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Items: 1 to 50 of 258

1.

Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsins.

Ryazantsev MN, Nikolaev DM, Struts AV, Brown MF.

J Membr Biol. 2019 Sep 30. doi: 10.1007/s00232-019-00095-0. [Epub ahead of print] Review.

PMID:
31570961
2.

Flexible lipid nanomaterials studied by NMR spectroscopy.

Mallikarjunaiah KJ, Kinnun JJ, Petrache HI, Brown MF.

Phys Chem Chem Phys. 2019 Aug 28;21(34):18422-18457. doi: 10.1039/c8cp06179c.

PMID:
31410425
3.

Synthesis of 9-CD3-9-cis-Retinal Cofactor of Isorhodopsin.

Navidi M, Yadav S, Struts AV, Brown MF, Nesnas N.

Tetrahedron Lett. 2018 Dec 19;59(51):4521-4524. doi: 10.1016/j.tetlet.2018.11.034. Epub 2018 Nov 10.

PMID:
30692701
4.

Cholesterol Effects on the Physical Properties of Lipid Membranes Viewed by Solid-state NMR Spectroscopy.

Molugu TR, Brown MF.

Adv Exp Med Biol. 2019;1115:99-133. doi: 10.1007/978-3-030-04278-3_5. Review.

PMID:
30649757
5.

Small-Angle Neutron Scattering Reveals Energy Landscape for Rhodopsin Photoactivation.

Perera SMDC, Chawla U, Shrestha UR, Bhowmik D, Struts AV, Qian S, Chu XQ, Brown MF.

J Phys Chem Lett. 2018 Dec 20;9(24):7064-7071. doi: 10.1021/acs.jpclett.8b03048. Epub 2018 Dec 7.

PMID:
30489081
6.

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Fensome A, Ambler CM, Arnold E, Banker ME, Brown MF, Chrencik J, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gopalsamy A, Hayward MM, Hegen M, Hollingshead BD, Jussif J, Knafels JD, Limburg DC, Lin D, Lin TH, Pierce BS, Saiah E, Sharma R, Symanowicz PT, Telliez JB, Trujillo JI, Vajdos FF, Vincent F, Wan ZK, Xing L, Yang X, Yang X, Zhang L.

J Med Chem. 2018 Oct 11;61(19):8597-8612. doi: 10.1021/acs.jmedchem.8b00917. Epub 2018 Aug 16.

PMID:
30113844
7.

Delineating the role of cooperativity in the design of potent PROTACs for BTK.

Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, Zhu H, Farley KA, Ding W, Schiemer J, Feng X, Chang JS, Uccello DP, Young JA, Garcia-Irrizary CN, Czabaniuk L, Schuff B, Oliver R, Montgomery J, Hayward MM, Coe J, Chen J, Niosi M, Luthra S, Shah JC, El-Kattan A, Qiu X, West GM, Noe MC, Shanmugasundaram V, Gilbert AM, Brown MF, Calabrese MF.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292. doi: 10.1073/pnas.1803662115. Epub 2018 Jul 16.

8.

Specificity and flexibility of social influence on spatial choice.

Brown MF, Saxon ME, Heslin KA.

Learn Behav. 2019 Mar;47(1):47-58. doi: 10.3758/s13420-018-0322-5.

PMID:
29564730
9.

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

Vazquez ML, Kaila N, Strohbach JW, Trzupek JD, Brown MF, Flanagan ME, Mitton-Fry MJ, Johnson TA, TenBrink RE, Arnold EP, Basak A, Heasley SE, Kwon S, Langille J, Parikh MD, Griffin SH, Casavant JM, Duclos BA, Fenwick AE, Harris TM, Han S, Caspers N, Dowty ME, Yang X, Banker ME, Hegen M, Symanowicz PT, Li L, Wang L, Lin TH, Jussif J, Clark JD, Telliez JB, Robinson RP, Unwalla R.

J Med Chem. 2018 Feb 8;61(3):1130-1152. doi: 10.1021/acs.jmedchem.7b01598. Epub 2018 Jan 23.

PMID:
29298069
10.

Concepts and Methods of Solid-State NMR Spectroscopy Applied to Biomembranes.

Molugu TR, Lee S, Brown MF.

Chem Rev. 2017 Oct 11;117(19):12087-12132. doi: 10.1021/acs.chemrev.6b00619. Epub 2017 Sep 14. Review.

PMID:
28906107
11.

Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example.

Eke I, Makinde AY, Aryankalayil MJ, Sandfort V, Palayoor ST, Rath BH, Liotta L, Pierobon M, Petricoin EF, Brown MF, Stommel JM, Ahmed MM, Coleman CN.

Mol Cancer Ther. 2018 Feb;17(2):355-367. doi: 10.1158/1535-7163.MCT-17-0262. Epub 2017 Aug 11.

12.

Soft Matter in Lipid-Protein Interactions.

Brown MF.

Annu Rev Biophys. 2017 May 22;46:379-410. doi: 10.1146/annurev-biophys-070816-033843. Review.

PMID:
28532212
13.

CONDENSED-MATTER SPECTROSCOPY SPECTRAL METHODS FOR STUDY OF THE G-PROTEIN-COUPLED RECEPTOR RHODOPSIN. II. MAGNETIC RESONANCE METHODS.

Struts AV, Barmasov AV, Brown MF.

Opt Spectrosc. 2016 Feb;120(2):286-293. doi: 10.1134/S0030400X16010197. Epub 2016 Apr 6.

14.

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.

Thorarensen A, Dowty ME, Banker ME, Juba B, Jussif J, Lin T, Vincent F, Czerwinski RM, Casimiro-Garcia A, Unwalla R, Trujillo JI, Liang S, Balbo P, Che Y, Gilbert AM, Brown MF, Hayward M, Montgomery J, Leung L, Yang X, Soucy S, Hegen M, Coe J, Langille J, Vajdos F, Chrencik J, Telliez JB.

J Med Chem. 2017 Mar 9;60(5):1971-1993. doi: 10.1021/acs.jmedchem.6b01694. Epub 2017 Feb 16.

PMID:
28139931
15.

Opposing roles of KIT and ABL1 in the therapeutic response of gastrointestinal stromal tumor (GIST) cells to imatinib mesylate.

Rausch JL, Boichuk S, Ali AA, Patil SS, Liu L, Lee DM, Brown MF, Makielski KR, Liu Y, Taguchi T, Kuan SF, Duensing A.

Oncotarget. 2017 Jan 17;8(3):4471-4483. doi: 10.18632/oncotarget.13882.

16.

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.

Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, Crouse K, Dickinson C, Symanowicz P, Hegen M, Banker ME, Vincent F, Unwalla R, Liang S, Gilbert AM, Brown MF, Hayward M, Montgomery J, Yang X, Bauman J, Trujillo JI, Casimiro-Garcia A, Vajdos FF, Leung L, Geoghegan KF, Quazi A, Xuan D, Jones L, Hett E, Wright K, Clark JD, Thorarensen A.

ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. Epub 2016 Nov 10.

PMID:
27791347
17.

Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.

Leung L, Yang X, Strelevitz TJ, Montgomery J, Brown MF, Zientek MA, Banfield C, Gilbert AM, Thorarensen A, Dowty ME.

Drug Metab Dispos. 2017 Jan;45(1):1-7. Epub 2016 Oct 26.

PMID:
27784718
18.

Powdered G-Protein-Coupled Receptors.

Perera SMDC, Chawla U, Brown MF.

J Phys Chem Lett. 2016 Oct 20;7(20):4230-4235. doi: 10.1021/acs.jpclett.6b02328. Epub 2016 Oct 12.

19.

The promise of cyborg intelligence.

Brown MF, Brown AA.

Learn Behav. 2017 Mar;45(1):5-6. doi: 10.3758/s13420-016-0249-7.

PMID:
27659293
20.

Quasi-elastic Neutron Scattering Reveals Ligand-Induced Protein Dynamics of a G-Protein-Coupled Receptor.

Shrestha UR, Perera SMDC, Bhowmik D, Chawla U, Mamontov E, Brown MF, Chu XQ.

J Phys Chem Lett. 2016 Oct 20;7(20):4130-4136. doi: 10.1021/acs.jpclett.6b01632. Epub 2016 Oct 4.

21.

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.

Ahn K, Boehm M, Brown MF, Calloway J, Che Y, Chen J, Fennell KF, Geoghegan KF, Gilbert AM, Gutierrez JA, Kalgutkar AS, Lanba A, Limberakis C, Magee TV, O'Doherty I, Oliver R, Pabst B, Pandit J, Parris K, Pfefferkorn JA, Rolph TP, Patel R, Schuff B, Shanmugasundaram V, Starr JT, Varghese AH, Vera NB, Vernochet C, Yan J.

ACS Chem Biol. 2016 Sep 16;11(9):2529-40. doi: 10.1021/acschembio.6b00266. Epub 2016 Jul 19.

PMID:
27391855
22.

Cholesterol-induced suppression of membrane elastic fluctuations at the atomistic level.

Molugu TR, Brown MF.

Chem Phys Lipids. 2016 Sep;199:39-51. doi: 10.1016/j.chemphyslip.2016.05.001. Epub 2016 May 3. Review.

23.

A Usual G-Protein-Coupled Receptor in Unusual Membranes.

Chawla U, Jiang Y, Zheng W, Kuang L, Perera SM, Pitman MC, Brown MF, Liang H.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):588-92. doi: 10.1002/anie.201508648. Epub 2015 Dec 3.

24.

Evaluating the Effect of Flow and Interface Type on Pressures Delivered With Bubble CPAP in a Simulated Model.

Bailes SA, Firestone KS, Dunn DK, McNinch NL, Brown MF, Volsko TA.

Respir Care. 2016 Mar;61(3):333-9. doi: 10.4187/respcare.04251. Epub 2015 Nov 3.

25.

Retinal Flip in Rhodopsin Activation?

Feng J, Brown MF, Mertz B.

Biophys J. 2015 Jun 16;108(12):2767-70. doi: 10.1016/j.bpj.2015.04.040.

26.

Factors modulating social influence on spatial choice in rats.

Bisbing TA, Saxon M, Sayde JM, Brown MF.

J Exp Psychol Anim Learn Cogn. 2015 Jul;41(3):286-300. doi: 10.1037/xan0000063. Epub 2015 May 25.

PMID:
26010213
27.

SPECTRAL METHODS FOR STUDY OF THE G-PROTEIN-COUPLED RECEPTOR RHODOPSIN. I. VIBRATIONAL AND ELECTRONIC SPECTROSCOPY.

Struts AV, Barmasov AV, Brown MF.

Opt Spectrosc. 2015 May;118(5):711-717. doi: 10.1134/S0030400X15050240. Epub 2015 May 27.

28.

Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.

Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J.

Cell Death Dis. 2015 Apr 23;6:e1729. doi: 10.1038/cddis.2015.104.

29.

Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype.

Frewen PA, Brown MF, Steuwe C, Lanius RA.

Eur J Psychotraumatol. 2015 Apr 1;6:26406. doi: 10.3402/ejpt.v6.26406. eCollection 2015.

30.

Investigation of rhodopsin dynamics in its signaling state by solid-state deuterium NMR spectroscopy.

Struts AV, Chawla U, Perera SM, Brown MF.

Methods Mol Biol. 2015;1271:133-58. doi: 10.1007/978-1-4939-2330-4_10. Review.

31.

Five on one side: personal and social information in spatial choice.

Brown MF, Saxon ME, Bisbing T, Evans J, Ruff J, Stokesbury A.

Behav Processes. 2015 Mar;112:130-7. doi: 10.1016/j.beproc.2014.12.012. Epub 2015 Jan 5.

PMID:
25572458
32.

Cognitive behaviorism: a tribute to the contributions of Thomas Zentall.

Brown MF.

Behav Processes. 2015 Mar;112:1-2. doi: 10.1016/j.beproc.2014.12.006. Epub 2014 Dec 27. No abstract available.

PMID:
25550152
33.

Area per lipid and cholesterol interactions in membranes from separated local-field (13)C NMR spectroscopy.

Leftin A, Molugu TR, Job C, Beyer K, Brown MF.

Biophys J. 2014 Nov 18;107(10):2274-86. doi: 10.1016/j.bpj.2014.07.044.

34.

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

Flanagan ME, Abramite JA, Anderson DP, Aulabaugh A, Dahal UP, Gilbert AM, Li C, Montgomery J, Oppenheimer SR, Ryder T, Schuff BP, Uccello DP, Walker GS, Wu Y, Brown MF, Chen JM, Hayward MM, Noe MC, Obach RS, Philippe L, Shanmugasundaram V, Shapiro MJ, Starr J, Stroh J, Che Y.

J Med Chem. 2014 Dec 11;57(23):10072-9. doi: 10.1021/jm501412a. Epub 2014 Nov 26.

PMID:
25375838
35.

LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens.

Tomaras AP, McPherson CJ, Kuhn M, Carifa A, Mullins L, George D, Desbonnet C, Eidem TM, Montgomery JI, Brown MF, Reilly U, Miller AA, O'Donnell JP.

MBio. 2014 Sep 30;5(5):e01551-14. doi: 10.1128/mBio.01551-14.

36.

Elastic deformation and area per lipid of membranes: atomistic view from solid-state deuterium NMR spectroscopy.

Kinnun JJ, Mallikarjunaiah KJ, Petrache HI, Brown MF.

Biochim Biophys Acta. 2015 Jan;1848(1 Pt B):246-59. doi: 10.1016/j.bbamem.2014.06.004. Epub 2014 Jun 16. Review.

37.

Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.

Starr J, Brown MF, Aschenbrenner L, Caspers N, Che Y, Gerstenberger BS, Huband M, Knafels JD, Lemmon MM, Li C, McCurdy SP, McElroy E, Rauckhorst MR, Tomaras AP, Young JA, Zaniewski RP, Shanmugasundaram V, Han S.

J Med Chem. 2014 May 8;57(9):3845-55. doi: 10.1021/jm500219c. Epub 2014 Apr 21.

PMID:
24694215
38.

Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.

Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA, Brown MF, Zewe J, Taguchi T, Kuan SF, Schöffski P, Debiec-Rychter M, Duensing A.

Cancer Res. 2014 Feb 15;74(4):1200-13. doi: 10.1158/0008-5472.CAN-13-1955. Epub 2014 Jan 2.

39.

Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures.

Leioatts N, Mertz B, Martínez-Mayorga K, Romo TD, Pitman MC, Feller SE, Grossfield A, Brown MF.

Biochemistry. 2014 Jan 21;53(2):376-85. doi: 10.1021/bi4013947. Epub 2014 Jan 8.

40.

High-resolution NMR reveals secondary structure and folding of amino acid transporter from outer chloroplast membrane.

Zook JD, Molugu TR, Jacobsen NE, Lin G, Soll J, Cherry BR, Brown MF, Fromme P.

PLoS One. 2013 Oct 29;8(10):e78116. doi: 10.1371/journal.pone.0078116. eCollection 2013.

41.

A consistent but non-coincident visual pattern facilitates the learning of spatial relations among locations.

Katz SS, Brown MF, Sturz BR.

Psychon Bull Rev. 2014 Feb;21(1):114-20. doi: 10.3758/s13423-013-0477-1.

PMID:
23843178
42.

Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa.

Tomaras AP, Crandon JL, McPherson CJ, Banevicius MA, Finegan SM, Irvine RL, Brown MF, O'Donnell JP, Nicolau DP.

Antimicrob Agents Chemother. 2013 Sep;57(9):4197-207. doi: 10.1128/AAC.00629-13. Epub 2013 Jun 17.

43.

Pyridone-conjugated monobactam antibiotics with gram-negative activity.

Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP.

J Med Chem. 2013 Jul 11;56(13):5541-52. doi: 10.1021/jm400560z. Epub 2013 Jun 27.

PMID:
23755848
44.

Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.

Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM Jr, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM.

J Med Chem. 2013 Jun 27;56(12):5079-93. doi: 10.1021/jm400416u. Epub 2013 Jun 18.

PMID:
23735048
45.

Retinal conformation governs pKa of protonated Schiff base in rhodopsin activation.

Zhu S, Brown MF, Feller SE.

J Am Chem Soc. 2013 Jun 26;135(25):9391-8. doi: 10.1021/ja4002986. Epub 2013 Jun 11.

46.

Solid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-Synuclein.

Leftin A, Job C, Beyer K, Brown MF.

J Mol Biol. 2013 Aug 23;425(16):2973-87. doi: 10.1016/j.jmb.2013.04.002. Epub 2013 Apr 11.

47.

Surgical reconstruction of the double lumen esophagus.

Hussain SZ, Abbas AE, Brown MF, Sankararaman S, Wellman G, Noel RA, Hyman P.

J Pediatr Surg. 2013 Mar;48(3):661-4. doi: 10.1016/j.jpedsurg.2012.12.033.

PMID:
23480929
48.

Curvature forces in membrane lipid-protein interactions.

Brown MF.

Biochemistry. 2012 Dec 11;51(49):9782-95. doi: 10.1021/bi301332v. Epub 2012 Nov 27.

49.

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.

McAllister LA, Montgomery JI, Abramite JA, Reilly U, Brown MF, Chen JM, Barham RA, Che Y, Chung SW, Menard CA, Mitton-Fry M, Mullins LM, Noe MC, O'Donnell JP, Oliver RM 3rd, Penzien JB, Plummer M, Price LM, Shanmugasundaram V, Tomaras AP, Uccello DP.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6832-8. doi: 10.1016/j.bmcl.2012.09.058. Epub 2012 Sep 24.

PMID:
23046961
50.

UV-visible and infrared methods for investigating lipid-rhodopsin membrane interactions.

Brown MF.

Methods Mol Biol. 2012;914:127-53. doi: 10.1007/978-1-62703-023-6_8.

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