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Items: 50


Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.

Ibrahim ML, Klement JD, Lu C, Redd PS, Xiao W, Yang D, Browning DD, Savage NM, Buckhaults PJ, Morse HC 3rd, Liu K.

Cell Rep. 2018 Dec 11;25(11):3036-3046.e6. doi: 10.1016/j.celrep.2018.11.050.


Phosphodiesterase-5 inhibitors for colon cancer chemoprevention.

Islam BN, Browning DD.

Aging (Albany NY). 2018 Sep 5;10(9):2216-2217. doi: 10.18632/aging.101545. No abstract available.


Clinical utility of plecanatide in the treatment of chronic idiopathic constipation.

Islam BN, Sharman SK, Browning DD.

Int J Gen Med. 2018 Aug 10;11:323-330. doi: 10.2147/IJGM.S125051. eCollection 2018. Review.


Cyclic-GMP-Elevating Agents Suppress Polyposis in ApcMin mice by Targeting the Preneoplastic Epithelium.

Sharman SK, Islam BN, Hou Y, Singh N, Berger FG, Sridhar S, Yoo W, Browning DD.

Cancer Prev Res (Phila). 2018 Feb;11(2):81-92. doi: 10.1158/1940-6207.CAPR-17-0267. Epub 2018 Jan 4.


Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity.

Zhu H, Lemos H, Bhatt B, Islam BN, Singh A, Gurav A, Huang L, Browning DD, Mellor A, Fulzele S, Singh N.

PLoS One. 2017 Sep 12;12(9):e0183484. doi: 10.1371/journal.pone.0183484. eCollection 2017.


Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.

Islam BN, Sharman SK, Hou Y, Bridges AE, Singh N, Kim S, Kolhe R, Trillo-Tinoco J, Rodriguez PC, Berger FG, Sridhar S, Browning DD.

Cancer Prev Res (Phila). 2017 Jul;10(7):377-388. doi: 10.1158/1940-6207.CAPR-17-0015. Epub 2017 May 3.


Sildenafil normalizes bowel transit in preclinical models of constipation.

Sharman SK, Islam BN, Hou Y, Usry M, Bridges A, Singh N, Sridhar S, Rao S, Browning DD.

PLoS One. 2017 Apr 27;12(4):e0176673. doi: 10.1371/journal.pone.0176673. eCollection 2017.


cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.

Wang R, Islam BN, Bridges A, Sharman SK, Hu M, Hou Y, Somanath PR, Venable L, Singh N, Kim S, Sridhar S, Hofmann F, Browning DD.

Am J Pathol. 2017 Feb;187(2):377-389. doi: 10.1016/j.ajpath.2016.10.016. Epub 2016 Dec 18.


IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer.

Bardhan K, Paschall AV, Yang D, Chen MR, Simon PS, Bhutia YD, Martin PM, Thangaraju M, Browning DD, Ganapathy V, Heaton CM, Gu K, Lee JR, Liu K.

Cancer Immunol Res. 2015 Jul;3(7):795-805. doi: 10.1158/2326-6066.CIR-14-0164. Epub 2015 Mar 3.


Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium.

Wang R, Kwon IK, Singh N, Islam B, Liu K, Sridhar S, Hofmann F, Browning DD.

Cell Death Differ. 2014 Mar;21(3):427-37. doi: 10.1038/cdd.2013.163. Epub 2013 Nov 22.


Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.

Wang R, Kwon IK, Thangaraju M, Singh N, Liu K, Jay P, Hofmann F, Ganapathy V, Browning DD.

Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15;303(2):G209-19. doi: 10.1152/ajpgi.00500.2011. Epub 2012 May 3.


SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer.

Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M.

Cancer Res. 2011 Nov 1;71(21):6654-64. doi: 10.1158/0008-5472.CAN-11-1446. Epub 2011 Sep 15.


Cyclic 3',5'-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia.

Kwon IK, Wang R, Prakash N, Bozard R, Baudino TA, Liu K, Thangaraju M, Dong Z, Browning DD.

Cancer. 2011 Dec 1;117(23):5282-93. doi: 10.1002/cncr.26192. Epub 2011 May 11.


PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.

Kwon IK, Wang R, Thangaraju M, Shuang H, Liu K, Dashwood R, Dulin N, Ganapathy V, Browning DD.

Oncogene. 2010 Jun 10;29(23):3423-34. doi: 10.1038/onc.2010.91. Epub 2010 Mar 29.


cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment.

Browning DD, Kwon IK, Wang R.

Future Med Chem. 2010 Jan;2(1):65-80. doi: 10.4155/fmc.09.142. Review.


Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells.

Zhu S, Browning DD, White RE, Fulton D, Barman SA.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L758-66. doi: 10.1152/ajplung.90518.2008. Epub 2009 Jul 10.


GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, Browning DD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V.

Cancer Res. 2009 Apr 1;69(7):2826-32. doi: 10.1158/0008-5472.CAN-08-4466. Epub 2009 Mar 10.


Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer.

Thangaraju M, Cresci G, Itagaki S, Mellinger J, Browning DD, Berger FG, Prasad PD, Ganapathy V.

J Gastrointest Surg. 2008 Oct;12(10):1773-81; discussion 1781-2. doi: 10.1007/s11605-008-0573-0. Epub 2008 Jul 26.


Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer.

Browning DD.

Expert Opin Ther Targets. 2008 Mar;12(3):367-76. doi: 10.1517/14728222.12.3.367. Review.


Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis.

Kwon IK, Schoenlein PV, Delk J, Liu K, Thangaraju M, Dulin NO, Ganapathy V, Berger FG, Browning DD.

Cancer. 2008 Apr 1;112(7):1462-70. doi: 10.1002/cncr.23334.


Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.

Ying L, Hofseth AB, Browning DD, Nagarkatti M, Nagarkatti PS, Hofseth LJ.

Cancer Res. 2007 Oct 1;67(19):9286-93.


IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression.

Yang D, Thangaraju M, Browning DD, Dong Z, Korchin B, Lev DC, Ganapathy V, Liu K.

J Immunol. 2007 Oct 1;179(7):4775-82.


Targeting lymphotoxin beta receptor with tumor-specific T lymphocytes for tumor regression.

Yang D, Ud Din N, Browning DD, Abrams SI, Liu K.

Clin Cancer Res. 2007 Sep 1;13(17):5202-10.


Cysteine redox sensor in PKGIa enables oxidant-induced activation.

Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P.

Science. 2007 Sep 7;317(5843):1393-7. Epub 2007 Aug 23.


Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni.

Barnes IH, Bagnall MC, Browning DD, Thompson SA, Manning G, Newell DG.

Microb Pathog. 2007 Nov-Dec;43(5-6):198-207. Epub 2007 May 21.


Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction.

Godfrey EW, Longacher M, Neiswender H, Schwarte RC, Browning DD.

Dev Biol. 2007 Jul 15;307(2):195-201. Epub 2007 Apr 24.


Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells.

Yang D, Thangaraju M, Greeneltch K, Browning DD, Schoenlein PV, Tamura T, Ozato K, Ganapathy V, Abrams SI, Liu K.

Cancer Res. 2007 Apr 1;67(7):3301-9.


A role for cyclic-GMP dependent protein kinase in anoikis.

Hou Y, Wong E, Martin J, Schoenlein PV, Dostmann WR, Browning DD.

Cell Signal. 2006 Jun;18(6):882-8. Epub 2005 Aug 31.


Activation of the small GTPase Rac1 by cGMP-dependent protein kinase.

Hou Y, Ye RD, Browning DD.

Cell Signal. 2004 Sep;16(9):1061-9.


Activation of cGMP-dependent protein kinase by protein kinase C.

Hou Y, Lascola J, Dulin NO, Ye RD, Browning DD.

J Biol Chem. 2003 May 9;278(19):16706-12. Epub 2003 Feb 27.


Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.

Shepard LW, Yang M, Xie P, Browning DD, Voyno-Yasenetskaya T, Kozasa T, Ye RD.

J Biol Chem. 2001 Dec 7;276(49):45979-87. Epub 2001 Oct 4.


Cyclic AMP-independent activation of protein kinase A by vasoactive peptides.

Dulin NO, Niu J, Browning DD, Ye RD, Voyno-Yasenetskaya T.

J Biol Chem. 2001 Jun 15;276(24):20827-30. Epub 2001 Apr 30.


Functional analysis of type 1alpha cGMP-dependent protein kinase using green fluorescent fusion proteins.

Browning DD, Mc Shane M, Marty C, Ye RD.

J Biol Chem. 2001 Apr 20;276(16):13039-48. Epub 2001 Jan 22.


Differential roles of the NPXXY motif in formyl peptide receptor signaling.

He R, Browning DD, Ye RD.

J Immunol. 2001 Mar 15;166(6):4099-105.


Autocrine regulation of interleukin-8 production in human monocytes.

Browning DD, Diehl WC, Hsu MH, Schraufstatter IU, Ye RD.

Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1129-36.


The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor.

He R, Tan L, Browning DD, Wang JM, Ye RD.

J Immunol. 2000 Oct 15;165(8):4598-605.


NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.

Hsu MH, Wang M, Browning DD, Mukaida N, Ye RD.

Blood. 1999 May 15;93(10):3241-9.


Cell type- and developmental stage-specific activation of NF-kappaB by fMet-Leu-Phe in myeloid cells.

Browning DD, Pan ZK, Prossnitz ER, Ye RD.

J Biol Chem. 1997 Mar 21;272(12):7995-8001.


Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts.

Pan ZK, Zuraw BL, Lung CC, Prossnitz ER, Browning DD, Ye RD.

J Clin Invest. 1996 Nov 1;98(9):2042-9.


Gene transcription through activation of G-protein-coupled chemoattractant receptors.

Ye RD, Pan Z, Kravchenko VV, Browning DD, Prossnitz ER.

Gene Expr. 1996;5(4-5):205-15.


The regulation of GTP-binding proteins during fertilization and zygote differentiation in Dictyostelium discoideum.

Browning DD, Poludnikiewicz MB, Proteau GA, O'Day DH.

Exp Cell Res. 1993 Apr;205(2):240-5.


Zygote giant cell differentiation in Dictyostelium discoideum: biochemical markers of specific stages of sexual development.

Browning DD, Lewis KE, O'Day DH.

Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1200-8.


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