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Items: 1 to 50 of 220

1.

First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma.

Bodeker KL, Allen BG, Smith MC, Monga V, Sandhu S, Hohl RJ, Carlisle TL, Brown HA, Hollenbeck NJ, Vollstedt S, Greenlee JDW, Howard MA, Mapuskar KA, Seyedin SN, Caster JM, Jones KA, Cullen JJ, Berg DJ, Wagner BA, Buettner GR, TenNapel MJ, Smith BJ, Spitz DR, Buatti JM.

Clin Cancer Res. 2019 Aug 19. pii: clincanres.0594.2019. doi: 10.1158/1078-0432.CCR-19-0594. [Epub ahead of print]

PMID:
31427282
2.

Solar-Powered Point-of-Care Sonography: Our Himalayan Experience.

Nolting L, Baker D, Hardy Z, Kushinka M, Brown HA.

J Ultrasound Med. 2019 Sep;38(9):2477-2484. doi: 10.1002/jum.14923. Epub 2019 Jan 17.

PMID:
30653683
3.

Using Future Employers' Expectations to Inform Global Health Fellowship Curricula.

Brown HA, Mulherin P, Ferrara WC, Humphrey ME, Vera A, Hall JW.

J Grad Med Educ. 2018 Oct;10(5):517-521. doi: 10.4300/JGME-D-18-00348.1.

PMID:
30386476
4.

Repurposing blue laser autofluorescence to measure ocular sun exposure.

Lingham G, Burton A, Brown HA, Huynh E, Yazar S, Coroneo MT, Mackey DA.

Clin Exp Ophthalmol. 2019 May;47(4):445-452. doi: 10.1111/ceo.13423. Epub 2018 Nov 14.

PMID:
30345715
5.

Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer.

Alexander MS, Wilkes JG, Schroeder SR, Buettner GR, Wagner BA, Du J, Gibson-Corley K, O'Leary BR, Spitz DR, Buatti JM, Berg DJ, Bodeker KL, Vollstedt S, Brown HA, Allen BG, Cullen JJ.

Cancer Res. 2018 Dec 15;78(24):6838-6851. doi: 10.1158/0008-5472.CAN-18-1680. Epub 2018 Sep 25.

6.

Utilization of Mobile Integrated Health Providers During a Flood Disaster in South Carolina (USA).

Gainey CE, Brown HA, Gerard WC.

Prehosp Disaster Med. 2018 Aug;33(4):432-435. doi: 10.1017/S1049023X18000572. Epub 2018 Jul 17.

PMID:
30012235
7.

The Mycobacterium tuberculosis complex has a pathway for the biosynthesis of 4-formamido-4,6-dideoxy-d-glucose.

Brown HA, Vinogradov E, Gilbert M, Holden HM.

Protein Sci. 2018 Aug;27(8):1491-1497. doi: 10.1002/pro.3443. Epub 2018 Jul 18.

8.

Differential retention of pollen grains on clothing and the effectiveness of laboratory retrieval methods in forensic settings.

Webb JC, Brown HA, Toms H, Goodenough AE.

Forensic Sci Int. 2018 Jul;288:36-45. doi: 10.1016/j.forsciint.2018.04.010. Epub 2018 Apr 15.

PMID:
29709713
9.

The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes.

Brown HA, Thoden JB, Tipton PA, Holden HM.

Protein Sci. 2018 Feb;27(2):441-450. doi: 10.1002/pro.3333. Epub 2017 Nov 9.

10.

Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni.

Taylor ZW, Brown HA, Holden HM, Raushel FM.

Biochemistry. 2017 Nov 21;56(46):6079-6082. doi: 10.1021/acs.biochem.7b00905. Epub 2017 Oct 24.

11.

Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni.

Taylor ZW, Brown HA, Narindoshvili T, Wenzel CQ, Szymanski CM, Holden HM, Raushel FM.

J Am Chem Soc. 2017 Jul 19;139(28):9463-9466. doi: 10.1021/jacs.7b04824. Epub 2017 Jul 3.

12.

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Rouzer CA, Tallman KA, Lamberson CR, Wang X, Hill S, Ivanova PT, Brown HA, Zhang B, Porter NA, Marnett LJ.

ACS Chem Biol. 2017 Aug 18;12(8):2062-2069. doi: 10.1021/acschembio.7b00480. Epub 2017 Jun 28.

13.

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials.

Zahra A, Fath MA, Opat E, Mapuskar KA, Bhatia SK, Ma DC, Rodman SN III, Snyders TP, Chenard CA, Eichenberger-Gilmore JM, Bodeker KL, Ahmann L, Smith BJ, Vollstedt SA, Brown HA, Hejleh TA, Clamon GH, Berg DJ, Szweda LI, Spitz DR, Buatti JM, Allen BG.

Radiat Res. 2017 Jun;187(6):743-754. doi: 10.1667/RR14668.1. Epub 2017 Apr 24.

14.

Targeting phospholipase D in cancer, infection and neurodegenerative disorders.

Brown HA, Thomas PG, Lindsley CW.

Nat Rev Drug Discov. 2017 May;16(5):351-367. doi: 10.1038/nrd.2016.252. Epub 2017 Feb 17. Review.

15.

Evaluation of a Short-term Training Program in Bedside Emergency Ultrasound in Southwestern Tanzania.

Shaffer M, Brown HA, McCoy C, Bashaka P.

J Ultrasound Med. 2017 Mar;36(3):515-521. doi: 10.7863/ultra.16.04006. Epub 2017 Jan 15.

PMID:
28088840
16.

Development and Implementation of a Novel Prehospital Care System in the State of Kerala, India.

Brown HA, Douglass KA, Ejas S, Poovathumparambil V.

Prehosp Disaster Med. 2016 Dec;31(6):663-666. Epub 2016 Sep 22.

PMID:
27655213
17.

Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts.

Tribble EK, Ivanova PT, Grabon A, Alb JG Jr, Faenza I, Cocco L, Brown HA, Bankaitis VA.

J Lipid Res. 2016 Aug;57(8):1492-506. doi: 10.1194/jlr.M068734. Epub 2016 Jun 2.

18.

Oral Health Status of Older Adults Attending Senior Centers and Congregate Meal Sites in New Hampshire.

Anderson L, Martin NR, Kelly SM, Brown HA.

J Dent Hyg. 2016 Apr;90(2):128-34.

PMID:
27105791
19.

Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions.

Sohn M, Ivanova P, Brown HA, Toth DJ, Varnai P, Kim YJ, Balla T.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4314-9. doi: 10.1073/pnas.1525719113. Epub 2016 Apr 4.

20.

Lipid composition of viral envelope of three strains of influenza virus - not all viruses are created equal.

Ivanova PT, Myers DS, Milne SB, McClaren JL, Thomas PG, Brown HA.

ACS Infect Dis. 2015 Sep 11;1(9):399-452. Epub 2015 Jun 24.

21.

Competition and allostery govern substrate selectivity of cyclooxygenase-2.

Mitchener MM, Hermanson DJ, Shockley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12366-71. doi: 10.1073/pnas.1507307112. Epub 2015 Sep 21. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1413.

22.

Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica.

Salinger AJ, Brown HA, Thoden JB, Holden HM.

Protein Sci. 2015 Oct;24(10):1633-9. doi: 10.1002/pro.2747. Epub 2015 Aug 13.

23.

Phospholipase D1 Couples CD4+ T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication.

Taylor HE, Simmons GE Jr, Mathews TP, Khatua AK, Popik W, Lindsley CW, D'Aquila RT, Brown HA.

PLoS Pathog. 2015 May 28;11(5):e1004864. doi: 10.1371/journal.ppat.1004864. eCollection 2015 May.

24.

A Next generation PLD2 inhibitor with improved physiochemical properties and DMPK profile for translational in vivo.

O'Reilly MC, Scott SA, Daniels JS, Morrison R, Engers JL, Oguin T, Thomas P, Brown HA, Lindsley CW.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

25.

Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas.

Mathews TP, Hill S, Rose KL, Ivanova PT, Lindsley CW, Brown HA.

ACS Chem Biol. 2015 May 15;10(5):1258-68. doi: 10.1021/cb500772c. Epub 2015 Feb 17.

26.

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM.

Cell Rep. 2015 Jan 20;10(3):326-338. doi: 10.1016/j.celrep.2014.12.036. Epub 2015 Jan 15.

27.

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.

Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH Jr, Russell DW, Subramaniam S, Brown HA.

J Lipid Res. 2015 Mar;56(3):722-36. doi: 10.1194/jlr.P056002. Epub 2015 Jan 17.

28.

Biochemical characterization of a Pseudomonas aeruginosa phospholipase D.

Spencer C, Brown HA.

Biochemistry. 2015 Feb 10;54(5):1208-18. doi: 10.1021/bi501291t. Epub 2015 Jan 22.

29.

Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.

O'Reilly MC, Scott SA, Brown HA, Lindsley CW.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5553-5557. doi: 10.1016/j.bmcl.2014.11.017. Epub 2014 Nov 15.

30.

Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.

Scott SA, Spencer CT, O'Reilly MC, Brown KA, Lavieri RR, Cho CH, Jung DI, Larock RC, Brown HA, Lindsley CW.

ACS Chem Biol. 2015 Feb 20;10(2):421-32. doi: 10.1021/cb500828m. Epub 2014 Nov 19.

31.

Development of an improved mammalian overexpression method for human CD62L.

Brown HA, Roth G, Holzapfel G, Shen S, Rahbari K, Ireland J, Zou Z, Sun PD.

Protein Expr Purif. 2015 Jan;105:8-13. doi: 10.1016/j.pep.2014.09.018. Epub 2014 Oct 5.

32.

Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer.

Bruntz RC, Lindsley CW, Brown HA.

Pharmacol Rev. 2014 Oct;66(4):1033-79. doi: 10.1124/pr.114.009217. Review.

33.

Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains.

O'Reilly MC, Oguin TH 3rd, Scott SA, Thomas PG, Locuson CW, Morrison RD, Daniels JS, Brown HA, Lindsley CW.

ChemMedChem. 2014 Dec;9(12):2633-7. doi: 10.1002/cmdc.201402333. Epub 2014 Sep 10.

34.

Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.

Oguin TH 3rd, Sharma S, Stuart AD, Duan S, Scott SA, Jones CK, Daniels JS, Lindsley CW, Thomas PG, Brown HA.

J Biol Chem. 2014 Sep 12;289(37):25405-17. doi: 10.1074/jbc.M114.558817. Epub 2014 Jul 27.

35.

A CLN8 nonsense mutation in the whole genome sequence of a mixed breed dog with neuronal ceroid lipofuscinosis and Australian Shepherd ancestry.

Guo J, Johnson GS, Brown HA, Provencher ML, da Costa RC, Mhlanga-Mutangadura T, Taylor JF, Schnabel RD, O'Brien DP, Katz ML.

Mol Genet Metab. 2014 Aug;112(4):302-9. doi: 10.1016/j.ymgme.2014.05.014. Epub 2014 Jun 4.

36.

Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster.

Faust JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler M, Stern M, McNew JA.

PLoS One. 2014 Jun 19;9(6):e100213. doi: 10.1371/journal.pone.0100213. eCollection 2014.

37.

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells.

Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD.

J Lipid Res. 2014 Jul;55(7):1478-88. doi: 10.1194/jlr.M050237. Epub 2014 May 23.

38.

Purpura, petechiae, and bullae as first signs of juvenile granulomatosis with polyangiitis.

Rawn S, Miettunen P, Brown HA, Schmeling H.

Eur J Pediatr. 2014 Dec;173(12):1685-9. doi: 10.1007/s00431-014-2298-2. Epub 2014 Mar 28.

PMID:
24677133
39.

Chemical modulation of glycerolipid signaling and metabolic pathways.

Scott SA, Mathews TP, Ivanova PT, Lindsley CW, Brown HA.

Biochim Biophys Acta. 2014 Aug;1841(8):1060-84. doi: 10.1016/j.bbalip.2014.01.009. Epub 2014 Jan 15. Review.

40.

Subclavian aneurysm presenting with massive hemoptysis: a case report and review of the literature.

Brown HA, Aruny JE, Elefteriades JA, Sumpio BE.

Int J Angiol. 2013 Mar;22(1):69-74. doi: 10.1055/s-0033-1333862.

41.

A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.

Ren J, Pei-Chen Lin C, Pathak MC, Temple BR, Nile AH, Mousley CJ, Duncan MC, Eckert DM, Leiker TJ, Ivanova PT, Myers DS, Murphy RC, Brown HA, Verdaasdonk J, Bloom KS, Ortlund EA, Neiman AM, Bankaitis VA.

Mol Biol Cell. 2014 Mar;25(5):712-27. doi: 10.1091/mbc.E13-11-0634. Epub 2014 Jan 8.

42.

Zwitterionic polymerization to generate high molecular weight cyclic poly(carbosiloxane)s.

Brown HA, Chang YA, Waymouth RM.

J Am Chem Soc. 2013 Dec 18;135(50):18738-41. doi: 10.1021/ja409843v. Epub 2013 Dec 5.

PMID:
24308512
43.

Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.

Bruntz RC, Taylor HE, Lindsley CW, Brown HA.

J Biol Chem. 2014 Jan 10;289(2):600-16. doi: 10.1074/jbc.M113.532978. Epub 2013 Nov 20.

44.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.

45.

Reply: To PMID 23375438.

Brown HA, Indes JE.

J Vasc Surg. 2013 Nov;58(5):1444-5. doi: 10.1016/j.jvs.2013.07.110. No abstract available.

46.

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.

Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM.

Cell Rep. 2013 Oct 31;5(2):508-20. doi: 10.1016/j.celrep.2013.08.047. Epub 2013 Oct 3.

47.

Diacylglycerol kinase delta promotes lipogenesis.

Shulga YV, Loukov D, Ivanova PT, Milne SB, Myers DS, Hatch GM, Umeh G, Jalan D, Fullerton MD, Steinberg GR, Topham MK, Brown HA, Epand RM.

Biochemistry. 2013 Nov 5;52(44):7766-76. doi: 10.1021/bi401178y. Epub 2013 Oct 23.

48.

Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B.

Cipriano R, Bryson BL, Miskimen KL, Bartel CA, Hernandez-Sanchez W, Bruntz RC, Scott SA, Lindsley CW, Brown HA, Jackson MW.

Oncogene. 2014 Jun 19;33(25):3298-306. doi: 10.1038/onc.2013.293. Epub 2013 Aug 5.

49.

Zwitterionic ring-opening polymerization for the synthesis of high molecular weight cyclic polymers.

Brown HA, Waymouth RM.

Acc Chem Res. 2013 Nov 19;46(11):2585-96. doi: 10.1021/ar400072z. Epub 2013 Jun 21.

PMID:
23789724
50.

Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency.

Kim SH, Scott SA, Bennett MJ, Carson RP, Fessel J, Brown HA, Ess KC.

PLoS Genet. 2013 Jun;9(6):e1003563. doi: 10.1371/journal.pgen.1003563. Epub 2013 Jun 13.

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