Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 214


Withdrawal: Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo : Role of mitochondrial reactive nitrogen species.

Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

J Biol Chem. 2019 Sep 6;294(36):13525. doi: 10.1074/jbc.W119.010595. No abstract available.


A randomized clinical trial of cyanoacrylate tissue adhesives in donor site of connective tissue grafts.

Stavropoulou C, Atout RN, Brownlee M, Schroth RJ, Kelekis-Cholakis A.

J Periodontol. 2019 Jun;90(6):608-615. doi: 10.1002/JPER.18-0475. Epub 2018 Dec 26.


Small molecule inhibition of dipeptidyl peptidase-4 enhances bone marrow progenitor cell function and angiogenesis in diabetic wounds.

Whittam AJ, Maan ZN, Duscher D, Barrera JA, Hu MS, Fischer LH, Khong S, Kwon SH, Wong VW, Walmsley GG, Giacco F, Januszyk M, Brownlee M, Longaker MT, Gurtner GC.

Transl Res. 2019 Mar;205:51-63. doi: 10.1016/j.trsl.2018.10.006. Epub 2018 Nov 2.


Urea Memory: Transient Cell Exposure to Urea Causes Persistent Mitochondrial ROS Production and Endothelial Dysfunction.

d'Apolito M, Colia AL, Manca E, Pettoello-Mantovani M, Sacco M, Maffione AB, Brownlee M, Giardino I.

Toxins (Basel). 2018 Oct 11;10(10). pii: E410. doi: 10.3390/toxins10100410.


Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy.

Zonszein J, Brownlee M.

Ann Intern Med. 2018 Oct 2;169(7):512-513. doi: 10.7326/L18-0372. No abstract available.


Implementation of a Mobile Clinical Decision Support Application to Augment Local Antimicrobial Stewardship.

Hoff BM, Ford DC, Ince D, Ernst EJ, Livorsi DJ, Heintz BH, Masse V, Brownlee MJ, Ford BA.

J Pathol Inform. 2018 Apr 2;9:10. doi: 10.4103/jpi.jpi_77_17. eCollection 2018.


Development and innovation of system resources to optimize patient care.

Johnson TJ, Brownlee MJ.

Am J Health Syst Pharm. 2018 Apr 1;75(7):465-472. doi: 10.2146/ajhp170402.


Vascular toxicity of urea, a new "old player" in the pathogenesis of chronic renal failure induced cardiovascular diseases.

Giardino I, D'Apolito M, Brownlee M, Maffione AB, Colia AL, Sacco M, Ferrara P, Pettoello-Mantovani M.

Turk Pediatri Ars. 2017 Dec 1;52(4):187-193. doi: 10.5152/TurkPediatriArs.2017.6314. eCollection 2017 Dec. Review.


Pharmacy informatics: A call to action for educators, administrators, and residency directors.

Steckler TJ, Brownlee MJ, Urick BY, Farley MJ.

Curr Pharm Teach Learn. 2017 Sep;9(5):746-749. doi: 10.1016/j.cptl.2017.05.003. Epub 2017 Jun 30.


Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction.

Blackburn NJR, Vulesevic B, McNeill B, Cimenci CE, Ahmadi A, Gonzalez-Gomez M, Ostojic A, Zhong Z, Brownlee M, Beisswenger PJ, Milne RW, Suuronen EJ.

Basic Res Cardiol. 2017 Sep 1;112(5):57. doi: 10.1007/s00395-017-0646-x.


Urea-induced ROS accelerate senescence in endothelial progenitor cells.

D'Apolito M, Colia AL, Lasalvia M, Capozzi V, Falcone MP, Pettoello-Mantovani M, Brownlee M, Maffione AB, Giardino I.

Atherosclerosis. 2017 Aug;263:127-136. doi: 10.1016/j.atherosclerosis.2017.06.028. Epub 2017 Jun 15.


Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.

Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4472-E4481. doi: 10.1073/pnas.1702302114. Epub 2017 May 15.


Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes.

Shah MS, Brownlee M.

Circ Res. 2016 May 27;118(11):1808-29. doi: 10.1161/CIRCRESAHA.116.306923. Review.


Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy.

Vulesevic B, McNeill B, Giacco F, Maeda K, Blackburn NJ, Brownlee M, Milne RW, Suuronen EJ.

Diabetes. 2016 Jun;65(6):1699-713. doi: 10.2337/db15-0568. Epub 2016 Mar 8.


Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.

McMurray KM, Du X, Brownlee M, Palmer AA.

Behav Brain Res. 2016 Mar 15;301:119-23. doi: 10.1016/j.bbr.2015.12.026. Epub 2015 Dec 19.


GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.

Giacco F, Du X, Carratú A, Gerfen GJ, D'Apolito M, Giardino I, Rasola A, Marin O, Divakaruni AS, Murphy AN, Shah MS, Brownlee M.

Diabetes. 2015 Sep;64(9):3273-84. doi: 10.2337/db15-0084.


Mitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy.

Nishikawa T, Brownlee M, Araki E.

J Diabetes Investig. 2015 Mar;6(2):137-9. doi: 10.1111/jdi.12258. Epub 2014 Jul 25. No abstract available.


Urea-induced ROS cause endothelial dysfunction in chronic renal failure.

D'Apolito M, Du X, Pisanelli D, Pettoello-Mantovani M, Campanozzi A, Giacco F, Maffione AB, Colia AL, Brownlee M, Giardino I.

Atherosclerosis. 2015 Apr;239(2):393-400. doi: 10.1016/j.atherosclerosis.2015.01.034. Epub 2015 Jan 31.


Diabetic kidney disease.

Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S, Rossing P, Groop PH, Cooper ME.

Nat Rev Dis Primers. 2015 Jul 30;1:15018. doi: 10.1038/nrdp.2015.18. Review.


Transdermal deferoxamine prevents pressure-induced diabetic ulcers.

Duscher D, Neofytou E, Wong VW, Maan ZN, Rennert RC, Inayathullah M, Januszyk M, Rodrigues M, Malkovskiy AV, Whitmore AJ, Walmsley GG, Galvez MG, Whittam AJ, Brownlee M, Rajadas J, Gurtner GC.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):94-9. doi: 10.1073/pnas.1413445112. Epub 2014 Dec 22.


Increased peritoneal damage in glyoxalase 1 knock-down mice treated with peritoneal dialysis.

Kihm LP, Müller-Krebs S, Holoch S, Schmuck S, Becker LE, Brownlee M, Zeier M, Fleming TH, Nawroth PP, Schwenger V.

Nephrol Dial Transplant. 2015 Mar;30(3):401-9. doi: 10.1093/ndt/gfu346. Epub 2014 Nov 11.


Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice.

Geoffrion M, Du X, Irshad Z, Vanderhyden BC, Courville K, Sui G, D'Agati VD, Ott-Braschi S, Rabbani N, Thornalley PJ, Brownlee M, Milne RW.

Physiol Rep. 2014 Jun 11;2(6). pii: e12043. doi: 10.14814/phy2.12043. Print 2014 Jun 1.


Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.

Brouwers O, Niessen PM, Miyata T, Østergaard JA, Flyvbjerg A, Peutz-Kootstra CJ, Sieber J, Mundel PH, Brownlee M, Janssen BJ, De Mey JG, Stehouwer CD, Schalkwijk CG.

Diabetologia. 2014 Jan;57(1):224-35. doi: 10.1007/s00125-013-3088-5. Epub 2013 Oct 26.


Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype.

Hanssen NM, Wouters K, Huijberts MS, Gijbels MJ, Sluimer JC, Scheijen JL, Heeneman S, Biessen EA, Daemen MJ, Brownlee M, de Kleijn DP, Stehouwer CD, Pasterkamp G, Schalkwijk CG.

Eur Heart J. 2014 May;35(17):1137-46. doi: 10.1093/eurheartj/eht402. Epub 2013 Oct 14.


Knockdown of glyoxalase 1 mimics diabetic nephropathy in nondiabetic mice.

Giacco F, Du X, D'Agati VD, Milne R, Sui G, Geoffrion M, Brownlee M.

Diabetes. 2014 Jan;63(1):291-9. doi: 10.2337/db13-0316. Epub 2013 Sep 23.


Visiting a climate-influenced national park: the stability of climate change perceptions.

Brownlee MT, Hallo JC, Wright BA, Moore D, Powell RB.

Environ Manage. 2013 Nov;52(5):1132-48. doi: 10.1007/s00267-013-0153-2. Epub 2013 Aug 31.


Aging-dependent reduction in glyoxalase 1 delays wound healing.

Fleming TH, Theilen TM, Masania J, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M, Nawroth PP.

Gerontology. 2013;59(5):427-37. doi: 10.1159/000351628. Epub 2013 Jun 22.


Hyperglycemia-stimulated myelopoiesis causes impaired regression of atherosclerosis in type 1 diabetes.

Brownlee M.

Cell Metab. 2013 May 7;17(5):631-3. doi: 10.1016/j.cmet.2013.04.015.


Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice.

Ma T, Du X, Pick JE, Sui G, Brownlee M, Klann E.

J Neurosci. 2012 Oct 3;32(40):13701-8. doi: 10.1523/JNEUROSCI.2107-12.2012.


Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.

Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP.

Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Erratum in: Nat Med. 2012 Sep;18(9):1445. Lasischka, Felix [corrected to Lasitschka, Felix].


Vacuum-induced Suction Stimulates Increased Numbers of Blood Vessels in Healthy Dog Gingiva.

Budinskaya OV, Kontogiorgos ED, Brownlee M, Lee JS, Budinskiy RA, Dechow PC, Wright JM, Svoboda KK, Opperman LA.

Wounds. 2012 Apr;24(4):99-109.


Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.

Berner AK, Brouwers O, Pringle R, Klaassen I, Colhoun L, McVicar C, Brockbank S, Curry JW, Miyata T, Brownlee M, Schlingemann RO, Schalkwijk C, Stitt AW.

Diabetologia. 2012 Mar;55(3):845-54. doi: 10.1007/s00125-011-2393-0. Epub 2011 Dec 6.


Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics).

Uchiki T, Weikel KA, Jiao W, Shang F, Caceres A, Pawlak D, Handa JT, Brownlee M, Nagaraj R, Taylor A.

Aging Cell. 2012 Feb;11(1):1-13. doi: 10.1111/j.1474-9726.2011.00752.x. Epub 2011 Nov 15.


What to look for in healthcare IT. As we enter the second decade of the 21st century, our experts weigh in on the year ahead in healthcare technology.

Schwend G, Surges J, Desrochers R, Ireland E, Klimek J, Schelhammer S, Bormel J, Schleck J, Margolis J, Tilley RF, Tarkoff K, Roga A, Brownlee M, Cox D.

Health Manag Technol. 2011 Feb;32(2):16, 18, 20-2 passim. No abstract available.


Diabetic retinopathy: targeting vasoregression.

Hammes HP, Feng Y, Pfister F, Brownlee M.

Diabetes. 2011 Jan;60(1):9-16. doi: 10.2337/db10-0454. Review. No abstract available.


Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.

Brouwers O, Niessen PM, Ferreira I, Miyata T, Scheffer PG, Teerlink T, Schrauwen P, Brownlee M, Stehouwer CD, Schalkwijk CG.

J Biol Chem. 2011 Jan 14;286(2):1374-80. doi: 10.1074/jbc.M110.144097. Epub 2010 Nov 5.


Oxidative stress and diabetic complications.

Giacco F, Brownlee M.

Circ Res. 2010 Oct 29;107(9):1058-70. doi: 10.1161/CIRCRESAHA.110.223545. Review.


Beyond hemoglobin A1c--need for additional markers of risk for diabetic microvascular complications.

Hirsch IB, Brownlee M.

JAMA. 2010 Jun 9;303(22):2291-2. doi: 10.1001/jama.2010.785. No abstract available.


Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation.

Folli F, Guzzi V, Perego L, Coletta DK, Finzi G, Placidi C, La Rosa S, Capella C, Socci C, Lauro D, Tripathy D, Jenkinson C, Paroni R, Orsenigo E, Cighetti G, Gregorini L, Staudacher C, Secchi A, Bachi A, Brownlee M, Fiorina P.

PLoS One. 2010 Mar 29;5(3):e9923. doi: 10.1371/journal.pone.0009923.


Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.

Schlotterer A, Hamann A, Kukudov G, Ibrahim Y, Heckmann B, Bozorgmehr F, Pfeiffer M, Hutter H, Stern D, Du X, Brownlee M, Bierhaus A, Nawroth P, Morcos M.

Aging Cell. 2010 Jun;9(3):420-32. doi: 10.1111/j.1474-9726.2010.00572.x. Epub 2010 Mar 24.


Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.

Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, De Mey JG, Schalkwijk CG.

Diabetologia. 2010 May;53(5):989-1000. doi: 10.1007/s00125-010-1677-0. Epub 2010 Feb 26.


HIF-1alpha dysfunction in diabetes.

Thangarajah H, Vial IN, Grogan RH, Yao D, Shi Y, Januszyk M, Galiano RD, Chang EI, Galvez MG, Glotzbach JP, Wong VW, Brownlee M, Gurtner GC.

Cell Cycle. 2010 Jan 1;9(1):75-9.


Hyperglycemia impairs proteasome function by methylglyoxal.

Queisser MA, Yao D, Geisler S, Hammes HP, Lochnit G, Schleicher ED, Brownlee M, Preissner KT.

Diabetes. 2010 Mar;59(3):670-8. doi: 10.2337/db08-1565. Epub 2009 Dec 15.


Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.

D'Apolito M, Du X, Zong H, Catucci A, Maiuri L, Trivisano T, Pettoello-Mantovani M, Campanozzi A, Raia V, Pessin JE, Brownlee M, Giardino I.

J Clin Invest. 2010 Jan;120(1):203-13. doi: 10.1172/JCI37672. Epub 2009 Dec 1. Erratum in: J Clin Invest. 2010 Mar 1;120(3):932.


C. elegans as model for the study of high glucose- mediated life span reduction.

Schlotterer A, Kukudov G, Bozorgmehr F, Hutter H, Du X, Oikonomou D, Ibrahim Y, Pfisterer F, Rabbani N, Thornalley P, Sayed A, Fleming T, Humpert P, Schwenger V, Zeier M, Hamann A, Stern D, Brownlee M, Bierhaus A, Nawroth P, Morcos M.

Diabetes. 2009 Nov;58(11):2450-6. doi: 10.2337/db09-0567. Epub 2009 Aug 12.


The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.

Thangarajah H, Yao D, Chang EI, Shi Y, Jazayeri L, Vial IN, Galiano RD, Du XL, Grogan R, Galvez MG, Januszyk M, Brownlee M, Gurtner GC.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13505-10. doi: 10.1073/pnas.0906670106. Epub 2009 Jul 28.


Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy.

Ma H, Li SY, Xu P, Babcock SA, Dolence EK, Brownlee M, Li J, Ren J.

J Cell Mol Med. 2009 Aug;13(8B):1751-64. doi: 10.1111/j.1582-4934.2008.00547.x.


Putting patient safety first.

Brownlee MA.

Provider. 2009 Apr;35(4):39, 41-3. No abstract available.


Supplemental Content

Loading ...
Support Center