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Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans.

Reed KJ, Svendsen JM, Brown KC, Montgomery BE, Marks TN, Vijayasarathy T, Parker DM, Nishimura EO, Updike DL, Montgomery TA.

Nucleic Acids Res. 2019 Dec 24. pii: gkz1178. doi: 10.1093/nar/gkz1178. [Epub ahead of print]


henn-1/HEN1 Promotes Germline Immortality in Caenorhabditis elegans.

Svendsen JM, Reed KJ, Vijayasarathy T, Montgomery BE, Tucci RM, Brown KC, Marks TN, Nguyen DAH, Phillips CM, Montgomery TA.

Cell Rep. 2019 Dec 3;29(10):3187-3199.e4. doi: 10.1016/j.celrep.2019.10.114.


Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation.

Ward DB, Brown KC, Valentovic MA.

Int J Mol Sci. 2019 Aug 21;20(17). pii: E4074. doi: 10.3390/ijms20174074.


Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers.

Friedman JR, Richbart SD, Merritt JC, Brown KC, Denning KL, Tirona MT, Valentovic MA, Miles SL, Dasgupta P.

Biomed Pharmacother. 2019 Oct;118:109317. doi: 10.1016/j.biopha.2019.109317. Epub 2019 Aug 9. Review.


Capsaicinoids enhance chemosensitivity to chemotherapeutic drugs.

Friedman JR, Richbart SD, Merritt JC, Perry HE, Brown KC, Akers AT, Nolan NA, Stevenson CD, Hurley JD, Miles SL, Tirona MT, Valentovic MA, Dasgupta P.

Adv Cancer Res. 2019;144:263-298. doi: 10.1016/bs.acr.2019.05.002.


Acetylcholine signaling system in progression of lung cancers.

Friedman JR, Richbart SD, Merritt JC, Brown KC, Nolan NA, Akers AT, Lau JK, Robateau ZR, Miles SL, Dasgupta P.

Pharmacol Ther. 2019 Feb;194:222-254. doi: 10.1016/j.pharmthera.2018.10.002. Epub 2018 Oct 3. Review.


Reproductive Health Knowledge, Attitudes, and Behaviors Among Women Enrolled in Medication-Assisted Treatment for Opioid Use Disorder.

Meschke LL, McNeely C, Brown KC, Prather JM.

J Womens Health (Larchmt). 2018 Oct;27(10):1215-1224. doi: 10.1089/jwh.2017.6564. Epub 2018 Jul 3.


The long and short of lifespan regulation by Argonautes.

Brown KC, Montgomery TA.

PLoS Genet. 2018 Jun 21;14(6):e1007415. doi: 10.1371/journal.pgen.1007415. eCollection 2018 Jun. No abstract available.


Anticancer Activity of Natural and Synthetic Capsaicin Analogs.

Friedman JR, Nolan NA, Brown KC, Miles SL, Akers AT, Colclough KW, Seidler JM, Rimoldi JM, Valentovic MA, Dasgupta P.

J Pharmacol Exp Ther. 2018 Mar;364(3):462-473. doi: 10.1124/jpet.117.243691. Epub 2017 Dec 15. Review.


Predictors of Back Pain in Firefighters.

Damrongsak M, Prapanjaroensin A, Brown KC.

Workplace Health Saf. 2018 Feb;66(2):61-69. doi: 10.1177/2165079917709020. Epub 2017 Jul 27.


ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline.

Brown KC, Svendsen JM, Tucci RM, Montgomery BE, Montgomery TA.

Nucleic Acids Res. 2017 Sep 6;45(15):9093-9107. doi: 10.1093/nar/gkx536.


Role of Free Radicals and Biotransformation in Trichloronitrobenzene-Induced Nephrotoxicity In Vitro.

Rankin GO, Tyree C, Pope D, Tate J, Racine C, Anestis DK, Brown KC, Dial M, Valentovic MA.

Int J Mol Sci. 2017 May 31;18(6). pii: E1165. doi: 10.3390/ijms18061165.


Transgenerational Inheritance: Perpetuating RNAi.

Brown KC, Montgomery TA.

Curr Biol. 2017 May 22;27(10):R383-R385. doi: 10.1016/j.cub.2017.03.061.


MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.

Weiser NE, Yang DX, Feng S, Kalinava N, Brown KC, Khanikar J, Freeberg MA, Snyder MJ, Csankovszki G, Chan RC, Gu SG, Montgomery TA, Jacobsen SE, Kim JK.

Dev Cell. 2017 May 22;41(4):408-423.e7. doi: 10.1016/j.devcel.2017.04.023.


Gait Speed and Variability for Usual Pace and Pedestrian Crossing Conditions in Older Adults Using the GAITRite Walkway.

Brown KC, Hanson HM, Firmani F, Liu D, McAllister MM, Merali K, Puyat JH, Ashe MC.

Gerontol Geriatr Med. 2015 Dec 4;1:2333721415618858. doi: 10.1177/2333721415618858. eCollection 2015 Jan-Dec.


Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway.

Friedman JR, Perry HE, Brown KC, Gao Y, Lin J, Stevenson CD, Hurley JD, Nolan NA, Akers AT, Chen YC, Denning KL, Brown LG, Dasgupta P.

Biochem Pharmacol. 2017 Apr 1;129:54-66. doi: 10.1016/j.bcp.2017.01.004. Epub 2017 Jan 16.


Seeing Students Squirm: Student Nurses' Bullying Experiences in Clinical Settings.

Smith CR, Gillespie GL, Brown KC, Grubb PL.

West J Nurs Res. 2016 Oct;38(10):1397-8. doi: 10.1177/0193945916658207. No abstract available.


Seeing Students Squirm: Nursing Students' Experiences of Bullying Behaviors During Clinical Rotations.

Smith CR, Gillespie GL, Brown KC, Grubb PL.

J Nurs Educ. 2016 Sep 1;55(9):505-13. doi: 10.3928/01484834-20160816-04.


Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers.

Hurley JD, Akers AT, Friedman JR, Nolan NA, Brown KC, Dasgupta P.

Cell Adh Migr. 2017 Jan 2;11(1):80-97. doi: 10.1080/19336918.2016.1187368. Epub 2016 May 19.


Obesity, Prediabetes, and Perceived Stress in Municipal Workers.

O'Keefe LC, Brown KC, Frith KH, Heaton KL, Maples EH, Phillips JA, Vance DE.

Workplace Health Saf. 2016 Oct;64(10):453-461. doi: 10.1177/2165079916632771. Epub 2016 Jul 10.


Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma.

Fowles JS, Brown KC, Hess AM, Duval DL, Gustafson DL.

BMC Bioinformatics. 2016 Feb 19;17:93. doi: 10.1186/s12859-016-0942-8.


Drug Selection in the Genomic Age: Application of the Coexpression Extrapolation Principle for Drug Repositioning in Cancer Therapy.

Gustafson DL, Fowles JS, Brown KC, Theodorescu D.

Assay Drug Dev Technol. 2015 Dec;13(10):623-7. doi: 10.1089/adt.2015.29012.dlgdrrr.


Back to the future - feasibility of recruitment and retention to patient education and telephone follow-up after hip fracture: a pilot randomized controlled trial.

Langford DP, Fleig L, Brown KC, Cho NJ, Frost M, Ledoyen M, Lehn J, Panagiotopoulos K, Sharpe N, Ashe MC.

Patient Prefer Adherence. 2015 Sep 22;9:1343-51. doi: 10.2147/PPA.S86922. eCollection 2015.


piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.

Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA.

Dev Cell. 2015 Aug 24;34(4):457-65. doi: 10.1016/j.devcel.2015.07.009. Epub 2015 Aug 13.


Modular Three-component Delivery System Facilitates HLA Class I Antigen Presentation and CD8(+) T-cell Activation Against Tumors.

Umlauf BJ, Chung CY, Brown KC.

Mol Ther. 2015 Jun;23(6):1092-1102. doi: 10.1038/mt.2015.42. Epub 2015 Mar 19.


The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway.

Chen J, Chen AY, Huang H, Ye X, Rollyson WD, Perry HE, Brown KC, Rojanasakul Y, Rankin GO, Dasgupta P, Chen YC.

Int J Oncol. 2015;46(6):2629-38. doi: 10.3892/ijo.2015.2946. Epub 2015 Apr 1.


Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning.

Umlauf BJ, McGuire MJ, Brown KC.

Biotechniques. 2015 Feb 1;58(2):81-4. doi: 10.2144/000114256. eCollection 2015 Feb.


Bioavailability of capsaicin and its implications for drug delivery.

Rollyson WD, Stover CA, Brown KC, Perry HE, Stevenson CD, McNees CA, Ball JG, Valentovic MA, Dasgupta P.

J Control Release. 2014 Dec 28;196:96-105. doi: 10.1016/j.jconrel.2014.09.027. Epub 2014 Oct 12. Review.


Identification of a novel lysosomal trafficking peptide using phage display biopanning coupled with endocytic selection pressure.

Umlauf BJ, Mercedes JS, Chung CY, Brown KC.

Bioconjug Chem. 2014 Oct 15;25(10):1829-37. doi: 10.1021/bc500326x. Epub 2014 Sep 15.


Policy perspectives on occupational stress.

O'Keefe LC, Brown KC, Christian BJ.

Workplace Health Saf. 2014 Oct;62(10):432-8; quiz 439. doi: 10.3928/21650799-20140813-02. Epub 2014 Aug 20. Review.


Bilateral variations of brachial plexus involving the median nerve and lateral cord: An anatomical case study with clinical implications.

Butz JJ, Shiwlochan DG, Brown KC, Prasad AM, Murlimanju BV, Viswanath S.

Australas Med J. 2014 May 31;7(5):227-31. doi: 10.4066/AMJ.2014.2070. eCollection 2014.


Dimerization of a phage-display selected peptide for imaging of αvβ6- integrin: two approaches to the multivalent effect.

Singh AN, McGuire MJ, Li S, Hao G, Kumar A, Sun X, Brown KC.

Theranostics. 2014 May 15;4(7):745-60. doi: 10.7150/thno.7811. eCollection 2014.


Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway.

Lau JK, Brown KC, Dom AM, Witte TR, Thornhill BA, Crabtree CM, Perry HE, Brown JM, Ball JG, Creel RG, Damron CL, Rollyson WD, Stevenson CD, Hardman WE, Valentovic MA, Carpenter AB, Dasgupta P.

Apoptosis. 2014 Aug;19(8):1190-201. doi: 10.1007/s10495-014-1007-y.


Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer.

McGuire MJ, Gray BP, Li S, Cupka D, Byers LA, Wu L, Rezaie S, Liu YH, Pattisapu N, Issac J, Oyama T, Diao L, Heymach JV, Xie XJ, Minna JD, Brown KC.

Sci Rep. 2014 Mar 27;4:4480. doi: 10.1038/srep04480.


Sleep deprivation and error in nurses who work the night shift.

Johnson AL, Jung L, Song Y, Brown KC, Weaver MT, Richards KC.

J Nurs Adm. 2014 Jan;44(1):17-22. doi: 10.1097/NNA.0000000000000016. Erratum in: J Nurs Adm. 2014 Mar;44(3):186. Song, Yeonsu [added].


Combinatorial peptide libraries: mining for cell-binding peptides.

Gray BP, Brown KC.

Chem Rev. 2014 Jan 22;114(2):1020-81. doi: 10.1021/cr400166n. Epub 2013 Dec 3. Review. No abstract available.


Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway.

Brown KC, Perry HE, Lau JK, Jones DV, Pulliam JF, Thornhill BA, Crabtree CM, Luo H, Chen YC, Dasgupta P.

J Biol Chem. 2013 Nov 15;288(46):33049-59. doi: 10.1074/jbc.M113.501601. Epub 2013 Oct 2.


A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density.

Gray BP, McGuire MJ, Brown KC.

PLoS One. 2013 Aug 23;8(8):e72938. doi: 10.1371/journal.pone.0072938. eCollection 2013.


The relationship between baseline nutritional status with subsequent parenteral nutrition and clinical outcomes in cancer patients undergoing hyperthermic intraperitoneal chemotherapy.

Vashi PG, Gupta D, Lammersfeld CA, Braun DP, Popiel B, Misra S, Brown KC.

Nutr J. 2013 Aug 14;12:118. doi: 10.1186/1475-2891-12-118.


Measurement of Acetylcholine from Cell Lines.

Lau JK, Brown KC, Dasgupta P.

Bio Protoc. 2013;3(24). pii: e1007. Epub 2013 Dec 20.


Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma.

Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P.

Cancer Res. 2013 Feb 15;73(4):1328-39. doi: 10.1158/0008-5472.CAN-12-3190. Epub 2012 Dec 7.


From phage display to nanoparticle delivery: functionalizing liposomes with multivalent peptides improves targeting to a cancer biomarker.

Gray BP, Li S, Brown KC.

Bioconjug Chem. 2013 Jan 16;24(1):85-96. doi: 10.1021/bc300498d. Epub 2013 Jan 7.


Nicotinic acetylcholine receptor signaling in atherogenesis.

Santanam N, Thornhill BA, Lau JK, Crabtree CM, Cook CR, Brown KC, Dasgupta P.

Atherosclerosis. 2012 Dec;225(2):264-73. doi: 10.1016/j.atherosclerosis.2012.07.041. Epub 2012 Aug 14. Review.


Predictors of pain and functioning over time in fibromyalgia syndrome: an autoregressive path analysis.

Van Liew C, Brown KC, Cronan TA, Bigatti SM, Kothari DJ.

Arthritis Care Res (Hoboken). 2013 Feb;65(2):251-6. doi: 10.1002/acr.21792.


Relationship of blood pressure self-monitoring, medication adherence, self-efficacy, stage of change, and blood pressure control among municipal workers with hypertension.

Breaux-Shropshire TL, Brown KC, Pryor ER, Maples EH.

Workplace Health Saf. 2012 Jul;60(7):303-11. doi: 10.3928/21650799-20120625-04.


Prevalence of blood pressure self-monitoring, medication adherence, self-efficacy, stage of change, and blood pressure control among municipal workers with hypertension.

Breaux-Shropshire TL, Brown KC, Pryor ER, Maples EH.

Workplace Health Saf. 2012 Jun;60(6):265-71. doi: 10.3928/21650799-20120523-18.


Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men.

Brown KC, Patterson KB, Jennings SH, Malone SA, Shaheen NJ, Asher Prince HM, Spacek M, Cohen MS, Kashuba AD.

J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):138-44.


N-glycans in liver-secreted and immunoglogulin-derived protein fractions.

Bekesova S, Kosti O, Chandler KB, Wu J, Madej HL, Brown KC, Simonyan V, Goldman R.

J Proteomics. 2012 Apr 3;75(7):2216-24. doi: 10.1016/j.jprot.2012.01.024. Epub 2012 Feb 3.


MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway.

Brown KC, Lau JK, Dom AM, Witte TR, Luo H, Crabtree CM, Shah YH, Shiflett BS, Marcelo AJ, Proper NA, Hardman WE, Egleton RD, Chen YC, Mangiarua EI, Dasgupta P.

Angiogenesis. 2012 Mar;15(1):99-114. doi: 10.1007/s10456-011-9246-9. Epub 2011 Dec 25. Erratum in: Angiogenesis. 2012 Jun;15(2):331. Dosage error in article text.


Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians.

Brown KC, Hosseinipour MC, Hoskins JM, Thirumaran RK, Tien HC, Weigel R, Tauzie J, Shumba I, Lamba JK, Schuetz EG, McLeod HL, Kashuba AD, Corbett AH.

Pharmacogenomics. 2012 Jan;13(1):113-21. doi: 10.2217/pgs.11.132. Epub 2011 Nov 23.

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