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Items: 47


UBE2S Learns Self-Control.

Bodrug T, Brown NG.

Structure. 2019 Aug 6;27(8):1185-1187. doi: 10.1016/j.str.2019.07.009.


Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26.


Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae.

Beggs GA, Zalucki YM, Brown NG, Rastegari S, Phillips RK, Palzkill T, Shafer WM, Kumaraswami M, Brennan RG.

J Bacteriol. 2019 Sep 20;201(20). pii: e00401-19. doi: 10.1128/JB.00401-19. Print 2019 Oct 15.


Is Surgery Necessary? Endoscopic Management of Post-transplant Biliary Complications in the Modern Era.

Cortez AR, Morris MC, Brown NG, Winer LK, Safdar K, Poreddy S, Shah SA, Quillin RC 3rd.

J Gastrointest Surg. 2019 Jun 21. doi: 10.1007/s11605-019-04292-z. [Epub ahead of print]


Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

Watson ER, Brown NG, Peters JM, Stark H, Schulman BA.

Trends Cell Biol. 2019 Feb;29(2):117-134. doi: 10.1016/j.tcb.2018.09.007. Epub 2018 Oct 25. Review.


Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.

Bonacci T, Suzuki A, Grant GD, Stanley N, Cook JG, Brown NG, Emanuele MJ.

EMBO J. 2018 Aug 15;37(16). pii: e98701. doi: 10.15252/embj.201798701. Epub 2018 Jul 4.


Advanced ERCP techniques for the extraction of complex biliary stones: a single referral center's 12-year experience.

Brown NG, Camilo J, Nordstrom E, Yen RD, Fukami N, Brauer BC, Wani S, Amateau SK, Attwell AR, Shah RJ.

Scand J Gastroenterol. 2018 May;53(5):626-631. doi: 10.1080/00365521.2018.1441434. Epub 2018 Apr 12.


The BeSMART (Best Supportive Management for Adults Referred with Tonsillopharyngitis) multicentre observational study.

Lau AS, Mamais C, McChesney E, Upile NS, Vaughan C, Veitch J, Abbas JR, Markey A, Brown NG, Evans M, Thomas J, Gaines M, Shehata Z, Wilkie MD, Leong SC.

Ann R Coll Surg Engl. 2017 Sep;99(7):573-578. doi: 10.1308/rcsann.2017.0106.


Minor papilla endotherapy in patients with ventral duct obstruction: identification and management.

Brown NG, Howell DA, Brauer BC, Walker J, Wani S, Shah RJ.

Gastrointest Endosc. 2017 Feb;85(2):365-370. doi: 10.1016/j.gie.2016.07.066. Epub 2016 Aug 13.


Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA.

Mol Cell. 2016 Aug 18;63(4):593-607. doi: 10.1016/j.molcel.2016.07.003. Epub 2016 Aug 10.


Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA.

Cell. 2016 Jun 2;165(6):1440-1453. doi: 10.1016/j.cell.2016.05.037.


Refractory Jaundice From Intraductal Papillary Mucinous Neoplasm Treated With Cholangioscopy-Guided Radiofrequency Ablation.

Brown NG, Camilo J, McCarter M, Shah RJ.

ACG Case Rep J. 2016 Apr 15;3(3):202-4. doi: 10.14309/crj.2016.50. eCollection 2016 Apr.


Mechanism of APC/CCDC20 activation by mitotic phosphorylation.

Qiao R, Weissmann F, Yamaguchi M, Brown NG, VanderLinden R, Imre R, Jarvis MA, Brunner MR, Davidson IF, Litos G, Haselbach D, Mechtler K, Stark H, Schulman BA, Peters JM.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2570-8. doi: 10.1073/pnas.1604929113. Epub 2016 Apr 25.


biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.

Weissmann F, Petzold G, VanderLinden R, Huis In 't Veld PJ, Brown NG, Lampert F, Westermann S, Stark H, Schulman BA, Peters JM.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2564-9. doi: 10.1073/pnas.1604935113. Epub 2016 Apr 25.


Measuring APC/C-Dependent Ubiquitylation In Vitro.

Jarvis MA, Brown NG, Watson ER, VanderLinden R, Schulman BA, Peters JM.

Methods Mol Biol. 2016;1342:287-303. doi: 10.1007/978-1-4939-2957-3_18.


RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.


Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.

Yamaguchi M, Yu S, Qiao R, Weissmann F, Miller DJ, VanderLinden R, Brown NG, Frye JJ, Peters JM, Schulman BA.

J Mol Biol. 2015 Apr 24;427(8):1748-64. doi: 10.1016/j.jmb.2014.11.020. Epub 2014 Dec 6.


Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.

Adamski CJ, Cardenas AM, Brown NG, Horton LB, Sankaran B, Prasad BV, Gilbert HF, Palzkill T.

Biochemistry. 2015 Jan 20;54(2):447-57. doi: 10.1021/bi501195g. Epub 2014 Dec 24.


Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Brown NG, Watson ER, Weissmann F, Jarvis MA, VanderLinden R, Grace CRR, Frye JJ, Qiao R, Dube P, Petzold G, Cho SE, Alsharif O, Bao J, Davidson IF, Zheng JJ, Nourse A, Kurinov I, Peters JM, Stark H, Schulman BA.

Mol Cell. 2014 Oct 23;56(2):246-260. doi: 10.1016/j.molcel.2014.09.009. Epub 2014 Oct 9.


Probing the sites of interactions of rotaviral proteins involved in replication.

Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BV.

J Virol. 2014 Nov;88(21):12866-81. doi: 10.1128/JVI.02251-14. Epub 2014 Aug 27.


Role of β-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.

Fryszczyn BG, Adamski CJ, Brown NG, Rice K, Huang W, Palzkill T.

Protein Sci. 2014 Sep;23(9):1235-46. doi: 10.1002/pro.2505. Epub 2014 Jul 1.


Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA.

Nat Struct Mol Biol. 2013 Jul;20(7):827-35. doi: 10.1038/nsmb.2593. Epub 2013 May 26.


Identification of the β-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A β-lactamases.

Brown NG, Chow DC, Ruprecht KE, Palzkill T.

J Biol Chem. 2013 Jun 14;288(24):17156-66. doi: 10.1074/jbc.M113.463521. Epub 2013 Apr 27.


BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2).

Brown NG, Chow DC, Palzkill T.

Antimicrob Agents Chemother. 2013 Jul;57(7):3398-401. doi: 10.1128/AAC.00215-13. Epub 2013 Apr 15.


Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase.

Cai G, Deng L, Fryszczyn BG, Brown NG, Liu Z, Jiang H, Palzkill T, Song Y.

ACS Med Chem Lett. 2012 Jun 14;3(6):496-500. Epub 2012 May 7.


Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution.

Deng Z, Huang W, Bakkalbasi E, Brown NG, Adamski CJ, Rice K, Muzny D, Gibbs RA, Palzkill T.

J Mol Biol. 2012 Dec 7;424(3-4):150-67. doi: 10.1016/j.jmb.2012.09.014. Epub 2012 Sep 25.


APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Uzunova K, Dye BT, Schutz H, Ladurner R, Petzold G, Toyoda Y, Jarvis MA, Brown NG, Poser I, Novatchkova M, Mechtler K, Hyman AA, Stark H, Schulman BA, Peters JM.

Nat Struct Mol Biol. 2012 Nov;19(11):1116-23. doi: 10.1038/nsmb.2412. Epub 2012 Sep 24.


Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-β-lactamase active site.

Horton LB, Shanker S, Mikulski R, Brown NG, Phillips KJ, Lykissa E, Venkataram Prasad BV, Palzkill T.

Antimicrob Agents Chemother. 2012 Nov;56(11):5667-77. doi: 10.1128/AAC.01276-12. Epub 2012 Aug 20.


An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.

Shelburne SA 3rd, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M.

Mol Microbiol. 2011 Dec;82(6):1481-95. doi: 10.1111/j.1365-2958.2011.07902.x. Epub 2011 Nov 21.


Use of periplasmic target protein capture for phage display engineering of tight-binding protein-protein interactions.

Fryszczyn BG, Brown NG, Huang W, Balderas MA, Palzkill T.

Protein Eng Des Sel. 2011 Nov;24(11):819-28. doi: 10.1093/protein/gzr043. Epub 2011 Sep 6.


Analysis of the functional contributions of Asn233 in metallo-β-lactamase IMP-1.

Brown NG, Horton LB, Huang W, Vongpunsawad S, Palzkill T.

Antimicrob Agents Chemother. 2011 Dec;55(12):5696-702. doi: 10.1128/AAC.00340-11. Epub 2011 Sep 6.


Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases.

Brown NG, Chow DC, Sankaran B, Zwart P, Prasad BV, Palzkill T.

J Biol Chem. 2011 Sep 16;286(37):32723-35. doi: 10.1074/jbc.M111.265058. Epub 2011 Jul 20.


Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding.

Kim JJ, Casteel DE, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim C.

PLoS One. 2011 Apr 19;6(4):e18413. doi: 10.1371/journal.pone.0018413.


Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases.

Brown NG, Pennington JM, Huang W, Ayvaz T, Palzkill T.

J Mol Biol. 2010 Dec 17;404(5):832-46. doi: 10.1016/j.jmb.2010.10.008. Epub 2010 Oct 16.


Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.

Brown NG, Palzkill T.

Protein Eng Des Sel. 2010 Jun;23(6):469-78. doi: 10.1093/protein/gzq017. Epub 2010 Mar 22.


Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis.

Brown NG, Shanker S, Prasad BV, Palzkill T.

J Biol Chem. 2009 Nov 27;284(48):33703-12. doi: 10.1074/jbc.M109.053819. Epub 2009 Oct 6.


Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase.

Marciano DC, Brown NG, Palzkill T.

Protein Sci. 2009 Oct;18(10):2080-9. doi: 10.1002/pro.220.


Health information technology and e-prescribing: a convergence of payor and provider interests.

Kappel ML, Brown NG.

Dis Manag. 2004;7 Suppl 2:S14-7. No abstract available.


Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R.

Brown NG, Nick Morrice D, Beaud G, Hardie G, Leader DP.

BMC Biochem. 2000;1:2. Epub 2000 Sep 5.


The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo.

Steinmetz R, Brown NG, Allen DL, Bigsby RM, Ben-Jonathan N.

Endocrinology. 1997 May;138(5):1780-6.


Mechanistic studies on rhodopsin kinase. Light-dependent phosphorylation of C-terminal peptides of rhodopsin.

Brown NG, Fowles C, Sharma R, Akhtar M.

Eur J Biochem. 1993 Mar 15;212(3):840. No abstract available.


Strikebound: a dispute involving hospital linen.

Lacy CA, Brown NG, McDonald MI.

Med J Aust. 1985 Jun 24;142(13):685-7.


Adaptive device for Polecat transfer.

Brown NG.

Phys Ther. 1979 Feb;59(2):172-3. No abstract available.


The assay of solanaceous drugs with the aid of an adsorption column.


J Am Pharm Assoc Am Pharm Assoc. 1948 Jan;37(1):24-7. No abstract available.


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