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Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

Bollu LR, Shepherd J, Zhao D, Ma Y, Tahaney W, Speers C, Mazumdar A, Mills GB, Brown PH.

NPJ Breast Cancer. 2020 Jan 3;6:2. doi: 10.1038/s41523-019-0143-5. eCollection 2020.


Boron: an essential element for vascular plants: A comment on Lewis (2019) 'Boron: the essential element for vascular plants that never was'.

Wimmer MA, Abreu I, Bell RW, Bienert MD, Brown PH, Dell B, Fujiwara T, Goldbach HE, Lehto T, Mock HP, von Wirén N, Bassil E, Bienert GP.

New Phytol. 2019 Nov 1. doi: 10.1111/nph.16127. [Epub ahead of print] No abstract available.


The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression.

Mazumdar A, Tahaney WM, Reddy Bollu L, Poage G, Hill J, Zhang Y, Mills GB, Brown PH.

NPJ Breast Cancer. 2019 Jul 26;5:22. doi: 10.1038/s41523-019-0118-6. eCollection 2019.


Efficient phloem remobilization of Zn protects apple trees during the early stages of Zn deficiency.

Xie R, Zhao J, Lu L, Ge J, Brown PH, Wei S, Wang R, Qiao Y, Webb SM, Tian S.

Plant Cell Environ. 2019 Dec;42(12):3167-3181. doi: 10.1111/pce.13621. Epub 2019 Aug 13.


Field-Aged Insecticide Residues on Chrysoperla johnsoni (Neuroptera: Chrysopidae).

Amarasekare KG, Brown PH, Shearer PW.

J Econ Entomol. 2019 Sep 23;112(5):2109-2115. doi: 10.1093/jee/toz149.


Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812).

Crew KD, Anderson GL, Hershman DL, Terry MB, Tehranifar P, Lew DL, Yee M, Brown EA, Kairouz SS, Kuwajerwala N, Bevers T, Doster JE, Zarwan C, Kruper L, Minasian LM, Ford L, Arun B, Neuhouser M, Goodman GE, Brown PH.

Cancer Prev Res (Phila). 2019 Jul;12(7):481-490. doi: 10.1158/1940-6207.CAPR-18-0444. Epub 2019 May 28.


A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment.

Lim B, Murthy RK, Lee J, Jackson SA, Iwase T, Davis DW, Willey JS, Wu J, Shen Y, Tripathy D, Alvarez R, Ibrahim NK, Brewster AM, Barcenas CH, Brown PH, Giordano SH, Moulder SL, Booser DJ, Moscow JA, Piekarz R, Valero V, Ueno NT.

Br J Cancer. 2019 Jun;120(12):1105-1112. doi: 10.1038/s41416-019-0473-y. Epub 2019 May 17.


Limited Cross Plant Movement and Non-Crop Preferences Reduce the Efficiency of Honey Bees as Pollinators of Hybrid Carrot Seed Crops.

Gaffney A, Bohman B, Quarrell SR, Brown PH, Allen GR.

Insects. 2019 Jan 23;10(2). pii: E34. doi: 10.3390/insects10020034.


Inverse modelling for predicting both water and nitrate movement in a structured-clay soil (Red Ferrosol).

Kirkham JM, Smith CJ, Doyle RB, Brown PH.

PeerJ. 2019 Jan 16;6:e6002. doi: 10.7717/peerj.6002. eCollection 2019.


Measuring macromolecular size distributions and interactions at high concentrations by sedimentation velocity.

Chaturvedi SK, Ma J, Brown PH, Zhao H, Schuck P.

Nat Commun. 2018 Oct 24;9(1):4415. doi: 10.1038/s41467-018-06902-x.


Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: implications for clinical use and genetic discovery efforts in human disease.

Ebbert MTW, Farrugia SL, Sens JP, Jansen-West K, Gendron TF, Prudencio M, McLaughlin IJ, Bowman B, Seetin M, DeJesus-Hernandez M, Jackson J, Brown PH, Dickson DW, van Blitterswijk M, Rademakers R, Petrucelli L, Fryer JD.

Mol Neurodegener. 2018 Aug 21;13(1):46. doi: 10.1186/s13024-018-0274-4.


Frequent Insect Visitors Are Not Always Pollen Carriers in Hybrid Carrot Pollination.

Gaffney A, Bohman B, Quarrell SR, Brown PH, Allen GR.

Insects. 2018 Jun 7;9(2). pii: E61. doi: 10.3390/insects9020061.


A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease.

Gucalp A, Zhou XK, Cook ED, Garber JE, Crew KD, Nangia JR, Bhardwaj P, Giri DD, Elemento O, Verma A, Wang H, Lee JJ, Vornik LA, Mays C, Weber D, Sepeda V, O'Kane H, Krasne M, Williams S, Morris PG, Heckman-Stoddard BM, Dunn BK, Hudis CA, Brown PH, Dannenberg AJ.

Cancer Prev Res (Phila). 2018 Apr;11(4):203-214. doi: 10.1158/1940-6207.CAPR-17-0354. Epub 2018 Feb 16.


Spatial patterns of tree yield explained by endogenous forces through a correspondence between the Ising model and ecology.

Noble AE, Rosenstock TS, Brown PH, Machta J, Hastings A.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1825-1830. doi: 10.1073/pnas.1618887115. Epub 2018 Feb 7.


Natural product β-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy.

Zhang L, Peng Y, Uray IP, Shen J, Wang L, Peng X, Brown PH, Tu W, Peng G.

DNA Repair (Amst). 2017 Dec;60:89-101. doi: 10.1016/j.dnarep.2017.10.009. Epub 2017 Oct 24.


Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation.

Bashour SI, Doostan I, Keyomarsi K, Valero V, Ueno NT, Brown PH, Litton JK, Koenig KB, Karuturi M, Abouharb S, Tripathy D, Moulder-Thompson SL, Ibrahim NK.

J Cancer. 2017 Jul 5;8(11):2004-2009. doi: 10.7150/jca.18196. eCollection 2017.


Grower Analysis of Organic Matter Amendments in California Orchards.

Khalsa SDS, Brown PH.

J Environ Qual. 2017 May;46(3):649-658. doi: 10.2134/jeq2016.11.0456.


Randomized trial of medroxyprogesterone acetate for the prevention of endometrial pathology from adjuvant tamoxifen for breast cancer: SWOG S9630.

Potkul RK, Unger JM, Livingston RB, Crew KD, Wilczynski SP, Salomon CG, Smith BL, Wong L, Campbell DL, Einspahr DE, Anderson GL, Hershman D, Goodman GE, Brown PH, Meyskens FL, Albain KS.

NPJ Breast Cancer. 2016 Aug 10;2:16024. doi: 10.1038/npjbcancer.2016.24. eCollection 2016.


Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers.

Finch NA, Wang X, Baker MC, Heckman MG, Gendron TF, Bieniek KF, Wuu J, DeJesus-Hernandez M, Brown PH, Chew J, Jansen-West KR, Daughrity LM, Nicholson AM, Murray ME, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Asmann YW, Dickson DW, Benatar M, Bowser R, Boylan KB, Rademakers R, van Blitterswijk M.

Neurol Genet. 2017 Jun 7;3(4):e161. doi: 10.1212/NXG.0000000000000161. eCollection 2017 Aug.


Molecularly targeted therapies for p53-mutant cancers.

Zhao D, Tahaney WM, Mazumdar A, Savage MI, Brown PH.

Cell Mol Life Sci. 2017 Nov;74(22):4171-4187. doi: 10.1007/s00018-017-2575-0. Epub 2017 Jun 22. Review.


Uptake, sequestration and tolerance of cadmium at cellular levels in the hyperaccumulator plant species Sedum alfredii.

Tian S, Xie R, Wang H, Hu Y, Hou D, Liao X, Brown PH, Yang H, Lin X, Labavitch JM, Lu L.

J Exp Bot. 2017 Apr 1;68(9):2387-2398. doi: 10.1093/jxb/erx112.


Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice.

Rossi EL, Dunlap SM, Bowers LW, Khatib SA, Doerstling SS, Smith LA, Ford NA, Holley D, Brown PH, Estecio MR, Kusewitt DF, deGraffenried LA, Bultman SJ, Hursting SD.

Cancer Res. 2017 May 1;77(9):2500-2511. doi: 10.1158/0008-5472.CAN-16-2795. Epub 2017 Apr 3.


Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening.

Zhang L, Shen J, Yin Y, Peng Y, Wang L, Hsieh HJ, Shen Q, Brown PH, Tao K, Uray IP, Peng G.

SLAS Discov. 2017 Aug;22(7):813-826. doi: 10.1177/2472555217698942. Epub 2017 Mar 15.


Biostimulants in Plant Science: A Global Perspective.

Yakhin OI, Lubyanov AA, Yakhin IA, Brown PH.

Front Plant Sci. 2017 Jan 26;7:2049. doi: 10.3389/fpls.2016.02049. eCollection 2016. Review.


Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.

Bollu LR, Mazumdar A, Savage MI, Brown PH.

Clin Cancer Res. 2017 May 1;23(9):2136-2142. doi: 10.1158/1078-0432.CCR-16-0934. Epub 2017 Jan 13. Review.


Effect of arginine on oligomerization and stability of N-acetylglutamate synthase.

Haskins N, Mumo A, Brown PH, Tuchman M, Morizono H, Caldovic L.

Sci Rep. 2016 Dec 9;6:38711. doi: 10.1038/srep38711.


Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer.

Speers C, Zhao SG, Kothari V, Santola A, Liu M, Wilder-Romans K, Evans J, Batra N, Bartelink H, Hayes DF, Lawrence TS, Brown PH, Pierce LJ, Feng FY.

Clin Cancer Res. 2016 Dec 1;22(23):5864-5875. Epub 2016 May 25.


Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration.

Sanchez-Contreras M, Heckman MG, Tacik P, Diehl N, Brown PH, Soto-Ortolaza AI, Christopher EA, Walton RL, Ross OA, Golbe LI, Graff-Radford N, Wszolek ZK, Dickson DW, Rademakers R.

Mov Disord. 2017 Jan;32(1):115-123. doi: 10.1002/mds.26815. Epub 2016 Oct 6.


TYROBP genetic variants in early-onset Alzheimer's disease.

Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, Guerreiro R, Bras JT, Zuchner S, Gonzalez MA, Bu G, Younkin S, Knopman DS, Josephs KA, Parisi JE, Petersen RC, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R.

Neurobiol Aging. 2016 Dec;48:222.e9-222.e15. doi: 10.1016/j.neurobiolaging.2016.07.028. Epub 2016 Aug 8.


Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.

Mazumdar A, Poage GM, Shepherd J, Tsimelzon A, Hartman ZC, Den Hollander P, Hill J, Zhang Y, Chang J, Hilsenbeck SG, Fuqua S, Kent Osborne C, Mills GB, Brown PH.

Breast Cancer Res Treat. 2016 Aug;158(3):441-54. doi: 10.1007/s10549-016-3892-y. Epub 2016 Jul 8.


Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer.

Kim J, Davis JW, Klein EA, Magi-Galluzzi C, Lotan Y, Ward JF, Pisters LL, Basler JW, Pettaway CA, Stephenson A, Li Ning Tapia EM, Efstathiou E, Wang X, Do KA, Lee JJ, Gorlov IP, Vornik LA, Hoque AM, Prokhorova IN, Parnes HL, Lippman SM, Thompson IM, Brown PH, Logothetis CJ, Troncoso P.

EBioMedicine. 2016 May;7:85-93. doi: 10.1016/j.ebiom.2016.03.047. Epub 2016 Apr 7.


A low dose of an organophosphate insecticide causes dysbiosis and sex-dependent responses in the intestinal microbiota of the Japanese quail (Coturnix japonica).

Crisol-Martínez E, Moreno-Moyano LT, Wilkinson N, Prasai T, Brown PH, Moore RJ, Stanley D.

PeerJ. 2016 May 5;4:e2002. doi: 10.7717/peerj.2002. eCollection 2016.


The presenilin 1 p.Gly206Ala mutation is a frequent cause of early-onset Alzheimer's disease in Hispanics in Florida.

Ravenscroft TA, Pottier C, Murray ME, Baker M, Christopher E, Levitch D, Brown PH, Barker W, Duara R, Greig-Custo M, Betancourt A, English M, Sun X, Ertekin-Taner N, Graff-Radford NR, Dickson DW, Rademakers R.

Am J Neurodegener Dis. 2016 Mar 1;5(1):94-101. eCollection 2016.


Seasonal cues induce phenotypic plasticity of Drosophila suzukii to enhance winter survival.

Shearer PW, West JD, Walton VM, Brown PH, Svetec N, Chiu JC.

BMC Ecol. 2016 Mar 22;16:11. doi: 10.1186/s12898-016-0070-3.


Retinoids and rexinoids in cancer prevention: from laboratory to clinic.

Uray IP, Dmitrovsky E, Brown PH.

Semin Oncol. 2016 Feb;43(1):49-64. doi: 10.1053/j.seminoncol.2015.09.002. Epub 2015 Sep 25. Review.


Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance.

Malorni L, Giuliano M, Migliaccio I, Wang T, Creighton CJ, Lupien M, Fu X, Hilsenbeck SG, Healy N, De Angelis C, Mazumdar A, Trivedi MV, Massarweh S, Gutierrez C, De Placido S, Jeselsohn R, Brown M, Brown PH, Osborne CK, Schiff R.

Mol Cancer Res. 2016 May;14(5):470-81. doi: 10.1158/1541-7786.MCR-15-0423. Epub 2016 Mar 10.


Predator-Free New Zealand: Conservation Country.

Russell JC, Innes JG, Brown PH, Byrom AE.

Bioscience. 2015 May 1;65(5):520-525. Epub 2015 Mar 10.


Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations.

Sousa AA, Hassan SA, Knittel LL, Balbo A, Aronova MA, Brown PH, Schuck P, Leapman RD.

Nanoscale. 2016 Mar 28;8(12):6577-88. doi: 10.1039/c5nr07642k.


Using Next-Generation Sequencing to Contrast the Diet and Explore Pest-Reduction Services of Sympatric Bird Species in Macadamia Orchards in Australia.

Crisol-Martínez E, Moreno-Moyano LT, Wormington KR, Brown PH, Stanley D.

PLoS One. 2016 Mar 1;11(3):e0150159. doi: 10.1371/journal.pone.0150159. eCollection 2016.


Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.

den Hollander P, Rawls K, Tsimelzon A, Shepherd J, Mazumdar A, Hill J, Fuqua SA, Chang JC, Osborne CK, Hilsenbeck SG, Mills GB, Brown PH.

Cancer Res. 2016 Apr 1;76(7):1942-53. doi: 10.1158/0008-5472.CAN-14-0673. Epub 2016 Feb 26.


The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression.

Shepherd JH, Uray IP, Mazumdar A, Tsimelzon A, Savage M, Hilsenbeck SG, Brown PH.

Oncotarget. 2016 Mar 15;7(11):13106-21. doi: 10.18632/oncotarget.7437.


Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus.

Joe AK, Schnoll-Sussman F, Bresalier RS, Abrams JA, Hibshoosh H, Cheung K, Friedman RA, Yang CS, Milne GL, Liu DD, Lee JJ, Abdul K, Bigg M, Foreman J, Su T, Wang X, Ahmed A, Neugut AI, Akpa E, Lippman SM, Perloff M, Brown PH, Lightdale CJ.

Cancer Prev Res (Phila). 2015 Dec;8(12):1131-7. doi: 10.1158/1940-6207.CAPR-14-0274-T. Epub 2015 Oct 15.


Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.

van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R.

Acta Neuropathol. 2015 Dec;130(6):863-76. doi: 10.1007/s00401-015-1480-6. Epub 2015 Oct 5.


Molecular cancer prevention: Current status and future directions.

Maresso KC, Tsai KY, Brown PH, Szabo E, Lippman S, Hawk ET.

CA Cancer J Clin. 2015 Sep-Oct;65(5):345-83. doi: 10.3322/caac.21287. Epub 2015 Aug 18. Review.


Death-associated protein kinase 1 promotes growth of p53-mutant cancers.

Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH.

J Clin Invest. 2015 Jul 1;125(7):2707-20. doi: 10.1172/JCI70805. Epub 2015 Jun 15.


ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.

Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G.

Cancer Discov. 2015 Jul;5(7):752-67. doi: 10.1158/2159-8290.CD-14-0849. Epub 2015 Jun 11.


A novel tau mutation, p.K317N, causes globular glial tauopathy.

Tacik P, DeTure M, Lin WL, Sanchez Contreras M, Wojtas A, Hinkle KM, Fujioka S, Baker MC, Walton RL, Carlomagno Y, Brown PH, Strongosky AJ, Kouri N, Murray ME, Petrucelli L, Josephs KA, Rademakers R, Ross OA, Wszolek ZK, Dickson DW.

Acta Neuropathol. 2015 Aug;130(2):199-214. doi: 10.1007/s00401-015-1425-0. Epub 2015 Apr 22.


Foliar application of microbial and plant based biostimulants increases growth and potassium uptake in almond (Prunus dulcis [Mill.] D. A. Webb).

Saa S, Olivos-Del Rio A, Castro S, Brown PH.

Front Plant Sci. 2015 Feb 23;6:87. doi: 10.3389/fpls.2015.00087. eCollection 2015.


Long-term effects of inhaled budesonide on screening-detected lung nodules.

Veronesi G, Lazzeroni M, Szabo E, Brown PH, DeCensi A, Guerrieri-Gonzaga A, Bellomi M, Radice D, Grimaldi MC, Spaggiari L, Bonanni B.

Ann Oncol. 2015 May;26(5):1025-30. doi: 10.1093/annonc/mdv064. Epub 2015 Feb 11.


Supplemental macronutrients and microbial fermentation products improve the uptake and transport of foliar applied zinc in sunflower (Helianthus annuus L.) plants. Studies utilizing micro X-ray florescence.

Tian S, Lu L, Xie R, Zhang M, Jernstedt JA, Hou D, Ramsier C, Brown PH.

Front Plant Sci. 2015 Jan 21;5:808. doi: 10.3389/fpls.2014.00808. eCollection 2014.

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