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The Effect of Improving Basic Preventive Measures in the Perioperative Arena on Staphylococcus aureus Transmission and Surgical Site Infections: A Randomized Clinical Trial.

Loftus RW, Dexter F, Goodheart MJ, McDonald M, Keech J, Noiseux N, Pugely A, Sharp W, Sharafuddin M, Lawrence WT, Fisher M, McGonagill P, Shanklin J, Skeete D, Tracy C, Erickson B, Granchi T, Evans L, Schmidt E, Godding J, Brenneke R, Persons D, Herber A, Yeager M, Hadder B, Brown JR.

JAMA Netw Open. 2020 Mar 2;3(3):e201934. doi: 10.1001/jamanetworkopen.2020.1934.


Perioperative COVID-19 Defense: An Evidence-Based Approach for Optimization of Infection Control and Operating Room Management.

Dexter F, Parra MC, Brown JR, Loftus RW.

Anesth Analg. 2020 Mar 26. doi: 10.1213/ANE.0000000000004829. [Epub ahead of print]


ALPINE: zanubrutinib versus ibrutinib in relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma.

Hillmen P, Brown JR, Eichhorst BF, Lamanna N, O'Brien SM, Qiu L, Salmi T, Hilger J, Wu K, Cohen A, Huang J, Tam CS.

Future Oncol. 2020 Apr;16(10):517-523. doi: 10.2217/fon-2019-0844. Epub 2020 Mar 24.


SONO case series: soft tissue infections, abscesses, pyomyositis and necrotising fasciitis.

Brown JR, Shyy W.

Emerg Med J. 2020 Mar 13. pii: emermed-2019-208919. doi: 10.1136/emermed-2019-208919. [Epub ahead of print] No abstract available.


Rituximab/bendamustine and rituximab/cytarabine induction therapy for transplant-eligible mantle cell lymphoma.

Merryman RW, Edwin N, Redd R, Bsat J, Chase M, LaCasce A, Freedman A, Jacobson C, Fisher D, Ng S, Crombie J, Kim A, Odejide O, Davids MS, Brown JR, Jacene H, Cashen A, Bartlett NL, Mehta-Shah N, Ghobadi A, Kahl B, Joyce R, Armand P, Jacobsen E.

Blood Adv. 2020 Mar 10;4(5):858-867. doi: 10.1182/bloodadvances.2019001355.


The Magnitude of the Warfarin-Amiodarone Drug-Drug Interaction Varies With Renal Function: A Propensity-Matched Cohort Study.

Miano TA, Yang W, Shashaty MGS, Zuppa A, Brown JR, Hennessy S.

Clin Pharmacol Ther. 2020 Feb 29. doi: 10.1002/cpt.1819. [Epub ahead of print]


Drug Court as an Intervention Point to Affect the Well-Being of Families of Parents with Substance Use Disorders.

Guastaferro K, Guastaferro WP, Brown JR, Holleran D, Whitaker DJ.

Subst Use Misuse. 2020 Feb 24:1-11. doi: 10.1080/10826084.2020.1726394. [Epub ahead of print]


Association of Sex With Repair Type and Long-term Mortality in Adults With Abdominal Aortic Aneurysm.

Ramkumar N, Suckow BD, Arya S, Sedrakyan A, Mackenzie TA, Goodney PP, Brown JR.

JAMA Netw Open. 2020 Feb 5;3(2):e1921240. doi: 10.1001/jamanetworkopen.2019.21240.


Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.

Grover A, Crippen-Harmon D, Nave L, Vincelette J, Wait JCM, Melton AC, Lawrence R, Brown JR, Webster KA, Yip BK, Baridon B, Vitelli C, Rigney S, Christianson TM, Tiger PMN, Lo MJ, Holtzinger J, Shaywitz AJ, Crawford BE, Fitzpatrick PA, LeBowitz JH, Bullens S, Aoyagi-Scharber M, Bunting S, O'Neill CA, Pinkstaff J, Bagri A.

Drug Deliv Transl Res. 2020 Apr;10(2):425-439. doi: 10.1007/s13346-019-00683-6.


The Association between Cytokines and 365-Day Readmission or Mortality in Adult Cardiac Surgery.

Everett AD, Alam SS, Owens SL, Parker DM, Goodrich C, Likosky DS, Thiessen-Philbrook H, Wyler von Ballmoos M, Lobdell K, MacKenzie TA, Jacobs J, Parikh CR, DiScipio AW, Malenka DJ, Brown JR.

J Extra Corpor Technol. 2019 Dec;51(4):201-209. doi: 10.1182/JECT-1900014.


Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery.

Patel DM, Thiessen-Philbrook H, Brown JR, McArthur E, Moledina DG, Mansour SG, Shlipak MG, Koyner JL, Kavsak P, Whitlock RP, Everett AD, Malenka DJ, Garg AX, Coca SG, Parikh CR.

Am Heart J. 2020 Feb;220:253-263. doi: 10.1016/j.ahj.2019.11.014. Epub 2019 Dec 3.


End-of-Life Spending and Healthcare Utilization Among Older Adults with Chronic Obstructive Pulmonary Disease.

Iyer AS, Goodrich CA, Dransfield MT, Alam SS, Brown CJ, Landefeld CS, Bakitas MA, Brown JR.

Am J Med. 2019 Dec 27. pii: S0002-9343(19)31105-2. doi: 10.1016/j.amjmed.2019.11.024. [Epub ahead of print]


Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results.

Byrd JC, Wierda WG, Schuh A, Devereux S, Chaves JM, Brown JR, Hillmen P, Martin P, Awan FT, Stephens DM, Ghia P, Barrientos J, Pagel JM, Woyach JA, Burke K, Covey T, Gulrajani M, Hamdy A, Izumi R, Frigault MM, Patel P, Rothbaum W, Wang MH, O'Brien S, Furman RR.

Blood. 2019 Dec 26. pii: blood.2018884940. doi: 10.1182/blood.2018884940. [Epub ahead of print]


Comparison of Body Composition Prediction Equations with Air Displacement Plethysmography in Overweight and Obese Caucasian Males.

Shannon CA, Brown JR, Del Pozzi AT.

Int J Exerc Sci. 2019 Nov 1;12(4):1034-1044. eCollection 2019.


Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.

Michalovich D, Rodriguez-Perez N, Smolinska S, Pirozynski M, Mayhew D, Uddin S, Van Horn S, Sokolowska M, Altunbulakli C, Eljaszewicz A, Pugin B, Barcik W, Kurnik-Lucka M, Saunders KA, Simpson KD, Schmid-Grendelmeier P, Ferstl R, Frei R, Sievi N, Kohler M, Gajdanowicz P, Graversen KB, Lindholm Bøgh K, Jutel M, Brown JR, Akdis CA, Hessel EM, O'Mahony L.

Nat Commun. 2019 Dec 13;10(1):5711. doi: 10.1038/s41467-019-13751-9.


In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.

Scangarella-Oman NE, Ingraham KA, Tiffany CA, Tomsho L, Van Horn SF, Mayhew DN, Perry CR, Ashton TC, Dumont EF, Huang J, Brown JR, Miller LA.

Antimicrob Agents Chemother. 2020 Feb 21;64(3). pii: e01302-19. doi: 10.1128/AAC.01302-19. Print 2020 Feb 21.


The Microbiome Factor in Drug Discovery and Development.

Nuzzo A, Brown JR.

Chem Res Toxicol. 2020 Jan 21;33(1):119-124. doi: 10.1021/acs.chemrestox.9b00333. Epub 2019 Dec 23.


Heart failure biomarker levels correlate with invasive haemodynamics in pulmonary valve replacement.

Zegelbone PM, Ringel RE, Coulson JD, Nies MK, Stabler ME, Brown JR, Everett AD.

Cardiol Young. 2020 Jan;30(1):50-54. doi: 10.1017/S1047951119002737. Epub 2019 Nov 27.


Evolving Strategies in First-Line Chronic Lymphocytic Leukemia: Is There a Role for Chemoimmunotherapy?

Brown JR, Wierda WG.

J Natl Compr Canc Netw. 2019 Nov;17(11.5):1408-1410. doi: 10.6004/jnccn.2019.5026.


Phosphatidylinositol 3 Kinase δ Inhibitors: Present and Future.

Brown JR.

Cancer J. 2019 Nov/Dec;25(6):394-400. doi: 10.1097/PPO.0000000000000414.


Chemo-immunotherapy for Older Patients with Chronic Lymphocytic Leukemia - Passé Yet?

Danilov AV, Pagel JM, Brown JR, Hill BT.

Hemasphere. 2019 Aug 7;3(4):e275. doi: 10.1097/HS9.0000000000000275. eCollection 2019 Aug. No abstract available.


Comparative Performance of Prediction Models for Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention.

Ma B, Allen DW, Graham MM, Har BJ, Tyrrell B, Tan Z, Spertus JA, Brown JR, Matheny ME, Hemmelgarn BR, Pannu N, James MT.

Circ Cardiovasc Qual Outcomes. 2019 Nov;12(11):e005854. doi: 10.1161/CIRCOUTCOMES.119.005854. Epub 2019 Nov 14.


Role of Solvation on Diffusion of Ions in Diblock Copolymers: Understanding the Molecular Weight Effect through Modeling.

Seo Y, Shen KH, Brown JR, Hall LM.

J Am Chem Soc. 2019 Nov 20;141(46):18455-18466. doi: 10.1021/jacs.9b07227. Epub 2019 Nov 12.


Evaluation of non-reducing end pathologic glycosaminoglycan detection method for monitoring therapeutic response to enzyme replacement therapy in human mucopolysaccharidosis I.

Vera MU, Le SQ, Victoroff A, Passage MB, Brown JR, Crawford BE, Polgreen LE, Chen AH, Dickson PI.

Mol Genet Metab. 2020 Feb;129(2):91-97. doi: 10.1016/j.ymgme.2019.09.001. Epub 2019 Sep 11.


Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome.

O'Donovan SM, Crowley EK, Brown JR, O'Sullivan O, O'Leary OF, Timmons S, Nolan YM, Clarke DJ, Hyland NP, Joyce SA, Sullivan AM, O'Neill C.

Neurogastroenterol Motil. 2020 Jan;32(1):e13726. doi: 10.1111/nmo.13726. Epub 2019 Oct 2.


Cardiovascular Toxicities Associated With Ibrutinib.

Salem JE, Manouchehri A, Bretagne M, Lebrun-Vignes B, Groarke JD, Johnson DB, Yang T, Reddy NM, Funck-Brentano C, Brown JR, Roden DM, Moslehi JJ.

J Am Coll Cardiol. 2019 Oct 1;74(13):1667-1678. doi: 10.1016/j.jacc.2019.07.056.


Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.

Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ.

Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19.


Ibrutinib-associated invasive fungal diseases in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: An observational study.

Ruchlemer R, Ben-Ami R, Bar-Meir M, Brown JR, Malphettes M, Mous R, Tonino SH, Soussain C, Barzic N, Messina JA, Jain P, Cohen R, Hill B, Mulligan SP, Nijland M, Herishanu Y, Benjamini O, Tadmor T, Okamoto K, Arthurs B, Gottesman B, Kater AP, Talha M, Eichhorst B, Korem M, Bogot N, De Boer F, Rowe JM, Lachish T.

Mycoses. 2019 Dec;62(12):1140-1147. doi: 10.1111/myc.13001. Epub 2019 Oct 22.


Final analysis from RESONATE: Up to six years of follow-up on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma.

Munir T, Brown JR, O'Brien S, Barrientos JC, Barr PM, Reddy NM, Coutre S, Tam CS, Mulligan SP, Jaeger U, Kipps TJ, Moreno C, Montillo M, Burger JA, Byrd JC, Hillmen P, Dai S, Szoke A, Dean JP, Woyach JA.

Am J Hematol. 2019 Dec;94(12):1353-1363. doi: 10.1002/ajh.25638. Epub 2019 Oct 13.


Role of Sex in Determining Treatment Type for Patients Undergoing Endovascular Lower Extremity Revascularization.

Ramkumar N, Suckow BD, Brown JR, Sedrakyan A, MacKenzie T, Stone DH, Cronenwett JL, Goodney PP.

J Am Heart Assoc. 2019 Sep 3;8(17):e013088. doi: 10.1161/JAHA.119.013088. Epub 2019 Aug 31.


Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia.

Kipps TJ, Fraser G, Coutre SE, Brown JR, Barrientos JC, Barr PM, Byrd JC, O'Brien SM, Dilhuydy MS, Hillmen P, Jaeger U, Moreno C, Cramer P, Stilgenbauer S, Chanan-Khan AA, Mahler M, Salman M, Eckert K, Solman IG, Balasubramanian S, Cheng M, Londhe A, Ninomoto J, Howes A, James DF, Hallek M.

Clin Lymphoma Myeloma Leuk. 2019 Nov;19(11):715-722.e6. doi: 10.1016/j.clml.2019.07.004. Epub 2019 Jul 15.


A comprehensive characterization of chronic norovirus infection in immunodeficient hosts.

Brown LK, Ruis C, Clark I, Roy S, Brown JR, Albuquerque AS, Patel SY, Miller J, Karim MY, Dervisevic S, Moore J, Williams CA, Cudini J, Moreira F, Neild P, Seneviratne SL, Workman S, Toumpanakis C, Atkinson C, Burns SO, Breuer J, Lowe DM.

J Allergy Clin Immunol. 2019 Nov;144(5):1450-1453. doi: 10.1016/j.jaci.2019.07.036. Epub 2019 Aug 13. No abstract available.


Immunofluorescence and image analysis pipeline for Drosophila motor neurons.

Brown JR, Phongthachit C, Sulkowski MJ.

Biol Methods Protoc. 2019;4(1):bpz010. doi: 10.1093/biomethods/bpz010. Epub 2019 Aug 1.


For CLL cells, there's no place like home.

Lampson BL, Brown JR.

Leuk Lymphoma. 2019 Dec;60(14):3347-3349. doi: 10.1080/10428194.2019.1646910. Epub 2019 Aug 2. No abstract available.


In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo.

Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J.

mSphere. 2019 Jul 31;4(4). pii: e00254-19. doi: 10.1128/mSphere.00254-19.


Transforming Triplet Vinylnitrene into Triplet Alkylnitrene at Cryogenic Temperatures.

Shields DJ, Sarkar SK, Sriyarathne HDM, Brown JR, Wentrup C, Abe M, Gudmundsdottir AD.

Org Lett. 2019 Sep 20;21(18):7194-7198. doi: 10.1021/acs.orglett.9b01950. Epub 2019 Jul 26.


Galectin-3 as a Predictor of Long-term Survival After Isolated Coronary Artery Bypass Grafting Surgery.

Parker DM, Owens SL, Ramkumar N, Likosky D, DiScipio AW, Malenka DJ, MacKenzie TA, Brown JR.

Ann Thorac Surg. 2020 Jan;109(1):132-138. doi: 10.1016/j.athoracsur.2019.05.072. Epub 2019 Jul 20.


Novel Biomarkers Improve Prediction of 365-Day Readmission After Pediatric Congenital Heart Surgery.

Parker DM, Everett AD, Stabler ME, Vricella L, Jacobs ML, Jacobs JP, Parikh CR, Pasquali SK, Brown JR.

Ann Thorac Surg. 2020 Jan;109(1):164-170. doi: 10.1016/j.athoracsur.2019.05.070. Epub 2019 Jul 16.


The Association Between Cardiac Biomarker NT-proBNP and 30-Day Readmission or Mortality After Pediatric Congenital Heart Surgery.

Parker DM, Everett AD, Stabler ME, Leyenaar J, Vricella L, Jacobs JP, Thiessen-Philbrook H, Parikh C, Greenberg JH, Brown JR.

World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):446-453. doi: 10.1177/2150135119842864.


Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia.

Giacopelli B, Zhao Q, Ruppert AS, Agyeman A, Weigel C, Wu YZ, Gerber MM, Rabe KG, Larson MC, Lu J, Blachly JS, Rogers KA, Wierda WG, Brown JR, Rai KR, Keating M, Rassenti LZ, Kipps TJ, Zenz T, Shanafelt TD, Kay NE, Abruzzo LV, Coombes KR, Woyach JA, Byrd JC, Oakes CC.

Blood. 2019 Aug 22;134(8):688-698. doi: 10.1182/blood.2019000490. Epub 2019 Jul 10.


Biomarkers improve prediction of 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

Brown JR, Stabler ME, Parker DM, Vricella L, Pasquali S, Leyenaar JK, Bohm AR, MacKenzie T, Parikh C, Jacobs ML, Jacobs JP, Everett AD.

Cardiol Young. 2019 Aug;29(8):1051-1056. doi: 10.1017/S1047951119001471. Epub 2019 Jul 10.


Healthcare spending in the State of Louisiana.

Kruger BP, Brown JR.

BMC Health Serv Res. 2019 Jul 9;19(1):471. doi: 10.1186/s12913-019-4275-y.


Cardiac Biomarkers Predict Long-term Survival After Cardiac Surgery.

Ramkumar N, Jacobs JP, Berman RB, Parker DM, MacKenzie TA, Likosky DS, DiScipio A, Malenka DJ, Brown JR.

Ann Thorac Surg. 2019 Dec;108(6):1776-1782. doi: 10.1016/j.athoracsur.2019.04.123. Epub 2019 Jun 27.


Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients: Center for International Blood and Marrow Transplant Research Report.

Kim HT, Ahn KW, Hu ZH, Davids MS, Volpe VO, Antin JH, Sorror ML, Shadman M, Press O, Pidala J, Hogan W, Negrin R, Devine S, Uberti J, Agura E, Nash R, Mehta J, McGuirk J, Forman S, Langston A, Giralt SA, Perales MA, Battiwalla M, Hale GA, Gale RP, Marks DI, Hamadani M, Ganguly S, Bacher U, Lazarus H, Reshef R, Hildebrandt GC, Inamoto Y, Cahn JY, Solh M, Kharfan-Dabaja MA, Ghosh N, Saad A, Aljurf M, Schouten HC, Hill BT, Pawarode A, Kindwall-Keller T, Saba N, Copelan EA, Nathan S, Beitinjaneh A, Savani BN, Cerny J, Grunwald MR, Yared J, Wirk BM, Nishihori T, Chhabra S, Olsson RF, Bashey A, Gergis U, Popat U, Sobecks R, Alyea E, Saber W, Brown JR.

Clin Cancer Res. 2019 Aug 15;25(16):5143-5155. doi: 10.1158/1078-0432.CCR-18-3988. Epub 2019 Jun 28.


A multi-center analysis of readmission after cardiac surgery: Experience of The Northern New England Cardiovascular Disease Study Group.

Trooboff SW, Magnus PC, Ross CS, Chaisson K, Kramer RS, Helm RE, Desaulniers H, De La Rosa RC, Westbrook BM, Duquette D, Brown JR, Olmstead EM, Malenka DJ, Iribarne A.

J Card Surg. 2019 Aug;34(8):655-662. doi: 10.1111/jocs.14086. Epub 2019 Jun 18.


Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with chronic lymphocytic leukaemia: a single-arm, multicentre, phase 2 trial.

Davids MS, Brander DM, Kim HT, Tyekucheva S, Bsat J, Savell A, Hellman JM, Bazemore J, Francoeur K, Alencar A, Shune L, Omaira M, Jacobson CA, Armand P, Ng S, Crombie J, LaCasce AS, Arnason J, Hochberg EP, Takvorian RW, Abramson JS, Fisher DC, Brown JR; Blood Cancer Research Partnership of the Leukemia & Lymphoma Society.

Lancet Haematol. 2019 Aug;6(8):e419-e428. doi: 10.1016/S2352-3026(19)30104-8. Epub 2019 Jun 14.


Airway host-microbiome interactions in chronic obstructive pulmonary disease.

Wang Z, Maschera B, Lea S, Kolsum U, Michalovich D, Van Horn S, Traini C, Brown JR, Hessel EM, Singh D.

Respir Res. 2019 Jun 6;20(1):113. doi: 10.1186/s12931-019-1085-z.


Growth dynamics in naturally progressing chronic lymphocytic leukaemia.

Gruber M, Bozic I, Leshchiner I, Livitz D, Stevenson K, Rassenti L, Rosebrock D, Taylor-Weiner A, Olive O, Goyetche R, Fernandes SM, Sun J, Stewart C, Wong A, Cibulskis C, Zhang W, Reiter JG, Gerold JM, Gribben JG, Rai KR, Keating MJ, Brown JR, Neuberg D, Kipps TJ, Nowak MA, Getz G, Wu CJ.

Nature. 2019 Jun;570(7762):474-479. doi: 10.1038/s41586-019-1252-x. Epub 2019 May 29.


Acalabrutinib monotherapy in patients with chronic lymphocytic leukemia who are intolerant to ibrutinib.

Awan FT, Schuh A, Brown JR, Furman RR, Pagel JM, Hillmen P, Stephens DM, Woyach J, Bibikova E, Charuworn P, Frigault MM, Hamdy A, Izumi R, Linghu B, Patel P, Wang MH, Byrd JC.

Blood Adv. 2019 May 14;3(9):1553-1562. doi: 10.1182/bloodadvances.2018030007.

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