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The crippling financial toxicity of cancer in the United States.

Collado L, Brownell I.

Cancer Biol Ther. 2019;20(10):1301-1303. doi: 10.1080/15384047.2019.1632132. Epub 2019 Jul 10.


Cancer-testis antigens as biomarkers for Merkel cell carcinoma: Pitfalls and opportunities.

Dasgeb B, Mehregan D, Ring C, Nartker N, Brownell I.

J Cutan Pathol. 2019 Oct;46(10):748-752. doi: 10.1111/cup.13528. Epub 2019 Jul 11.


Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report.

Cardis MA, Jiang H, Strauss J, Gulley JL, Brownell I.

BMC Cancer. 2019 Jun 4;19(1):539. doi: 10.1186/s12885-019-5759-1.


Immunotherapy for skin cancer.

Paulson KG, Lahman MC, Chapuis AG, Brownell I.

Int Immunol. 2019 Jul 13;31(7):465-475. doi: 10.1093/intimm/dxz012.


Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.

D'Angelo SP, Hunger M, Brohl AS, Nghiem P, Bhatia S, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Schlichting M, Hennessy MH, Bharmal M.

Cancer Immunol Immunother. 2019 Apr;68(4):609-618. doi: 10.1007/s00262-018-02295-4. Epub 2019 Feb 5.


Innumerable lentigines in a mother and daughter.

Cardis MA, Hathaway O, Brownell I.

Pediatr Dermatol. 2019 Jan;36(1):160-162. doi: 10.1111/pde.13701. No abstract available.


Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

Pastrana DV, Peretti A, Welch NL, Borgogna C, Olivero C, Badolato R, Notarangelo LD, Gariglio M, FitzGerald PC, McIntosh CE, Reeves J, Starrett GJ, Bliskovsky V, Velez D, Brownell I, Yarchoan R, Wyvill KM, Uldrick TS, Maldarelli F, Lisco A, Sereti I, Gonzalez CM, Androphy EJ, McBride AA, Van Doorslaer K, Garcia F, Dvoretzky I, Liu JS, Han J, Murphy PM, McDermott DH, Buck CB.

mSphere. 2018 Dec 12;3(6). pii: e00645-18. doi: 10.1128/mSphereDirect.00645-18.


The biology and treatment of Merkel cell carcinoma: current understanding and research priorities.

Harms PW, Harms KL, Moore PS, DeCaprio JA, Nghiem P, Wong MKK, Brownell I; International Workshop on Merkel Cell Carcinoma Research (IWMCC) Working Group.

Nat Rev Clin Oncol. 2018 Dec;15(12):763-776. doi: 10.1038/s41571-018-0103-2. Review.


The biology of cutaneous neurofibromas: Consensus recommendations for setting research priorities.

Brosseau JP, Pichard DC, Legius EH, Wolkenstein P, Lavker RM, Blakeley JO, Riccardi VM, Verma SK, Brownell I, Le LQ.

Neurology. 2018 Jul 10;91(2 Suppl 1):S14-S20. doi: 10.1212/WNL.0000000000005788.


Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells.

Gaiser MR, Weis CA, Gaiser T, Jiang H, Buder-Bakhaya K, Herpel E, Warth A, Xiao Y, Miao L, Brownell I.

Oncoimmunology. 2018 Feb 8;7(5):e1426517. doi: 10.1080/2162402X.2018.1426517. eCollection 2018.


Avelumab: a new standard for treating metastatic Merkel cell carcinoma.

Baker M, Cordes L, Brownell I.

Expert Rev Anticancer Ther. 2018 Apr;18(4):319-326. doi: 10.1080/14737140.2018.1445528. Epub 2018 Feb 28. Review.


PD-L1 inhibition with avelumab for metastatic Merkel cell carcinoma.

Gaiser MR, Bongiorno M, Brownell I.

Expert Rev Clin Pharmacol. 2018 Apr;11(4):345-359. doi: 10.1080/17512433.2018.1445966. Epub 2018 Mar 14. Review.


Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial.

Kaufman HL, Russell JS, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Milella M, Brownell I, Lewis KD, Lorch JH, von Heydebreck A, Hennessy M, Nghiem P.

J Immunother Cancer. 2018 Jan 19;6(1):7. doi: 10.1186/s40425-017-0310-x.


Anti-PD-L1 Treatment Induced Central Diabetes Insipidus.

Zhao C, Tella SH, Del Rivero J, Kommalapati A, Ebenuwa I, Gulley J, Strauss J, Brownell I.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):365-369. doi: 10.1210/jc.2017-01905.


PD-L1 blockade with avelumab: A new paradigm for treating Merkel cell carcinoma.

Barkdull S, Brownell I.

Cancer Biol Ther. 2017 Dec 2;18(12):937-939. doi: 10.1080/15384047.2017.1394552. Epub 2017 Nov 27.


Melanoma in patients with GATA2 deficiency.

Nguyen J, Alexander T, Jiang H, Hill N, Abdullaev Z, Pack SD, Hsu AP, Holland SM, Hickstein DD, Engels EA, Brownell I.

Pigment Cell Melanoma Res. 2018 Mar;31(2):337-340. doi: 10.1111/pcmr.12671. Epub 2017 Dec 10.


Colchicine: an ancient drug with novel applications.

Dasgeb B, Kornreich D, McGuinn K, Okon L, Brownell I, Sackett DL.

Br J Dermatol. 2018 Feb;178(2):350-356. doi: 10.1111/bjd.15896. Epub 2018 Jan 3. Review.


Seeking Standards for the Detection of Merkel Cell Polyomavirus and its Clinical Significance.

Eid M, Nguyen J, Brownell I.

J Invest Dermatol. 2017 Apr;137(4):797-799. doi: 10.1016/j.jid.2016.12.024.


Hedgehog Signaling Inhibitors Fail to Reduce Merkel Cell Carcinoma Viability.

Carroll TM, Williams JS, Daily K, Rogers T, Gelb T, Coxon A, Wang SQ, Crago AM, Busam KJ, Brownell I.

J Invest Dermatol. 2017 May;137(5):1187-1190. doi: 10.1016/j.jid.2017.01.008. Epub 2017 Jan 25. No abstract available.


PD-1 checkpoint blockade is an emerging treatment for Merkel cell carcinoma.

Cassler NM, Brownell I.

Br J Dermatol. 2017 Jan;176(1):18. doi: 10.1111/bjd.14828. No abstract available.


Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.

Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P.

Lancet Oncol. 2016 Oct;17(10):1374-1385. doi: 10.1016/S1470-2045(16)30364-3. Epub 2016 Sep 1.


A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.

Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, Wong SY, Brownell I.

PLoS Genet. 2016 Jul 14;12(7):e1006150. doi: 10.1371/journal.pgen.1006150. eCollection 2016 Jul.


Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease.

Peterson SC, Brownell I, Wong SY.

J Vis Exp. 2016 Jun 26;(112). doi: 10.3791/54050.


Merkel Cell Carcinoma Therapeutic Update.

Cassler NM, Merrill D, Bichakjian CK, Brownell I.

Curr Treat Options Oncol. 2016 Jul;17(7):36. doi: 10.1007/s11864-016-0409-1. Review.


Evaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers.

Gaiser MR, Daily K, Hoffmann J, Brune M, Enk A, Brownell I.

Oncotarget. 2015 Sep 22;6(28):26472-82. doi: 10.18632/oncotarget.4500.


Individualized iterative phenotyping for genome-wide analysis of loss-of-function mutations.

Johnston JJ, Lewis KL, Ng D, Singh LN, Wynter J, Brewer C, Brooks BP, Brownell I, Candotti F, Gonsalves SG, Hart SP, Kong HH, Rother KI, Sokolic R, Solomon BD, Zein WM, Cooper DN, Stenson PD, Mullikin JC, Biesecker LG.

Am J Hum Genet. 2015 Jun 4;96(6):913-25. doi: 10.1016/j.ajhg.2015.04.013.


Cutaneous squamous and neuroendocrine carcinoma: genetically and immunohistochemically different from Merkel cell carcinoma.

Pulitzer MP, Brannon AR, Berger MF, Louis P, Scott SN, Jungbluth AA, Coit DG, Brownell I, Busam KJ.

Mod Pathol. 2015 Aug;28(8):1023-32. doi: 10.1038/modpathol.2015.60. Epub 2015 May 29.


Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium.

Xiao Y, Thoresen DT, Williams JS, Wang C, Perna J, Petrova R, Brownell I.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7195-200. doi: 10.1073/pnas.1504177112. Epub 2015 May 26.


Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma.

Daily K, Coxon A, Williams JS, Lee CR, Coit DG, Busam KJ, Brownell I.

J Invest Dermatol. 2015 Apr;135(4):1138-1146. doi: 10.1038/jid.2014.518. Epub 2014 Dec 18.


Merkel cells and touch domes: more than mechanosensory functions?

Xiao Y, Williams JS, Brownell I.

Exp Dermatol. 2014 Oct;23(10):692-5. doi: 10.1111/exd.12456. Epub 2014 Jul 16. Review.


Low pH reprograms somatic murine cells into pluripotent stem cells: a novel technique with therapeutic implications.

Williams JS, Xiao Y, Brownell I.

Cancer Biol Ther. 2014 Jun 1;15(6):675-7. doi: 10.4161/cbt.28414. Epub 2014 Mar 11. Review.


Mosaic partial deletion of the PTEN gene in a patient with Cowden syndrome.

Salo-Mullen EE, Shia J, Brownell I, Allen P, Girotra M, Robson ME, Offit K, Guillem JG, Markowitz AJ, Stadler ZK.

Fam Cancer. 2014 Sep;13(3):459-67. doi: 10.1007/s10689-014-9709-4.


Recurrent erythematous plaques on sun-exposed sites in an African American boy with chronic granulomatous disease.

Turegano MM, Lee CC, Malech HL, De Ravin SS, Cowen EW, Brownell I.

J Am Acad Dermatol. 2014 Mar;70(3):576-80. doi: 10.1016/j.jaad.2013.09.051. No abstract available.


Levamisole toxicity mimicking autoimmune disease.

Strazzula L, Brown KK, Brieva JC, Camp BJ, Frankel HC, Kissin E, Mahlberg MJ, Mina MA, Pomeranz MK, Brownell I, Kroshinsky D.

J Am Acad Dermatol. 2013 Dec;69(6):954-9. doi: 10.1016/j.jaad.2013.07.037. Epub 2013 Sep 24.


Targeting the hedgehog pathway to treat basal cell carcinoma.

Geeraert P, Williams JS, Brownell I.

J Drugs Dermatol. 2013 May;12(5):519-23. Review.


Perivascular hair follicle stem cells associate with a venule annulus.

Xiao Y, Woo WM, Nagao K, Li W, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I.

J Invest Dermatol. 2013 Oct;133(10):2324-2331. doi: 10.1038/jid.2013.167. Epub 2013 Apr 4.


Hedgehog signaling in neonatal and adult lung.

Liu L, Kugler MC, Loomis CA, Samdani R, Zhao Z, Chen GJ, Brandt JP, Brownell I, Joyner AL, Rom WN, Munger JS.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):703-10. doi: 10.1165/rcmb.2012-0347OC.


The abscopal effect associated with a systemic anti-melanoma immune response.

Stamell EF, Wolchok JD, Gnjatic S, Lee NY, Brownell I.

Int J Radiat Oncol Biol Phys. 2013 Feb 1;85(2):293-5. doi: 10.1016/j.ijrobp.2012.03.017. Epub 2012 May 5.


Allergic contact dermatitis to gamma-irradiated WEBCOL alcohol prep pads.

Firoz EF, Turnbull RK, Loomis CA, Brownell I.

Pediatr Dermatol. 2013 Nov-Dec;30(6):e281-2. doi: 10.1111/j.1525-1470.2012.01727.x. Epub 2012 Apr 4.


Selective radiotherapy for the treatment of head and neck Merkel cell carcinoma.

Lok B, Khan S, Mutter R, Liu J, Fields R, Pulitzer M, Shi W, Zhang Z, Kraus D, Pfister D, Busam KJ, Brownell I, Lee N.

Cancer. 2012 Aug 15;118(16):3937-44. doi: 10.1002/cncr.26738. Epub 2011 Dec 16.


Donor-derived lymphomatoid papulosis in a stem-cell transplantation recipient.

Camp BJ, Busam KJ, Brownell I, Koehne G, Hedvat C, Pulitzer MP.

J Clin Oncol. 2011 Dec 10;29(35):e855-8. doi: 10.1200/JCO.2011.37.7101. Epub 2011 Oct 31. No abstract available.


Cyclophosphamide-associated acneiform drug eruption in a patient with multiple myeloma.

Kovalyshyn I, Bijal AD, Lacouture ME, Brownell I.

J Am Acad Dermatol. 2011 Sep;65(3):657-659. doi: 10.1016/j.jaad.2010.05.003. No abstract available.


Radiation therapy in the management of Merkel cell carcinoma: current perspectives.

Rush Z, Fields RC, Lee N, Brownell I.

Expert Rev Dermatol. 2011 Aug;6(4):395-404.


Longitudinal lift biopsy technique with flat fixation for the diagnosis of mycosis fungoides.

Brooks C, Pulitzer MP, Brownell I.

Int J Dermatol. 2011 Jul;50(7):875-6. doi: 10.1111/j.1365-4632.2010.04806.x. No abstract available.


Evidence for mycobacteria in sarcoidosis.

Brownell I, Ramírez-Valle F, Sanchez M, Prystowsky S.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):899-905. doi: 10.1165/rcmb.2010-0433TR. Epub 2011 Jun 9. Review.


Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.

Brownell I, Guevara E, Bai CB, Loomis CA, Joyner AL.

Cell Stem Cell. 2011 May 6;8(5):552-65. doi: 10.1016/j.stem.2011.02.021.


Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development.

Tran TH, Jarrell A, Zentner GE, Welsh A, Brownell I, Scacheri PC, Atit R.

Development. 2010 Dec;137(23):3973-84. doi: 10.1242/dev.056473. Epub 2010 Oct 27.


Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.

Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD.

Development. 2010 Nov;137(22):3753-61. doi: 10.1242/dev.056358.


Treatments for genital warts.

Cook K, Brownell I.

J Drugs Dermatol. 2008 Aug;7(8):801-7. Review. No abstract available.


Cutaneous Rosai-Dorfman disease.

Merola JF, Pulitzer M, Rosenman K, Brownell I.

Dermatol Online J. 2008 May 15;14(5):8.


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