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Effect of once-only flexible sigmoidoscopy screening on the outcomes of subsequent faecal occult blood test screening.

Brown JP, Wooldrage K, Kralj-Hans I, Wright S, Cross AJ, Atkin WS.

J Med Screen. 2018 Oct 3:969141318785654. doi: 10.1177/0969141318785654. [Epub ahead of print]


Persistence at 24 months with denosumab among postmenopausal women with osteoporosis: results of a prospective cohort study.

Silverman SL, Siris E, Belazi D, Recknor C, Papaioannou A, Brown JP, Gold DT, Lewiecki EM, Quinn G, Balasubramanian A, Yue S, Stolshek B, Kendler DL.

Arch Osteoporos. 2018 Aug 7;13(1):85. doi: 10.1007/s11657-018-0491-z.


Number, Location, and Time Since Prior Fracture as Predictors of Future Fracture in the Elderly From the General Population.

Beaudoin C, Jean S, Moore L, Gamache P, Bessette L, Ste-Marie LG, Brown JP.

J Bone Miner Res. 2018 Nov;33(11):1956-1966. doi: 10.1002/jbmr.3526. Epub 2018 Jun 29.


Molecular effect of an OPTN common variant associated to Paget's disease of bone.

Silva IAL, Conceição N, Gagnon É, Brown JP, Cancela ML, Michou L.

PLoS One. 2018 May 21;13(5):e0197543. doi: 10.1371/journal.pone.0197543. eCollection 2018.


Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study.

McClung MR, Brown JP, Diez-Perez A, Resch H, Caminis J, Meisner P, Bolognese MA, Goemaere S, Bone HG, Zanchetta JR, Maddox J, Bray S, Grauer A.

J Bone Miner Res. 2018 Aug;33(8):1397-1406. doi: 10.1002/jbmr.3452. Epub 2018 May 22.


Effects of Long-Term Denosumab on Bone Histomorphometry and Mineralization in Women With Postmenopausal Osteoporosis.

Dempster DW, Brown JP, Fahrleitner-Pammer A, Kendler D, Rizzo S, Valter I, Wagman RB, Yin X, Yue SV, Boivin G.

J Clin Endocrinol Metab. 2018 Jul 1;103(7):2498-2509. doi: 10.1210/jc.2017-02669.


Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth.

Oyama K, El-Nachef D, Fang C, Kajimoto H, Brown JP, Singh PB, MacLellan WR.

Epigenetics Chromatin. 2018 Apr 17;11(1):18. doi: 10.1186/s13072-018-0187-z.


Positive airway pressure therapy for sleep-disordered breathing confers short-term benefits to patients with spinal cord injury despite widely ranging patterns of use.

Brown JP, Bauman KA, Kurili A, Rodriguez GM, Chiodo AE, Sitrin RG, Schotland HM.

Spinal Cord. 2018 Aug;56(8):777-789. doi: 10.1038/s41393-018-0077-z. Epub 2018 Mar 7.


Response to Dr Lamy and Dr Gonzalez-Rodriguez.

Cummings SR, Ferrari S, Brown JP, Wang AT.

J Bone Miner Res. 2018 Mar;33(3):548. doi: 10.1002/jbmr.3403. No abstract available.


Defining toxicological tipping points in neuronal network development.

Frank CL, Brown JP, Wallace K, Wambaugh JF, Shah I, Shafer TJ.

Toxicol Appl Pharmacol. 2018 Sep 1;354:81-93. doi: 10.1016/j.taap.2018.01.017. Epub 2018 Feb 3.


College students' perceived benefit-to-risk tradeoffs for nonmedical use of prescription stimulants: Implications for intervention designs.

Ross MM, Arria AM, Brown JP, Mullins CD, Schiffman J, Simoni-Wastila L, dosReis S.

Addict Behav. 2018 Apr;79:45-51. doi: 10.1016/j.addbeh.2017.12.002. Epub 2017 Dec 6.


Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization.

Bosch-Presegué L, Raurell-Vila H, Thackray JK, González J, Casal C, Kane-Goldsmith N, Vizoso M, Brown JP, Gómez A, Ausió J, Zimmermann T, Esteller M, Schotta G, Singh PB, Serrano L, Vaquero A.

Cell Rep. 2017 Nov 21;21(8):2048-2057. doi: 10.1016/j.celrep.2017.10.092.


Is whole-colon investigation by colonoscopy, computerised tomography colonography or barium enema necessary for all patients with colorectal cancer symptoms, and for which patients would flexible sigmoidoscopy suffice? A retrospective cohort study.

Atkin W, Wooldrage K, Shah U, Skinner K, Brown JP, Hamilton W, Kralj-Hans I, Thompson MR, Flashman KG, Halligan S, Thomas-Gibson S, Vance M, Cross AJ.

Health Technol Assess. 2017 Nov;21(66):1-80. doi: 10.3310/hta21660.


Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget's disease of bone.

Laurier E, Amiable N, Gagnon E, Brown JP, Michou L.

BMC Med Genet. 2017 Nov 16;18(1):133. doi: 10.1186/s12881-017-0495-3.


Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension.

Cummings SR, Ferrari S, Eastell R, Gilchrist N, Jensen JB, McClung M, Roux C, Törring O, Valter I, Wang AT, Brown JP.

J Bone Miner Res. 2018 Feb;33(2):190-198. doi: 10.1002/jbmr.3337. Epub 2017 Nov 22.


Following NEWS trend: charting progress in obstetrics?

Brown JPR.

Int J Obstet Anesth. 2018 Feb;33:1-3. doi: 10.1016/j.ijoa.2017.09.006. Epub 2017 Oct 10. No abstract available.


Antiresorptives: Safety Concerns-Clinical Perspective.

Brown JP.

Toxicol Pathol. 2017 Oct;45(7):859-863. doi: 10.1177/0192623317737066. Epub 2017 Oct 24. Review.


Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study.

Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Melby TE, Ruff VA.

J Bone Miner Res. 2018 Feb;33(2):298-306. doi: 10.1002/jbmr.3309. Epub 2017 Nov 15.


Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone.

Silva IAL, Conceição N, Gagnon É, Caiado H, Brown JP, Gianfrancesco F, Michou L, Cancela ML.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):143-151. doi: 10.1016/j.bbadis.2017.10.008. Epub 2017 Oct 6.


Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice.

LeBel M, Egarnes B, Brunet A, Lacerte P, Paré A, Lacroix S, Brown JP, Gosselin J.

Eur J Immunol. 2018 Feb;48(2):250-257. doi: 10.1002/eji.201747048. Epub 2017 Nov 22.


From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.

Frank CL, Brown JP, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci. 2017 Nov 1;160(1):121-135. doi: 10.1093/toxsci/kfx169.


Can National Healthcare-Associated Infections (HAIs) Data Differentiate Hospitals in the United States?

Masnick M, Morgan DJ, Sorkin JD, Macek MD, Brown JP, Rheingans P, Harris AD.

Infect Control Hosp Epidemiol. 2017 Oct;38(10):1167-1171. doi: 10.1017/ice.2017.179.


Atypical femur fractures: a survey of current practices in orthopedic surgery.

Schneider PS, Wall M, Brown JP, Cheung AM, Harvey EJ, Morin SN.

Osteoporos Int. 2017 Nov;28(11):3271-3276. doi: 10.1007/s00198-017-4155-4. Epub 2017 Aug 2.


Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial.

Langdahl BL, Libanati C, Crittenden DB, Bolognese MA, Brown JP, Daizadeh NS, Dokoupilova E, Engelke K, Finkelstein JS, Genant HK, Goemaere S, Hyldstrup L, Jodar-Gimeno E, Keaveny TM, Kendler D, Lakatos P, Maddox J, Malouf J, Massari FE, Molina JF, Ulla MR, Grauer A.

Lancet. 2017 Sep 30;390(10102):1585-1594. doi: 10.1016/S0140-6736(17)31613-6. Epub 2017 Jul 26.


Comparative Analysis of the Radiology of Osteoporotic Vertebral Fractures in Women and Men: Cross-Sectional and Longitudinal Observations from the Canadian Multicentre Osteoporosis Study (CaMos).

Lentle BC, Berger C, Probyn L, Brown JP, Langsetmo L, Fine B, Lian K, Shergill AK, Trollip J, Jackson S, Leslie WD, Prior JC, Kaiser SM, Hanley DA, Adachi JD, Towheed T, Davison KS, Cheung AM, Goltzman D; CaMos Research Group.

J Bone Miner Res. 2018 Apr;33(4):569-579. doi: 10.1002/jbmr.3222. Epub 2017 Aug 7.


Patient education in the management of coronary heart disease.

Anderson L, Brown JP, Clark AM, Dalal H, Rossau HK, Bridges C, Taylor RS.

Cochrane Database Syst Rev. 2017 Jun 28;6:CD008895. doi: 10.1002/14651858.CD008895.pub3. Review.


10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.

Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S.

Lancet Diabetes Endocrinol. 2017 Jul;5(7):513-523. doi: 10.1016/S2213-8587(17)30138-9. Epub 2017 May 22.


Greater Gains in Spine and Hip Strength for Romosozumab Compared With Teriparatide in Postmenopausal Women With Low Bone Mass.

Keaveny TM, Crittenden DB, Bolognese MA, Genant HK, Engelke K, Oliveri B, Brown JP, Langdahl BL, Yan C, Grauer A, Libanati C.

J Bone Miner Res. 2017 Sep;32(9):1956-1962. doi: 10.1002/jbmr.3176. Epub 2017 Jun 26.


Assaying Spontaneous Network Activity and Cellular Viability Using Multi-well Microelectrode Arrays.

Brown JP, Lynch BS, Curry-Chisolm IM, Shafer TJ, Strickland JD.

Methods Mol Biol. 2017;1601:153-170. doi: 10.1007/978-1-4939-6960-9_13.


High test positivity and low positive predictive value for colorectal cancer of continued faecal occult blood test screening after negative colonoscopy.

Brown JP, Wooldrage K, Wright S, Nickerson C, Cross AJ, Atkin WS.

J Med Screen. 2018 Jun;25(2):70-75. doi: 10.1177/0969141317698501. Epub 2017 May 3.


Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study.

Atkin W, Wooldrage K, Brenner A, Martin J, Shah U, Perera S, Lucas F, Brown JP, Kralj-Hans I, Greliak P, Pack K, Wood J, Thomson A, Veitch A, Duffy SW, Cross AJ.

Lancet Oncol. 2017 Jun;18(6):823-834. doi: 10.1016/S1470-2045(17)30187-0. Epub 2017 Apr 28.


Safety Observations With 3 Years of Denosumab Exposure: Comparison Between Subjects Who Received Denosumab During the Randomized FREEDOM Trial and Subjects Who Crossed Over to Denosumab During the FREEDOM Extension.

Watts NB, Brown JP, Papapoulos S, Lewiecki EM, Kendler DL, Dakin P, Wagman RB, Wang A, Daizadeh NS, Smith S, Bone HG.

J Bone Miner Res. 2017 Jul;32(7):1481-1485. doi: 10.1002/jbmr.3119. Epub 2017 Apr 3.


An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.

Raurell-Vila H, Bosch-Presegue L, Gonzalez J, Kane-Goldsmith N, Casal C, Brown JP, Marazuela-Duque A, Singh PB, Serrano L, Vaquero A.

Epigenetics. 2017 Feb;12(2):166-175. doi: 10.1080/15592294.2016.1278096. Epub 2017 Jan 6.


Case-Based Review of Osteonecrosis of the Jaw (ONJ) and Application of the International Recommendations for Management From the International Task Force on ONJ.

Khan AA, Morrison A, Kendler DL, Rizzoli R, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Dabagh RA, Davison KS, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw.

J Clin Densitom. 2017 Jan - Mar;20(1):8-24. doi: 10.1016/j.jocd.2016.09.005. Epub 2016 Dec 9. Review.


Environmental factors associated with familial or non-familial forms of Paget's disease of bone.

Audet MC, Jean S, Beaudoin C, Guay-Bélanger S, Dumont J, Brown JP, Michou L.

Joint Bone Spine. 2017 Dec;84(6):719-723. doi: 10.1016/j.jbspin.2016.11.010. Epub 2016 Dec 6.


Editor's Highlight: Evaluation of a Microelectrode Array-Based Assay for Neural Network Ontogeny Using Training Set Chemicals.

Brown JP, Hall D, Frank CL, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci. 2016 Nov;154(1):126-139. Epub 2016 Aug 4.


Improving the Understanding of Publicly Reported Healthcare-Associated Infection (HAI) Data.

Masnick M, Morgan DJ, Macek MD, Sorkin JD, Brown JP, Rheingans P, Harris AD.

Infect Control Hosp Epidemiol. 2016 Nov;37(11):1349-1354. Epub 2016 Aug 30.


NR4A1-dependent Ly6Clow monocytes contribute to reducing joint inflammation in arthritic mice through Treg cells.

Brunet A, LeBel M, Egarnes B, Paquet-Bouchard C, Lessard AJ, Brown JP, Gosselin J.

Eur J Immunol. 2016 Dec;46(12):2789-2800. doi: 10.1002/eji.201646406. Epub 2016 Oct 18.


Bone strength and management of postmenopausal fracture risk with antiresorptive therapies: considerations for women's health practice.

Cheung AM, Frame H, Ho M, Mackinnon ES, Brown JP.

Int J Womens Health. 2016 Sep 28;8:537-547. eCollection 2016. Review.


Sex-specific association between obesity and self-reported falls and injuries among community-dwelling Canadians aged 65 years and older.

Handrigan GA, Maltais N, Gagné M, Lamontagne P, Hamel D, Teasdale N, Hue O, Corbeil P, Brown JP, Jean S.

Osteoporos Int. 2017 Feb;28(2):483-494. doi: 10.1007/s00198-016-3745-x. Epub 2016 Aug 25.


Effects of Romosozumab Compared With Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women With Low Bone Mass.

Genant HK, Engelke K, Bolognese MA, Mautalen C, Brown JP, Recknor C, Goemaere S, Fuerst T, Yang YC, Grauer A, Libanati C.

J Bone Miner Res. 2017 Jan;32(1):181-187. doi: 10.1002/jbmr.2932. Epub 2016 Sep 20.


Retraction Notice to "Kidney Function and Rate of Bone Loss at the Hip and Spine: The Canadian Multicentre Osteoporosis Study" [Am J Kidney Dis. 55(2):291-299].

Jamal SA, Swan VJD, Brown JP, Hanley DA, Prior JC, Papaioannou A, Langsetmo L, Josse RG; Canadian Multicentre Osteoporosis Study Research Group.

Am J Kidney Dis. 2016 Aug;68(2):333. doi: 10.1053/j.ajkd.2016.06.005. Epub 2016 Jul 21. No abstract available.


Determinants of time to antiretroviral treatment initiation and subsequent mortality on treatment in a cohort in rural northern Malawi.

Brown JP, Ngwira B, Tafatatha T, Crampin AC, French N, Koole O.

AIDS Res Ther. 2016 Jul 8;13:24. doi: 10.1186/s12981-016-0110-2. eCollection 2016.


Denosumab or Zoledronic Acid in Postmenopausal Women With Osteoporosis Previously Treated With Oral Bisphosphonates.

Miller PD, Pannacciulli N, Brown JP, Czerwinski E, Nedergaard BS, Bolognese MA, Malouf J, Bone HG, Reginster JY, Singer A, Wang C, Wagman RB, Cummings SR.

J Clin Endocrinol Metab. 2016 Aug;101(8):3163-70. doi: 10.1210/jc.2016-1801. Epub 2016 Jun 6.


Recurrence of cervical intraepithelial lesions after thermo-coagulation in HIV-positive and HIV-negative Nigerian women.

Oga EA, Brown JP, Brown C, Dareng E, Adekanmbi V, Odutola M, Olaniyan O, Offiong R, Obende K, Adewole AS, Peter A, Dakum P, Adebamowo C.

BMC Womens Health. 2016 May 11;16:25. doi: 10.1186/s12905-016-0304-8.


The current economic burden of illness of osteoporosis in Canada.

Hopkins RB, Burke N, Von Keyserlingk C, Leslie WD, Morin SN, Adachi JD, Papaioannou A, Bessette L, Brown JP, Pericleous L, Tarride J.

Osteoporos Int. 2016 Oct;27(10):3023-32. doi: 10.1007/s00198-016-3631-6. Epub 2016 May 11.


Response to letter to the editor by Leder et al. regarding commentary "Concurrent administration of PTH and antiresorptives: Additive effects or DXA cosmetics".

Eriksen EF, Brown JP.

Bone. 2016 Aug;89:75-76. doi: 10.1016/j.bone.2016.04.027. Epub 2016 Apr 30. No abstract available.


Denosumab compared to other treatments to prevent or treat osteoporosis in individuals at risk of fracture: a systematic review and meta-analysis.

Beaudoin C, Jean S, Bessette L, Ste-Marie LG, Moore L, Brown JP.

Osteoporos Int. 2016 Sep;27(9):2835-2844. doi: 10.1007/s00198-016-3607-6. Epub 2016 Apr 27. Review.


Loss of health related quality of life following low-trauma fractures in the elderly.

Tarride JE, Burke N, Leslie WD, Morin SN, Adachi JD, Papaioannou A, Bessette L, Brown JP, Pericleous L, Muratov S, Hopkins RB.

BMC Geriatr. 2016 Apr 19;16:84. doi: 10.1186/s12877-016-0259-5.


Bone turnover markers: Defining a therapeutic target.

Brown JP.

Clin Biochem. 2016 May;49(7-8):527-8. doi: 10.1016/j.clinbiochem.2016.04.001. Epub 2016 Apr 6. No abstract available.


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