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5-amino-2-methylpyridinium hydrogen fumarate: an XRD and NMR crystallography analysis.

Corlett EK, Blade H, Hughes LP, Sidebottom PJ, Walker D, Walton RI, Brown SP.

Magn Reson Chem. 2020 Mar 18. doi: 10.1002/mrc.5021. [Epub ahead of print]


Information growth for sequential monitoring of clinical trials with a stepped wedge cluster randomized design and unknown intracluster correlation.

Brown SP, Shoben AB.

Clin Trials. 2020 Feb 6:1740774520901488. doi: 10.1177/1740774520901488. [Epub ahead of print]


Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors.

Ramurthy S, Pfister KB, Boyce RS, Brown SP, Costales AQ, Desai MC, Fang E, Levine BH, Ng SC, Nuss JM, Ring DB, Shafer CM, Shu W, Subramanian S, Wagman AS, Wang H, Bussiere DE.

Bioorg Med Chem Lett. 2020 Feb 15;30(4):126930. doi: 10.1016/j.bmcl.2019.126930. Epub 2019 Dec 23.


Revealing Intermolecular Hydrogen Bonding Structure and Dynamics in a Deep Eutectic Pharmaceutical by Magic-Angle Spinning NMR Spectroscopy.

Mann SK, Pham TN, McQueen LL, Lewandowski JR, Brown SP.

Mol Pharm. 2020 Feb 3;17(2):622-631. doi: 10.1021/acs.molpharmaceut.9b01075. Epub 2020 Jan 13.


Weak Intermolecular CH···N Hydrogen Bonding: Determination of 13CH-15N Hydrogen-Bond Mediated J Couplings by Solid-State NMR Spectroscopy and First-Principles Calculations.

Webber AL, Yates JR, Zilka M, Sturniolo S, Uldry AC, Corlett EK, Pickard CJ, Pérez-Torralba M, Angeles Garcia M, Santa Maria D, Claramunt RM, Brown SP.

J Phys Chem A. 2020 Jan 23;124(3):560-572. doi: 10.1021/acs.jpca.9b10726. Epub 2020 Jan 9.


Evolving Antibiotics against Resistance: a Potential Platform for Natural Product Development?

Wollein Waldetoft K, Gurney J, Lachance J, Hoskisson PA, Brown SP.

mBio. 2019 Dec 24;10(6). pii: e02946-19. doi: 10.1128/mBio.02946-19.


Non-inferiority designs comparing placebo to a proven therapy for childhood pneumonia in low-resource settings.

May S, Brown SP, Schmicker RH, Emerson SS, Nkwopara E, Ginsburg AS.

Clin Trials. 2019 Dec 8:1740774519888460. doi: 10.1177/1740774519888460. [Epub ahead of print]


Steering Phages to Combat Bacterial Pathogens.

Gurney J, Brown SP, Kaltz O, Hochberg ME.

Trends Microbiol. 2020 Feb;28(2):85-94. doi: 10.1016/j.tim.2019.10.007. Epub 2019 Nov 16. Review. No abstract available.


Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.

Rescourio G, Gonzalez AZ, Jabri S, Belmontes B, Moody G, Whittington D, Huang X, Caenepeel S, Cardozo M, Cheng AC, Chow D, Dou H, Jones A, Kelly RC, Li Y, Lizarzaburu M, Lo MC, Mallari R, Meleza C, Rew Y, Simonovich S, Sun D, Turcotte S, Yan X, Wong SG, Yanez E, Zancanella M, Houze J, Medina JC, Hughes PE, Brown SP.

J Med Chem. 2019 Nov 27;62(22):10258-10271. doi: 10.1021/acs.jmedchem.9b01310. Epub 2019 Nov 18.


Molecular architecture of softwood revealed by solid-state NMR.

Terrett OM, Lyczakowski JJ, Yu L, Iuga D, Franks WT, Brown SP, Dupree R, Dupree P.

Nat Commun. 2019 Oct 31;10(1):4978. doi: 10.1038/s41467-019-12979-9.


The Synaptic Organization of Layer 6 Circuits Reveals Inhibition as a Major Output of a Neocortical Sublamina.

Frandolig JE, Matney CJ, Lee K, Kim J, Chevée M, Kim SJ, Bickert AA, Brown SP.

Cell Rep. 2019 Sep 17;28(12):3131-3143.e5. doi: 10.1016/j.celrep.2019.08.048.


Modified Antibiotic Adjuvant Ratios Can Slow and Steer the Evolution of Resistance: Co-amoxiclav as a Case Study.

Allen RC, Brown SP.

mBio. 2019 Sep 17;10(5). pii: e01831-19. doi: 10.1128/mBio.01831-19.


Identifying the components of the solid-electrolyte interphase in Li-ion batteries.

Wang L, Menakath A, Han F, Wang Y, Zavalij PY, Gaskell KJ, Borodin O, Iuga D, Brown SP, Wang C, Xu K, Eichhorn BW.

Nat Chem. 2019 Sep;11(9):789-796. doi: 10.1038/s41557-019-0304-z. Epub 2019 Aug 19.


Patient Reminders and Longitudinal Adherence to Lung Cancer Screening in an Academic Setting.

Hirsch EA, New ML, Brown SP, Barón AE, Malkoski SP.

Ann Am Thorac Soc. 2019 Oct;16(10):1329-1332. doi: 10.1513/AnnalsATS.201902-152RL. No abstract available.


Modulation of Transmembrane Domain Interactions in Neu Receptor Tyrosine Kinase by Membrane Fluidity and Cholesterol.

Hasan M, Patel D, Ellis N, Brown SP, Lewandowski JR, Dixon AM.

J Membr Biol. 2019 Oct;252(4-5):357-369. doi: 10.1007/s00232-019-00075-4. Epub 2019 Jun 20.


Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation.

McAdams D, Wollein Waldetoft K, Tedijanto C, Lipsitch M, Brown SP.

PLoS Biol. 2019 May 16;17(5):e3000250. doi: 10.1371/journal.pbio.3000250. eCollection 2019 May.


Haemolymph removal by Varroa mite destabilizes the dynamical interaction between immune effectors and virus in bees, as predicted by Volterra's model.

Annoscia D, Brown SP, Di Prisco G, De Paoli E, Del Fabbro S, Frizzera D, Zanni V, Galbraith DA, Caprio E, Grozinger CM, Pennacchio F, Nazzi F.

Proc Biol Sci. 2019 Apr 24;286(1901):20190331. doi: 10.1098/rspb.2019.0331.


Psychological Care Augmented by Telemedicine after a Polar Bear Encounter at an Arctic Research Station: A Case Report.

Brown SP, Davis HE, McGladrey L, Brooks L, Lorentzen AK, Penninga L, Davis C, Lemery J.

Telemed J E Health. 2020 Mar;26(3):369-373. doi: 10.1089/tmj.2019.0008. Epub 2019 Mar 25.


International variation in survival after out-of-hospital cardiac arrest: A validation study of the Utstein template.

Dyson K, Brown SP, May S, Smith K, Koster RW, Beesems SG, Kuisma M, Salo A, Finn J, Sterz F, Nürnberger A, Morrison LJ, Olasveengen TM, Callaway CW, Shin SD, Gräsner JT, Daya M, Ma MH, Herlitz J, Strömsöe A, Aufderheide TP, Masterson S, Wang H, Christenson J, Stiell I, Vilke GM, Idris A, Nishiyama C, Iwami T, Nichol G.

Resuscitation. 2019 May;138:168-181. doi: 10.1016/j.resuscitation.2019.03.018. Epub 2019 Mar 18.


Microbial Ecology of Snow Reveals Taxa-Specific Biogeographical Structure.

Brown SP, Jumpponen A.

Microb Ecol. 2019 May;77(4):946-958. doi: 10.1007/s00248-019-01357-z. Epub 2019 Mar 13.


Individual- versus group-optimality in the production of secreted bacterial compounds.

Schiessl KT, Ross-Gillespie A, Cornforth DM, Weigert M, Bigosch C, Brown SP, Ackermann M, Kümmerli R.

Evolution. 2019 Apr;73(4):675-688. doi: 10.1111/evo.13701. Epub 2019 Feb 28.


Bystander automated external defibrillator application in non-shockable out-of-hospital cardiac arrest.

Pollack RA, Brown SP, May S, Rea T, Kudenchuk PJ, Weisfeldt ML.

Resuscitation. 2019 Apr;137:168-174. doi: 10.1016/j.resuscitation.2019.02.007. Epub 2019 Feb 18.


Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon.

Shen P, Lees JA, Bee GCW, Brown SP, Weiser JN.

Nat Microbiol. 2019 Jan;4(1):198-208. doi: 10.1038/s41564-018-0314-4. Epub 2018 Dec 10.


Wood decomposition in aquatic and terrestrial ecosystems in the tropics: contrasting biotic and abiotic processes.

Jones JM, Heath KD, Ferrer A, Brown SP, Canam T, Dalling JW.

FEMS Microbiol Ecol. 2019 Jan 1;95(1). doi: 10.1093/femsec/fiy223.


Evolution of bacterial trade in a two-species community.

Farrell JM, Brown SP.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11874-11875. doi: 10.1073/pnas.1817344115. Epub 2018 Nov 12. No abstract available.


Environmentally Mediated Social Dilemmas.

Estrela S, Libby E, Van Cleve J, Débarre F, Deforet M, Harcombe WR, Peña J, Brown SP, Hochberg ME.

Trends Ecol Evol. 2019 Jan;34(1):6-18. doi: 10.1016/j.tree.2018.10.004. Epub 2018 Nov 8. Review.


Intraosseous versus intravenous access in patients with out-of-hospital cardiac arrest: Insights from the resuscitation outcomes consortium continuous chest compression trial.

Mody P, Brown SP, Kudenchuk PJ, Chan PS, Khera R, Ayers C, Pandey A, Kern KB, de Lemos JA, Link MS, Idris AH.

Resuscitation. 2019 Jan;134:69-75. doi: 10.1016/j.resuscitation.2018.10.031. Epub 2018 Nov 1.


AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE.

Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Erratum in: Cancer Discov. 2019 Jul;9(7):980.


Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer.

Nangia V, Siddiqui FM, Caenepeel S, Timonina D, Bilton SJ, Phan N, Gomez-Caraballo M, Archibald HL, Li C, Fraser C, Rigas D, Vajda K, Ferris LA, Lanuti M, Wright CD, Raskin KA, Cahill DP, Shin JH, Keyes C, Sequist LV, Piotrowska Z, Farago AF, Azzoli CG, Gainor JF, Sarosiek KA, Brown SP, Coxon A, Benes CH, Hughes PE, Hata AN.

Cancer Discov. 2018 Dec;8(12):1598-1613. doi: 10.1158/2159-8290.CD-18-0277. Epub 2018 Sep 25.


Protocols for Investigating the Leaf Mycobiome Using High-Throughput DNA Sequencing.

Brown SP, Leopold DR, Busby PE.

Methods Mol Biol. 2018;1848:39-51. doi: 10.1007/978-1-4939-8724-5_4.


An NMR crystallography investigation of furosemide.

Zilka M, Yates JR, Brown SP.

Magn Reson Chem. 2019 May;57(5):191-199. doi: 10.1002/mrc.4789. Epub 2018 Oct 11.


The use of variable temperature 13 C solid-state MAS NMR and GIPAW DFT calculations to explore the dynamics of diethylcarbamazine citrate.

Venâncio T, Oliveira LM, Pawlak T, Ellena J, Boechat N, Brown SP.

Magn Reson Chem. 2019 May;57(5):200-210. doi: 10.1002/mrc.4790. Epub 2018 Oct 15.


A Tautoleptic Approach to Chiral Hydrogen-Bonded Supramolecular Tubular Polymers with Large Cavity.

Neniškis A, Račkauskaitė D, Shi Q, Robertson AJ, Marsh A, Ulčinas A, Valiokas R, Brown SP, Wärnmark K, Orentas E.

Chemistry. 2018 Sep 20;24(53):14028-14033. doi: 10.1002/chem.201803701. Epub 2018 Sep 6.


The development of local circuits in the neocortex: recent lessons from the mouse visual cortex.

Chevée M, Brown SP.

Curr Opin Neurobiol. 2018 Dec;53:103-109. doi: 10.1016/j.conb.2018.06.009. Epub 2018 Jul 24. Review.


Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.

Brown SP, Dransfield P, Vimolratana M, Zhu L, Luo J, Zhang J, Jiao X, Pattaropong V, Wong S, Zhuang R, Swaminath G, Houze JB, Lin DC.

ACS Med Chem Lett. 2018 Jun 6;9(7):757-760. doi: 10.1021/acsmedchemlett.8b00213. eCollection 2018 Jul 12.


Community interactions and spatial structure shape selection on antibiotic resistant lineages.

Estrela S, Brown SP.

PLoS Comput Biol. 2018 Jun 21;14(6):e1006179. doi: 10.1371/journal.pcbi.1006179. eCollection 2018 Jun.


A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices.

Minamisawa G, Kwon SE, Chevée M, Brown SP, O'Connor DH.

Cell Rep. 2018 May 29;23(9):2718-2731.e6. doi: 10.1016/j.celrep.2018.04.115.


The State of the Union Is Strong: a Review of ASM's 6th Conference on Cell-Cell Communication in Bacteria.

Brown SP, Blackwell HE, Hammer BK.

J Bacteriol. 2018 Jun 25;200(14). pii: e00291-18. doi: 10.1128/JB.00291-18. Print 2018 Jul 15. Review.


Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests.

Pollack RA, Brown SP, Rea T, Aufderheide T, Barbic D, Buick JE, Christenson J, Idris AH, Jasti J, Kampp M, Kudenchuk P, May S, Muhr M, Nichol G, Ornato JP, Sopko G, Vaillancourt C, Morrison L, Weisfeldt M; ROC Investigators.

Circulation. 2018 May 15;137(20):2104-2113. doi: 10.1161/CIRCULATIONAHA.117.030700. Epub 2018 Feb 26.


Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons.

Chevée M, Robertson JJ, Cannon GH, Brown SP, Goff LA.

Cell Rep. 2018 Jan 9;22(2):441-455. doi: 10.1016/j.celrep.2017.12.046.


Alternative therapeutics for self-limiting infections-An indirect approach to the antibiotic resistance challenge.

Wollein Waldetoft K, Brown SP.

PLoS Biol. 2017 Dec 28;15(12):e2003533. doi: 10.1371/journal.pbio.2003533. eCollection 2017 Dec.


New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum.

Brown SP, Mathur BN, Olsen SR, Luppi PH, Bickford ME, Citri A.

J Neurosci. 2017 Nov 8;37(45):10877-10881. doi: 10.1523/JNEUROSCI.1837-17.2017. Review.


Isotope-Labeled Aspartate Sidechain as a Non-Perturbing Infrared Probe: Application to Investigate the Dynamics of a Carboxylate Buried Inside a Protein.

Abaskharon RM, Brown SP, Zhang W, Chen J, Smith AB 3rd, Gai F.

Chem Phys Lett. 2017 Sep 1;683:193-198. doi: 10.1016/j.cplett.2017.03.064. Epub 2017 Mar 23.


Visualising crystal packing interactions in solid-state NMR: Concepts and applications.

Zilka M, Sturniolo S, Brown SP, Yates JR.

J Chem Phys. 2017 Oct 14;147(14):144203. doi: 10.1063/1.4996750.


Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.

Wagman AS, Boyce RS, Brown SP, Fang E, Goff D, Jansen JM, Le VP, Levine BH, Ng SC, Ni ZJ, Nuss JM, Pfister KB, Ramurthy S, Renhowe PA, Ring DB, Shu W, Subramanian S, Zhou XA, Shafer CM, Harrison SD, Johnson KW, Bussiere DE.

J Med Chem. 2017 Oct 26;60(20):8482-8514. doi: 10.1021/acs.jmedchem.7b00922. Epub 2017 Oct 10.


Use of Immunolabeling to Analyze Stable, Dynamic, and Nascent Microtubules in the Zebrafish Embryo.

McFarland RJ, Brown SP, Vital E, Werner JM, Brewster RM.

J Vis Exp. 2017 Sep 20;(127). doi: 10.3791/55792.


An even pattern of xylan substitution is critical for interaction with cellulose in plant cell walls.

Grantham NJ, Wurman-Rodrich J, Terrett OM, Lyczakowski JJ, Stott K, Iuga D, Simmons TJ, Durand-Tardif M, Brown SP, Dupree R, Busse-Wicher M, Dupree P.

Nat Plants. 2017 Nov;3(11):859-865. doi: 10.1038/s41477-017-0030-8. Epub 2017 Oct 9.


Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.

Liu K, Kim J, Kim DW, Stephanie Zhang Y, Bao H, Denaxa M, Lim SA, Kim E, Liu C, Wickersham IR, Pachnis V, Hattar S, Song J, Brown SP, Blackshaw S.

Nature. 2017 Oct 26;550(7677):548. doi: 10.1038/nature24274. Epub 2017 Sep 27.

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