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Efficacy and safety of denosumab vs. bisphosphonates in postmenopausal women previously treated with oral bisphosphonates.

Miller PD, Pannacciulli N, Malouf-Sierra J, Singer A, Czerwiński E, Bone HG, Wang C, Huang S, Chines A, Lems W, Brown JP.

Osteoporos Int. 2019 Nov 28. doi: 10.1007/s00198-019-05233-x. [Epub ahead of print]


Self-reported sleep duration is associated with time in work physical activity but not transportation or leisure physical activity among Hispanic/Latino adults in the U.S.: results from the Hispanic Community Health Study/Study of Latinos.

Tom SE, Brown JP, Avilés-Santa ML, Sotres-Alvarez D, Castañeda SF, Patel SR, Perreira K, Sanchez-Johnsen LAP, Shah NA, Zee PC, Redline S.

Sleep Health. 2019 Nov 15. pii: S2352-7218(19)30215-3. doi: 10.1016/j.sleh.2019.10.001. [Epub ahead of print]


Change in Quantitative Ultrasound-assessed Speed of Sound as a Function of Age in Women and Men and Association With the Use of Antiresorptive Agents: The Canadian Multicentre Osteoporosis Study.

Olszynski WP, Davison KS, Adachi JD, Brown JP, Hanley DA.

J Clin Densitom. 2019 Oct 9. pii: S1094-6950(19)30177-5. doi: 10.1016/j.jocd.2019.10.001. [Epub ahead of print]


Use of real-world evidence in postmarketing medicines regulation in the European Union: a systematic assessment of European Medicines Agency referrals 2013-2017.

Brown JP, Wing K, Evans SJ, Bhaskaran K, Smeeth L, Douglas IJ.

BMJ Open. 2019 Oct 28;9(10):e028133. doi: 10.1136/bmjopen-2018-028133.


Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression.

Root A, Brown JP, Forbes HJ, Bhaskaran K, Hayes J, Smeeth L, Douglas IJ.

JAMA Pediatr. 2019 Sep 23. doi: 10.1001/jamapediatrics.2019.3194. [Epub ahead of print]


Special Report From the Society for the Advancement of Blood Management: The Choosing Wisely Campaign.

Burns CD, Brown JP, Corwin HL, Gross I, Ozawa SJ, Shander A.

Anesth Analg. 2019 Nov;129(5):1381-1386. doi: 10.1213/ANE.0000000000004415.


Adapting systems thinking and safety reporting in high-consequence industries to healthcare.

Patankar MS, Brown JP.

Semin Perinatol. 2019 Dec;43(8):151180. doi: 10.1053/j.semperi.2019.08.009. Epub 2019 Aug 10. Review.


Bone-Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment.

Chavassieux P, Chapurlat R, Portero-Muzy N, Roux JP, Garcia P, Brown JP, Libanati C, Boyce RW, Wang A, Grauer A.

J Bone Miner Res. 2019 Sep;34(9):1597-1608. doi: 10.1002/jbmr.3735. Epub 2019 Jun 24.


Long-term denosumab treatment restores cortical bone loss and reduces fracture risk at the forearm and humerus: analyses from the FREEDOM Extension cross-over group.

Bilezikian JP, Lin CJF, Brown JP, Wang AT, Yin X, Ebeling PR, Fahrleitner-Pammer A, Franek E, Gilchrist N, Miller PD, Simon JA, Valter I, Zerbini CAF, Libanati C, Chines A.

Osteoporos Int. 2019 Sep;30(9):1855-1864. doi: 10.1007/s00198-019-05020-8. Epub 2019 Jun 14.


Parity and lactation are not associated with incident fragility fractures or radiographic vertebral fractures over 16 years of follow-up: Canadian Multicentre Osteoporosis Study (CaMos).

Cooke-Hubley S, Gao Z, Mugford G, Kaiser SM, Goltzman D, Leslie WD, Davison KS, Brown JP, Probyn L, Lentle B, Prior JC, Kovacs CS.

Arch Osteoporos. 2019 Apr 29;14(1):49. doi: 10.1007/s11657-019-0601-6.


Relationship Between Bone Mineral Density T-Score and Nonvertebral Fracture Risk Over 10 Years of Denosumab Treatment.

Ferrari S, Libanati C, Lin CJF, Brown JP, Cosman F, Czerwiński E, de Gregόrio LH, Malouf-Sierra J, Reginster JY, Wang A, Wagman RB, Lewiecki EM.

J Bone Miner Res. 2019 Jun;34(6):1033-1040. doi: 10.1002/jbmr.3722. Epub 2019 May 29.


Performance of predictive tools to identify individuals at risk of non-traumatic fracture: a systematic review, meta-analysis, and meta-regression.

Beaudoin C, Moore L, Gagné M, Bessette L, Ste-Marie LG, Brown JP, Jean S.

Osteoporos Int. 2019 Apr;30(4):721-740. doi: 10.1007/s00198-019-04919-6. Epub 2019 Mar 14.


Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays.

Shafer TJ, Brown JP, Lynch B, Davila-Montero S, Wallace K, Friedman KP.

Toxicol Sci. 2019 Jun 1;169(2):436-455. doi: 10.1093/toxsci/kfz052.


The Radiology of Osteoporotic Vertebral Fractures Revisited.

Lentle B, Koromani F, Brown JP, Oei L, Ward L, Goltzman D, Rivadeneira F, Leslie WD, Probyn L, Prior J, Hammond I, Cheung AM, Oei EH; Vertebral Fracture Research Groups of the CaMos, STOPP, and Rotterdam Studies.

J Bone Miner Res. 2019 Mar;34(3):409-418. doi: 10.1002/jbmr.3669. Epub 2019 Feb 27. Review.


Gene-environment interactions in Paget's disease of bone.

Numan MS, Jean S, Dessay M, Gagnon E, Amiable N, Brown JP, Michou L.

Joint Bone Spine. 2019 May;86(3):373-380. doi: 10.1016/j.jbspin.2018.12.007. Epub 2018 Dec 27.


Whole-colon investigation vs. flexible sigmoidoscopy for suspected colorectal cancer based on presenting symptoms and signs: a multicentre cohort study.

Cross AJ, Wooldrage K, Robbins EC, Pack K, Brown JP, Hamilton W, Thompson MR, Flashman KG, Halligan S, Thomas-Gibson S, Vance M, Saunders BP, Atkin W.

Br J Cancer. 2019 Jan;120(2):154-164. doi: 10.1038/s41416-018-0335-z. Epub 2018 Dec 19.


Effect of once-only flexible sigmoidoscopy screening on the outcomes of subsequent faecal occult blood test screening.

Brown JP, Wooldrage K, Kralj-Hans I, Wright S, Cross AJ, Atkin WS.

J Med Screen. 2019 Mar;26(1):11-18. doi: 10.1177/0969141318785654. Epub 2018 Oct 3.


Persistence at 24 months with denosumab among postmenopausal women with osteoporosis: results of a prospective cohort study.

Silverman SL, Siris E, Belazi D, Recknor C, Papaioannou A, Brown JP, Gold DT, Lewiecki EM, Quinn G, Balasubramanian A, Yue S, Stolshek B, Kendler DL.

Arch Osteoporos. 2018 Aug 7;13(1):85. doi: 10.1007/s11657-018-0491-z.


Number, Location, and Time Since Prior Fracture as Predictors of Future Fracture in the Elderly From the General Population.

Beaudoin C, Jean S, Moore L, Gamache P, Bessette L, Ste-Marie LG, Brown JP.

J Bone Miner Res. 2018 Nov;33(11):1956-1966. doi: 10.1002/jbmr.3526. Epub 2018 Jun 29.


Molecular effect of an OPTN common variant associated to Paget's disease of bone.

Silva IAL, Conceição N, Gagnon É, Brown JP, Cancela ML, Michou L.

PLoS One. 2018 May 21;13(5):e0197543. doi: 10.1371/journal.pone.0197543. eCollection 2018.


Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study.

McClung MR, Brown JP, Diez-Perez A, Resch H, Caminis J, Meisner P, Bolognese MA, Goemaere S, Bone HG, Zanchetta JR, Maddox J, Bray S, Grauer A.

J Bone Miner Res. 2018 Aug;33(8):1397-1406. doi: 10.1002/jbmr.3452. Epub 2018 May 22.


Effects of Long-Term Denosumab on Bone Histomorphometry and Mineralization in Women With Postmenopausal Osteoporosis.

Dempster DW, Brown JP, Fahrleitner-Pammer A, Kendler D, Rizzo S, Valter I, Wagman RB, Yin X, Yue SV, Boivin G.

J Clin Endocrinol Metab. 2018 Jul 1;103(7):2498-2509. doi: 10.1210/jc.2017-02669.


Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth.

Oyama K, El-Nachef D, Fang C, Kajimoto H, Brown JP, Singh PB, MacLellan WR.

Epigenetics Chromatin. 2018 Apr 17;11(1):18. doi: 10.1186/s13072-018-0187-z.


Positive airway pressure therapy for sleep-disordered breathing confers short-term benefits to patients with spinal cord injury despite widely ranging patterns of use.

Brown JP, Bauman KA, Kurili A, Rodriguez GM, Chiodo AE, Sitrin RG, Schotland HM.

Spinal Cord. 2018 Aug;56(8):777-789. doi: 10.1038/s41393-018-0077-z. Epub 2018 Mar 7.


Response to Dr Lamy and Dr Gonzalez-Rodriguez.

Cummings SR, Ferrari S, Brown JP, Wang AT.

J Bone Miner Res. 2018 Mar;33(3):548. doi: 10.1002/jbmr.3403. No abstract available.


Defining toxicological tipping points in neuronal network development.

Frank CL, Brown JP, Wallace K, Wambaugh JF, Shah I, Shafer TJ.

Toxicol Appl Pharmacol. 2018 Sep 1;354:81-93. doi: 10.1016/j.taap.2018.01.017. Epub 2018 Feb 3.


College students' perceived benefit-to-risk tradeoffs for nonmedical use of prescription stimulants: Implications for intervention designs.

Ross MM, Arria AM, Brown JP, Mullins CD, Schiffman J, Simoni-Wastila L, dosReis S.

Addict Behav. 2018 Apr;79:45-51. doi: 10.1016/j.addbeh.2017.12.002. Epub 2017 Dec 6.


Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization.

Bosch-Presegué L, Raurell-Vila H, Thackray JK, González J, Casal C, Kane-Goldsmith N, Vizoso M, Brown JP, Gómez A, Ausió J, Zimmermann T, Esteller M, Schotta G, Singh PB, Serrano L, Vaquero A.

Cell Rep. 2017 Nov 21;21(8):2048-2057. doi: 10.1016/j.celrep.2017.10.092.


Is whole-colon investigation by colonoscopy, computerised tomography colonography or barium enema necessary for all patients with colorectal cancer symptoms, and for which patients would flexible sigmoidoscopy suffice? A retrospective cohort study.

Atkin W, Wooldrage K, Shah U, Skinner K, Brown JP, Hamilton W, Kralj-Hans I, Thompson MR, Flashman KG, Halligan S, Thomas-Gibson S, Vance M, Cross AJ.

Health Technol Assess. 2017 Nov;21(66):1-80. doi: 10.3310/hta21660.


Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget's disease of bone.

Laurier E, Amiable N, Gagnon E, Brown JP, Michou L.

BMC Med Genet. 2017 Nov 16;18(1):133. doi: 10.1186/s12881-017-0495-3.


Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension.

Cummings SR, Ferrari S, Eastell R, Gilchrist N, Jensen JB, McClung M, Roux C, Törring O, Valter I, Wang AT, Brown JP.

J Bone Miner Res. 2018 Feb;33(2):190-198. doi: 10.1002/jbmr.3337. Epub 2017 Nov 22.


Following NEWS trend: charting progress in obstetrics?

Brown JPR.

Int J Obstet Anesth. 2018 Feb;33:1-3. doi: 10.1016/j.ijoa.2017.09.006. Epub 2017 Oct 10. No abstract available.


Antiresorptives: Safety Concerns-Clinical Perspective.

Brown JP.

Toxicol Pathol. 2017 Oct;45(7):859-863. doi: 10.1177/0192623317737066. Epub 2017 Oct 24. Review.


Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study.

Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Melby TE, Ruff VA.

J Bone Miner Res. 2018 Feb;33(2):298-306. doi: 10.1002/jbmr.3309. Epub 2017 Nov 15.


Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone.

Silva IAL, Conceição N, Gagnon É, Caiado H, Brown JP, Gianfrancesco F, Michou L, Cancela ML.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):143-151. doi: 10.1016/j.bbadis.2017.10.008. Epub 2017 Oct 6.


Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice.

LeBel M, Egarnes B, Brunet A, Lacerte P, Paré A, Lacroix S, Brown JP, Gosselin J.

Eur J Immunol. 2018 Feb;48(2):250-257. doi: 10.1002/eji.201747048. Epub 2017 Nov 22.


From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.

Frank CL, Brown JP, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci. 2017 Nov 1;160(1):121-135. doi: 10.1093/toxsci/kfx169.


Can National Healthcare-Associated Infections (HAIs) Data Differentiate Hospitals in the United States?

Masnick M, Morgan DJ, Sorkin JD, Macek MD, Brown JP, Rheingans P, Harris AD.

Infect Control Hosp Epidemiol. 2017 Oct;38(10):1167-1171. doi: 10.1017/ice.2017.179.


Atypical femur fractures: a survey of current practices in orthopedic surgery.

Schneider PS, Wall M, Brown JP, Cheung AM, Harvey EJ, Morin SN.

Osteoporos Int. 2017 Nov;28(11):3271-3276. doi: 10.1007/s00198-017-4155-4. Epub 2017 Aug 2.


Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial.

Langdahl BL, Libanati C, Crittenden DB, Bolognese MA, Brown JP, Daizadeh NS, Dokoupilova E, Engelke K, Finkelstein JS, Genant HK, Goemaere S, Hyldstrup L, Jodar-Gimeno E, Keaveny TM, Kendler D, Lakatos P, Maddox J, Malouf J, Massari FE, Molina JF, Ulla MR, Grauer A.

Lancet. 2017 Sep 30;390(10102):1585-1594. doi: 10.1016/S0140-6736(17)31613-6. Epub 2017 Jul 26.


Comparative Analysis of the Radiology of Osteoporotic Vertebral Fractures in Women and Men: Cross-Sectional and Longitudinal Observations from the Canadian Multicentre Osteoporosis Study (CaMos).

Lentle BC, Berger C, Probyn L, Brown JP, Langsetmo L, Fine B, Lian K, Shergill AK, Trollip J, Jackson S, Leslie WD, Prior JC, Kaiser SM, Hanley DA, Adachi JD, Towheed T, Davison KS, Cheung AM, Goltzman D; CaMos Research Group.

J Bone Miner Res. 2018 Apr;33(4):569-579. doi: 10.1002/jbmr.3222. Epub 2017 Aug 7.


Patient education in the management of coronary heart disease.

Anderson L, Brown JP, Clark AM, Dalal H, Rossau HK, Bridges C, Taylor RS.

Cochrane Database Syst Rev. 2017 Jun 28;6:CD008895. doi: 10.1002/14651858.CD008895.pub3. Review.


10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.

Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S.

Lancet Diabetes Endocrinol. 2017 Jul;5(7):513-523. doi: 10.1016/S2213-8587(17)30138-9. Epub 2017 May 22.


Greater Gains in Spine and Hip Strength for Romosozumab Compared With Teriparatide in Postmenopausal Women With Low Bone Mass.

Keaveny TM, Crittenden DB, Bolognese MA, Genant HK, Engelke K, Oliveri B, Brown JP, Langdahl BL, Yan C, Grauer A, Libanati C.

J Bone Miner Res. 2017 Sep;32(9):1956-1962. doi: 10.1002/jbmr.3176. Epub 2017 Jun 26.


Assaying Spontaneous Network Activity and Cellular Viability Using Multi-well Microelectrode Arrays.

Brown JP, Lynch BS, Curry-Chisolm IM, Shafer TJ, Strickland JD.

Methods Mol Biol. 2017;1601:153-170. doi: 10.1007/978-1-4939-6960-9_13.


High test positivity and low positive predictive value for colorectal cancer of continued faecal occult blood test screening after negative colonoscopy.

Brown JP, Wooldrage K, Wright S, Nickerson C, Cross AJ, Atkin WS.

J Med Screen. 2018 Jun;25(2):70-75. doi: 10.1177/0969141317698501. Epub 2017 May 3.


Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study.

Atkin W, Wooldrage K, Brenner A, Martin J, Shah U, Perera S, Lucas F, Brown JP, Kralj-Hans I, Greliak P, Pack K, Wood J, Thomson A, Veitch A, Duffy SW, Cross AJ.

Lancet Oncol. 2017 Jun;18(6):823-834. doi: 10.1016/S1470-2045(17)30187-0. Epub 2017 Apr 28.


Safety Observations With 3 Years of Denosumab Exposure: Comparison Between Subjects Who Received Denosumab During the Randomized FREEDOM Trial and Subjects Who Crossed Over to Denosumab During the FREEDOM Extension.

Watts NB, Brown JP, Papapoulos S, Lewiecki EM, Kendler DL, Dakin P, Wagman RB, Wang A, Daizadeh NS, Smith S, Bone HG.

J Bone Miner Res. 2017 Jul;32(7):1481-1485. doi: 10.1002/jbmr.3119. Epub 2017 Apr 3.


An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.

Raurell-Vila H, Bosch-Presegue L, Gonzalez J, Kane-Goldsmith N, Casal C, Brown JP, Marazuela-Duque A, Singh PB, Serrano L, Vaquero A.

Epigenetics. 2017 Feb;12(2):166-175. doi: 10.1080/15592294.2016.1278096. Epub 2017 Jan 6.


Case-Based Review of Osteonecrosis of the Jaw (ONJ) and Application of the International Recommendations for Management From the International Task Force on ONJ.

Khan AA, Morrison A, Kendler DL, Rizzoli R, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Dabagh RA, Davison KS, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw.

J Clin Densitom. 2017 Jan - Mar;20(1):8-24. doi: 10.1016/j.jocd.2016.09.005. Epub 2016 Dec 9. Review.


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