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INFERNO: inferring the molecular mechanisms of noncoding genetic variants.

Amlie-Wolf A, Tang M, Mlynarski EE, Kuksa PP, Valladares O, Katanic Z, Tsuang D, Brown CD, Schellenberg GD, Wang LS.

Nucleic Acids Res. 2018 Aug 3. doi: 10.1093/nar/gky686. [Epub ahead of print]


The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance.

Kumar V, Yin J, Billington S, Prasad B, Brown CDA, Wang J, Unadkat JD.

Drug Metab Dispos. 2018 Oct;46(10):1441-1445. doi: 10.1124/dmd.118.082313. Epub 2018 Aug 9.


Biotic and abiotic drivers of tree seedling recruitment across an alpine treeline ecotone.

Frei ER, Bianchi E, Bernareggi G, Bebi P, Dawes MA, Brown CD, Trant AJ, Mamet SD, Rixen C.

Sci Rep. 2018 Jul 18;8(1):10894. doi: 10.1038/s41598-018-28808-w.


Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans.

Khetarpal SA, Babb PL, Zhao W, Hancock-Cerutti WF, Brown CD, Rader DJ, Voight BF.

Circ Genom Precis Med. 2018 Jul;11(7):e002070. doi: 10.1161/CIRCGEN.117.002070.


Transposable elements generate regulatory novelty in a tissue-specific fashion.

Trizzino M, Kapusta A, Brown CD.

BMC Genomics. 2018 Jun 18;19(1):468. doi: 10.1186/s12864-018-4850-3.


High-density lipoprotein carbamylation and dysfunction in vascular disease.

Santana JM, Brown CD.

Front Biosci (Landmark Ed). 2018 Jun 1;23:2227-2234.


Assessment of exposure of professional agricultural operators to pesticides.

Wong HL, Garthwaite DG, Ramwell CT, Brown CD.

Sci Total Environ. 2018 Apr 1;619-620:874-882. doi: 10.1016/j.scitotenv.2017.11.127. Epub 2017 Nov 29.


Impact of social complexity on outcomes in cystic fibrosis after transfer to adult care.

Crowley EM, Bosslet GT, Khan B, Ciccarelli M, Brown CD.

Pediatr Pulmonol. 2018 Jun;53(6):735-740. doi: 10.1002/ppul.23997. Epub 2018 Apr 2.


Assessment of acute toxicity tests and rhizotron experiments to characterize lethal and sublethal control of soil-based pests.

Agatz A, Schumann MM, French BW, Brown CD, Vidal S.

Pest Manag Sci. 2018 Mar 24. doi: 10.1002/ps.4922. [Epub ahead of print]


Prospective aquatic risk assessment for chemical mixtures in agricultural landscapes.

Holmes CM, Brown CD, Hamer M, Jones R, Maltby L, Posthuma L, Silberhorn E, Teeter JS, Warne MSJ, Weltje L.

Environ Toxicol Chem. 2018 Mar;37(3):674-689. doi: 10.1002/etc.4049. Epub 2018 Feb 12.


A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

Gallagher MD, Posavi M, Huang P, Unger TL, Berlyand Y, Gruenewald AL, Chesi A, Manduchi E, Wells AD, Grant SFA, Blobel GA, Brown CD, Chen-Plotkin AS.

Am J Hum Genet. 2017 Nov 2;101(5):643-663. doi: 10.1016/j.ajhg.2017.09.004. Epub 2017 Oct 19.


Genetic effects on gene expression across human tissues.

GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz; Lead analysts:; Laboratory, Data Analysis &Coordinating Center (LDACC):; NIH program management:; Biospecimen collection:; Pathology:; eQTL manuscript working group:, Battle A, Brown CD, Engelhardt BE, Montgomery SB.

Nature. 2017 Oct 11;550(7675):204-213. doi: 10.1038/nature24277. Erratum in: Nature. 2017 Dec 20;:.


How does exposure to pesticides vary in space and time for residents living near to treated orchards?

Wong HL, Garthwaite DG, Ramwell CT, Brown CD.

Environ Sci Pollut Res Int. 2017 Dec;24(34):26444-26461. doi: 10.1007/s11356-017-0064-5. Epub 2017 Sep 25.


Transposable elements are the primary source of novelty in primate gene regulation.

Trizzino M, Park Y, Holsbach-Beltrame M, Aracena K, Mika K, Caliskan M, Perry GH, Lynch VJ, Brown CD.

Genome Res. 2017 Oct;27(10):1623-1633. doi: 10.1101/gr.218149.116. Epub 2017 Aug 30.


Prospective mixture risk assessment and management prioritizations for river catchments with diverse land uses.

Posthuma L, Brown CD, de Zwart D, Diamond J, Dyer SD, Holmes CM, Marshall S, Burton GA Jr.

Environ Toxicol Chem. 2018 Mar;37(3):715-728. doi: 10.1002/etc.3960. Epub 2018 Feb 12.


Stercoral perforation of the colon in a heroin addict.

Brown CD, Maxwell F, French P, Nicholson G.

BMJ Case Rep. 2017 Aug 1;2017. pii: bcr-2016-218875. doi: 10.1136/bcr-2016-218875.


Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.

Ko YA, Yi H, Qiu C, Huang S, Park J, Ledo N, Köttgen A, Li H, Rader DJ, Pack MA, Brown CD, Susztak K.

Am J Hum Genet. 2017 Jun 1;100(6):940-953. doi: 10.1016/j.ajhg.2017.05.004.


Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.

Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, Marchadier DH, Rogov P, Shi J, Slovik KJ, Stylianou IM, Wang L, Yan R, Zhang X, Kathiresan S, Duncan SA, Mikkelsen TS, Morrisey EE, Rader DJ, Brown CD, Musunuru K.

Cell Stem Cell. 2017 Apr 6;20(4):558-570.e10. doi: 10.1016/j.stem.2017.03.017.


Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance.

Scotcher D, Billington S, Brown J, Jones CR, Brown CDA, Rostami-Hodjegan A, Galetin A.

Drug Metab Dispos. 2017 May;45(5):556-568. doi: 10.1124/dmd.117.075242. Epub 2017 Mar 7.


Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression.

Stricker TP, Brown CD, Bandlamudi C, McNerney M, Kittler R, Montoya V, Peterson A, Grossman R, White KP.

PLoS Genet. 2017 Mar 6;13(3):e1006589. doi: 10.1371/journal.pgen.1006589. eCollection 2017 Mar.


Prediction of pest pressure on corn root nodes: the POPP-Corn model.

Agatz A, Ashauer R, Sweeney P, Brown CD.

J Pest Sci (2004). 2017;90(1):161-172. doi: 10.1007/s10340-016-0788-x. Epub 2016 Jun 21.


Introducing the 2-DROPS model for two-dimensional simulation of crop roots and pesticide within the soil-root zone.

Agatz A, Brown CD.

Sci Total Environ. 2017 May 15;586:966-975. doi: 10.1016/j.scitotenv.2017.02.076. Epub 2017 Feb 16.


Increased burden of deleterious variants in essential genes in autism spectrum disorder.

Ji X, Kember RL, Brown CD, Bućan M.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15054-15059. doi: 10.1073/pnas.1613195113. Epub 2016 Dec 12.


Bringing PLOS Genetics Editors to Preprint Servers.

Barsh GS, Bergman CM, Brown CD, Singh ND, Copenhaver GP.

PLoS Genet. 2016 Dec 1;12(12):e1006448. doi: 10.1371/journal.pgen.1006448. eCollection 2016 Dec. No abstract available.


Increased seedling establishment via enemy release at the upper elevational range limit of sugar maple.

Urli M, Brown CD, Narváez Perez R, Chagnon PL, Vellend M.

Ecology. 2016 Nov;97(11):3058-3069. doi: 10.1002/ecy.1566.


Estimates of local biodiversity change over time stand up to scrutiny.

Vellend M, Dornelas M, Baeten L, Beauséjour R, Brown CD, De Frenne P, Elmendorf SC, Gotelli NJ, Moyes F, Myers-Smith IH, Magurran AE, McGill BJ, Shimadzu H, Sievers C.

Ecology. 2017 Feb;98(2):583-590. doi: 10.1002/ecy.1660. Epub 2017 Jan 9.


Influence of commercial formulation on the sorption and leaching behaviour of propyzamide in soil.

Khan MA, Brown CD.

Sci Total Environ. 2017 Feb 1;578:158-166. doi: 10.1016/j.scitotenv.2016.11.011. Epub 2016 Nov 12.


The Effectiveness of Neuromuscular Electrical Stimulation in Improving Voluntary Activation of the Quadriceps: A Critically Appraised Topic.

Bremner CB, Holcomb WR, Brown CD, Perreault ME.

J Sport Rehabil. 2017 Jul;26(4):316-323. doi: 10.1123/jsr.2015-0100. Epub 2016 Nov 11.


Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics.

Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD.

Drug Metab Dispos. 2016 Dec;44(12):1920-1924. Epub 2016 Sep 12.


Efficacy of intraoperative cell salvage in decreasing perioperative blood transfusion rates in first-time cardiac surgery patients: a retrospective study.

Côté CL, Yip AM, MacLeod JB, O'Reilly B, Murray J, Ouzounian M, Brown CD, Forgie R, Pelletier MP, Hassan A.

Can J Surg. 2016 Sep;59(5):330-6.


Influence of commercial formulation on leaching of four pesticides through soil.

Khan MA, Brown CD.

Sci Total Environ. 2016 Dec 15;573:1573-1579. doi: 10.1016/j.scitotenv.2016.09.076. Epub 2016 Sep 15.


Rheology Guided Rational Selection of Processing Temperature To Prepare Copovidone-Nifedipine Amorphous Solid Dispersions via Hot Melt Extrusion (HME).

Yang F, Su Y, Zhang J, DiNunzio J, Leone A, Huang C, Brown CD.

Mol Pharm. 2016 Oct 3;13(10):3494-3505. Epub 2016 Sep 14.


Utilizing Clinical Pharmacy Specialists to Address Access to Care Barriers in the Veteran Population for the Management of Diabetes.

Edwards KL, Hadley RL, Baby N, Yeary JC, Chastain LM, Brown CD.

J Pharm Pract. 2017 Aug;30(4):412-418. doi: 10.1177/0897190016663952. Epub 2016 Aug 27.


Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.


Long-term experiments to investigate irreversibility in sorption of pesticides to soil.

Suddaby LA, Beulke S, van Beinum W, Oliver RG, Kuet S, Brown CD.

Chemosphere. 2016 Nov;162:40-7. doi: 10.1016/j.chemosphere.2016.07.062. Epub 2016 Jul 29.


Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.

Gao C, McDowell IC, Zhao S, Brown CD, Engelhardt BE.

PLoS Comput Biol. 2016 Jul 28;12(7):e1004791. doi: 10.1371/journal.pcbi.1004791. eCollection 2016 Jul.


Plasma scale-length effects on electron energy spectra in high-irradiance laser plasmas.

Culfa O, Tallents GJ, Rossall AK, Wagenaars E, Ridgers CP, Murphy CD, Dance RJ, Gray RJ, McKenna P, Brown CD, James SF, Hoarty DJ, Booth N, Robinson AP, Lancaster KL, Pikuz SA, Faenov AY, Kampfer T, Schulze KS, Uschmann I, Woolsey NC.

Phys Rev E. 2016 Apr;93:043201. doi: 10.1103/PhysRevE.93.043201. Epub 2016 Apr 6.


Disentangling legacy effects from environmental filters of postfire assembly of boreal tree assemblages.

Brown CD, Liu J, Yan G, Johnstone JF.

Ecology. 2015 Nov;96(11):3023-32.


Rheological and solid-state NMR assessments of copovidone/clotrimazole model solid dispersions.

Yang F, Su Y, Zhu L, Brown CD, Rosen LA, Rosenberg KJ.

Int J Pharm. 2016 Mar 16;500(1-2):20-31. doi: 10.1016/j.ijpharm.2016.01.026. Epub 2016 Jan 15.


Crystal structure of rac-3-[2,3-bis-(phenyl-sulfan-yl)-3H-indol-3-yl]propanoic acid.

Noland WE, Brown CD, Bisel AM, Schneerer AK, Tritch KJ.

Acta Crystallogr E Crystallogr Commun. 2015 Oct 31;71(Pt 11):1414-7. doi: 10.1107/S2056989015020241. eCollection 2015 Nov 1.


Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.

Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP.

Mol Biol Evol. 2016 Feb;33(2):501-17. doi: 10.1093/molbev/msv248. Epub 2015 Nov 17.


Diving deeper to predict noncoding sequence function.

Engelhardt BE, Brown CD.

Nat Methods. 2015 Oct;12(10):925-6. doi: 10.1038/nmeth.3604. No abstract available.


Increased Distance From the Tertiary Cardiac Center Is Associated With Worse 30-Day Outcomes After Cardiac Operations.

Cote CL, Singh S, Yip AM, Murray J, MacLeod JB, Lutchmedial S, Brown CD, Forgie R, Pelletier MP, Hassan A.

Ann Thorac Surg. 2015 Dec;100(6):2213-8. doi: 10.1016/j.athoracsur.2015.05.058. Epub 2015 Aug 11.


Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster.

Jha AR, Miles CM, Lippert NR, Brown CD, White KP, Kreitman M.

Mol Biol Evol. 2015 Oct;32(10):2616-32. doi: 10.1093/molbev/msv136. Epub 2015 Jun 3.


Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines.

Dalzell AM, Mistry P, Wright J, Williams FM, Brown CD.

Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.


Autonomous actions of the human growth hormone long-range enhancer.

Yoo EJ, Brown CD, Tsai YC, Cooke NE, Liebhaber SA.

Nucleic Acids Res. 2015 Feb 27;43(4):2091-101. doi: 10.1093/nar/gkv093. Epub 2015 Feb 6.


Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.

Guo C, Ludvik AE, Arlotto ME, Hayes MG, Armstrong LL, Scholtens DM, Brown CD, Newgard CB, Becker TC, Layden BT, Lowe WL, Reddy TE.

Nat Commun. 2015 Feb 4;6:6069. doi: 10.1038/ncomms7069.


Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes.

Keck MK, Zuo Z, Khattri A, Stricker TP, Brown CD, Imanguli M, Rieke D, Endhardt K, Fang P, Brägelmann J, DeBoer R, El-Dinali M, Aktolga S, Lei Z, Tan P, Rozen SG, Salgia R, Weichselbaum RR, Lingen MW, Story MD, Ang KK, Cohen EE, White KP, Vokes EE, Seiwert TY.

Clin Cancer Res. 2015 Feb 15;21(4):870-81. doi: 10.1158/1078-0432.CCR-14-2481. Epub 2014 Dec 9.


Perceptions of oral health, preventive care, and care-seeking behaviors among rural adolescents.

Dodd VJ, Logan H, Brown CD, Calderon A, Catalanotto F.

J Sch Health. 2014 Dec;84(12):802-9. doi: 10.1111/josh.12215.


A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer.

Ferrara AM, Pappa T, Fu J, Brown CD, Peterson A, Moeller LC, Wyne K, White KP, Pluzhnikov A, Trubetskoy V, Nobrega M, Weiss RE, Dumitrescu AM, Refetoff S.

J Clin Endocrinol Metab. 2015 Jan;100(1):E173-81. doi: 10.1210/jc.2014-3490.

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