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Management of metastatic renal cell carcinoma: The complexity of choice.

Brown JT, Bilen MA.

EBioMedicine. 2019 Sep;47:2-3. doi: 10.1016/j.ebiom.2019.08.049. Epub 2019 Sep 6. No abstract available.


Cardiovascular magnetic resonance-guided right heart catheterization in a conventional CMR environment - predictors of procedure success and duration in pulmonary artery hypertension.

Knight DS, Kotecha T, Martinez-Naharro A, Brown JT, Bertelli M, Fontana M, Muthurangu V, Coghlan JG.

J Cardiovasc Magn Reson. 2019 Sep 9;21(1):57. doi: 10.1186/s12968-019-0569-9.


Molecular Bases for Anesthetic Agents: Halothane as a Halogen- and Hydrogen-Bond Donor.

Nayak SK, Terraneo G, Piacevoli Q, Bertolotti F, Scilabra P, Brown JT, Rosokha SV, Resnati G.

Angew Chem Int Ed Engl. 2019 Sep 2;58(36):12456-12459. doi: 10.1002/anie.201907829. Epub 2019 Jul 30.


Network substrates of cognitive impairment in Alzheimer's Disease.

Tait L, Stothart G, Coulthard E, Brown JT, Kazanina N, Goodfellow M.

Clin Neurophysiol. 2019 Sep;130(9):1581-1595. doi: 10.1016/j.clinph.2019.05.027. Epub 2019 Jun 27.


Gene-Based Dose Optimization in Children.

Ramsey LB, Brown JT, Vear SI, Bishop JR, Van Driest SL.

Annu Rev Pharmacol Toxicol. 2019 Jul 5. doi: 10.1146/annurev-pharmtox-010919-023459. [Epub ahead of print]


Mistakes, I've Had a Few.

Brown JT.

J Gen Intern Med. 2019 Aug;34(8):1670. doi: 10.1007/s11606-019-05107-2. No abstract available.


Corrigendum to "Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury" [Bioorg. Med. Chem. Lett. 29(8) (2019) 995-1000].

Goncalves MB, Clarke E, Jarvis CI, Kalindjian SB, Pitcher T, Grist J, Hobbs C, Carlstedt T, Jack J, Brown JT, Mills M, Mumford P, Borthwick AD, Corcoran JPT.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2440-2441. doi: 10.1016/j.bmcl.2019.05.058. Epub 2019 Jun 14. No abstract available.


Analytical Validation of a Highly Sensitive, Multiplexed Chronic Myeloid Leukemia Monitoring System Targeting BCR-ABL1 RNA.

Brown JT, Beldorth IJ, Laosinchai-Wolf W, Fahey ME, Jefferson KL, Ruskin AK, Roth JJ, Cai L, Watt CD, Press RD, Yang F, Hedges JB, Andruss BF.

J Mol Diagn. 2019 Jul;21(4):718-733. doi: 10.1016/j.jmoldx.2019.03.002. Epub 2019 Apr 23.


PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics.

Stevens T, Sangkuhl K, Brown JT, Altman RB, Klein TE.

Pharmacogenet Genomics. 2019 Aug;29(6):136-154. doi: 10.1097/FPC.0000000000000376. No abstract available.


Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type.

Smithers HE, Terry JR, Brown JT, Randall AD.

Neurobiol Stress. 2018 Dec 19;10:100143. doi: 10.1016/j.ynstr.2018.100143. eCollection 2019 Feb.


Anxiety sensitivity and smoking outcome expectancies among Spanish-speaking Latinx adult smokers.

Zvolensky MJ, Bakhshaie J, Shepherd JM, Garey L, Peraza N, Viana AG, Brown JT, Brown RA.

Exp Clin Psychopharmacol. 2019 Mar 21. doi: 10.1037/pha0000270. [Epub ahead of print]


Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS.

Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13. Review.


Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.

Goncalves MB, Clarke E, Jarvis CI, Barret Kalindjian S, Pitcher T, Grist J, Hobbs C, Carlstedt T, Jack J, Brown JT, Mills M, Mumford P, Borthwick AD, Corcoran JPT.

Bioorg Med Chem Lett. 2019 Apr 15;29(8):995-1000. doi: 10.1016/j.bmcl.2019.02.011. Epub 2019 Feb 11. Erratum in: Bioorg Med Chem Lett. 2019 Aug 15;29(16):2440-2441.


Documenting Potential Sunn Hemp (Crotalaria juncea L.) (Fabaceae) Pollinators in Florida.

Meagher RL, Watrous KM, Fleischer SJ, Nagoshi RN, Brown JT, Bowers K, Miller N, Hight SD, Legaspi JC, Westbrook JK.

Environ Entomol. 2019 Apr 3;48(2):343-350. doi: 10.1093/ee/nvy190.


The Role of the Pediatric Pharmacist in Precision Medicine and Clinical Pharmacogenomics for Children.

Brown JT, Gregornik D, Kennedy MJ; Advocacy and Research Committees.

J Pediatr Pharmacol Ther. 2018 Nov-Dec;23(6):499-501. doi: 10.5863/1551-6776-23.6.499.


β3-Adrenergic receptor-dependent modulation of the medium afterhyperpolarization in rat hippocampal CA1 pyramidal neurons.

Church TW, Brown JT, Marrion NV.

J Neurophysiol. 2019 Mar 1;121(3):773-784. doi: 10.1152/jn.00334.2018. Epub 2019 Jan 9.


Anxiety sensitivity and smoking among Spanish-speaking Latinx smokers.

Zvolensky MJ, Bakhshaie J, Shepherd JM, Peraza N, Garey L, Viana AG, Glover N, Brown JT, Brown RA.

Addict Behav. 2019 Mar;90:55-61. doi: 10.1016/j.addbeh.2018.10.022. Epub 2018 Oct 19.


Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, Moger J, Randall AD, Tyler CR.

Sci Rep. 2018 Oct 23;8(1):15903. doi: 10.1038/s41598-018-32731-5.


Molding Idle Musings Into Art: What Reflective Writing Does for Me?

Brown JT.

J Pain Symptom Manage. 2019 Apr;57(4):856-860. doi: 10.1016/j.jpainsymman.2018.09.011. Epub 2018 Sep 22. No abstract available.


The effect of chemical clarification of oral fluids on porcine epidemic diarrhea virus antibody responses.

Poonsuk K, Giménez-Lirola LG, Magtoto RL, Ji J, Baum DH, Rademacher CJ, Brown JT, Zhang J, Wang C, Main RG, Zimmerman JJ.

J Vet Diagn Invest. 2018 Nov;30(6):937-941. doi: 10.1177/1040638718798672. Epub 2018 Sep 11.


Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains.

Heberlig GW, Brown JTC, Simard RD, Wirz M, Zhang W, Wang M, Susser LI, Horsman ME, Boddy CN.

Org Biomol Chem. 2018 Aug 15;16(32):5771-5779. doi: 10.1039/c8ob01512k.


Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons.

Telezhkin V, Straccia M, Yarova P, Pardo M, Yung S, Vinh NN, Hancock JM, Barriga GG, Brown DA, Rosser AE, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ.

Pflugers Arch. 2018 Sep;470(9):1359-1376. doi: 10.1007/s00424-018-2155-7. Epub 2018 May 24.


Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells.

Tait L, Wedgwood K, Tsaneva-Atanasova K, Brown JT, Goodfellow M.

J Theor Biol. 2018 Jul 14;449:23-34. doi: 10.1016/j.jtbi.2018.04.013. Epub 2018 Apr 11.


Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient.

Ridler T, Matthews P, Phillips KG, Randall AD, Brown JT.

J Physiol. 2018 Jun;596(11):2251-2266. doi: 10.1113/JP275871. Epub 2018 Apr 25.


Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy.

Scullion SE, Barker GRI, Warburton EC, Randall AD, Brown JT.

Neurochem Res. 2019 Mar;44(3):617-626. doi: 10.1007/s11064-018-2487-x. Epub 2018 Feb 26.


Toxicokinetics of the neonicotinoid insecticide imidacloprid in rainbow trout (Oncorhynchus mykiss).

Frew JA, Brown JT, Fitzsimmons PN, Hoffman AD, Sadilek M, Grue CE, Nichols JW.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Feb;205:34-42. doi: 10.1016/j.cbpc.2018.01.002. Epub 2018 Feb 3.


Aging-Associated Changes to Intrinsic Neuronal Excitability in the Bed Nucleus of the Stria Terminalis Is Cell Type-Dependent.

Smithers HE, Terry JR, Brown JT, Randall AD.

Front Aging Neurosci. 2017 Dec 22;9:424. doi: 10.3389/fnagi.2017.00424. eCollection 2017.


Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.

Clarke E, Jarvis CI, Goncalves MB, Kalindjian SB, Adams DR, Brown JT, Shiers JJ, Taddei DMA, Ravier E, Barlow S, Miller I, Smith V, Borthwick AD, Corcoran JPT.

Bioorg Med Chem. 2018 Feb 15;26(4):798-814. doi: 10.1016/j.bmc.2017.12.015. Epub 2017 Dec 9.


Detection of Aβ plaque-associated astrogliosis in Alzheimer's disease brain by spectroscopic imaging and immunohistochemistry.

Palombo F, Tamagnini F, Jeynes JCG, Mattana S, Swift I, Nallala J, Hancock J, Brown JT, Randall AD, Stone N.

Analyst. 2018 Feb 12;143(4):850-857. doi: 10.1039/c7an01747b.


Brief Report: Self-Reported Academic, Social, and Mental Health Experiences of Post-Secondary Students with Autism Spectrum Disorder.

Jackson SLJ, Hart L, Brown JT, Volkmar FR.

J Autism Dev Disord. 2018 Mar;48(3):643-650. doi: 10.1007/s10803-017-3315-x.


Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.

Tamagnini F, Walsh DA, Brown JT, Bondulich MK, Hanger DP, Randall AD.

Neurobiol Aging. 2017 Dec;60:44-56. doi: 10.1016/j.neurobiolaging.2017.07.005. Epub 2017 Jul 20.


Current Events (With Apologies to Leonard Cohen).

Brown JT.

J Pain Symptom Manage. 2017 Oct;54(4):617. doi: 10.1016/j.jpainsymman.2017.05.015. Epub 2017 Aug 19. No abstract available.


A psychometric analysis of the Ottawa self-injury inventory-f.

Brown JT, Volk F, Gearhart GL.

J Am Coll Health. 2018 Jan;66(1):23-31. doi: 10.1080/07448481.2017.1366496. Epub 2017 Sep 15.


4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, Moger J, Randall AD, Tyler CR.

Sci Rep. 2017 Jul 26;7(1):6581. doi: 10.1038/s41598-017-06646-6. Erratum in: Sci Rep. 2018 Oct 23;8(1):15903.


Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Manso Y, Holland PR, Kitamura A, Szymkowiak S, Duncombe J, Hennessy E, Searcy JL, Marangoni M, Randall AD, Brown JT, McColl BW, Horsburgh K.

Glia. 2018 Jan;66(1):34-46. doi: 10.1002/glia.23190. Epub 2017 Jul 19.


Pharmacogenetic evaluation to assess breakthrough psychosis with aripiprazole long-acting injection: a case report.

Eum S, Schneiderhan ME, Brown JT, Lee AM, Bishop JR.

BMC Psychiatry. 2017 Jul 3;17(1):238. doi: 10.1186/s12888-017-1396-x.


Serum clomipramine and desmethylclomipramine levels in a CYP2C19 and CYP2D6 intermediate metabolizer.

Brown JT, Schneiderhan M, Eum S, Bishop JR.

Pharmacogenomics. 2017 May;18(7):601-605. doi: 10.2217/pgs-2017-0015. Epub 2017 May 4. Review.


In vitro characterization of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice.

Walsh DA, Brown JT, Randall AD.

J Physiol. 2017 Jun 1;595(11):3549-3572. doi: 10.1113/JP273915. Epub 2017 Apr 25.


An Internist Listens on Pediatric Rounds.

Brown JT.

J Palliat Med. 2017 Jul;20(7):793. doi: 10.1089/jpm.2017.0059. Epub 2017 Mar 2. No abstract available.


Pharmacogenomics of autism spectrum disorder.

Brown JT, Eum S, Cook EH, Bishop JR.

Pharmacogenomics. 2017 Mar;18(4):403-414. doi: 10.2217/pgs-2016-0167. Epub 2017 Feb 22. Review.


Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.

Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, Riccardi D, Randall AD, Brown JT, Allen ND, Telezhkin V.

J Physiol. 2016 Nov 15;594(22):6583-6594. doi: 10.1113/JP270655. Review.


Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy.

Booth CA, Witton J, Nowacki J, Tsaneva-Atanasova K, Jones MW, Randall AD, Brown JT.

J Neurosci. 2016 Jan 13;36(2):350-63. doi: 10.1523/JNEUROSCI.2151-15.2016.


Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy.

Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT.

J Neurosci. 2016 Jan 13;36(2):312-24. doi: 10.1523/JNEUROSCI.2845-14.2016.


Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.

Telezhkin V, Schnell C, Yarova P, Yung S, Cope E, Hughes A, Thompson BA, Sanders P, Geater C, Hancock JM, Joy S, Badder L, Connor-Robson N, Comella A, Straccia M, Bombau G, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ.

Am J Physiol Cell Physiol. 2016 Apr 1;310(7):C520-41. doi: 10.1152/ajpcell.00166.2015. Epub 2015 Dec 30.


Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.

Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Lin YS, Leeder JS.

Clin Pharmacol Ther. 2016 Jun;99(6):642-50. doi: 10.1002/cpt.319. Epub 2016 Jan 12.


Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.

Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova K, Randall AD.

Front Cell Neurosci. 2015 Oct 14;9:372. doi: 10.3389/fncel.2015.00372. eCollection 2015.


Atomoxetine pharmacogenetics: associations with pharmacokinetics, treatment response and tolerability.

Brown JT, Bishop JR.

Pharmacogenomics. 2015;16(13):1513-20. doi: 10.2217/PGS.15.93. Epub 2015 Aug 28. Review.


Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission.

Banks PJ, Burroughs AC, Barker GR, Brown JT, Warburton EC, Bashir ZI.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11096-101. doi: 10.1073/pnas.1512064112. Epub 2015 Aug 18.


Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.

Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, Fisher EMC, Bannerman DM, Randall AD, Brown JT, Edwards FA, Rusakov DA, Stewart MG, Jones MW.

Nat Neurosci. 2015 Sep;18(9):1291-1298. doi: 10.1038/nn.4072. Epub 2015 Aug 3.


Developmental Changes of Normal Pupil Size and Reactivity in Children.

Brown JT, Connelly M, Nickols C, Neville KA.

J Pediatr Ophthalmol Strabismus. 2015 May-Jun;52(3):147-51.


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