

Zheng C, Brownlie R, Babiuk LA, van Drunen Littel-van den Hurk S.

J Virol. 2005 Sep;79(18):11864-72.

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