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Items: 1 to 50 of 104


Cytomegalovirus Colitis Masquerading as Apple-Core Lesion after Systemic Chemotherapy in a Patient with Relapsed Acute Myeloid Leukemia.

An J, Brownell J, Barker D, Stockinger T, Brady R, Cebe K, Baur R.

Case Rep Oncol Med. 2018 Mar 20;2018:5683417. doi: 10.1155/2018/5683417. eCollection 2018.


A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF.

Nat Med. 2018 Feb;24(2):186-193. doi: 10.1038/nm.4474. Epub 2018 Jan 15.


Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.

He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM.

Nat Chem Biol. 2017 Nov;13(11):1164-1171. doi: 10.1038/nchembio.2463. Epub 2017 Sep 11.


The Role of Photodynamic Therapy in Acne: An Evidence-Based Review.

Boen M, Brownell J, Patel P, Tsoukas MM.

Am J Clin Dermatol. 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. Review.


A case report of iatrogenic cutaneous Kaposi sarcoma due to rituximab therapy for thrombotic thrombocytopenic purpura.

Jerdan K, Brownell J, Singh M, Braniecki M, Chan L.

Acta Oncol. 2017 Jan;56(1):111-113. doi: 10.1080/0284186X.2016.1253867. Epub 2016 Nov 25. No abstract available.


Phototherapy in cosmetic dermatology.

Brownell J, Wang S, Tsoukas MM.

Clin Dermatol. 2016 Sep-Oct;34(5):623-7. doi: 10.1016/j.clindermatol.2016.05.013. Epub 2016 May 20. Review.


Compliance and phototherapy.

Brownell J, Wang S, Tsoukas MM.

Clin Dermatol. 2016 Sep-Oct;34(5):582-6. doi: 10.1016/j.clindermatol.2016.05.007. Epub 2016 May 20. Review.


A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.

He H, Yang Y, Xiang Z, Yu L, Chouitar J, Yu J, D'Amore NR, Li P, Li Z, Bowman D, Theisen M, Brownell JE, Tirrell S.

J Biomark. 2016;2016:1274603. doi: 10.1155/2016/1274603. Epub 2016 May 10.


Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling.

Lovelace ES, Wagoner J, MacDonald J, Bammler T, Bruckner J, Brownell J, Beyer RP, Zink EM, Kim YM, Kyle JE, Webb-Robertson BJ, Waters KM, Metz TO, Farin F, Oberlies NH, Polyak SJ.

J Nat Prod. 2015 Aug 28;78(8):1990-2000. doi: 10.1021/acs.jnatprod.5b00288. Epub 2015 Jul 17.


A Plasmodium α/β-hydrolase modulates the development of invasive stages.

Groat-Carmona AM, Kain H, Brownell J, Douglass AN, Aly AS, Kappe SH.

Cell Microbiol. 2015 Dec;17(12):1848-67. doi: 10.1111/cmi.12477. Epub 2015 Jul 24.


Identification of a lung cancer cell line deficient in atg7-dependent autophagy.

Mandelbaum J, Rollins N, Shah P, Bowman D, Lee JY, Tayber O, Bernard H, LeRoy P, Li P, Koenig E, Brownell JE, D'Amore N.

Autophagy. 2015 Jun 19:0. [Epub ahead of print]


Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.

He X, Riceberg J, Pulukuri SM, Grossman S, Shinde V, Shah P, Brownell JE, Dick L, Newcomb J, Bence N.

PLoS One. 2015 Apr 10;10(4):e0123882. doi: 10.1371/journal.pone.0123882. eCollection 2015.


Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression.

Stone AE, Mitchell A, Brownell J, Miklin DJ, Golden-Mason L, Polyak SJ, Gale MJ Jr, Rosen HR.

PLoS One. 2014 May 1;9(5):e95627. doi: 10.1371/journal.pone.0095627. eCollection 2014.


Emergency department charges for asthma-related outpatient visits by insurance status.

Wang T, Srebotnjak T, Brownell J, Hsia RY.

J Health Care Poor Underserved. 2014 Feb;25(1):396-405. doi: 10.1353/hpu.2014.0051.


Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection.

Brownell J, Bruckner J, Wagoner J, Thomas E, Loo YM, Gale M Jr, Liang TJ, Polyak SJ.

J Virol. 2014 Feb;88(3):1582-90. doi: 10.1128/JVI.02007-13. Epub 2013 Nov 20.


Trends in emergency department visits for ambulatory care sensitive conditions by elderly nursing home residents, 2001 to 2010.

Brownell J, Wang J, Smith A, Stephens C, Hsia RY.

JAMA Intern Med. 2014 Jan;174(1):156-8. doi: 10.1001/jamainternmed.2013.11821. No abstract available.


Trends in adult emergency department visits in California by insurance status, 2005-2010.

Hsia RY, Brownell J, Wilson S, Gordon N, Baker LC.

JAMA. 2013 Sep 18;310(11):1181-3. doi: 10.1001/jama.2013.228331. No abstract available.


Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes.

Brownell J, Wagoner J, Lovelace ES, Thirstrup D, Mohar I, Smith W, Giugliano S, Li K, Crispe IN, Rosen HR, Polyak SJ.

J Hepatol. 2013 Oct;59(4):701-8. doi: 10.1016/j.jhep.2013.06.001. Epub 2013 Jun 12.


Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry.

Yang X, Brownell JE, Xu Q, Zhu F, Ma J, Loke HK, Rollins N, Soucy TA, Minissale JJ, Thomas MP, Mallender WD, Dick LR, Li P, Liao H.

Cell Biochem Biophys. 2013 Sep;67(1):139-47. doi: 10.1007/s12013-013-9625-5.


Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancer.

Brownell J, Polyak SJ.

Clin Cancer Res. 2013 Mar 15;19(6):1347-52. doi: 10.1158/1078-0432.CCR-12-0928. Epub 2013 Jan 15. Review.


In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models.

Smith WE, Brownell J, White CC, Afsharinejad Z, Tsai J, Hu X, Polyak SJ, Gao X, Kavanagh TJ, Eaton DL.

ACS Nano. 2012 Nov 27;6(11):9475-84. doi: 10.1021/nn302288r. Epub 2012 Oct 18.


Geographic proximity of HRSA, VA, and DOD clinics: opportunities for interagency collaboration to improve quality.

Brownell J, Xierali I, Herrera AP, Calvo A.

J Health Care Poor Underserved. 2012 Aug;23(3 Suppl):125-35. doi: 10.1353/hpu.2012.0130.


Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

Milhollen MA, Thomas MP, Narayanan U, Traore T, Riceberg J, Amidon BS, Bence NF, Bolen JB, Brownell J, Dick LR, Loke HK, McDonald AA, Ma J, Manfredi MG, Sells TB, Sintchak MD, Yang X, Xu Q, Koenig EM, Gavin JM, Smith PG.

Cancer Cell. 2012 Mar 20;21(3):388-401. doi: 10.1016/j.ccr.2012.02.009.


Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.

Gavin JM, Chen JJ, Liao H, Rollins N, Yang X, Xu Q, Ma J, Loke HK, Lingaraj T, Brownell JE, Mallender WD, Gould AE, Amidon BS, Dick LR.

J Biol Chem. 2012 May 4;287(19):15512-22. doi: 10.1074/jbc.M111.336198. Epub 2012 Mar 15.


Identification and application of NEDD8 E1 inhibitors.

Bruzzese FJ, Milhollen MA, Gavin JM, Josephine HR, Brownell JE.

Methods Mol Biol. 2012;832:577-88. doi: 10.1007/978-1-61779-474-2_40.


Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues.

Chen JJ, Tsu CA, Gavin JM, Milhollen MA, Bruzzese FJ, Mallender WD, Sintchak MD, Bump NJ, Yang X, Ma J, Loke HK, Xu Q, Li P, Bence NF, Brownell JE, Dick LR.

J Biol Chem. 2011 Nov 25;286(47):40867-77. doi: 10.1074/jbc.M111.279984. Epub 2011 Oct 3.


The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.

Soucy TA, Dick LR, Smith PG, Milhollen MA, Brownell JE.

Genes Cancer. 2010 Jul;1(7):708-16. doi: 10.1177/1947601910382898.


Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.

Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE.

Nat Rev Drug Discov. 2011 Jan;10(1):29-46. doi: 10.1038/nrd3321. Epub 2010 Dec 10. Review.


Can you defend the actions of your medical assistants?

Brownell J.

Del Med J. 2010 Mar;82(3):101-2. No abstract available.


Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.

Brownell JE, Sintchak MD, Gavin JM, Liao H, Bruzzese FJ, Bump NJ, Soucy TA, Milhollen MA, Yang X, Burkhardt AL, Ma J, Loke HK, Lingaraj T, Wu D, Hamman KB, Spelman JJ, Cullis CA, Langston SP, Vyskocil S, Sells TB, Mallender WD, Visiers I, Li P, Claiborne CF, Rolfe M, Bolen JB, Dick LR.

Mol Cell. 2010 Jan 15;37(1):102-11. doi: 10.1016/j.molcel.2009.12.024.


An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, Brownell JE, Burke KE, Cardin DP, Critchley S, Cullis CA, Doucette A, Garnsey JJ, Gaulin JL, Gershman RE, Lublinsky AR, McDonald A, Mizutani H, Narayanan U, Olhava EJ, Peluso S, Rezaei M, Sintchak MD, Talreja T, Thomas MP, Traore T, Vyskocil S, Weatherhead GS, Yu J, Zhang J, Dick LR, Claiborne CF, Rolfe M, Bolen JB, Langston SP.

Nature. 2009 Apr 9;458(7239):732-6. doi: 10.1038/nature07884.


Control of self-assembly of DNA tubules through integration of gold nanoparticles.

Sharma J, Chhabra R, Cheng A, Brownell J, Liu Y, Yan H.

Science. 2009 Jan 2;323(5910):112-6. doi: 10.1126/science.1165831.


Detectability of dissipative motion in quantum vacuum via superradiance.

Kim WJ, Brownell JH, Onofrio R.

Phys Rev Lett. 2006 May 26;96(20):200402. Epub 2006 May 22. Erratum in: Phys Rev Lett. 2006 Aug 25;97(8):089902.


Necrotizing pneumonia with a questionable lung mass in a 59-year-old man.

Brownell J, Lin H, Bewtra A, Townley R, Casale TB.

Ann Allergy Asthma Immunol. 2006 Jan;96(1):116-21. No abstract available.


Anti-IgE therapy.

Brownell J, Casale TB.

Immunol Allergy Clin North Am. 2004 Nov;24(4):551-68, v. Review.


Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH.

J Biol Chem. 2004 Aug 27;279(35):36440-4. Epub 2004 Jul 9.


High-order Cerenkov laser gain.

Owens IJ, Brownell JH.

Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Mar;67(3 Pt 2):036611. Epub 2003 Mar 20.


Amplified-spontaneous-emission power oscillation in a beam-wave interaction.

Bakhtyari A, Walsh JE, Brownell JH.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Jun;65(6 Pt 2):066503. Epub 2002 Jun 11.


Optimization of Smith-Purcell radiation at very high energies.

Trotz SR, Brownell JH, Walsh JE, Doucas G.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Jun;61(6 Pt B):7057-64.


An SDS-PAGE-based enzyme activity assay for the detection and identification of histone acetyltransferases.

Brownell JE, Mizzen CA, Allis CD.

Methods Mol Biol. 1999;119:343-53. Review. No abstract available.


A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.

Podust VN, Brownell JE, Gladysheva TB, Luo RS, Wang C, Coggins MB, Pierce JW, Lightcap ES, Chau V.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4579-84.


Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.

Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ.

Mol Cell Biol. 2000 Apr;20(7):2326-33.


Signaling to chromatin through histone modifications: how clear is the signal?

Mizzen C, Kuo MH, Smith E, Brownell J, Zhou J, Ohba R, Wei Y, Monaco L, Sassone-Corsi P, Allis CD.

Cold Spring Harb Symp Quant Biol. 1998;63:469-81. Review. No abstract available.


Histone acetyltransferases: preparation of substrates and assay procedures.

Mizzen CA, Brownell JE, Cook RG, Allis CD.

Methods Enzymol. 1999;304:675-96. No abstract available.


A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila.

Ohba R, Steger DJ, Brownell JE, Mizzen CA, Cook RG, Côté J, Workman JL, Allis CD.

Mol Cell Biol. 1999 Mar;19(3):2061-8.


Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

Grant PA, Duggan L, Côté J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL.

Genes Dev. 1997 Jul 1;11(13):1640-50.


Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.

Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL.

Mol Cell Biol. 1997 Jan;17(1):519-27.


The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.

Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD.

Cell. 1996 Dec 27;87(7):1261-70.


Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines.

Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD.

Nature. 1996 Sep 19;383(6597):269-72.


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