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Transcriptional responses of Candida glabrata biofilm cells to fluconazole are modulated by the carbon source.

Alves R, Kastora SL, Gomes-Gonçalves A, Azevedo N, Rodrigues CF, Silva S, Demuyser L, Van Dijck P, Casal M, Brown AJP, Henriques M, Paiva S.

NPJ Biofilms Microbiomes. 2020 Jan 23;6:4. doi: 10.1038/s41522-020-0114-5. eCollection 2020.


The mast cell receptor MrgX2 and drug-induced anaphylaxis.

Brown AJ, Grimes J, Desai S, Santos RM, Llobet AI, Mason A, Wu Z, Wolfe L, Wilk DD, Green A, Charter N.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106595. doi: 10.1016/j.vascn.2019.05.084. Epub 2019 Oct 17. No abstract available.


Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS.

Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6.


The environmental stress sensitivities of pathogenic Candida species, including Candida auris, and implications for their spread in the hospital setting.

Heaney H, Laing J, Paterson L, Walker AW, Gow NAR, Johnson EM, MacCallum DM, Brown AJP.

Med Mycol. 2020 Jan 7. pii: myz127. doi: 10.1093/mmy/myz127. [Epub ahead of print]


Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.

Capell-Hattam IM, Sharpe LJ, Qian L, Hart-Smith G, Prabhu AV, Brown AJ.

J Biol Chem. 2020 Jan 7. pii: jbc.RA119.011323. doi: 10.1074/jbc.RA119.011323. [Epub ahead of print]


The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.

Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ.

Biochem J. 2020 Jan 31;477(2):541-555. doi: 10.1042/BCJ20190647.


APOBEC3A is a prominent cytidine deaminase in breast cancer.

Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA.

PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec.


MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions.

Grimes J, Desai S, Charter NW, Lodge J, Moita Santos R, Isidro-Llobet A, Mason AM, Wu Z, Wolfe LA 3rd, Anantharaman L, Green A, Bridges AM, Dalmas Wilk DA, Brown AJ.

Pharmacol Res Perspect. 2019 Dec 2;7(6):e00547. doi: 10.1002/prp2.547. eCollection 2019 Dec.


Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance.

Childers DS, Avelar GM, Bain JM, Larcombe DE, Pradhan A, Budge S, Heaney H, Brown AJP.

Curr Top Microbiol Immunol. 2019 Nov 29. doi: 10.1007/82_2019_182. [Epub ahead of print]


A pilot randomised controlled trial evaluating the pharmacodynamic effects of furosemide versus acetazolamide in critically ill patients.

Brown AJ, Cutuli SL, Eastwood GM, Bitker L, Marsh P, Bellomo R.

Crit Care Resusc. 2019 Dec;21(4):258-64.


N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132.

Foster JR, Ueno S, Chen MX, Harvey J, Dowell SJ, Irving AJ, Brown AJ.

Pharmacol Res Perspect. 2019 Nov 21;7(6):e00542. doi: 10.1002/prp2.542. eCollection 2019 Dec.


Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion.

Pradhan A, Avelar GM, Bain JM, Childers D, Pelletier C, Larcombe DE, Shekhova E, Netea MG, Brown GD, Erwig L, Gow NAR, Brown AJP.

Nat Commun. 2019 Nov 22;10(1):5315. doi: 10.1038/s41467-019-13298-9.


Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function.

Xu Y, Du X, Turner N, Brown AJ, Yang H.

J Biol Chem. 2019 Dec 13;294(50):19306-19321. doi: 10.1074/jbc.RA119.011160. Epub 2019 Nov 14.


Association of Preoperative Patient Frailty and Operative Stress With Postoperative Mortality.

Shinall MC Jr, Arya S, Youk A, Varley P, Shah R, Massarweh NN, Shireman PK, Johanning JM, Brown AJ, Christie NA, Crist L, Curtin CM, Drolet BC, Dhupar R, Griffin J, Ibinson JW, Johnson JT, Kinney S, LaGrange C, Langerman A, Loyd GE, Mady LJ, Mott MP, Patri M, Siebler JC, Stimson CJ, Thorell WE, Vincent SA, Hall DE.

JAMA Surg. 2019 Nov 13:e194620. doi: 10.1001/jamasurg.2019.4620. [Epub ahead of print]


Synthesis-Controlled Polymorphism and Magnetic and Electrochemical Properties of Li3Co2SbO6.

Brown AJ, Xia Q, Avdeev M, Kennedy BJ, Ling CD.

Inorg Chem. 2019 Oct 21;58(20):13881-13891. doi: 10.1021/acs.inorgchem.9b01708. Epub 2019 Oct 4.


Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders.

Erskine D, Taylor JP, Bakker G, Brown AJH, Tasker T, Nathan PJ.

Drug Discov Today. 2019 Dec;24(12):2307-2314. doi: 10.1016/j.drudis.2019.08.009. Epub 2019 Sep 6. Review.


Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.

Chua NK, Scott NA, Brown AJ.

Biochem J. 2019 Sep 20;476(18):2545-2560. doi: 10.1042/BCJ20190418.


A wolf in sheep's clothing: unmasking the lanosterol-induced degradation of HMG-CoA reductase.

Coates HW, Brown AJ.

J Lipid Res. 2019 Oct;60(10):1643-1645. doi: 10.1194/jlr.C119000358. Epub 2019 Aug 28. No abstract available.


Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.

O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M.

Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9.


Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.

Coates HW, Chua NK, Brown AJ.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Nov;1864(11):1656-1668. doi: 10.1016/j.bbalip.2019.08.006. Epub 2019 Aug 15.


Discordance of intracoronary pressure-based indices in severe angiographic stenosis: are we missing the flow?

Michail M, Ihdayhid AR, Brown AJ, Ko B.

Cardiovasc Interv Ther. 2019 Aug 6. doi: 10.1007/s12928-019-00609-6. [Epub ahead of print] No abstract available.


The Most Valuable Resource Is Time: Insights From a Novel National Program to Improve Retention of Physician-Scientists With Caregiving Responsibilities.

Jones RD, Miller J, Vitous CA, Krenz C, Brady KT, Brown AJ, Daumit GL, Drake AF, Fraser VJ, Hartmann KE, Hochman JS, Girdler S, Libby AM, Mangurian C, Regensteiner JG, Yonkers K, Jagsi R.

Acad Med. 2019 Nov;94(11):1746-1756. doi: 10.1097/ACM.0000000000002903.


Comparative efficacy of gypsy moth (Lepidoptera: Erebidae) entomopathogens on transgenic blight-tolerant and wild-type American, Chinese, and hybrid chestnuts (Fagales: Fagaceae).

Brown AJ, Newhouse AE, Powell WA, Parry D.

Insect Sci. 2019 Jul 24. doi: 10.1111/1744-7917.12713. [Epub ahead of print]


Heterogeneity of Plaque Structural Stress Is Increased in Plaques Leading to MACE: Insights From the PROSPECT Study.

Costopoulos C, Maehara A, Huang Y, Brown AJ, Gillard JH, Teng Z, Stone GW, Bennett MR.

JACC Cardiovasc Imaging. 2019 Jul 11. pii: S1936-878X(19)30559-5. doi: 10.1016/j.jcmg.2019.05.024. [Epub ahead of print]


Prehospital Diagnosis and Management of Acute Myocardial Infarction.

Brown AJ, Ha FJ, Michail M, West NEJ.

In: Watson TJ, Ong PJL, Tcheng JE, editors. Primary Angioplasty: A Practical Guide [Internet]. Singapore: Springer; 2018. Chapter 2.
2018 Jul 14.


Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata.

Chew SY, Ho KL, Cheah YK, Sandai D, Brown AJP, Than LTL.

Int J Mol Sci. 2019 Jun 28;20(13). pii: E3172. doi: 10.3390/ijms20133172.


Peripheral Circadian Oscillators.

Brown AJ, Pendergast JS, Yamazaki S.

Yale J Biol Med. 2019 Jun 27;92(2):327-335. eCollection 2019 Jun. Review.


Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.


Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease.

Ballard E, Zoll J, Melchers WJG, Brown AJP, Warris A, Verweij PE.

Data Brief. 2019 May 23;25:104021. doi: 10.1016/j.dib.2019.104021. eCollection 2019 Aug.


DNA Damage and Repair in Patients With Coronary Artery Disease: Correlation With Plaque Morphology Using Optical Coherence Tomography (DECODE Study).

Shah N, Meira LB, Elliott RM, Hoole SP, West NE, Brown AJ, Bennett MR, Garcia-Garcia HM, Kuku KO, Dan K, Kolm P, Mariathas M, Curzen N, Mahmoudi M.

Cardiovasc Revasc Med. 2019 Sep;20(9):812-818. doi: 10.1016/j.carrev.2019.04.028. Epub 2019 May 23.


The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.

Alrosan A, Aleidi SM, Yang A, Brown AJ, Gelissen IC.

Int J Mol Sci. 2019 Jun 2;20(11). pii: E2714. doi: 10.3390/ijms20112714.


Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism.

Ballard E, Weber J, Melchers WJG, Tammireddy S, Whitfield PD, Brakhage AA, Brown AJP, Verweij PE, Warris A.

Fungal Genet Biol. 2019 Sep;130:98-106. doi: 10.1016/j.fgb.2019.05.005. Epub 2019 May 23.


The FTO Gene and Measured Food Intake in 5- to 10-Year-Old Children Without Obesity.

Ranzenhofer LM, Mayer LES, Davis HA, Mielke-Maday HK, McInerney H, Korn R, Gupta N, Brown AJ, Schebendach J, Tanofsky-Kraff M, Thaker V, Chung WK, Leibel RL, Walsh BT, Rosenbaum M.

Obesity (Silver Spring). 2019 Jun;27(6):1023-1029. doi: 10.1002/oby.22464.


A very persistent chicken bone: two separate perforations from the same foreign object 2 months apart.

Brown AJ, Whitehead-Clarke T, Tudyka V.

BMJ Case Rep. 2019 May 15;12(5). pii: e228050. doi: 10.1136/bcr-2018-228050.


Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.

Chua NK, Hart-Smith G, Brown AJ.

J Biol Chem. 2019 May 17;294(20):8134-8147. doi: 10.1074/jbc.RA119.007798. Epub 2019 Apr 2.


Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression, and changes in composition.

Costopoulos C, Timmins LH, Huang Y, Hung OY, Molony DS, Brown AJ, Davis EL, Teng Z, Gillard JH, Samady H, Bennett MR.

Eur Heart J. 2019 May 7;40(18):1411-1422. doi: 10.1093/eurheartj/ehz132.


Adaptations to Coronary Physiology in a Patient With Severe Aortic Stenosis and Complete Heart Block Undergoing Transcatheter Aortic Valve Replacement.

Michail M, Asrress KN, Cameron JD, Gooley R, McCormick LM, Hughes AD, Brown AJ.

JACC Cardiovasc Interv. 2019 Apr 8;12(7):687-689. doi: 10.1016/j.jcin.2019.01.215. Epub 2019 Mar 13. No abstract available.


Requirements for Portable Instrument Suites during Human Scientific Exploration of Mars.

Sehlke A, Mirmalek Z, Burtt D, Haberle CW, Santiago-Materese D, Kobs Nawotniak SE, Hughes SS, Garry WB, Bramall N, Brown AJ, Heldmann JL, Lim DSS.

Astrobiology. 2019 Mar;19(3):401-425. doi: 10.1089/ast.2018.1841.


Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata.

Chew SY, Ho KL, Cheah YK, Ng TS, Sandai D, Brown AJP, Than LTL.

Sci Rep. 2019 Feb 26;9(1):2843. doi: 10.1038/s41598-019-39117-1.


Recurrent Noncoding Mutations in Skin Cancers: UV Damage Susceptibility or Repair Inhibition as Primary Driver?

Roberts SA, Brown AJ, Wyrick JJ.

Bioessays. 2019 Mar;41(3):e1800152. doi: 10.1002/bies.201800152. Epub 2019 Feb 25. Review.


The shape of human squalene epoxidase expands the arsenal against cancer.

Brown AJ, Chua NK, Yan N.

Nat Commun. 2019 Feb 21;10(1):888. doi: 10.1038/s41467-019-08866-y. Review.


Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.

Dong J, Du X, Wang H, Wang J, Lu C, Chen X, Zhu Z, Luo Z, Yu L, Brown AJ, Yang H, Wu JW.

Nat Commun. 2019 Feb 19;10(1):829. doi: 10.1038/s41467-019-08791-0.


CHO genome mining for synthetic promoter design.

Johari YB, Brown AJ, Alves CS, Zhou Y, Wright CM, Estes SD, Kshirsagar R, James DC.

J Biotechnol. 2019 Mar 20;294:1-13. doi: 10.1016/j.jbiotec.2019.01.015. Epub 2019 Jan 28.


Off- vs. On-Pump Coronary Artery Bypass Grafting Long-Term Survival is Driven by Incompleteness of Revascularisation.

Thakur U, Nerlekar N, Muthalaly RG, Comella A, Wong NC, Cameron JD, Harper RW, Smith JA, Brown AJ.

Heart Lung Circ. 2020 Jan;29(1):149-155. doi: 10.1016/j.hlc.2018.11.019. Epub 2018 Dec 13.


A detour to sterol synthesis.

Baker MAB, Brown AJ.

Nat Microbiol. 2019 Feb;4(2):214-215. doi: 10.1038/s41564-018-0347-8. No abstract available.


Application of the DILEMMA score to improve lesion selection for invasive physiological assessment.

Michail M, Dehbi HM, Nerlekar N, Davies JE, Sharp ASP, Talwar S, Cameron JD, Brown AJ, Wong DT, Mathur A, Hughes AD, Narayan O.

Catheter Cardiovasc Interv. 2019 Sep 1;94(3):E96-E103. doi: 10.1002/ccd.28054. Epub 2019 Jan 2.


ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).

Wang H, Ma Q, Qi Y, Dong J, Du X, Rae J, Wang J, Wu WF, Brown AJ, Parton RG, Wu JW, Yang H.

Mol Cell. 2019 Feb 7;73(3):458-473.e7. doi: 10.1016/j.molcel.2018.11.014. Epub 2018 Dec 20.


Biodegradable-Polymer Versus Polymer-Free Drug-Eluting Stents for the Treatment of Coronary Artery Disease.

Nogic J, Thein P, Mirzaee S, Comella A, Soon K, Cameron JD, West NEJ, Brown AJ.

Cardiovasc Revasc Med. 2019 Oct;20(10):865-870. doi: 10.1016/j.carrev.2018.12.010. Epub 2018 Dec 14.


Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function.

Nerlekar N, Muthalaly RG, Wong N, Thakur U, Wong DTL, Brown AJ, Marwick TH.

J Am Heart Assoc. 2018 Dec 4;7(23):e009975. doi: 10.1161/JAHA.118.009975.


Periprocedural Myocardial Injury Predicts Short- and Long-Term Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement.

Michail M, Cameron JN, Nerlekar N, Ihdayhid AR, McCormick LM, Gooley R, Niccoli G, Crea F, Montone RA, Brown AJ.

Circ Cardiovasc Interv. 2018 Nov;11(11):e007106. doi: 10.1161/CIRCINTERVENTIONS.118.007106.


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