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Items: 25


Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.

He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM.

Nat Chem Biol. 2017 Nov;13(11):1164-1171. doi: 10.1038/nchembio.2463. Epub 2017 Sep 11.


A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.

He H, Yang Y, Xiang Z, Yu L, Chouitar J, Yu J, D'Amore NR, Li P, Li Z, Bowman D, Theisen M, Brownell JE, Tirrell S.

J Biomark. 2016;2016:1274603. doi: 10.1155/2016/1274603. Epub 2016 May 10.


Identification of a lung cancer cell line deficient in atg7-dependent autophagy.

Mandelbaum J, Rollins N, Shah P, Bowman D, Lee JY, Tayber O, Bernard H, LeRoy P, Li P, Koenig E, Brownell JE, D'Amore N.

Autophagy. 2015 Jun 19:0. [Epub ahead of print]


Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.

He X, Riceberg J, Pulukuri SM, Grossman S, Shinde V, Shah P, Brownell JE, Dick L, Newcomb J, Bence N.

PLoS One. 2015 Apr 10;10(4):e0123882. doi: 10.1371/journal.pone.0123882. eCollection 2015.


Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry.

Yang X, Brownell JE, Xu Q, Zhu F, Ma J, Loke HK, Rollins N, Soucy TA, Minissale JJ, Thomas MP, Mallender WD, Dick LR, Li P, Liao H.

Cell Biochem Biophys. 2013 Sep;67(1):139-47. doi: 10.1007/s12013-013-9625-5.


Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.

Gavin JM, Chen JJ, Liao H, Rollins N, Yang X, Xu Q, Ma J, Loke HK, Lingaraj T, Brownell JE, Mallender WD, Gould AE, Amidon BS, Dick LR.

J Biol Chem. 2012 May 4;287(19):15512-22. doi: 10.1074/jbc.M111.336198. Epub 2012 Mar 15.


Identification and application of NEDD8 E1 inhibitors.

Bruzzese FJ, Milhollen MA, Gavin JM, Josephine HR, Brownell JE.

Methods Mol Biol. 2012;832:577-88. doi: 10.1007/978-1-61779-474-2_40.


Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.

Chen JJ, Tsu CA, Gavin JM, Milhollen MA, Bruzzese FJ, Mallender WD, Sintchak MD, Bump NJ, Yang X, Ma J, Loke HK, Xu Q, Li P, Bence NF, Brownell JE, Dick LR.

J Biol Chem. 2011 Nov 25;286(47):40867-77. doi: 10.1074/jbc.M111.279984. Epub 2011 Oct 3.


The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.

Soucy TA, Dick LR, Smith PG, Milhollen MA, Brownell JE.

Genes Cancer. 2010 Jul;1(7):708-16. doi: 10.1177/1947601910382898.


Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.

Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE.

Nat Rev Drug Discov. 2011 Jan;10(1):29-46. doi: 10.1038/nrd3321. Epub 2010 Dec 10. Review.


Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.

Brownell JE, Sintchak MD, Gavin JM, Liao H, Bruzzese FJ, Bump NJ, Soucy TA, Milhollen MA, Yang X, Burkhardt AL, Ma J, Loke HK, Lingaraj T, Wu D, Hamman KB, Spelman JJ, Cullis CA, Langston SP, Vyskocil S, Sells TB, Mallender WD, Visiers I, Li P, Claiborne CF, Rolfe M, Bolen JB, Dick LR.

Mol Cell. 2010 Jan 15;37(1):102-11. doi: 10.1016/j.molcel.2009.12.024.


An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, Brownell JE, Burke KE, Cardin DP, Critchley S, Cullis CA, Doucette A, Garnsey JJ, Gaulin JL, Gershman RE, Lublinsky AR, McDonald A, Mizutani H, Narayanan U, Olhava EJ, Peluso S, Rezaei M, Sintchak MD, Talreja T, Thomas MP, Traore T, Vyskocil S, Weatherhead GS, Yu J, Zhang J, Dick LR, Claiborne CF, Rolfe M, Bolen JB, Langston SP.

Nature. 2009 Apr 9;458(7239):732-6. doi: 10.1038/nature07884.


An SDS-PAGE-based enzyme activity assay for the detection and identification of histone acetyltransferases.

Brownell JE, Mizzen CA, Allis CD.

Methods Mol Biol. 1999;119:343-53. Review. No abstract available.


A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.

Podust VN, Brownell JE, Gladysheva TB, Luo RS, Wang C, Coggins MB, Pierce JW, Lightcap ES, Chau V.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4579-84.


Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.

Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ.

Mol Cell Biol. 2000 Apr;20(7):2326-33.


Histone acetyltransferases: preparation of substrates and assay procedures.

Mizzen CA, Brownell JE, Cook RG, Allis CD.

Methods Enzymol. 1999;304:675-96. No abstract available.


A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila.

Ohba R, Steger DJ, Brownell JE, Mizzen CA, Cook RG, Côté J, Workman JL, Allis CD.

Mol Cell Biol. 1999 Mar;19(3):2061-8.


Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

Grant PA, Duggan L, Côté J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL.

Genes Dev. 1997 Jul 1;11(13):1640-50.


The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.

Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD.

Cell. 1996 Dec 27;87(7):1261-70.


Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines.

Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD.

Nature. 1996 Sep 19;383(6597):269-72.


Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation.

Brownell JE, Allis CD.

Curr Opin Genet Dev. 1996 Apr;6(2):176-84. Review.


Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.

Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD.

Cell. 1996 Mar 22;84(6):843-51.


Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus.

Alvarez ME, Houck DR, White CB, Brownell JE, Bobko MA, Rodger CA, Stawicki MB, Sun HH, Gillum AM, Cooper R.

J Antibiot (Tokyo). 1994 Nov;47(11):1195-201.


WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. I. Fermentation and isolation.

Sedlock DM, Barrow CJ, Brownell JE, Hong A, Gillum AM, Houck DR.

J Antibiot (Tokyo). 1994 Apr;47(4):391-8.

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