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Anti-tumor T-cell homeostatic activation is uncoupled from homeostatic inhibition by checkpoint blockade.

Marshall N, Hutchinson K, Marron TU, Aleynick M, Hammerich L, Upadhyay R, Svensson-Arvelund J, Brown BD, Merad M, Brody JD.

Cancer Discov. 2019 Aug 2. pii: CD-19-0391. doi: 10.1158/2159-8290.CD-19-0391. [Epub ahead of print]


CSF-1 controls cerebellar microglia and is required for motor function and social interaction.

Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M.

J Exp Med. 2019 Jul 26. pii: jem.20182037. doi: 10.1084/jem.20182037. [Epub ahead of print]


β-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma.

Ruiz de Galarreta M, Bresnahan E, Molina-Sánchez P, Lindblad KE, Maier B, Sia D, Puigvehi M, Miguela V, Casanova-Acebes M, Dhainaut M, Villacorta-Martin C, Singhi AD, Moghe A, von Felden J, Tal Grinspan L, Wang S, Kamphorst AO, Monga SP, Brown BD, Villanueva A, Llovet JM, Merad M, Lujambio A.

Cancer Discov. 2019 Aug;9(8):1124-1141. doi: 10.1158/2159-8290.CD-19-0074. Epub 2019 Jun 11.


Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination.

Hammerich L, Marron TU, Upadhyay R, Svensson-Arvelund J, Dhainaut M, Hussein S, Zhan Y, Ostrowski D, Yellin M, Marsh H, Salazar AM, Rahman AH, Brown BD, Merad M, Brody JD.

Nat Med. 2019 May;25(5):814-824. doi: 10.1038/s41591-019-0410-x. Epub 2019 Apr 8.


Direct Inhibition of β-catenin: A new strategy for colorectal cancer.

Ganesh S, Brown BD, Abrams M.

Oncoscience. 2019 Jan 31;6(1-2):294-295. doi: 10.18632/oncoscience.477. eCollection 2019 Jan. No abstract available.


The cis-Regulatory Atlas of the Mouse Immune System.

Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, Qi Y, Yu B, Robinette M, Kim KW, Wagers A, Rhoads A, Nutt SL, Brown BD, Mostafavi S, Buenrostro JD, Benoist C; Immunological Genome Project.

Cell. 2019 Feb 7;176(4):897-912.e20. doi: 10.1016/j.cell.2018.12.036. Epub 2019 Jan 24.


A miRNA-Mediated Approach to Dissect the Complexity of Tumor-Initiating Cell Function and Identify miRNA-Targeting Drugs.

Belur Nagaraj A, Joseph P, Ponting E, Fedorov Y, Singh S, Cole A, Lee W, Yoon E, Baccarini A, Scacheri P, Buckanovich R, Adams DJ, Drapkin R, Brown BD, DiFeo A.

Stem Cell Reports. 2019 Jan 8;12(1):122-134. doi: 10.1016/j.stemcr.2018.12.002.


miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy.

Oh JG, Watanabe S, Lee A, Gorski PA, Lee P, Jeong D, Liang L, Liang Y, Baccarini A, Sahoo S, Brown BD, Hajjar RJ, Kho C.

Circ Res. 2018 Aug 31;123(6):673-685. doi: 10.1161/CIRCRESAHA.118.312751.


Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.

Wroblewska A, Dhainaut M, Ben-Zvi B, Rose SA, Park ES, Amir ED, Bektesevic A, Baccarini A, Merad M, Rahman AH, Brown BD.

Cell. 2018 Nov 1;175(4):1141-1155.e16. doi: 10.1016/j.cell.2018.09.022. Epub 2018 Oct 18.


RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade.

Ganesh S, Shui X, Craig KP, Park J, Wang W, Brown BD, Abrams MT.

Mol Ther. 2018 Nov 7;26(11):2567-2579. doi: 10.1016/j.ymthe.2018.09.005. Epub 2018 Sep 13.


Acute Carpal Tunnel Syndrome After Canine Bite.

Brown BD, Roth TS, Gasner KA.

J Am Acad Orthop Surg Glob Res Rev. 2017 Dec 6;1(9):e069. doi: 10.5435/JAAOSGlobal-D-17-00069. eCollection 2017 Dec.


Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria.

Lai C, Pursell N, Gierut J, Saxena U, Zhou W, Dills M, Diwanji R, Dutta C, Koser M, Nazef N, Storr R, Kim B, Martin-Higueras C, Salido E, Wang W, Abrams M, Dudek H, Brown BD.

Mol Ther. 2018 Aug 1;26(8):1983-1995. doi: 10.1016/j.ymthe.2018.05.016. Epub 2018 Jun 15.


Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases.

Pursell N, Gierut J, Zhou W, Dills M, Diwanji R, Gjorgjieva M, Saxena U, Yang JS, Shah A, Venkat N, Storr R, Kim B, Wang W, Abrams M, Raffin M, Mithieux G, Rajas F, Dudek H, Brown BD, Lai C.

Mol Ther. 2018 Jul 5;26(7):1771-1782. doi: 10.1016/j.ymthe.2018.04.023. Epub 2018 Apr 27.


Quiescent Tissue Stem Cells Evade Immune Surveillance.

Agudo J, Park ES, Rose SA, Alibo E, Sweeney R, Dhainaut M, Kobayashi KS, Sachidanandam R, Baccarini A, Merad M, Brown BD.

Immunity. 2018 Feb 20;48(2):271-285.e5. doi: 10.1016/j.immuni.2018.02.001.


β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models.

Ganesh S, Shui X, Craig KP, Koser ML, Chopda GR, Cyr WA, Lai C, Dudek H, Wang W, Brown BD, Abrams MT.

Mol Cancer Ther. 2018 Feb;17(2):544-553. doi: 10.1158/1535-7163.MCT-17-0605. Epub 2017 Dec 27.


miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure.

Jeong D, Yoo J, Lee P, Kepreotis SV, Lee A, Wahlquist C, Brown BD, Kho C, Mercola M, Hajjar RJ.

Mol Ther. 2018 Mar 7;26(3):718-729. doi: 10.1016/j.ymthe.2017.11.014. Epub 2017 Nov 26.


Increased risk for complications following removal of hardware in patients with liver disease, pilon or pelvic fractures: A regression analysis.

Brown BD, Steinert JN, Stelzer JW, Yoon RS, Langford JR, Koval KJ.

Injury. 2017 Dec;48(12):2705-2708. doi: 10.1016/j.injury.2017.09.030. Epub 2017 Oct 3.


Micromanaging Tolerance in Hemophilia A Gene Therapy.

Jobson J, Brown BD.

Mol Ther. 2017 Aug 2;25(8):1739-1740. doi: 10.1016/j.ymthe.2017.06.001. Epub 2017 Jun 16. No abstract available.


Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.

Chia G, Agudo J, Treff N, Sauer MV, Billing D, Brown BD, Baer R, Egli D.

Nat Cell Biol. 2017 Apr;19(4):282-291. doi: 10.1038/ncb3485. Epub 2017 Mar 6.


WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma.

Wen J, Lee J, Malhotra A, Nahta R, Arnold AR, Buss MC, Brown BD, Maier C, Kenney AM, Remke M, Ramaswamy V, Taylor MD, Castellino RC.

Oncogene. 2016 Oct 20;35(42):5552-5564. doi: 10.1038/onc.2016.96. Epub 2016 Apr 18.


Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.

Ganesh S, Koser ML, Cyr WA, Chopda GR, Tao J, Shui X, Ying B, Chen D, Pandya P, Chipumuro E, Siddiquee Z, Craig K, Lai C, Dudek H, Monga SP, Wang W, Brown BD, Abrams MT.

Mol Cancer Ther. 2016 Sep;15(9):2143-54. doi: 10.1158/1535-7163.MCT-16-0309. Epub 2016 Jul 7.


Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis.

Chung CY, Sun Z, Mullokandov G, Bosch A, Qadeer ZA, Cihan E, Rapp Z, Parsons R, Aguirre-Ghiso JA, Farias EF, Brown BD, Gaspar-Maia A, Bernstein E.

Cell Rep. 2016 Jul 12;16(2):472-486. doi: 10.1016/j.celrep.2016.06.002. Epub 2016 Jun 23.


Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

Salmon H, Idoyaga J, Rahman A, Leboeuf M, Remark R, Jordan S, Casanova-Acebes M, Khudoynazarova M, Agudo J, Tung N, Chakarov S, Rivera C, Hogstad B, Bosenberg M, Hashimoto D, Gnjatic S, Bhardwaj N, Palucka AK, Brown BD, Brody J, Ginhoux F, Merad M.

Immunity. 2016 Apr 19;44(4):924-38. doi: 10.1016/j.immuni.2016.03.012.


Silence of the ROS.

Agudo J, Brown BD.

Immunity. 2016 Mar 15;44(3):520-522. doi: 10.1016/j.immuni.2016.02.027.


Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.

Dutta C, Avitahl-Curtis N, Pursell N, Larsson Cohen M, Holmes B, Diwanji R, Zhou W, Apponi L, Koser M, Ying B, Chen D, Shui X, Saxena U, Cyr WA, Shah A, Nazef N, Wang W, Abrams M, Dudek H, Salido E, Brown BD, Lai C.

Mol Ther. 2016 Apr;24(4):770-8. doi: 10.1038/mt.2016.4. Epub 2016 Jan 13.


Authorship: Archives and citation miss equal authors.

Brown BD, Merad M.

Nature. 2015 Dec 17;528(7582):333. doi: 10.1038/528333a. No abstract available.


Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report.

Brown BD, Rais T.

Innov Clin Neurosci. 2015 Sep-Oct;12(9-10):29-32.


Mapping the effects of drugs on the immune system.

Kidd BA, Wroblewska A, Boland MR, Agudo J, Merad M, Tatonetti NP, Brown BD, Dudley JT.

Nat Biotechnol. 2016 Jan;34(1):47-54. doi: 10.1038/nbt.3367. Epub 2015 Nov 30.


GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions.

Agudo J, Ruzo A, Park ES, Sweeney R, Kana V, Wu M, Zhao Y, Egli D, Merad M, Brown BD.

Nat Biotechnol. 2015 Dec;33(12):1287-1292. doi: 10.1038/nbt.3386. Epub 2015 Nov 2.


Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia.

Mulero-Navarro S, Sevilla A, Roman AC, Lee DF, D'Souza SL, Pardo S, Riess I, Su J, Cohen N, Schaniel C, Rodriguez NA, Baccarini A, Brown BD, Cavé H, Caye A, Strullu M, Yalcin S, Park CY, Dhandapany PS, Yongchao G, Edelmann L, Bahieg S, Raynal P, Flex E, Tartaglia M, Moore KA, Lemischka IR, Gelb BD.

Cell Rep. 2015 Oct 20;13(3):504-515. doi: 10.1016/j.celrep.2015.09.019. Epub 2015 Oct 8.


A shot in the bone corrects a genetic disease.

Brown BD.

Mol Ther. 2015 Apr;23(4):614-5. doi: 10.1038/mt.2015.38. No abstract available.


Cardiac arrest caused by a pacemaker check.

Orsborne C, Morris GM, Brown BD.

BMJ Case Rep. 2015 Jan 7;2015. pii: bcr2014206621. doi: 10.1136/bcr-2014-206621. No abstract available.


Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors.

Israelow B, Mullokandov G, Agudo J, Sourisseau M, Bashir A, Maldonado AY, Dar AC, Brown BD, Evans MJ.

Nat Commun. 2014 Nov 18;5:5408. doi: 10.1038/ncomms6408.


Retrospective analysis of safety and feasibility of a 3 days on/11 days off temozolomide dosing regimen in recurrent adult malignant gliomas.

van Vugt VA, Piccioni DE, Brown BD, Brown T, Saria MG, Juarez T, Kesari S.

CNS Oncol. 2014 Jul;3(4):257-65. doi: 10.2217/cns.14.29.


TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.

Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampé R, Brown BD, Amsen D, Whiteheart SW, Blander JM.

Cell. 2014 Jul 31;158(3):506-21. doi: 10.1016/j.cell.2014.04.054.


Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospective cohort study.

Scott BJ, van Vugt VA, Rush T, Brown T, Chen CC, Carter BS, Schwab R, Fanta P, Helsten T, Bazhenova L, Parker B, Pingle S, Saria MG, Brown BD, Piccioni DE, Kesari S.

J Neurooncol. 2014 Sep;119(2):361-8. doi: 10.1007/s11060-014-1486-2. Epub 2014 Jun 19.


Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.

Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Chen ZJ, Sanchez R, Shaw GS, Huang L, Pan ZQ.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8434-9. doi: 10.1073/pnas.1407849111. Epub 2014 May 27.


microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.

Parikh A, Lee C, Joseph P, Marchini S, Baccarini A, Kolev V, Romualdi C, Fruscio R, Shah H, Wang F, Mullokandov G, Fishman D, D'Incalci M, Rahaman J, Kalir T, Redline RW, Brown BD, Narla G, DiFeo A.

Nat Commun. 2014;5:2977. doi: 10.1038/ncomms3977.


The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.

Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD.

Nat Immunol. 2014 Jan;15(1):54-62. doi: 10.1038/ni.2767. Epub 2013 Nov 24.


Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.

Dudek H, Wong DH, Arvan R, Shah A, Wortham K, Ying B, Diwanji R, Zhou W, Holmes B, Yang H, Cyr WA, Zhou Y, Shah A, Farkiwala R, Lee M, Li Y, Rettig GR, Collingwood MA, Basu SK, Behlke MA, Brown BD.

Mol Ther. 2014 Jan;22(1):92-101. doi: 10.1038/mt.2013.233. Epub 2013 Oct 3.


Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study.

Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE.

Nutr Res. 2013 May;33(5):367-75. doi: 10.1016/j.nutres.2013.02.012. Epub 2013 Apr 1.


Stealth gene therapy.

Brown BD.

Blood. 2013 Mar 21;121(12):2168-9. doi: 10.1182/blood-2013-01-480368. No abstract available.


Retrospective analysis of the tolerability and activity of lacosamide in patients with brain tumors: clinical article.

Saria MG, Corle C, Hu J, Rudnick JD, Phuphanich S, Mrugala MM, Crew LK, Bota DA, Dan Fu B, Kim RY, Brown T, Feely H, Brechlin J, Brown BD, Drappatz J, Wen PY, Chen CC, Carter B, Lee JW, Kesari S.

J Neurosurg. 2013 Jun;118(6):1183-7. doi: 10.3171/2013.1.JNS12397. Epub 2013 Mar 1.


Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M.

J Clin Invest. 2012 Nov;122(11):4037-47. doi: 10.1172/JCI60659. Epub 2012 Oct 8.


A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade.

Agudo J, Ruzo A, Kitur K, Sachidanandam R, Blander JM, Brown BD.

Mol Ther. 2012 Dec;20(12):2257-67. doi: 10.1038/mt.2012.150. Epub 2012 Aug 7.


Deciphering the transcriptional network of the dendritic cell lineage.

Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium.

Nat Immunol. 2012 Sep;13(9):888-99. doi: 10.1038/ni.2370. Epub 2012 Jul 15.


High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries.

Mullokandov G, Baccarini A, Ruzo A, Jayaprakash AD, Tung N, Israelow B, Evans MJ, Sachidanandam R, Brown BD.

Nat Methods. 2012 Jul 1;9(8):840-6. doi: 10.1038/nmeth.2078.


GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.

Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M.

Immunity. 2012 Jun 29;36(6):1031-46. doi: 10.1016/j.immuni.2012.03.027.


Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.

Mena S, Rodriguez ML, Ortega A, Priego S, Obrador E, Asensi M, Petschen I, Cerdá M, Brown BD, Estrela JM.

J Transl Med. 2012 Jan 10;10:8. doi: 10.1186/1479-5876-10-8.


Quantitative analysis of dicer substrate oligonucleotides in mouse liver by ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

Jiao K, Rashid A, Basu SK, Zhu S, Brown BD, Guerciolini R, Fambrough DM.

Assay Drug Dev Technol. 2012 Jun;10(3):278-88. doi: 10.1089/adt.2011.0435. Epub 2011 Dec 22.


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