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Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.

Newham E, Kague E, Aggleton JA, Fernee C, Brown KR, Hammond CL.

J R Soc Interface. 2019 Nov 29;16(160):20190430. doi: 10.1098/rsif.2019.0430. Epub 2019 Nov 6.


Assessment of a novel antimicrobial surface disinfectant on inert surfaces in the intensive care unit environment using ATP-bioluminesence assay.

Edmiston CE Jr, Spencer M, Lewis BD, Rossi PJ, Brown KR, Malinowski M, Seabrook GR, Leaper D.

Am J Infect Control. 2020 Feb;48(2):143-146. doi: 10.1016/j.ajic.2019.08.026. Epub 2019 Oct 9.


Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Cinà DP, Ketela T, Brown KR, Chandrashekhar M, Mero P, Li C, Onay T, Fu Y, Han Z, Saleem M, Moffat J, Quaggin SE.

Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1593-F1604. doi: 10.1152/ajprenal.00195.2019. Epub 2019 Sep 30.


Pooled CRISPR-Based Genetic Screens in Mammalian Cells.

Chan K, Tong AHY, Brown KR, Mero P, Moffat J.

J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780.


CRISPR screens are feasible in TP53 wild-type cells.

Brown KR, Mair B, Soste M, Moffat J.

Mol Syst Biol. 2019 Aug;15(8):e8679. doi: 10.15252/msb.20188679.


Unplanned 30-day readmissions after endovascular aneurysm repair: An analysis using the Nationwide Readmissions Database.

Dua A, Rothenberg KA, Wohlaer M, Rossi PJ, Lewis BD, Brown KR, Seabrook GR, Lee CJ.

J Vasc Surg. 2019 Nov;70(5):1603-1611. doi: 10.1016/j.jvs.2019.02.034. Epub 2019 May 27. Erratum in: J Vasc Surg. 2020 Feb;71(2):720.


Current issues and future directions for vascular surgery training from the results of the 2016-2017 and 2017-2018 Association of Program Directors in Vascular Surgery annual training survey.

Hekman KE, Wohlauer MV, Magee GA, Shokrzadeh CL, Brown KR, Carsten CG 3rd, Chaer R, Jazaeri O, Lee AM, Singh N, Coleman DM.

J Vasc Surg. 2019 Dec;70(6):2014-2020. doi: 10.1016/j.jvs.2019.02.050. Epub 2019 May 27.


Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.

Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.

J Neurooncol. 2019 Jul;143(3):417-428. doi: 10.1007/s11060-019-03192-1. Epub 2019 May 21.


Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.

Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041.


A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.

Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J.

Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1.


Stabilizer Slicing: Coherent Error Cancellations in Low-Density Parity-Check Stabilizer Codes.

Debroy DM, Li M, Newman M, Brown KR.

Phys Rev Lett. 2018 Dec 21;121(25):250502. doi: 10.1103/PhysRevLett.121.250502.


Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.

Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS.

J Biol Chem. 2019 Jan 25;294(4):1396-1409. doi: 10.1074/jbc.RA118.004420. Epub 2018 Dec 6.


Quantum Error Correction Decoheres Noise.

Beale SJ, Wallman JJ, Gutiérrez M, Brown KR, Laflamme R.

Phys Rev Lett. 2018 Nov 9;121(19):190501. doi: 10.1103/PhysRevLett.121.190501.


Spectroscopy of Molecular Ions in Coulomb Crystals.

Calvin AT, Brown KR.

J Phys Chem Lett. 2018 Oct 4;9(19):5797-5804. doi: 10.1021/acs.jpclett.8b01387. Epub 2018 Sep 21.


Repeated cyclone events reveal potential causes of sociality in coral-dwelling Gobiodon fishes.

Hing ML, Klanten OS, Dowton M, Brown KR, Wong MYL.

PLoS One. 2018 Sep 5;13(9):e0202407. doi: 10.1371/journal.pone.0202407. eCollection 2018.


Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.

Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu A, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, Brown KR, Murty NK, Nilvebrant J, Kaplan D, Moffat J, Sidhu S, Singh SK.

Cancer Res. 2018 Sep 1;78(17):5023-5037. doi: 10.1158/0008-5472.CAN-18-0267. Epub 2018 Jun 26.


Sex-dependent outcomes following elective endovascular aortic repair.

Truong C, Kugler NW, Rossi PJ, Patel PJ, Hieb RA, Brown KR, Lewis BD, Seabrook G, Lee CJ.

J Surg Res. 2018 Sep;229:177-185. doi: 10.1016/j.jss.2018.03.015. Epub 2018 Apr 30.


Clinicopathologic Correlation of a Subretinal Proliferative Vitreoretinopathy Band in a Patient with Chronic Recurrent Retinal Detachment.

Brown KR, Dubovy SR, Relhan N, Flynn HW Jr.

Case Rep Ophthalmol. 2018 May 24;9(2):279-282. doi: 10.1159/000488931. eCollection 2018 May-Aug.



Eagleton MJ, Schanzer A, Brown KR, Kashyap VS.

J Vasc Surg. 2018 Jun;67(6):e45-e48. doi: 10.1016/j.jvs.2018.04.004. No abstract available.


The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium.

Gouras P, Brown KR, Mattison JA, Neuringer M, Nagasaki T, Ivert L.

Curr Eye Res. 2018 Aug;43(8):1019-1023. doi: 10.1080/02713683.2018.1464194. Epub 2018 May 14.


Rovibronic Spectroscopy of Sympathetically Cooled 40CaH.

Calvin AT, Janardan S, Condoluci J, Rugango R, Pretzsch E, Shu G, Brown KR.

J Phys Chem A. 2018 Mar 29;122(12):3177-3181. doi: 10.1021/acs.jpca.7b12823. Epub 2018 Mar 16.


Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth.

Kague E, Witten PE, Soenens M, Campos CL, Lubiana T, Fisher S, Hammond C, Brown KR, Passos-Bueno MR, Huysseune A.

Dev Biol. 2018 Mar 15;435(2):176-184. doi: 10.1016/j.ydbio.2018.01.021. Epub 2018 Feb 2.


Robust 2-Qubit Gates in a Linear Ion Crystal Using a Frequency-Modulated Driving Force.

Leung PH, Landsman KA, Figgatt C, Linke NM, Monroe C, Brown KR.

Phys Rev Lett. 2018 Jan 12;120(2):020501. doi: 10.1103/PhysRevLett.120.020501.


Reassigning the CaH+ 11Σ → 21Σ vibronic transition with CaD.

Condoluci J, Janardan S, Calvin AT, Rugango R, Shu G, Sherrill CD, Brown KR.

J Chem Phys. 2017 Dec 7;147(21):214309. doi: 10.1063/1.5016556.


Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study.

Almquist LD, Likes CE, Stone B, Brown KR, Savaris R, Forstein DA, Miller PB, Lessey BA.

Fertil Steril. 2017 Dec;108(6):1063-1069. doi: 10.1016/j.fertnstert.2017.09.017. Epub 2017 Nov 7.


Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384d.


Fault-tolerant quantum error detection.

Linke NM, Gutierrez M, Landsman KA, Figgatt C, Debnath S, Brown KR, Monroe C.

Sci Adv. 2017 Oct 20;3(10):e1701074. doi: 10.1126/sciadv.1701074. eCollection 2017 Oct.


RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK.

Acta Neuropathol. 2017 Dec;134(6):923-940. doi: 10.1007/s00401-017-1757-z. Epub 2017 Aug 1.


Endotypes of difficult-to-control asthma in inner-city African American children.

Brown KR, Krouse RZ, Calatroni A, Visness CM, Sivaprasad U, Kercsmar CM, Matsui EC, West JB, Makhija MM, Gill MA, Kim H, Kattan M, Pillai D, Gern JE, Busse WW, Togias A, Liu AH, Khurana Hershey GK.

PLoS One. 2017 Jul 7;12(7):e0180778. doi: 10.1371/journal.pone.0180778. eCollection 2017.


Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.


Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S.

Oncotarget. 2017 Apr 18;8(16):27380-27392. doi: 10.18632/oncotarget.16068.


An update on the currently available nonthermal ablative options in the management of superficial venous disease.

Kugler NW, Brown KR.

J Vasc Surg Venous Lymphat Disord. 2017 May;5(3):422-429. doi: 10.1016/j.jvsv.2017.01.014. Review.


Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R.

Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028.


Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. Epub 2016 Nov 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.


Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring.

Venter C, Brown KR, Maslin K, Palmer DJ.

Pediatr Allergy Immunol. 2017 Mar;28(2):135-143. doi: 10.1111/pai.12682. Review.


An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

Kent OA, Sandí MJ, Burston HE, Brown KR, Rottapel R.

Oncotarget. 2017 Jan 17;8(3):4484-4500. doi: 10.18632/oncotarget.13152.


Vibronic Spectroscopy of Sympathetically Cooled CaH.

Rugango R, Calvin AT, Janardan S, Shu G, Brown KR.

Chemphyschem. 2016 Nov 18;17(22):3764-3768. doi: 10.1002/cphc.201600645. Epub 2016 Aug 25.


Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine.

Lobo NC, Gedye C, Apostoli AJ, Brown KR, Paterson J, Stickle N, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Moffat J, Jewett MA, Ailles L.

BMC Cancer. 2016 Jul 16;16:485. doi: 10.1186/s12885-016-2539-z.



Dalman RL, Brown KR.

J Vasc Surg. 2016 Jun;63(6 Suppl):1S-3S. doi: 10.1016/j.jvs.2016.03.419. No abstract available.


The effect of exercise training with an additional inspiratory load on inspiratory muscle fatigue and time-trial performance.

McEntire SJ, Smith JR, Ferguson CS, Brown KR, Kurti SP, Harms CA.

Respir Physiol Neurobiol. 2016 Aug;230:54-9. doi: 10.1016/j.resp.2016.05.001. Epub 2016 May 16.


System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SS.

Mol Cell. 2016 Apr 7;62(1):121-36. doi: 10.1016/j.molcel.2016.02.005. Epub 2016 Mar 3.


Preventable Complications Driving Rising Costs in Management of Patients with Critical Limb Ischemia.

Dua A, Desai SS, Patel B, Seabrook GR, Brown KR, Lewis B, Rossi PJ, Malinowski M, Lee CJ.

Ann Vasc Surg. 2016 May;33:144-8. doi: 10.1016/j.avsg.2015.11.026. Epub 2016 Feb 23.


Bioequivalence of Alendronate and Vitamin D3 in a Combination Tablet Versus Corresponding-Dose Individual Tablets in Healthy Taiwanese Volunteers, Determined Using a Novel Plasma Alendronate Assay.

Wright DH, Mols R, Brown KR, Yeh GC, Woolf E, Hickey L, Zajic S.

Curr Ther Res Clin Exp. 2015 Oct 14;77:116-21. doi: 10.1016/j.curtheres.2015.10.001. eCollection 2015 Dec.


Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe'er D, Moffat J, Neel BG.

Cell. 2016 Jan 14;164(1-2):293-309. doi: 10.1016/j.cell.2015.11.062.


Preadmission Application of 2% Chlorhexidine Gluconate (CHG): Enhancing Patient Compliance While Maximizing Skin Surface Concentrations.

Edmiston CE, Krepel CJ, Spencer MP, Ferraz AA, Seabrook GR, Lee CJ, Lewis BD, Brown KR, Rossi PJ, Malinowski MJ, Edmiston SE, Ferraz EM, Leaper DJ.

Infect Control Hosp Epidemiol. 2016 Mar;37(3):254-9. doi: 10.1017/ice.2015.303. Epub 2015 Dec 28.


High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.

Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25.


Improved lung function following dietary antioxidant supplementation in exercise-induced asthmatics.

Kurti SP, Murphy JD, Ferguson CS, Brown KR, Smith JR, Harms CA.

Respir Physiol Neurobiol. 2016 Jan;220:95-101. doi: 10.1016/j.resp.2015.09.012. Epub 2015 Nov 16.


Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ.

Oncotarget. 2015 Sep 29;6(29):26909-21. doi: 10.18632/oncotarget.4817.


Biomimetic Total Syntheses of (-)-Leucoridines A and C through the Dimerization of (-)-Dihydrovalparicine.

Kokkonda P, Brown KR, Seguin TJ, Wheeler SE, Vaddypally S, Zdilla MJ, Andrade RB.

Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12632-5. doi: 10.1002/anie.201505198. Epub 2015 Aug 28.


Evidence for a Standardized Preadmission Showering Regimen to Achieve Maximal Antiseptic Skin Surface Concentrations of Chlorhexidine Gluconate, 4%, in Surgical Patients.

Edmiston CE Jr, Lee CJ, Krepel CJ, Spencer M, Leaper D, Brown KR, Lewis BD, Rossi PJ, Malinowski MJ, Seabrook GR.

JAMA Surg. 2015 Nov;150(11):1027-33. doi: 10.1001/jamasurg.2015.2210. Erratum in: JAMA Surg. 2016 Mar;151(3):297.


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