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Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer.

Gallo D, Brown GW.

Crit Rev Biochem Mol Biol. 2019 Jun;54(3):301-332. doi: 10.1080/10409238.2019.1651817. Epub 2019 Aug 20.


The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay.

D'Orazio KN, Wu CC, Sinha N, Loll-Krippleber R, Brown GW, Green R.

Elife. 2019 Jun 20;8. pii: e49117. doi: 10.7554/eLife.49117.


Exploiting DNA Replication Stress for Cancer Treatment.

Ubhi T, Brown GW.

Cancer Res. 2019 Apr 15;79(8):1730-1739. doi: 10.1158/0008-5472.CAN-18-3631. Epub 2019 Apr 9. Review.


Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates.

Gallo D, Kim T, Szakal B, Saayman X, Narula A, Park Y, Branzei D, Zhang Z, Brown GW.

Mol Cell. 2019 Mar 7;73(5):900-914.e9. doi: 10.1016/j.molcel.2019.01.001. Epub 2019 Feb 4.


Exploration of the influence of insecure attachment and parental maltreatment on the incidence and course of adult clinical depression.

Brown GW, Harris TO, Craig TKJ.

Psychol Med. 2019 Apr;49(6):1025-1032. doi: 10.1017/S0033291718001721. Epub 2018 Aug 15.


Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis.

Bellnier T, Brown GW, Ortega TR.

Ment Health Clin. 2018 Apr 26;8(3):110-115. doi: 10.9740/mhc.2018.05.110. eCollection 2018 May.


The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.

Sing TL, Hung MP, Ohnuki S, Suzuki G, San Luis BJ, McClain M, Unruh JR, Yu Z, Ou J, Marshall-Sheppard J, Huh WK, Costanzo M, Boone C, Ohya Y, Jaspersen SL, Brown GW.

J Cell Biol. 2018 Jul 2;217(7):2445-2462. doi: 10.1083/jcb.201709009. Epub 2018 Jun 6.


Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.

Díaz-Mejía JJ, Celaj A, Mellor JC, Coté A, Balint A, Ho B, Bansal P, Shaeri F, Gebbia M, Weile J, Verby M, Karkhanina A, Zhang Y, Wong C, Rich J, Prendergast D, Gupta G, Öztürk S, Durocher D, Brown GW, Roth FP.

Mol Syst Biol. 2018 May 28;14(5):e7985. doi: 10.15252/msb.20177985.


Examining the chemical and structural properties that influence the sensitivity of energetic nitrate esters.

Manner VW, Cawkwell MJ, Kober EM, Myers TW, Brown GW, Tian H, Snyder CJ, Perriot R, Preston DN.

Chem Sci. 2018 Mar 9;9(15):3649-3663. doi: 10.1039/c8sc00903a. eCollection 2018 Apr 21.


Application of a Pharmacokinetic Model of Metformin Clearance in a Population with Acute Myeloid Leukemia.

Ceacareanu AC, Brown GW, Moussa HA, Wintrob ZAP.

J Res Pharm Pract. 2018 Jan-Mar;7(1):41-45. doi: 10.4103/jrpp.JRPP_17_53.


Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.

Becker JR, Gallo D, Leung W, Croissant T, Thu YM, Nguyen HD, Starr TK, Brown GW, Bielinsky AK.

Nucleic Acids Res. 2018 Jun 20;46(11):5634-5650. doi: 10.1093/nar/gky313.


Systematic analysis of complex genetic interactions.

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL.

Science. 2018 Apr 20;360(6386). pii: eaao1729. doi: 10.1126/science.aao1729.


Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome.

Ho B, Baryshnikova A, Brown GW.

Cell Syst. 2018 Feb 28;6(2):192-205.e3. doi: 10.1016/j.cels.2017.12.004. Epub 2018 Jan 17.


Errata: Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286a.


Errata: Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286b.


DNA Replication Profiling Using Deep Sequencing.

Saayman X, Ramos-Pérez C, Brown GW.

Methods Mol Biol. 2018;1672:195-207. doi: 10.1007/978-1-4939-7306-4_15.


P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance.

Loll-Krippleber R, Brown GW.

Nat Commun. 2017 Sep 15;8(1):558. doi: 10.1038/s41467-017-00632-2.


Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae.

Ramos-Pérez C, Ayra-Plasencia J, Matos-Perdomo E, Lisby M, Brown GW, Machín F.

G3 (Bethesda). 2017 Oct 5;7(10):3379-3391. doi: 10.1534/g3.117.300104.


Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Sep;13(9):982-993. doi: 10.1038/nchembio.2436. Epub 2017 Jul 24. Erratum in: Nat Chem Biol. 2017 Nov 21;13(12 ):1286. Nat Chem Biol. 2017 Nov 21;13(12 ):1286.


Prophylactic and therapeutic efficacy of Australian-registered insecticide formulations against Old World screwworm (Chrysomya bezziana) infestation.

James PJ, Wardhana AH, Brown GW, Mayer DG, Urech R.

Aust Vet J. 2017 Aug;95(8):265-272. doi: 10.1111/avj.12609.


Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.

Wheaton K, Campuzano D, Ma W, Sheinis M, Ho B, Brown GW, Benchimol S.

Mol Cell Biol. 2017 Jun 29;37(14). pii: e00659-16. doi: 10.1128/MCB.00659-16. Print 2017 Jul 15.


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.


Introducing Jus ante Bellum as a cosmopolitan approach to humanitarian intervention.

Brown GW, Bohm A.

Eur J Int Relat. 2016 Dec;22(4):897-919. doi: 10.1177/1354066115607370. Epub 2015 Oct 14.


Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.

Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C, Andrews BJ.

Cell Syst. 2016 Sep 28;3(3):264-277.e10. doi: 10.1016/j.cels.2016.08.008. Epub 2016 Sep 8.


Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.

Abraham KJ, Chan JN, Salvi JS, Ho B, Hall A, Vidya E, Guo R, Killackey SA, Liu N, Lee JE, Brown GW, Mekhail K.

Nucleic Acids Res. 2016 Oct 14;44(18):8870-8884. Epub 2016 Aug 29.


Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.

Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X.

Cell Rep. 2016 Jul 12;16(2):368-378. doi: 10.1016/j.celrep.2016.06.015. Epub 2016 Jun 30.


Understanding global health and development partnerships: Perspectives from African and global health system professionals.

Barnes A, Brown GW, Harman S.

Soc Sci Med. 2016 Jun;159:22-9. doi: 10.1016/j.socscimed.2016.04.033. Epub 2016 Apr 29.


MTE1 Functions with MPH1 in Double-Strand Break Repair.

Yimit A, Kim T, Anand RP, Meister S, Ou J, Haber JE, Zhang Z, Brown GW.

Genetics. 2016 May;203(1):147-57. doi: 10.1534/genetics.115.185454. Epub 2016 Feb 26.


High-throughput fluorescence microscopic analysis of protein abundance and localization in budding yeast.

Torres NP, Ho B, Brown GW.

Crit Rev Biochem Mol Biol. 2016;51(2):110-9. doi: 10.3109/10409238.2016.1145185. Epub 2016 Feb 19.


Single-Molecule Analysis of Replicating Yeast Chromosomes.

Gallo D, Wang G, Yip CM, Brown GW.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.top077784. doi: 10.1101/pdb.top077784.


Analysis of Replicating Yeast Chromosomes by DNA Combing.

Gallo D, Wang G, Yip CM, Brown GW.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot085118. doi: 10.1101/pdb.prot085118.


HELB Is a Feedback Inhibitor of DNA End Resection.

Tkáč J, Xu G, Adhikary H, Young JTF, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY, Durocher D.

Mol Cell. 2016 Feb 4;61(3):405-418. doi: 10.1016/j.molcel.2015.12.013. Epub 2016 Jan 7.


Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.

Dibitetto D, Ferrari M, Rawal CC, Balint A, Kim T, Zhang Z, Smolka MB, Brown GW, Marini F, Pellicioli A.

Nucleic Acids Res. 2016 Jan 29;44(2):669-82. doi: 10.1093/nar/gkv1080. Epub 2015 Oct 20.


Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase.

Jablonowski CM, Cussiol JR, Oberly S, Yimit A, Balint A, Kim T, Zhang Z, Brown GW, Smolka MB.

Genetics. 2015 Nov;201(3):937-49. doi: 10.1534/genetics.115.181479. Epub 2015 Sep 11.


Genetic Regulation of Dna2 Localization During the DNA Damage Response.

Yimit A, Riffle M, Brown GW.

G3 (Bethesda). 2015 Jul 10;5(9):1937-44. doi: 10.1534/g3.115.019208.


Assembly of Slx4 signaling complexes behind DNA replication forks.

Balint A, Kim T, Gallo D, Cussiol JR, Bastos de Oliveira FM, Yimit A, Ou J, Nakato R, Gurevich A, Shirahige K, Smolka MB, Zhang Z, Brown GW.

EMBO J. 2015 Aug 13;34(16):2182-97. doi: 10.15252/embj.201591190. Epub 2015 Jun 25.


The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans.

Chaillot J, Tebbji F, Remmal A, Boone C, Brown GW, Bellaoui M, Sellam A.

Antimicrob Agents Chemother. 2015 Aug;59(8):4584-92. doi: 10.1128/AAC.00551-15. Epub 2015 May 26.


A high-throughput confocal fluorescence microscopy platform to study DNA replication stress in yeast cells.

Torres NP, Brown GW.

Methods Mol Biol. 2015;1300:1-12. doi: 10.1007/978-1-4939-2596-4_1.


Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.

Cussiol JR, Jablonowski CM, Yimit A, Brown GW, Smolka MB.

EMBO J. 2015 Jun 12;34(12):1704-17. doi: 10.15252/embj.201490834. Epub 2015 Apr 20.


E4F1 is a master regulator of CHK1-mediated functions.

Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G.

Cell Rep. 2015 Apr 14;11(2):210-9. doi: 10.1016/j.celrep.2015.03.019. Epub 2015 Apr 2.


Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.

Hendry JA, Tan G, Ou J, Boone C, Brown GW.

G3 (Bethesda). 2015 Feb 26;5(5):997-1006. doi: 10.1534/g3.115.016576.


Knowledge, politics and power in global health: Comment on "Knowledge, moral claims and the exercise of power in global health".

Brown GW.

Int J Health Policy Manag. 2015 Jan 30;4(2):111-3. doi: 10.15171/ijhpm.2015.20. eCollection 2015 Feb.


The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.

Bende NS, Dziemborowicz S, Herzig V, Ramanujam V, Brown GW, Bosmans F, Nicholson GM, King GF, Mobli M.

FEBS J. 2015 Mar;282(5):904-20. doi: 10.1111/febs.13189. Epub 2015 Jan 23.


Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair.

Larin M, Gallo D, Tamblyn L, Yang J, Liao H, Sabat N, Brown GW, McPherson JP.

Nucleic Acids Res. 2014 Sep;42(15):9807-20. doi: 10.1093/nar/gku676. Epub 2014 Jul 23.


Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.

Coschi CH, Ishak CA, Gallo D, Marshall A, Talluri S, Wang J, Cecchini MJ, Martens AL, Percy V, Welch I, Boutros PC, Brown GW, Dick FA.

Cancer Discov. 2014 Jul;4(7):840-53. doi: 10.1158/2159-8290.CD-14-0215. Epub 2014 Apr 16.


Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, Suresh S, Duby G, Heisler LE, Surendra A, Fung E, Urbanus ML, Gebbia M, Lissina E, Miranda M, Chiang JH, Aparicio AM, Zeghouf M, Davis RW, Cherfils J, Boutry M, Kaiser CA, Cummins CL, Trimble WS, Brown GW, Schimmer AD, Bankaitis VA, Nislow C, Bader GD, Giaever G.

Science. 2014 Apr 11;344(6180):208-11. doi: 10.1126/science.1250217. Erratum in: Science. 2014 May 23;344(6186):1255771.


Cattle herd inspections and fly trapping for the detection of the Old World screw-worm fly (Chrysomya bezziana).

Urech R, Muharsini S, Tozer RS, Sumartono, Green PE, Brown GW, Spradbery JP, Mayer DG, Tack Kan Y, Kison A.

Aust Vet J. 2014 Jan;92(1-2):28-32. doi: 10.1111/avj.12142.


Functional polymorphism in the brain-derived neurotrophic factor gene interacts with stressful life events but not childhood maltreatment in the etiology of depression.

Brown GW, Craig TK, Harris TO, Herbert J, Hodgson K, Tansey KE, Uher R.

Depress Anxiety. 2014 Apr;31(4):326-34. doi: 10.1002/da.22221. Epub 2013 Dec 12.


A role for USP7 in DNA replication.

Jagannathan M, Nguyen T, Gallo D, Luthra N, Brown GW, Saridakis V, Frappier L.

Mol Cell Biol. 2014 Jan;34(1):132-45. doi: 10.1128/MCB.00639-13. Epub 2013 Nov 4.


Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.

Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D 3rd, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W.

Nat Neurosci. 2013 Sep;16(9):1238-47. doi: 10.1038/nn.3479. Epub 2013 Aug 4.

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