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Framework for advancing rigorous research.

Koroshetz WJ, Behrman S, Brame CJ, Branchaw JL, Brown EN, Clark EA, Dockterman D, Elm JJ, Gay PL, Green KM, Hsi S, Kaplitt MG, Kolber BJ, Kolodkin AL, Lipscombe D, MacLeod MR, McKinney CC, Munafò MR, Oakley B, Olimpo JT, Percie du Sert N, Raman IM, Riley C, Shelton AL, Uzzo SM, Crawford DC, Silberberg SD.

Elife. 2020 Mar 4;9. pii: e55915. doi: 10.7554/eLife.55915.


Evaluation of the efficacy and safety of apixaban and rivaroxaban in cancer patients receiving concomitant active anti-neoplastic therapy at an outpatient cancer setting.

Yassine D, Brown EN, Putney D, Fasoranti O.

J Oncol Pharm Pract. 2020 Feb 16:1078155220901777. doi: 10.1177/1078155220901777. [Epub ahead of print] No abstract available.


A Multitaper Frequency-Domain Bootstrap Method.

Kim SE, Ba D, Brown EN.

IEEE Signal Process Lett. 2018 Dec;25(12):1805-1809. doi: 10.1109/lsp.2018.2876606. Epub 2018 Oct 17.


A hidden semi-Markov model for estimating burst suppression EEG.

Chakravarty S, Baum TE, An J, Kahali P, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:7076-7079. doi: 10.1109/EMBC.2019.8856802.


A Systematic Method for Preprocessing and Analyzing Electrodermal Activity.

Subramanian S, Barbieri R, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:6902-6905. doi: 10.1109/EMBC.2019.8857757.


State-Space Global Coherence to Estimate the Spatio-Temporal Dynamics of the Coordinated Brain Activity.

Yousefi A, Fard RS, Eden UT, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:5794-5798. doi: 10.1109/EMBC.2019.8856634.


Delta oscillations phase limit neural activity during sevoflurane anesthesia.

Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O.

Commun Biol. 2019 Nov 15;2:415. doi: 10.1038/s42003-019-0664-3. eCollection 2019.


Model-based physiological noise removal in fast fMRI.

Agrawal U, Brown EN, Lewis LD.

Neuroimage. 2020 Jan 15;205:116231. doi: 10.1016/j.neuroimage.2019.116231. Epub 2019 Oct 4.


Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study.

Koch S, Feinkohl I, Chakravarty S, Windmann V, Lichtner G, Pischon T, Brown EN, Spies C; BioCog Study Group.

Dement Geriatr Cogn Disord. 2019;48(1-2):83-92. doi: 10.1159/000502950. Epub 2019 Oct 2.


Disruption of the ascending arousal network in acute traumatic disorders of consciousness.

Snider SB, Bodien YG, Bianciardi M, Brown EN, Wu O, Edlow BL.

Neurology. 2019 Sep 24;93(13):e1281-e1287. doi: 10.1212/WNL.0000000000008163. Epub 2019 Sep 4.


Neurologic Examination for Anesthesiologists: Reply.

Brown EN.

Anesthesiology. 2019 Oct;131(4):946. doi: 10.1097/ALN.0000000000002913. No abstract available.


Influence of midazolam premedication on intraoperative EEG signatures in elderly patients.

Windmann V, Spies C, Brown EN, Kishnan D, Lichtner G, Koch S; BioCog Study Group.

Clin Neurophysiol. 2019 Sep;130(9):1673-1681. doi: 10.1016/j.clinph.2019.05.035. Epub 2019 Jul 10.


Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy.

Ghassemi MM, Amorim E, Alhanai T, Lee JW, Herman ST, Sivaraju A, Gaspard N, Hirsch LJ, Scirica BM, Biswal S, Moura Junior V, Cash SS, Brown EN, Mark RG, Westover MB; Critical Care Electroencephalogram Monitoring Research Consortium.

Crit Care Med. 2019 Oct;47(10):1416-1423. doi: 10.1097/CCM.0000000000003840.


In Response.

Brown EN.

Anesth Analg. 2019 Jun;128(6):e131. doi: 10.1213/ANE.0000000000004168. No abstract available.


The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray/Dorsal Raphe: Separating Analgesia and Anxiety.

Taylor NE, Pei J, Zhang J, Vlasov KY, Davis T, Taylor E, Weng FJ, Van Dort CJ, Solt K, Brown EN.

eNeuro. 2019 Feb 19;6(1). pii: ENEURO.0018-18.2019. doi: 10.1523/ENEURO.0018-18.2019. eCollection 2019 Jan-Feb.


Computational Neuroscience: Mathematical and Statistical Perspectives.

Kass RE, Amari SI, Arai K, Brown EN, Diekman CO, Diesmann M, Doiron B, Eden UT, Fairhall AL, Fiddyment GM, Fukai T, Grün S, Harrison MT, Helias M, Nakahara H, Teramae JN, Thomas PJ, Reimers M, Rodu J, Rotstein HG, Shea-Brown E, Shimazaki H, Shinomoto S, Yu BM, Kramer MA.

Annu Rev Stat Appl. 2018 Mar;5:183-214. doi: 10.1146/annurev-statistics-041715-033733. Epub 2017 Dec 8.


Correction: Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile.

MacCormick IJC, Williams BM, Zheng Y, Li K, Al-Bander B, Czanner S, Cheeseman R, Willoughby CE, Brown EN, Spaeth GL, Czanner G.

PLoS One. 2019 Apr 3;14(4):e0215056. doi: 10.1371/journal.pone.0215056. eCollection 2019.


Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.

Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH.

Cell. 2019 Apr 4;177(2):256-271.e22. doi: 10.1016/j.cell.2019.02.014. Epub 2019 Mar 14.


Developing a personalized closed-loop controller of medically-induced coma in a rodent model.

Yang Y, Lee JT, Guidera JA, Vlasov KY, Pei J, Brown EN, Solt K, Shanechi MM.

J Neural Eng. 2019 Jun;16(3):036022. doi: 10.1088/1741-2552/ab0ea4. Epub 2019 Mar 11.


A Neurologic Examination for Anesthesiologists: Assessing Arousal Level during Induction, Maintenance, and Emergence.

Reshef ER, Schiff ND, Brown EN.

Anesthesiology. 2019 Mar;130(3):462-471. doi: 10.1097/ALN.0000000000002559. Review.


Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile.

MacCormick IJC, Williams BM, Zheng Y, Li K, Al-Bander B, Czanner S, Cheeseman R, Willoughby CE, Brown EN, Spaeth GL, Czanner G.

PLoS One. 2019 Jan 10;14(1):e0209409. doi: 10.1371/journal.pone.0209409. eCollection 2019. Erratum in: PLoS One. 2019 Apr 3;14(4):e0215056.


Automated Assessment of Loss of Consciousness Using Whisker And Paw Movements During Anesthetic Dosing in Head-Fixed Rodents.

An J, Flores FJ, Kodandaramaiah SB, Dalla Betta I, Nikolaeva K, Boyden ES, Forest CR, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:730-733. doi: 10.1109/EMBC.2018.8512377.


A Point Process Characterization Of Electrodermal Activity.

Subramanian S, Barbieri R, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:37-40. doi: 10.1109/EMBC.2018.8512211.


A Smoother State Space Multitaper Spectrogram.

Song AH, Chakravarty S, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:33-36. doi: 10.1109/EMBC.2018.8512190.


Variability in pharmacologically-induced coma for treatment of refractory status epilepticus.

An J, Jonnalagadda D, Moura V Junior, Purdon PL, Brown EN, Westover MB.

PLoS One. 2018 Oct 31;13(10):e0205789. doi: 10.1371/journal.pone.0205789. eCollection 2018.


Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial.

Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C.

J Affect Disord. 2019 Jan 15;243:516-524. doi: 10.1016/j.jad.2018.09.037. Epub 2018 Sep 17.


Multimodal General Anesthesia: Theory and Practice.

Brown EN, Pavone KJ, Naranjo M.

Anesth Analg. 2018 Nov;127(5):1246-1258. doi: 10.1213/ANE.0000000000003668. Review.


A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans.

Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL.

Elife. 2018 Aug 10;7. pii: e33250. doi: 10.7554/eLife.33250.


SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism.

Liu M, Shi R, Hwang H, Han KS, Wong MH, Ren X, Lewis LD, Brown EN, Xu W.

J Neurophysiol. 2018 Oct 1;120(4):1578-1586. doi: 10.1152/jn.00731.2017. Epub 2018 Aug 1.


Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia.

Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH.

Nature. 2018 Oct;562(7725):E1. doi: 10.1038/s41586-018-0351-4.


Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder.

Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL.

Front Syst Neurosci. 2018 Jun 22;12:23. doi: 10.3389/fnsys.2018.00023. eCollection 2018.


Using EEG markers to make inferences about anaesthetic-induced altered states of arousal.

Brown EN, Purdon PL, Akeju O, An J.

Br J Anaesth. 2018 Jul;121(1):325-327. doi: 10.1016/j.bja.2017.12.034. Epub 2018 Mar 14. No abstract available.


Left-Lateralized Contributions of Saccades to Cortical Activity During a One-Back Word Recognition Task.

Chang YC, Khan S, Taulu S, Kuperberg G, Brown EN, Hämäläinen MS, Temereanca S.

Front Neural Circuits. 2018 May 16;12:38. doi: 10.3389/fncir.2018.00038. eCollection 2018.


Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old.

Cornelissen L, Kim SE, Lee JM, Brown EN, Purdon PL, Berde CB.

Br J Anaesth. 2018 Jun;120(6):1274-1286. doi: 10.1016/j.bja.2018.01.037. Epub 2018 Apr 5.


Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.

Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM.

Cell. 2018 May 31;173(6):1329-1342.e18. doi: 10.1016/j.cell.2018.04.004. Epub 2018 May 3.


Rate of Unverifiable Publications Among Ophthalmology Residency Applicants Invited to Interview.

Tamez HM, Tauscher R, Brown EN, Wayman L, Mawn LA.

JAMA Ophthalmol. 2018 Jun 1;136(6):630-635. doi: 10.1001/jamaophthalmol.2018.0846.


Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial.

Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O.

BMJ Open. 2018 Apr 20;8(4):e020316. doi: 10.1136/bmjopen-2017-020316.


Similar Performance of Trabectome and Ahmed Glaucoma Devices in a Propensity Score-matched Comparison.

Esfandiari H, Shazly TA, Waxman SA, Kola S, Kaplowitz KB, Brown EN, Loewen NA.

J Glaucoma. 2018 Jun;27(6):490-495. doi: 10.1097/IJG.0000000000000960.


Multi-neuron intracellular recording in vivo via interacting autopatching robots.

Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR.

Elife. 2018 Jan 3;7. pii: e24656. doi: 10.7554/eLife.24656.


State-space multitaper time-frequency analysis.

Kim SE, Behr MK, Ba D, Brown EN.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E5-E14. doi: 10.1073/pnas.1702877115. Epub 2017 Dec 18.


Thalamocortical control of propofol phase-amplitude coupling.

Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N.

PLoS Comput Biol. 2017 Dec 11;13(12):e1005879. doi: 10.1371/journal.pcbi.1005879. eCollection 2017 Dec.


Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study.

Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN.

Clin Neurophysiol. 2018 Jan;129(1):69-78. doi: 10.1016/j.clinph.2017.10.005. Epub 2017 Oct 20.


Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma.

Jingzhi An, Purdon PL, Solt K, Sims NM, Brown EN, Westover MB.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:4313-4316. doi: 10.1109/EMBC.2017.8037810.


Automated ovarian follicular monitoring: A novel real-time approach.

Faghih RT, Styer AK, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:632-635. doi: 10.1109/EMBC.2017.8036904.


Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching.

Kostanyan T, Shazly T, Kaplowitz KB, Wang SZ, Kola S, Brown EN, Loewen NA.

Graefes Arch Clin Exp Ophthalmol. 2017 Dec;255(12):2423-2428. doi: 10.1007/s00417-017-3804-9. Epub 2017 Sep 25.


Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness.

Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6660-E6668. doi: 10.1073/pnas.1700148114. Epub 2017 Jul 25.


Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats.

Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K.

Front Neural Circuits. 2017 Jul 4;11:36. doi: 10.3389/fncir.2017.00036. eCollection 2017.


A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children.

Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL.

Anesthesiology. 2017 Aug;127(2):293-306. doi: 10.1097/ALN.0000000000001717.


Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis.

Plapp BV, Savarimuthu BR, Ferraro DJ, Rubach JK, Brown EN, Ramaswamy S.

Biochemistry. 2017 Jul 18;56(28):3632-3646. doi: 10.1021/acs.biochem.7b00446. Epub 2017 Jul 7.


Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans.

Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O.

J Neurosci. 2017 Jul 19;37(29):6938-6945. doi: 10.1523/JNEUROSCI.0446-17.2017. Epub 2017 Jun 16.

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