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Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling.

Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR.

J Alzheimers Dis. 2019;67(3):1089-1106. doi: 10.3233/JAD-180923.


Genome-wide Significance Thresholds for Admixture Mapping Studies.

Grinde KE, Brown LA, Reiner AP, Thornton TA, Browning SR.

Am J Hum Genet. 2019 Feb 4. pii: S0002-9297(19)30008-4. doi: 10.1016/j.ajhg.2019.01.008. [Epub ahead of print]


Perpetration of sexual aggression among adolescents in South Africa.

Kuo C, Mathews C, LoVette A, Harrison A, Orchowski L, Pellowski JA, Atujuna M, Stein DJ, Brown LK.

J Adolesc. 2019 Feb 13;72:32-36. doi: 10.1016/j.adolescence.2019.02.002. [Epub ahead of print]


Improving child weight management uptake through enhanced National Child Measurement Programme parental feedback letters: A randomised controlled trial.

Sallis A, Porter L, Tan K, Howard R, Brown L, Jones A, Ells L, Adamson A, Taylor R, Vlaev I, Chadborn T.

Prev Med. 2019 Feb 13. pii: S0091-7435(19)30031-3. doi: 10.1016/j.ypmed.2019.01.023. [Epub ahead of print]


VisMET: a passive, efficient, and sensitive assessment of visuospatial memory in healthy aging, mild cognitive impairment, and Alzheimer's disease.

Haque RU, Manzanares CM, Brown LN, Pongos AL, Lah JJ, Clifford GD, Levey AI.

Learn Mem. 2019 Feb 15;26(3):93-100. doi: 10.1101/lm.048124.118. Print 2019 Mar.


Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications.

Cortegiani A, Gregoretti C, Neto AS, Hemmes SNT, Ball L, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Melo MFV, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Schultz MJ, Pelosi P; LAS VEGAS Investigators, the PROVE Network, and the Clinical Trial Network of the European Society of Anaesthesiology.

Br J Anaesth. 2019 Mar;122(3):361-369. doi: 10.1016/j.bja.2018.10.063. Epub 2019 Feb 8.


Constant-adiabaticity radiofrequency pulses for generating long-lived singlet spin states in NMR.

Rodin BA, Sheberstov KF, Kiryutin AS, Hill-Cousins JT, Brown LJ, Brown RCD, Jamain B, Zimmermann H, Sagdeev RZ, Yurkovskaya AV, Ivanov KL.

J Chem Phys. 2019 Feb 14;150(6):064201. doi: 10.1063/1.5079436.


Nuclear singlet relaxation by scalar relaxation of the second kind in the slow-fluctuation regime.

Elliott SJ, Bengs C, Brown LJ, Hill-Cousins JT, O'Leary DJ, Pileio G, Levitt MH.

J Chem Phys. 2019 Feb 14;150(6):064315. doi: 10.1063/1.5074199.


Influenza Virus Neuraminidase Structure and Functions.

McAuley JL, Gilbertson BP, Trifkovic S, Brown LE, McKimm-Breschkin JL.

Front Microbiol. 2019 Jan 29;10:39. doi: 10.3389/fmicb.2019.00039. eCollection 2019. Review.


Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2019 Feb 13. doi: 10.1152/ajpregu.00359.2018. [Epub ahead of print]


Older Adults' Perspectives on Using Digital Technology to Maintain Good Mental Health: Interactive Group Study.

Andrews JA, Brown LJ, Hawley MS, Astell AJ.

J Med Internet Res. 2019 Feb 13;21(2):e11694. doi: 10.2196/11694.


Patient outcomes following carotid endarterectomy are not adversely affected by surgical trainees' operative involvement: A retrospective cohort study.

Brown LR, Anderson J, Bhattacharya V.

Ann Med Surg (Lond). 2019 Jan 21;39:1-4. doi: 10.1016/j.amsu.2019.01.001. eCollection 2019 Mar.


Chronic Thromboembolic Pulmonary Hypertension Cases Cluster in Families.

Dodson MW, Allen-Brady K, Brown LM, Elliott CG, Cannon-Albright LA.

Chest. 2019 Feb;155(2):384-390. doi: 10.1016/j.chest.2018.10.004.


Loudness Trumps Pitch in Politeness Judgments: Evidence from Korean Deferential Speech.

Idemaru K, Winter B, Brown L, Oh GE.

Lang Speech. 2019 Feb 8:23830918824344. doi: 10.1177/0023830918824344. [Epub ahead of print]


Specific, sensitive and stable reporting of human mesenchymal stromal cell chondrogenesis.

De La Vega RE, Scheu M, Brown LA, Evans C, Ferreira E, Porter RM.

Tissue Eng Part C Methods. 2019 Feb 6. doi: 10.1089/ten.TEC.2018.0295. [Epub ahead of print]


Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials: Bridging Clinical and Patient Perspectives.

Siddiqui S, Denlinger LC, Fowler SJ, Akuthota P, Shaw DE, Heaney LG, Brown L, Castro M, Winders TA, Kraft M, Wagers S, Peters MC, Pavord ID, Walker S, Jarjour NN.

Am J Respir Crit Care Med. 2019 Feb 6. doi: 10.1164/rccm.201809-1817PP. [Epub ahead of print]


Biosynthetic production of fully carbon-13 labeled retinal in E. coli for structural and functional studies of rhodopsins.

Munro RA, de Vlugt J, Ward ME, Kim SY, Lee KA, Jung KH, Ladizhansky V, Brown LS.

J Biomol NMR. 2019 Feb 4. doi: 10.1007/s10858-019-00225-9. [Epub ahead of print]


Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation.

Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA Jr, Pelletier J.

Sci Rep. 2019 Feb 4;9(1):1265. doi: 10.1038/s41598-018-37666-5.


Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.

Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL.

J Clin Oncol. 2019 Feb 4:JCO1801207. doi: 10.1200/JCO.18.01207. [Epub ahead of print]


Oral dexamethasone in the management of cancer-related pain: A feasibility study.

Eastman P, Currow DC, Fazekas B, Brown L, Le B.

Palliat Med. 2019 Feb 4:269216319827802. doi: 10.1177/0269216319827802. [Epub ahead of print] No abstract available.


Rectal ultrasound with fine needle aspiration: an underutilized modality for delineating and diagnosing perirectal, presacral, and pelvic lesions.

Brown LK, Clark NR, Conway J, Mishra G.

Endosc Int Open. 2019 Feb;7(2):E171-E177. doi: 10.1055/a-0743-5356. Epub 2019 Jan 18.


Evaluating the Role of Family Context Within a Randomized Adolescent HIV-Risk Prevention Trial.

Barker DH, Hadley W, McGee H, Donenberg GR, DiClemente RJ, Brown LK.

AIDS Behav. 2019 Jan 31. doi: 10.1007/s10461-019-02400-3. [Epub ahead of print]


A Systematic Review of the Psychometric Properties of Self-Report Measures of Attitudes to Aging.

Faudzi FNM, Armitage CJ, Bryant C, Brown LJE.

Res Aging. 2019 Jan 30:164027518825117. doi: 10.1177/0164027518825117. [Epub ahead of print]


Directionality of change in obsessive compulsive disorder (OCD) and suicidal ideation over six years in a naturalistic clinical sample.

Brown LA, Wakschal E, Russman-Block S, Boisseau CL, Mancebo MC, Eisen JL, Rasmussen SA.

J Affect Disord. 2019 Feb 15;245:841-847. doi: 10.1016/j.jad.2018.11.006. Epub 2018 Nov 13.


Multicomponent non-pharmacological intervention to prevent delirium for hospitalised people with advanced cancer: study protocol for a phase II cluster randomised controlled trial.

Hosie A, Phillips J, Lam L, Kochovska S, Noble B, Brassil M, Kurrle SE, Cumming A, Caplan GA, Chye R, Le B, Ely EW, Lawlor PG, Bush SH, Davis JM, Lovell M, Brown L, Fazekas B, Cheah SL, Edwards L, Agar M.

BMJ Open. 2019 Jan 28;9(1):e026177. doi: 10.1136/bmjopen-2018-026177.


Commentaries on Viewpoint: Rejuvenation of the term sarcopenia.

Langer HT, Mossakowski AA, Baar K, Alcazar J, Martin-Rincon M, Alegre LM, Ara I, Calbet JAL, Hinkley JM, Coen PM, Irving BA, Allerton TD, Nair S, Lima RM, Rey-López JP, Scott D, Daly RM, Ebeling PR, Hayes A, Tessier AJ, Chevalier S, Yates BA, Brown LR, Storer TW, Westcott WL, Nifli AP, Musci RV, Konopka AR, Hamilton KL, Hepple RT.

J Appl Physiol (1985). 2019 Jan 1;126(1):257-262. doi: 10.1152/japplphysiol.00816.2018. No abstract available.


Rural versus urban women: An examination of anthropometry and body composition.

Tan M, Brown LJ, Mathews KI, Whatnall MC, Hutchesson MJ, MacDonald-Wicks LK, Patterson AJ.

Aust J Rural Health. 2019 Feb;27(1):70-77. doi: 10.1111/ajr.12466. Epub 2019 Jan 29.


Beyond romance: Neural and genetic correlates of altruism in pair-bonds.

Acevedo BP, Poulin MJ, Brown LL.

Behav Neurosci. 2019 Feb;133(1):18-31. doi: 10.1037/bne0000293.


Quantitative myocardial perfusion in coronary artery disease: A perfusion mapping study.

Knott KD, Camaioni C, Ramasamy A, Augusto JA, Bhuva AN, Xue H, Manisty C, Hughes RK, Brown LAE, Amersey R, Bourantas C, Kellman P, Plein S, Moon JC.

J Magn Reson Imaging. 2019 Jan 25. doi: 10.1002/jmri.26668. [Epub ahead of print]


Bibliometric Analysis of Electronic Cigarette Publications: 2003⁻2018.

Briganti M, Delnevo CD, Brown L, Hastings SE, Steinberg MB.

Int J Environ Res Public Health. 2019 Jan 24;16(3). pii: E320. doi: 10.3390/ijerph16030320.


Data electronically extracted from the electronic health record require validation.

Scheid LM, Brown LS, Clark C, Rosenfeld CR.

J Perinatol. 2019 Jan 24. doi: 10.1038/s41372-018-0311-8. [Epub ahead of print]


Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE.

Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w.


Factors predictive of successful retention in care among HIV-infected men in a universal test-and-treat setting in Uganda and Kenya: A mixed methods analysis.

Brown LB, Getahun M, Ayieko J, Kwarisiima D, Owaraganise A, Atukunda M, Olilo W, Clark T, Bukusi EA, Cohen CR, Kamya MR, Petersen ML, Charlebois ED, Havlir DV, Camlin CS.

PLoS One. 2019 Jan 23;14(1):e0210126. doi: 10.1371/journal.pone.0210126. eCollection 2019.


Evaluating the effects of surgical subspecialisation on patient outcomes following emergency laparotomy: A retrospective cohort study.

Brown LR, McLean RC, Perren D, O'Loughlin P, McCallum IJ.

Int J Surg. 2019 Feb;62:67-73. doi: 10.1016/j.ijsu.2019.01.010. Epub 2019 Jan 20.


Global patterns and drivers of ecosystem functioning in rivers and riparian zones.

Tiegs SD, Costello DM, Isken MW, Woodward G, McIntyre PB, Gessner MO, Chauvet E, Griffiths NA, Flecker AS, Acuña V, Albariño R, Allen DC, Alonso C, Andino P, Arango C, Aroviita J, Barbosa MVM, Barmuta LA, Baxter CV, Bell TDC, Bellinger B, Boyero L, Brown LE, Bruder A, Bruesewitz DA, Burdon FJ, Callisto M, Canhoto C, Capps KA, Castillo MM, Clapcott J, Colas F, Colón-Gaud C, Cornut J, Crespo-Pérez V, Cross WF, Culp JM, Danger M, Dangles O, de Eyto E, Derry AM, Villanueva VD, Douglas MM, Elosegi A, Encalada AC, Entrekin S, Espinosa R, Ethaiya D, Ferreira V, Ferriol C, Flanagan KM, Fleituch T, Follstad Shah JJ, Frainer Barbosa A, Friberg N, Frost PC, Garcia EA, García Lago L, García Soto PE, Ghate S, Giling DP, Gilmer A, Gonçalves JF Jr, Gonzales RK, Graça MAS, Grace M, Grossart HP, Guérold F, Gulis V, Hepp LU, Higgins S, Hishi T, Huddart J, Hudson J, Imberger S, Iñiguez-Armijos C, Iwata T, Janetski DJ, Jennings E, Kirkwood AE, Koning AA, Kosten S, Kuehn KA, Laudon H, Leavitt PR, Lemes da Silva AL, Leroux SJ, LeRoy CJ, Lisi PJ, MacKenzie R, Marcarelli AM, Masese FO, McKie BG, Oliveira Medeiros A, Meissner K, Miliša M, Mishra S, Miyake Y, Moerke A, Mombrikotb S, Mooney R, Moulton T, Muotka T, Negishi JN, Neres-Lima V, Nieminen ML, Nimptsch J, Ondruch J, Paavola R, Pardo I, Patrick CJ, Peeters ETHM, Pozo J, Pringle C, Prussian A, Quenta E, Quesada A, Reid B, Richardson JS, Rigosi A, Rincón J, Rîşnoveanu G, Robinson CT, Rodríguez-Gallego L, Royer TV, Rusak JA, Santamans AC, Selmeczy GB, Simiyu G, Skuja A, Smykla J, Sridhar KR, Sponseller R, Stoler A, Swan CM, Szlag D, Teixeira-de Mello F, Tonkin JD, Uusheimo S, Veach AM, Vilbaste S, Vought LBM, Wang CP, Webster JR, Wilson PB, Woelfl S, Xenopoulos MA, Yates AG, Yoshimura C, Yule CM, Zhang YX, Zwart JA.

Sci Adv. 2019 Jan 9;5(1):eaav0486. doi: 10.1126/sciadv.aav0486. eCollection 2019 Jan.


Diagnosis and management of glycogen storage diseases type VI and IX: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).

Kishnani PS, Goldstein J, Austin SL, Arn P, Bachrach B, Bali DS, Chung WK, El-Gharbawy A, Brown LM, Kahler S, Pendyal S, Ross KM, Tsilianidis L, Weinstein DA, Watson MS; ACMG Work Group on Diagnosis and Management of Glycogen Storage Diseases Type VI and IX.

Genet Med. 2019 Jan 19. doi: 10.1038/s41436-018-0364-2. [Epub ahead of print]


Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.

Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA Jr, Kelley MR, Georgiadis MM.

J Med Chem. 2019 Feb 6. doi: 10.1021/acs.jmedchem.8b01529. [Epub ahead of print]


Is Use of Warning Lights and Sirens Associated With Increased Risk of Ambulance Crashes? A Contemporary Analysis Using National EMS Information System (NEMSIS) Data.

Watanabe BL, Patterson GS, Kempema JM, Magallanes O, Brown LH.

Ann Emerg Med. 2018 Nov 14. pii: S0196-0644(18)31325-8. doi: 10.1016/j.annemergmed.2018.09.032. [Epub ahead of print]


Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.


Motivators, Barriers, and Facilitators to Traveling to the Safest Hospitals in the United States for Complex Cancer Surgery.

Resio BJ, Chiu AS, Hoag JR, Brown LB, White M, Omar A, Monsalve A, Dhanasopon AP, Blasberg JD, Boffa DJ.

JAMA Netw Open. 2018 Nov 2;1(7):e184595. doi: 10.1001/jamanetworkopen.2018.4595.


How can transition to adult care be best orchestrated for adolescents with epilepsy?

Camfield PR, Andrade D, Camfield CS, Carrizosa-Moog J, Appleton R, Baulac M, Brown L, Menachem EB, Cross H, Desguerre I, Grant C, Hosny H, Jurasek L, Mula M, Pfäfflin M, Rheims S, Ring H, Shellhaas RA, Vinayan KP, Wirrell E, Nabbout R.

Epilepsy Behav. 2019 Jan 11. pii: S1525-5050(18)31022-9. doi: 10.1016/j.yebeh.2018.12.015. [Epub ahead of print] Review.


Variable impact of prior cancer history on the survival of lung cancer patients.

Monsalve AF, Hoag JR, Resio BJ, Chiu AS, Brown LB, Detterbeck FC, Blasberg JD, Boffa DJ.

Lung Cancer. 2019 Jan;127:130-137. doi: 10.1016/j.lungcan.2018.11.040. Epub 2018 Nov 30.


Contextualizing pubertal development: The combination of sexual partners' age and girls' pubertal development confers risk for externalizing but not internalizing symptoms among girls in therapeutic day schools.

Javdani S, Sadeh N, White HI, Emerson E, Houck C, Brown LK, Donenberg GR.

J Adolesc. 2019 Feb;71:84-90. doi: 10.1016/j.adolescence.2019.01.001. Epub 2019 Jan 11.


Enhancing health among youth living with HIV using an iPhone game.

Whiteley L, Brown LK, Mena L, Craker L, Arnold T.

AIDS Care. 2019 Jan 9:1-13. doi: 10.1080/09540121.2018.1503224. [Epub ahead of print]


Self-referential processing during observation of a speech performance task in social anxiety disorder from pre- to post-treatment: Evidence of disrupted neural activation.

Brown LA, Young KS, Goldin PR, Torre JB, Burklund LJ, Davies CD, Niles AN, Lieberman MD, Saxbe DE, Craske MG.

Psychiatry Res Neuroimaging. 2019 Jan 2;284:13-20. doi: 10.1016/j.pscychresns.2018.12.017. [Epub ahead of print]


Characterization of the L29Q Hypertrophic Cardiomyopathy Mutation in Cardiac Troponin C by Paramagnetic Relaxation Enhancement Nuclear Magnetic Resonance.

Potluri PR, Cordina NM, Kachooei E, Brown LJ.

Biochemistry. 2019 Feb 19;58(7):908-917. doi: 10.1021/acs.biochem.8b01140. Epub 2019 Jan 23.


Consider the full spectrum of household food insecurity.

Wong PD, Thadani SH, Brown LL, Moodie RG.

CMAJ. 2019 Jan 7;191(1):E20. doi: 10.1503/cmaj.69952. No abstract available.


Clinical evaluation of two dark blood methods of late gadolinium quantification of ischemic scar.

Foley JRJ, Broadbent DA, Fent GJ, Garg P, Brown LAE, Chew PG, Dobson LE, Swoboda PP, Plein S, Higgins DM, Greenwood JP.

J Magn Reson Imaging. 2019 Jan 3. doi: 10.1002/jmri.26613. [Epub ahead of print]


Quality Improvement Project to Decrease Delivery Room Intubations in Preterm Infants.

Kakkilaya V, Jubran I, Mashruwala V, Ramon E, Simcik VN, Marshall M, Brown LS, Jaleel MA, Kapadia VS.

Pediatrics. 2019 Jan 2. pii: e20180201. doi: 10.1542/peds.2018-0201. [Epub ahead of print]


Improving the Affordability of Prescription Medications for People with Chronic Respiratory Disease. An Official American Thoracic Society Policy Statement.

Patel MR, Press VG, Gerald LB, Barnes T, Blake K, Brown LK, Costello RW, Crim C, Forshag M, Gershon AS, Goss CH, Han MK, Lee TA, Sweet S, Gerald JK.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1367-1374. doi: 10.1164/rccm.201810-1865ST.


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