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AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies.

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DCS, Wei A, Canon J, Coxon A, Hughes PE.

Cancer Discov. 2018 Sep 25. pii: CD-18-0387. doi: 10.1158/2159-8290.CD-18-0387. [Epub ahead of print]


Exploiting MCL-1 dependency with combination MEK + MCL-1 inhibitors leads to induction of apoptosis and tumor regression in KRAS mutant non-small cell lung cancer.

Nangia V, Siddiqui FM, Caenepeel S, Timonina D, Bilton SJ, Phan N, Gomez-Caraballo M, Archibald HL, Li C, Fraser C, Rigas D, Vajda K, Ferris LA, Lanuti M, Wright CD, Raskin KA, Cahill DP, Shin JH, Keyes C, Sequist LV, Piotrowska Z, Farago AF, Azzoli CG, Gainor JF, Sarosiek KA, Brown SP, Coxon A, Benes CH, Hughes PE, Hata AN.

Cancer Discov. 2018 Sep 25. pii: CD-18-0277. doi: 10.1158/2159-8290.CD-18-0277. [Epub ahead of print]


Protocols for Investigating the Leaf Mycobiome Using High-Throughput DNA Sequencing.

Brown SP, Leopold DR, Busby PE.

Methods Mol Biol. 2018;1848:39-51. doi: 10.1007/978-1-4939-8724-5_4.


An NMR crystallography investigation of furosemide.

Zilka M, Yates JR, Brown SP.

Magn Reson Chem. 2018 Aug 23. doi: 10.1002/mrc.4789. [Epub ahead of print]


The use of variable temperature 13 C solid-state MAS NMR and GIPAW DFT calculations to explore the dynamics of diethylcarbamazine citrate.

Venâncio T, Oliveira LM, Pawlak T, Ellena J, Boechat N, Brown SP.

Magn Reson Chem. 2018 Aug 16. doi: 10.1002/mrc.4790. [Epub ahead of print]


A Tautoleptic Approach to Chiral Hydrogen-Bonded Supramolecular Tubular Polymers with Large Cavity.

Neniškis A, Račkauskaitė D, Shi Q, Robertson AJ, Marsh A, Ulčinas A, Valiokas R, Brown SP, Wärnmark K, Orentas E.

Chemistry. 2018 Sep 20;24(53):14028-14033. doi: 10.1002/chem.201803701. Epub 2018 Sep 6.


The development of local circuits in the neocortex: recent lessons from the mouse visual cortex.

Chevée M, Brown SP.

Curr Opin Neurobiol. 2018 Jul 24;53:103-109. doi: 10.1016/j.conb.2018.06.009. [Epub ahead of print] Review.


Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.

Brown SP, Dransfield P, Vimolratana M, Zhu L, Luo J, Zhang J, Jiao X, Pattaropong V, Wong S, Zhuang R, Swaminath G, Houze JB, Lin DC.

ACS Med Chem Lett. 2018 Jun 6;9(7):757-760. doi: 10.1021/acsmedchemlett.8b00213. eCollection 2018 Jul 12.


Community interactions and spatial structure shape selection on antibiotic resistant lineages.

Estrela S, Brown SP.

PLoS Comput Biol. 2018 Jun 21;14(6):e1006179. doi: 10.1371/journal.pcbi.1006179. eCollection 2018 Jun.


A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices.

Minamisawa G, Kwon SE, Chevée M, Brown SP, O'Connor DH.

Cell Rep. 2018 May 29;23(9):2718-2731.e6. doi: 10.1016/j.celrep.2018.04.115.


The State of the Union Is Strong: a Review of ASM's 6th Conference on Cell-Cell Communication in Bacteria.

Brown SP, Blackwell HE, Hammer BK.

J Bacteriol. 2018 Jun 25;200(14). pii: e00291-18. doi: 10.1128/JB.00291-18. Print 2018 Jul 15. Review.


Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests.

Pollack RA, Brown SP, Rea T, Aufderheide T, Barbic D, Buick JE, Christenson J, Idris AH, Jasti J, Kampp M, Kudenchuk P, May S, Muhr M, Nichol G, Ornato JP, Sopko G, Vaillancourt C, Morrison L, Weisfeldt M; ROC Investigators.

Circulation. 2018 May 15;137(20):2104-2113. doi: 10.1161/CIRCULATIONAHA.117.030700. Epub 2018 Feb 26.


Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons.

Chevée M, Robertson JJ, Cannon GH, Brown SP, Goff LA.

Cell Rep. 2018 Jan 9;22(2):441-455. doi: 10.1016/j.celrep.2017.12.046.


Alternative therapeutics for self-limiting infections-An indirect approach to the antibiotic resistance challenge.

Wollein Waldetoft K, Brown SP.

PLoS Biol. 2017 Dec 28;15(12):e2003533. doi: 10.1371/journal.pbio.2003533. eCollection 2017 Dec.


New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum.

Brown SP, Mathur BN, Olsen SR, Luppi PH, Bickford ME, Citri A.

J Neurosci. 2017 Nov 8;37(45):10877-10881. doi: 10.1523/JNEUROSCI.1837-17.2017. Review.


Isotope-Labeled Aspartate Sidechain as a Non-Perturbing Infrared Probe: Application to Investigate the Dynamics of a Carboxylate Buried Inside a Protein.

Abaskharon RM, Brown SP, Zhang W, Chen J, Smith AB 3rd, Gai F.

Chem Phys Lett. 2017 Sep 1;683:193-198. doi: 10.1016/j.cplett.2017.03.064. Epub 2017 Mar 23.


Visualising crystal packing interactions in solid-state NMR: Concepts and applications.

Zilka M, Sturniolo S, Brown SP, Yates JR.

J Chem Phys. 2017 Oct 14;147(14):144203. doi: 10.1063/1.4996750.


Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.

Wagman AS, Boyce RS, Brown SP, Fang E, Goff D, Jansen JM, Le VP, Levine BH, Ng SC, Ni ZJ, Nuss JM, Pfister KB, Ramurthy S, Renhowe PA, Ring DB, Shu W, Subramanian S, Zhou XA, Shafer CM, Harrison SD, Johnson KW, Bussiere DE.

J Med Chem. 2017 Oct 26;60(20):8482-8514. doi: 10.1021/acs.jmedchem.7b00922. Epub 2017 Oct 10.


Use of Immunolabeling to Analyze Stable, Dynamic, and Nascent Microtubules in the Zebrafish Embryo.

McFarland RJ, Brown SP, Vital E, Werner JM, Brewster RM.

J Vis Exp. 2017 Sep 20;(127). doi: 10.3791/55792.


An even pattern of xylan substitution is critical for interaction with cellulose in plant cell walls.

Grantham NJ, Wurman-Rodrich J, Terrett OM, Lyczakowski JJ, Stott K, Iuga D, Simmons TJ, Durand-Tardif M, Brown SP, Dupree R, Busse-Wicher M, Dupree P.

Nat Plants. 2017 Nov;3(11):859-865. doi: 10.1038/s41477-017-0030-8. Epub 2017 Oct 9.


Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.

Liu K, Kim J, Kim DW, Stephanie Zhang Y, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham IR, Pachnis V, Hattar S, Song J, Brown SP, Blackshaw S.

Nature. 2017 Oct 26;550(7677):548. doi: 10.1038/nature24274. Epub 2017 Sep 27.


Ab initio random structure searching of organic molecular solids: assessment and validation against experimental data.

Zilka M, Dudenko DV, Hughes CE, Williams PA, Sturniolo S, Franks WT, Pickard CJ, Yates JR, Harris KDM, Brown SP.

Phys Chem Chem Phys. 2017 Oct 4;19(38):25949-25960. doi: 10.1039/c7cp04186a.


Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.

Liu K, Kim J, Kim DW, Zhang YS, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham IR, Pachnis V, Hattar S, Song J, Brown SP, Blackshaw S.

Nature. 2017 Aug 31;548(7669):582-587. doi: 10.1038/nature23663. Epub 2017 Aug 23. Erratum in: Nature. 2017 Sep 27;:.


Strong-coupling induced damping of spin-echo modulations in magic-angle-spinning NMR: Implications for J coupling measurements in disordered solids.

Guerry P, Brown SP, Smith ME.

J Magn Reson. 2017 Oct;283:22-32. doi: 10.1016/j.jmr.2017.08.006. Epub 2017 Aug 19.


Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease.

Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP.

J Neurosci. 2017 Sep 13;37(37):9037-9053. doi: 10.1523/JNEUROSCI.0811-17.2017. Epub 2017 Aug 17.


Division of Labor, Bet Hedging, and the Evolution of Mixed Biofilm Investment Strategies.

Lowery NV, McNally L, Ratcliff WC, Brown SP.

MBio. 2017 Aug 8;8(4). pii: e00672-17. doi: 10.1128/mBio.00672-17.


Assessing the Detection Limit of a Minority Solid-State Form of a Pharmaceutical by 1H Double-Quantum Magic-Angle Spinning Nuclear Magnetic Resonance Spectroscopy.

Maruyoshi K, Iuga D, Watts AE, Hughes CE, Harris KDM, Brown SP.

J Pharm Sci. 2017 Nov;106(11):3372-3377. doi: 10.1016/j.xphs.2017.07.014. Epub 2017 Jul 25.


Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog.

Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP.

Sci Rep. 2017 Jul 18;7(1):5685. doi: 10.1038/s41598-017-05864-2.


The evolution of library design: crafting smart compound collections for phenotypic screens.

Spear KL, Brown SP.

Drug Discov Today Technol. 2017 Mar;23:61-67. doi: 10.1016/j.ddtec.2017.05.001. Epub 2017 May 30. Review.


The route of infection determines Wolbachia antibacterial protection in Drosophila.

Gupta V, Vasanthakrishnan RB, Siva-Jothy J, Monteith KM, Brown SP, Vale PF.

Proc Biol Sci. 2017 Jun 14;284(1856). pii: 20170809. doi: 10.1098/rspb.2017.0809.


Within-host interference competition can prevent invasion of rare parasites.

Quigley BJZ, Brown SP, Leggett HC, Scanlan PD, Buckling A.

Parasitology. 2018 May;145(6):770-774. doi: 10.1017/S003118201700052X. Epub 2017 May 15.


Probing intermolecular interactions in a diethylcarbamazine citrate salt by fast MAS 1H solid-state NMR spectroscopy and GIPAW calculations.

Venâncio T, Oliveira LM, Ellena J, Boechat N, Brown SP.

Solid State Nucl Magn Reson. 2017 Oct;87:73-79. doi: 10.1016/j.ssnmr.2017.02.006. Epub 2017 Mar 2.


Single-crystal X-ray diffraction and NMR crystallography of a 1:1 cocrystal of dithianon and pyrimethanil.

Pöppler AC, Corlett EK, Pearce H, Seymour MP, Reid M, Montgomery MG, Brown SP.

Acta Crystallogr C Struct Chem. 2017 Mar 1;73(Pt 3):149-156. doi: 10.1107/S2053229617000870. Epub 2017 Feb 6.


Killing by Type VI secretion drives genetic phase separation and correlates with increased cooperation.

McNally L, Bernardy E, Thomas J, Kalziqi A, Pentz J, Brown SP, Hammer BK, Yunker PJ, Ratcliff WC.

Nat Commun. 2017 Feb 6;8:14371. doi: 10.1038/ncomms14371.


Superhero physiology: the case for Captain America.

Brown SP, Smith JW, McAllister M, Joe L.

Adv Physiol Educ. 2017 Mar 1;41(1):16-24. doi: 10.1152/advan.00106.2016.


Rationalising Heteronuclear Decoupling in Refocussing Applications of Solid-State NMR Spectroscopy.

Frantsuzov I, Vasa SK, Ernst M, Brown SP, Zorin V, Kentgens AP, Hodgkinson P.

Chemphyschem. 2017 Feb 17;18(4):394-405. doi: 10.1002/cphc.201601003. Epub 2017 Jan 23.


Manipulating virulence factor availability can have complex consequences for infections.

Weigert M, Ross-Gillespie A, Leinweber A, Pessi G, Brown SP, Kümmerli R.

Evol Appl. 2016 Oct 24;10(1):91-101. doi: 10.1111/eva.12431. eCollection 2017 Jan.


Folding of xylan onto cellulose fibrils in plant cell walls revealed by solid-state NMR.

Simmons TJ, Mortimer JC, Bernardinelli OD, Pöppler AC, Brown SP, deAzevedo ER, Dupree R, Dupree P.

Nat Commun. 2016 Dec 21;7:13902. doi: 10.1038/ncomms13902.


Co-existence of Distinct Supramolecular Assemblies in Solution and in the Solid State.

Reddy GN, Huqi A, Iuga D, Sakurai S, Marsh A, Davis JT, Masiero S, Brown SP.

Chemistry. 2017 Feb 16;23(10):2315-2322. doi: 10.1002/chem.201604832. Epub 2016 Dec 22.


An oscillating tragedy of the commons in replicator dynamics with game-environment feedback.

Weitz JS, Eksin C, Paarporn K, Brown SP, Ratcliff WC.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7518-E7525. Epub 2016 Nov 8.


Fast Magic-Angle Spinning Three-Dimensional NMR Experiment for Simultaneously Probing H-H and N-H Proximities in Solids.

Reddy GN, Malon M, Marsh A, Nishiyama Y, Brown SP.

Anal Chem. 2016 Dec 6;88(23):11412-11419. Epub 2016 Nov 11.


Challenges in microbial ecology: building predictive understanding of community function and dynamics.

Widder S, Allen RJ, Pfeiffer T, Curtis TP, Wiuf C, Sloan WT, Cordero OX, Brown SP, Momeni B, Shou W, Kettle H, Flint HJ, Haas AF, Laroche B, Kreft JU, Rainey PB, Freilich S, Schuster S, Milferstedt K, van der Meer JR, Groβkopf T, Huisman J, Free A, Picioreanu C, Quince C, Klapper I, Labarthe S, Smets BF, Wang H; Isaac Newton Institute Fellows, Soyer OS.

ISME J. 2016 Nov;10(11):2557-2568. doi: 10.1038/ismej.2016.45. Epub 2016 Mar 29. Review.


Visualizing evolution as it happens.

McNally L, Brown SP.

Science. 2016 Sep 9;353(6304):1096-7. doi: 10.1126/science.aah5641. No abstract available.


Microbiome: Ecology of stable gut communities.

McNally L, Brown SP.

Nat Microbiol. 2016 Jan 11;1:15016. doi: 10.1038/nmicrobiol.2015.16. No abstract available.


What change in outcomes after cardiac arrest is necessary to change practice? Results of an international survey.

Nichol G, Brown SP, Perkins GD, Kim F, Sterz F, Broeckel Elrod JA, Mentzelopoulos S, Lyon R, Arabi Y, Castren M, Larsen P, Valenzuela T, Graesner JT, Youngquist S, Khunkhlai N, Wang HE, Ondrej F, Sastrias JM, Barasa A, Sayre MR.

Resuscitation. 2016 Oct;107:115-20. doi: 10.1016/j.resuscitation.2016.08.004. Epub 2016 Aug 23.


Spatial and successional dynamics of microbial biofilm communities in a grassland stream ecosystem.

Veach AM, Stegen JC, Brown SP, Dodds WK, Jumpponen A.

Mol Ecol. 2016 Sep;25(18):4674-88. doi: 10.1111/mec.13784. Epub 2016 Sep 6.


Visualization and processing of computed solid-state NMR parameters: MagresView and MagresPython.

Sturniolo S, Green TFG, Hanson RM, Zilka M, Refson K, Hodgkinson P, Brown SP, Yates JR.

Solid State Nucl Magn Reson. 2016 Sep;78:64-70. doi: 10.1016/j.ssnmr.2016.05.004. Epub 2016 Jun 4.


Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis.

Zhang Y, Nikolovski N, Sorieul M, Vellosillo T, McFarlane HE, Dupree R, Kesten C, Schneider R, Driemeier C, Lathe R, Lampugnani E, Yu X, Ivakov A, Doblin MS, Mortimer JC, Brown SP, Persson S, Dupree P.

Nat Commun. 2016 Jun 9;7:11656. doi: 10.1038/ncomms11656.


Indirect Fitness Benefits Enable the Spread of Host Genes Promoting Costly Transfer of Beneficial Plasmids.

Dimitriu T, Misevic D, Lotton C, Brown SP, Lindner AB, Taddei F.

PLoS Biol. 2016 Jun 7;14(6):e1002478. doi: 10.1371/journal.pbio.1002478. eCollection 2016 Jun.

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