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An N-Ethyl-N-Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion.

Esapa CT, Piret SE, Nesbit MA, Thomas GP, Coulton LA, Gallagher OM, Simon MM, Kumar S, Mallon AM, Bellantuono I, Brown MA, Croucher PI, Potter PK, Brown SD, Cox RD, Thakker RV.

JBMR Plus. 2018 Mar 8;2(3):154-163. doi: 10.1002/jbm4.10033. eCollection 2018 May.


Cellular content plays a crucial role in Non-typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear.

Vikhe PP, Purnell T, Brown SDM, Hood DW.

Cell Microbiol. 2018 Sep 28:e12960. doi: 10.1111/cmi.12960. [Epub ahead of print]


The effects of provider-prescribed obesogenic drugs on post-laparoscopic sleeve gastrectomy outcomes: a retrospective cohort study.

Leggett CB, Desalermos A, Brown SD, Lee E, Proudfoot JA, Horgan S, Gupta S, Grunvald E, Ho SB, Zarrinpar A.

Int J Obes (Lond). 2018 Sep 21. doi: 10.1038/s41366-018-0207-x. [Epub ahead of print]


Development and characterization of stable anaerobic thermophilic methanogenic microbiomes fermenting switchgrass at decreasing residence times.

Liang X, Whitham JM, Holwerda EK, Shao X, Tian L, Wu YW, Lombard V, Henrissat B, Klingeman DM, Yang ZK, Podar M, Richard TL, Elkins JG, Brown SD, Lynd LR.

Biotechnol Biofuels. 2018 Sep 6;11:243. doi: 10.1186/s13068-018-1238-1. eCollection 2018.


Transcriptomic and proteomic changes from medium supplementation and strain evolution in high-yielding Clostridium thermocellum strains.

Papanek B, O'Dell KB, Manga P, Giannone RJ, Klingeman DM, Hettich RL, Brown SD, Guss AM.

J Ind Microbiol Biotechnol. 2018 Nov;45(11):1007-1015. doi: 10.1007/s10295-018-2073-x. Epub 2018 Sep 5.


Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.

Kharenko OA, Patel RG, Brown SD, Calosing C, White A, Lakshminarasimhan D, Suto RK, Duffy BC, Kitchen DB, McLure KG, Hansen HC, van der Horst EH, Young PR.

J Med Chem. 2018 Sep 27;61(18):8202-8211. doi: 10.1021/acs.jmedchem.8b00666. Epub 2018 Sep 13.


Multifunctional Enzyme Packaging and Catalysis in the Qβ Protein Nanoparticle.

Fiedler JD, Fishman MR, Brown SD, Lau J, Finn MG.

Biomacromolecules. 2018 Oct 8;19(10):3945-3957. doi: 10.1021/acs.biomac.8b00885. Epub 2018 Aug 30.


Band target entropy minimization and target partial least squares for spectral recovery and quantitation.

Kneale C, Brown SD.

Anal Chim Acta. 2018 Nov 15;1031:38-46. doi: 10.1016/j.aca.2018.07.054. Epub 2018 Jul 26.


The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation.

Muñoz-Fuentes V, Cacheiro P, Meehan TF, Aguilar-Pimentel JA, Brown SDM, Flenniken AM, Flicek P, Galli A, Mashhadi HH, Hrabě de Angelis M, Kim JK, Lloyd KCK, McKerlie C, Morgan H, Murray SA, Nutter LMJ, Reilly PT, Seavitt JR, Seong JK, Simon M, Wardle-Jones H, Mallon AM, Smedley D, Parkinson HE; IMPC consortium.

Conserv Genet. 2018;19(4):995-1005. doi: 10.1007/s10592-018-1072-9. Epub 2018 May 19.


Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a "Plug and Play" Domain.

Holliday GL, Akiva E, Meng EC, Brown SD, Calhoun S, Pieper U, Sali A, Booker SJ, Babbitt PC.

Methods Enzymol. 2018;606:1-71. doi: 10.1016/bs.mie.2018.06.004. Epub 2018 Jul 24.


Uncharted forest: A technique for exploratory data analysis.

Kneale C, Brown SD.

Talanta. 2018 Nov 1;189:71-78. doi: 10.1016/j.talanta.2018.06.061. Epub 2018 Jun 20.


When Extremists Win: Cultural Transmission Via Iterated Learning When Populations Are Heterogeneous.

Navarro DJ, Perfors A, Kary A, Brown SD, Donkin C.

Cogn Sci. 2018 Sep;42(7):2108-2149. doi: 10.1111/cogs.12667. Epub 2018 Jul 31.


A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen CM, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S.

Sci Rep. 2018 Jul 11;8(1):10439. doi: 10.1038/s41598-018-28714-1.


Refining the law of practice.

Evans NJ, Brown SD, Mewhort DJK, Heathcote A.

Psychol Rev. 2018 Jul;125(4):592-605. doi: 10.1037/rev0000105.


Bone matrix development in steroid-induced osteoporosis is associated with a consistently reduced fibrillar stiffness linked to altered bone mineral quality.

Xi L, De Falco P, Barbieri E, Karunaratne A, Bentley L, Esapa CT, Terrill NJ, Brown SDM, Cox RD, Davis GR, Pugno NM, Thakker RV, Gupta HS.

Acta Biomater. 2018 Aug;76:295-307. doi: 10.1016/j.actbio.2018.05.053. Epub 2018 Jun 15.


Multivalent Display Using Hybrid Virus Nanoparticles.

Brown SD.

Methods Mol Biol. 2018;1798:119-140. doi: 10.1007/978-1-4939-7893-9_10.


"I Sleep, But My Heart Is Awake": <i>Negotiating marginal states in life and death</i>.

Hayden MC, Brown SD.

Perspect Biol Med. 2018;61(1):106-117. doi: 10.1353/pbm.2018.0030.


Rex in Caldicellulosiruptor bescii: Novel regulon members and its effect on the production of ethanol and overflow metabolites.

Sander K, Chung D, Hyatt D, Westpheling J, Klingeman DM, Rodriguez M Jr, Engle NL, Tschaplinski TJ, Davison BH, Brown SD.

Microbiologyopen. 2018 May 23:e00639. doi: 10.1002/mbo3.639. [Epub ahead of print]


Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

Zhang AW, McPherson A, Milne K, Kroeger DR, Hamilton PT, Miranda A, Funnell T, Little N, de Souza CPE, Laan S, LeDoux S, Cochrane DR, Lim JLP, Yang W, Roth A, Smith MA, Ho J, Tse K, Zeng T, Shlafman I, Mayo MR, Moore R, Failmezger H, Heindl A, Wang YK, Bashashati A, Grewal DS, Brown SD, Lai D, Wan ANC, Nielsen CB, Huebner C, Tessier-Cloutier B, Anglesio MS, Bouchard-Côté A, Yuan Y, Wasserman WW, Gilks CB, Karnezis AN, Aparicio S, McAlpine JN, Huntsman DG, Holt RA, Nelson BH, Shah SP.

Cell. 2018 Jun 14;173(7):1755-1769.e22. doi: 10.1016/j.cell.2018.03.073. Epub 2018 May 10.


Complete genome sequence and the expression pattern of plasmids of the model ethanologen Zymomonas mobilis ZM4 and its xylose-utilizing derivatives 8b and 2032.

Yang S, Vera JM, Grass J, Savvakis G, Moskvin OV, Yang Y, McIlwain SJ, Lyu Y, Zinonos I, Hebert AS, Coon JJ, Bates DM, Sato TK, Brown SD, Himmel ME, Zhang M, Landick R, Pappas KM, Zhang Y.

Biotechnol Biofuels. 2018 May 2;11:125. doi: 10.1186/s13068-018-1116-x. eCollection 2018.


Genetic landscape of auditory dysfunction.

Bowl MR, Brown SDM.

Hum Mol Genet. 2018 Aug 1;27(R2):R130-R135. doi: 10.1093/hmg/ddy158.


Quality versus quantity in end-of-life choices of cancer patients and support persons: a discrete choice experiment.

Waller A, Sanson-Fisher R, Brown SD, Wall L, Walsh J.

Support Care Cancer. 2018 Oct;26(10):3593-3599. doi: 10.1007/s00520-018-4226-x. Epub 2018 May 3.


A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes Mellitus: The Gestational Diabetes' Effects on Moms (GEM) Cluster-Randomized Controlled Trial.

Hedderson MM, Brown SD, Ehrlich SF, Tsai AL, Zhu Y, Quesenberry CP, Crites Y, Ferrara A.

Diabetes Care. 2018 Jul;41(7):1370-1377. doi: 10.2337/dc17-1133. Epub 2018 Apr 18.


Clostridium thermocellum LL1210 pH homeostasis mechanisms informed by transcriptomics and metabolomics.

Whitham JM, Moon JW, Rodriguez M Jr, Engle NL, Klingeman DM, Rydzak T, Abel MM, Tschaplinski TJ, Guss AM, Brown SD.

Biotechnol Biofuels. 2018 Apr 5;11:98. doi: 10.1186/s13068-018-1095-y. eCollection 2018.


The Immune Landscape of Cancer.

Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Sivakumar IKA, Gentles AJ, Malhotra R, Farshidfar F, Colaprico A, Parker JS, Mose LE, Vo NS, Liu J, Liu Y, Rader J, Dhankani V, Reynolds SM, Bowlby R, Califano A, Cherniack AD, Anastassiou D, Bedognetti D, Rao A, Chen K, Krasnitz A, Hu H, Malta TM, Noushmehr H, Pedamallu CS, Bullman S, Ojesina AI, Lamb A, Zhou W, Shen H, Choueiri TK, Weinstein JN, Guinney J, Saltz J, Holt RA, Rabkin CE; Cancer Genome Atlas Research Network, Lazar AJ, Serody JS, Demicco EG, Disis ML, Vincent BG, Shmulevich L.

Immunity. 2018 Apr 17;48(4):812-830.e14. doi: 10.1016/j.immuni.2018.03.023. Epub 2018 Apr 5.


High-throughput mouse phenomics for characterizing mammalian gene function.

Brown SDM, Holmes CC, Mallon AM, Meehan TF, Smedley D, Wells S.

Nat Rev Genet. 2018 Jun;19(6):357-370. doi: 10.1038/s41576-018-0005-2. Review.


Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M.

Nat Methods. 2018 Apr;15(4):235-236. doi: 10.1038/nmeth.4559. Epub 2018 Mar 30. No abstract available.


Genetic interactions between the chromosome axis-associated protein Hop1 and homologous recombination determinants in Schizosaccharomyces pombe.

Brown SD, Jarosinska OD, Lorenz A.

Curr Genet. 2018 Oct;64(5):1089-1104. doi: 10.1007/s00294-018-0827-7. Epub 2018 Mar 17.


A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.

Corrochano S, Blanco G, Williams D, Wettstein J, Simon M, Kumar S, Moir L, Agnew T, Stewart M, Landman A, Kotiadis VN, Duchen MR, Wackerhage H, Rubinsztein DC, Brown SDM, Acevedo-Arozena A.

Hum Mol Genet. 2018 May 15;27(10):1723-1731. doi: 10.1093/hmg/ddy077.


Microbial community structure with trends in methylation gene diversity and abundance in mercury-contaminated rice paddy soils in Guizhou, China.

Vishnivetskaya TA, Hu H, Van Nostrand JD, Wymore AM, Xu X, Qiu G, Feng X, Zhou J, Brown SD, Brandt CC, Podar M, Gu B, Elias DA.

Environ Sci Process Impacts. 2018 Apr 25;20(4):673-685. doi: 10.1039/c7em00558j.


N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice.

Gorvin CM, Rogers A, Stewart M, Paudyal A, Hough TA, Teboul L, Wells S, Brown SD, Cox RD, Thakker RV.

JBMR Plus. 2017 May 2;1(1):3-15. doi: 10.1002/jbm4.10001.


The Quality of Response Time Data Inference: A Blinded, Collaborative Assessment of the Validity of Cognitive Models.

Dutilh G, Annis J, Brown SD, Cassey P, Evans NJ, Grasman RPPP, Hawkins GE, Heathcote A, Holmes WR, Krypotos AM, Kupitz CN, Leite FP, Lerche V, Lin YS, Logan GD, Palmeri TJ, Starns JJ, Trueblood JS, van Maanen L, van Ravenzwaaij D, Vandekerckhove J, Visser I, Voss A, White CN, Wiecki TV, Rieskamp J, Donkin C.

Psychon Bull Rev. 2018 Feb 15. doi: 10.3758/s13423-017-1417-2. [Epub ahead of print]


Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model.

Mulay A, Hood DW, Williams D, Russell C, Brown SDM, Bingle L, Cheeseman M, Bingle CD.

Sci Rep. 2018 Feb 15;8(1):3128. doi: 10.1038/s41598-018-21166-7.


A Review of Resources and Methodologies Available for Teaching and Assessing Patient-Related Communication Skills in Radiology.

Sarkany D, DeBenedectis CM, Brown SD.

Acad Radiol. 2018 Jul;25(7):955-961. doi: 10.1016/j.acra.2017.11.018. Epub 2018 Feb 1.


Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M.

Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2.


Quantitative Disentanglement of the Spin Seebeck, Proximity-Induced, and Ferromagnetic-Induced Anomalous Nernst Effect in Normal-Metal-Ferromagnet Bilayers.

Bougiatioti P, Klewe C, Meier D, Manos O, Kuschel O, Wollschläger J, Bouchenoire L, Brown SD, Schmalhorst JM, Reiss G, Kuschel T.

Phys Rev Lett. 2017 Dec 1;119(22):227205. doi: 10.1103/PhysRevLett.119.227205. Epub 2017 Nov 29.


Chromatographic methods in HIV medicine: Application to therapeutic drug monitoring.

Archibald TL, Murrell DE, Brown SD.

Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4170. Review.


Stability of a pyrimethamine suspension compounded from bulk powder.

Lewis PO, Cluck DB, Huffman JD, Ogle AP, Brown SD.

Am J Health Syst Pharm. 2017 Dec 15;74(24):2060-2064. doi: 10.2146/ajhp160551.


Targeted redox and energy cofactor metabolomics in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum.

Sander K, Asano KG, Bhandari D, Van Berkel GJ, Brown SD, Davison B, Tschaplinski TJ.

Biotechnol Biofuels. 2017 Nov 30;10:270. doi: 10.1186/s13068-017-0960-4. eCollection 2017.


The computations that support simple decision-making: A comparison between the diffusion and urgency-gating models.

Evans NJ, Hawkins GE, Boehm U, Wagenmakers EJ, Brown SD.

Sci Rep. 2017 Nov 27;7(1):16433. doi: 10.1038/s41598-017-16694-7.


Carbon Amendments Alter Microbial Community Structure and Net Mercury Methylation Potential in Sediments.

Christensen GA, Somenahally AC, Moberly JG, Miller CM, King AJ, Gilmour CC, Brown SD, Podar M, Brandt CC, Brooks SC, Palumbo AV, Wall JD, Elias DA.

Appl Environ Microbiol. 2018 Jan 17;84(3). pii: e01049-17. doi: 10.1128/AEM.01049-17. Print 2018 Feb 1.


Corrigendum: High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie Helmut Fuchs SM, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Nutter SNLMJ, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium, Wurst W, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SDM, Adams DJ, Lloyd KCK, McKerlie C, Beaudet AL, Murray MBSA.

Nature. 2017 Nov 16;551(7680):398. doi: 10.1038/nature24643. Epub 2017 Nov 8.


Anaerobic microplate assay for direct microbial conversion of switchgrass and Avicel using Clostridium thermocellum.

Oguntimein GB, Rodriguez M Jr, Dumitrache A, Shollenberger T, Decker SR, Davison BH, Brown SD.

Biotechnol Lett. 2018 Feb;40(2):303-308. doi: 10.1007/s10529-017-2467-2. Epub 2017 Nov 9.


Austromonticola, a new genus of broad-nosed weevil (Coleoptera, Curculionidae, Entiminae) from montane areas of New Zealand.

Brown SDJ.

Zookeys. 2017 Oct 10;(707):73-130. doi: 10.3897/zookeys.707.12649. eCollection 2017.


Weighing the Social and Ethical Considerations of Maternal-Fetal Surgery.

Antiel RM, Flake AW, Collura CA, Johnson MP, Rintoul NE, Lantos JD, Curlin FA, Tilburt JC, Brown SD, Feudtner C.

Pediatrics. 2017 Dec;140(6). pii: e20170608. doi: 10.1542/peds.2017-0608. Epub 2017 Nov 3.


CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.

Michel V, Booth KT, Patni P, Cortese M, Azaiez H, Bahloul A, Kahrizi K, Labbé M, Emptoz A, Lelli A, Dégardin J, Dupont T, Aghaie A, Oficjalska-Pham D, Picaud S, Najmabadi H, Smith RJ, Bowl MR, Brown SD, Avan P, Petit C, El-Amraoui A.

EMBO Mol Med. 2017 Dec;9(12):1711-1731. doi: 10.15252/emmm.201708087.


Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.

Howles SA, Hannan FM, Gorvin CM, Piret SE, Paudyal A, Stewart M, Hough TA, Nesbit MA, Wells S, Brown SD, Cox RD, Thakker RV.

JCI Insight. 2017 Oct 19;2(20). pii: 96540. doi: 10.1172/jci.insight.96540. [Epub ahead of print]


A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L; International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM.

Nat Commun. 2017 Oct 12;8(1):886. doi: 10.1038/s41467-017-00595-4.

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