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Advances in Geant4 applications in medicine.

Incerti S, Brown JMC, Guatelli S.

Phys Med. 2020 Feb 5. pii: S1120-1797(20)30022-3. doi: 10.1016/j.ejmp.2020.01.019. [Epub ahead of print] No abstract available.


Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer.

Williams JP, Morrison LJ, Brown JM, Beckman JS, Voinov VG, Lermyte F.

Anal Chem. 2020 Feb 11. doi: 10.1021/acs.analchem.9b04763. [Epub ahead of print]


Ability of the wider dental team to triage patients with acute conditions: a qualitative study.

Kirton JA, Thompson W, Pearce M, Brown JM.

Br Dent J. 2020 Jan;228(2):103-107. doi: 10.1038/s41415-020-1199-1.


Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells.

Rhodes JDP, Feldmann A, Hernández-Rodríguez B, Díaz N, Brown JM, Fursova NA, Blackledge NP, Prathapan P, Dobrinic P, Huseyin MK, Szczurek A, Kruse K, Nasmyth KA, Buckle VJ, Vaquerizas JM, Klose RJ.

Cell Rep. 2020 Jan 21;30(3):820-835.e10. doi: 10.1016/j.celrep.2019.12.057.


Cardioprotective diabetes drugs: what cardiologists need to know.

Brown JM, Everett BM.

Cardiovasc Endocrinol Metab. 2019 Nov 13;8(4):96-105. doi: 10.1097/XCE.0000000000000181. eCollection 2019 Dec. Review.


The influence of object structure on visual short-term memory for multipart objects.

McDunn BA, Brown JM, Plummer RW.

Atten Percept Psychophys. 2020 Jan 2. doi: 10.3758/s13414-019-01957-4. [Epub ahead of print]


Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function.

McDaniel DK, Ringel-Scaia VM, Morrison HA, Coutermarsh-Ott S, Council-Troche M, Angle JW, Perry JB, Davis G, Leng W, Minarchick V, Yang Y, Chen B, Reece SW, Brown DA, Cecere TE, Brown JM, Gowdy KM, Hochella MF Jr, Allen IC.

Front Immunol. 2019 Nov 28;10:2714. doi: 10.3389/fimmu.2019.02714. eCollection 2019.


Charting the Complexity of the Marine Microbiome through Single-Cell Genomics.

Pachiadaki MG, Brown JM, Brown J, Bezuidt O, Berube PM, Biller SJ, Poulton NJ, Burkart MD, La Clair JJ, Chisholm SW, Stepanauskas R.

Cell. 2019 Dec 12;179(7):1623-1635.e11. doi: 10.1016/j.cell.2019.11.017.


Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases.

Choucair I, Nemet I, Li L, Cole MA, Skye SM, Kirsop JD, Fischbach MA, Gogonea V, Brown JM, Tang WHW, Hazen SL.

J Lipid Res. 2020 Feb;61(2):159-177. doi: 10.1194/jlr.RA119000311. Epub 2019 Dec 9.


Macrophage exclusion after radiation therapy (MERT): A new and effective way to increase the therapeutic ratio of radiotherapy.

Brown JM, Thomas R, Nagpal S, Recht L.

Radiother Oncol. 2019 Dec 5;144:159-164. doi: 10.1016/j.radonc.2019.11.020. [Epub ahead of print] Review.


Bladder reinnervation by somatic nerve transfer to pelvic nerve vesical branches does not reinnervate the urethra.

Barbe MF, Braverman AS, Salvadeo DM, Gomez-Amaya SM, Lamarre NS, Brown JM, De EJ, McIntyre BS, Day EP, Cruz GE, Frara N, Ruggieri MR Sr.

Neurourol Urodyn. 2020 Jan;39(1):181-189. doi: 10.1002/nau.24217. Epub 2019 Nov 13.


Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial.

Walsh JS, Marshall H, Smith IL, Greenfield DM, Swain J, Best E, Ashton J, Brown JM, Huddart R, Coleman RE, Snowden JA, Ross RJ.

PLoS Med. 2019 Nov 12;16(11):e1002960. doi: 10.1371/journal.pmed.1002960. eCollection 2019 Nov.


Nerve transfer for restoration of lower motor neuron-lesioned bladder and urethra function: establishment of a canine model and interim pilot study results.

Tiwari E, Salvadeo DM, Braverman AS, Frara NA, Hobson L, Cruz G, Brown JM, Mazzei M, Pontari MA, White AR, Barbe MF, Ruggieri MR.

J Neurosurg Spine. 2019 Nov 8;32(2):258-268. doi: 10.3171/2019.8.SPINE19265.


Detection of quantitative trait loci associated with drought tolerance in St. Augustinegrass.

Yu X, Brown JM, Graham SE, Carbajal EM, Zuleta MC, Milla-Lewis SR.

PLoS One. 2019 Oct 31;14(10):e0224620. doi: 10.1371/journal.pone.0224620. eCollection 2019.


Nerve lengthening and subsequent end-to-end repair yield more favourable outcomes compared with autograft repair of rat sciatic nerve defects.

Howarth HM, Kadoor A, Salem R, Nicolds B, Adachi S, Kanaris A, Lovering RM, Brown JM, Shah SB.

J Tissue Eng Regen Med. 2019 Dec;13(12):2266-2278. doi: 10.1002/term.2980. Epub 2019 Nov 26.


Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM.

Elife. 2019 Oct 17;8. pii: e49882. doi: 10.7554/eLife.49882.


Hinge Region in DNA Packaging Terminase pUL15 of Herpes Simplex Virus: A Potential Allosteric Target for Antiviral Drugs.

Thaljeh LF, Rothschild JA, Naderi M, Coghill LM, Brown JM, Brylinski M.

Biomolecules. 2019 Oct 12;9(10). pii: E603. doi: 10.3390/biom9100603.


Identification and Visualization of Functionally Important Domains and Residues in Herpes Simplex Virus Glycoprotein K(gK) Using a Combination of Phylogenetics and Protein Modeling.

Rider PJF, Coghill LM, Naderi M, Brown JM, Brylinski M, Kousoulas KG.

Sci Rep. 2019 Oct 10;9(1):14625. doi: 10.1038/s41598-019-50490-9.


Correction to: Solochrome cyanine: A histological stain for cobalt-chromium wear particles in metal-on-metal periprosthetic tissues.

Papadimitriou-Olivgeri I, Brown JM, Kilpatrick AFR, Gill HS, Athanasou NA.

J Mater Sci Mater Med. 2019 Sep 25;30(9):110. doi: 10.1007/s10856-019-6312-0.


Defect-induced electronic states amplify the cellular toxicity of ZnO nanoparticles.

Persaud I, Raghavendra AJ, Paruthi A, Alsaleh NB, Minarchick VC, Roede JR, Podila R, Brown JM.

Nanotoxicology. 2019 Sep 25:1-17. doi: 10.1080/17435390.2019.1668067. [Epub ahead of print]


The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic Plasticity.

Walsh HR, Cruickshank BM, Brown JM, Marcato P.

Front Oncol. 2019 Aug 20;9:753. doi: 10.3389/fonc.2019.00753. eCollection 2019. Review.


Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma.

Thomas RP, Nagpal S, Iv M, Soltys SG, Bertrand S, Pelpola JS, Ball R, Yang J, Sundaram V, Lavezo J, Born D, Vogel H, Brown JM, Recht LD.

Clin Cancer Res. 2019 Dec 1;25(23):6948-6957. doi: 10.1158/1078-0432.CCR-19-1421. Epub 2019 Sep 19.


Exposure to silver nanoparticles primes mast cells for enhanced activation through the high-affinity IgE receptor.

Alsaleh NB, Mendoza RP, Brown JM.

Toxicol Appl Pharmacol. 2019 Nov 1;382:114746. doi: 10.1016/j.taap.2019.114746. Epub 2019 Sep 5.


Solochrome cyanine: A histological stain for cobalt-chromium wear particles in metal-on-metal periprosthetic tissues.

Papadimitriou-Olivgeri I, Brown JM, Kilpatrick AFR, Gill HS, Athanasou NA.

J Mater Sci Mater Med. 2019 Sep 6;30(9):103. doi: 10.1007/s10856-019-6304-0. Erratum in: J Mater Sci Mater Med. 2019 Sep 25;30(9):110.


A mixed-methods pilot study to evaluate a collaborative anaesthetic and surgical training package for emergency surgical cricothyroidotomy.

Berwick RJ, Gauntlett W, Silverio SA, Wallace H, Mercer S, Brown JM, Sandars JE, Morton B, Groom P.

Anaesth Intensive Care. 2019 Jul;47(4):357-367. doi: 10.1177/0310057X19861978. Epub 2019 Aug 18. No abstract available.


Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial.

Mullane KM, Morrison VA, Camacho LH, Arvin A, McNeil SA, Durrand J, Campbell B, Su SC, Chan ISF, Parrino J, Kaplan SS, Popmihajlov Z, Annunziato PW; V212 Protocol 011 Trial Team.

Lancet Infect Dis. 2019 Sep;19(9):1001-1012. doi: 10.1016/S1473-3099(19)30310-X. Epub 2019 Aug 6. Erratum in: Lancet Infect Dis. 2019 Aug 23;:.


Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.

Brown JM, Dahlman JE, Neuman KK, Prata CAH, Krampert MC, Hadwiger PM, Vornlocher HP.

Nucleic Acid Ther. 2019 Oct;29(5):231-244. doi: 10.1089/nat.2019.0782. Epub 2019 Aug 8.


Response of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive.

Huang TY, Goldsmith FR, Fuller SE, Simon J, Batdorf HM, Scott MC, Essajee NM, Brown JM, Burk DH, Morrison CD, Burke SJ, Collier JJ, Noland RC.

Med Sci Sports Exerc. 2020 Jan;52(1):37-48. doi: 10.1249/MSS.0000000000002105.


Multi-disciplinary training hubs in North West England: the training hub lead perspective.

Brown JM, Sandars JE, Nwolise C, Silverio SA, Agius S, Patel M, Mamelok J.

Educ Prim Care. 2019 Sep;30(5):289-294. doi: 10.1080/14739879.2019.1639553. Epub 2019 Jul 28.


Rethinking the role of the brain in glucose homeostasis and diabetes pathogenesis.

Brown JM, Scarlett JM, Schwartz MW.

J Clin Invest. 2019 Jul 22;129(8):3035-3037. doi: 10.1172/JCI130904. eCollection 2019 Jul 22. No abstract available.


Silver nanoparticle immunomodulatory potential in absence of direct cytotoxicity in RAW 264.7 macrophages and MPRO 2.1 neutrophils.

Alsaleh NB, Minarchick VC, Mendoza RP, Sharma B, Podila R, Brown JM.

J Immunotoxicol. 2019 Dec;16(1):63-73. doi: 10.1080/1547691X.2019.1588928.


Monitoring Disease Progression With a Quantitative Severity Scale for Retinopathy of Prematurity Using Deep Learning.

Taylor S, Brown JM, Gupta K, Campbell JP, Ostmo S, Chan RVP, Dy J, Erdogmus D, Ioannidis S, Kim SJ, Kalpathy-Cramer J, Chiang MF; Imaging and Informatics in Retinopathy of Prematurity Consortium.

JAMA Ophthalmol. 2019 Jul 3. doi: 10.1001/jamaophthalmol.2019.2433. [Epub ahead of print]


A Quantitative Severity Scale for Retinopathy of Prematurity Using Deep Learning to Monitor Disease Regression After Treatment.

Gupta K, Campbell JP, Taylor S, Brown JM, Ostmo S, Chan RVP, Dy J, Erdogmus D, Ioannidis S, Kalpathy-Cramer J, Kim SJ, Chiang MF; Imaging and Informatics in Retinopathy of Prematurity Consortium.

JAMA Ophthalmol. 2019 Jul 3. doi: 10.1001/jamaophthalmol.2019.2442. [Epub ahead of print]


Engineered nanomaterials and oxidative stress: current understanding and future challenges.

Mendoza RP, Brown JM.

Curr Opin Toxicol. 2019 Feb;13:74-80. doi: 10.1016/j.cotox.2018.09.001. Epub 2018 Sep 7.


Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus.

Mirzadeh Z, Alonge KM, Cabrales E, Herranz-Pérez V, Scarlett JM, Brown JM, Hassouna R, Matsen ME, Nguyen HT, Garcia-Verdugo JM, Zeltser LM, Schwartz MW.

Nat Metab. 2019 Feb;1(2):212-221. doi: 10.1038/s42255-018-0029-0. Epub 2019 Jan 21.


Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling.

Gimple RC, Kidwell RL, Kim LJY, Sun T, Gromovsky AD, Wu Q, Wolf M, Lv D, Bhargava S, Jiang L, Prager BC, Wang X, Ye Q, Zhu Z, Zhang G, Dong Z, Zhao L, Lee D, Bi J, Sloan AE, Mischel PS, Brown JM, Cang H, Huan T, Mack SC, Xie Q, Rich JN.

Cancer Discov. 2019 Sep;9(9):1248-1267. doi: 10.1158/2159-8290.CD-19-0061. Epub 2019 Jun 14.


Automatic assessment of glioma burden: a deep learning algorithm for fully automated volumetric and bidimensional measurement.

Chang K, Beers AL, Bai HX, Brown JM, Ly KI, Li X, Senders JT, Kavouridis VK, Boaro A, Su C, Bi WL, Rapalino O, Liao W, Shen Q, Zhou H, Xiao B, Wang Y, Zhang PJ, Pinho MC, Wen PY, Batchelor TT, Boxerman JL, Arnaout O, Rosen BR, Gerstner ER, Yang L, Huang RY, Kalpathy-Cramer J.

Neuro Oncol. 2019 Nov 4;21(11):1412-1422. doi: 10.1093/neuonc/noz106.


Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours.

Malzahn J, Kastrenopoulou A, Papadimitriou-Olivgeri I, Papachristou DJ, Brown JM, Oppermann U, Athanasou NA.

Clin Sarcoma Res. 2019 May 13;9:8. doi: 10.1186/s13569-019-0118-1. eCollection 2019.


Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA.

Sakata D, Lampe N, Karamitros M, Kyriakou I, Belov O, Bernal MA, Bolst D, Bordage MC, Breton V, Brown JMC, Francis Z, Ivanchenko V, Meylan S, Murakami K, Okada S, Petrovic I, Ristic-Fira A, Santin G, Sarramia D, Sasaki T, Shin WG, Tang N, Tran HN, Villagrasa C, Emfietzoglou D, Nieminen P, Guatelli S, Incerti S.

Phys Med. 2019 Jun;62:152-157. doi: 10.1016/j.ejmp.2019.04.010. Epub 2019 May 17.


Low-intensity exercise induces acute shifts in liver and skeletal muscle substrate metabolism but not chronic adaptations in tissue oxidative capacity.

Fuller SE, Huang TY, Simon J, Batdorf HM, Essajee NM, Scott MC, Waskom CM, Brown JM, Burke SJ, Collier JJ, Noland RC.

J Appl Physiol (1985). 2019 Jul 1;127(1):143-156. doi: 10.1152/japplphysiol.00820.2018. Epub 2019 May 16.


Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.

Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1045-1054. doi: 10.1161/ATVBAHA.119.312592.


Early Proteome Shift and Serum Bioactivity Precede Diesel Exhaust-induced Impairment of Cardiovascular Recovery in Spontaneously Hypertensive Rats.

Thompson LC, Shannahan JH, Perez CM, Haykal-Coates N, King C, Hazari MS, Brown JM, Farraj AK.

Sci Rep. 2019 May 3;9(1):6885. doi: 10.1038/s41598-019-43339-8.


Automated Fundus Image Quality Assessment in Retinopathy of Prematurity Using Deep Convolutional Neural Networks.

Coyner AS, Swan R, Campbell JP, Ostmo S, Brown JM, Kalpathy-Cramer J, Kim SJ, Jonas KE, Chan RVP, Chiang MF; Imaging and Informatics in Retinopathy of Prematurity Research Consortium.

Ophthalmol Retina. 2019 May;3(5):444-450. doi: 10.1016/j.oret.2019.01.015. Epub 2019 Jan 31.


Dynamin 2, cell trafficking, and the triple-negative paradox.

Chernikova SB, Game JC, Brown JM.

Oncotarget. 2019 Mar 22;10(24):2336-2337. doi: 10.18632/oncotarget.26778. eCollection 2019 Mar 22. No abstract available.


Eremothecium coryli bloodstream infection in a patient with acute myeloid leukemia: first case report of human infection.

Multani A, Rustagi A, Epstein DJ, Gomez CA, Budvytiene I, Banaei N, Brown JM, Liu AY.

Diagn Microbiol Infect Dis. 2019 Sep;95(1):77-79. doi: 10.1016/j.diagmicrobio.2019.03.011. Epub 2019 Mar 27.


Patient-Reported Outcome Results From the Open-Label, Randomized Phase III Myeloma X Trial Evaluating Salvage Autologous Stem-Cell Transplantation in Relapsed Multiple Myeloma.

Ahmedzai SH, Snowden JA, Ashcroft AJ, Cairns DA, Williams C, Hockaday A, Cavenagh JD, Ademokun D, Tholouli E, Allotey D, Dhanapal V, Jenner M, Yong K, Cavet J, Hunter H, Bird JM, Pratt G, Parrish C, Brown JM, Morris TCM, Cook G; National Cancer Research Institute Haemato-Oncology Clinical Studies Group.

J Clin Oncol. 2019 Jul 1;37(19):1617-1628. doi: 10.1200/JCO.18.01006. Epub 2019 Apr 10.


Systematic Evaluation of Patient-Reported Outcome Protocol Content and Reporting in Cancer Trials.

Kyte D, Retzer A, Ahmed K, Keeley T, Armes J, Brown JM, Calman L, Gavin A, Glaser AW, Greenfield DM, Lanceley A, Taylor RM, Velikova G, Brundage M, Efficace F, Mercieca-Bebber R, King MT, Turner G, Calvert M.

J Natl Cancer Inst. 2019 Nov 1;111(11):1170-1178. doi: 10.1093/jnci/djz038.


GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells.

Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel HG, Riviere I, Liu C, Sather B, Brentjens RJ.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau7746. doi: 10.1126/scitranslmed.aau7746.


Semi-quantitative electromyography as a predictor of nerve transfer outcome.

Mandeville RM, Brown JM, Sheean GL.

Clin Neurophysiol. 2019 May;130(5):701-706. doi: 10.1016/j.clinph.2019.02.008. Epub 2019 Feb 28.


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