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Items: 1 to 50 of 57

1.

Regulation of a Eukaryotic Gene by GTP-Dependent Start Site Selection and Transcription Attenuation.

Kuehner JN, Brow DA.

Mol Cell. 2019 May 2;74(3):634. doi: 10.1016/j.molcel.2019.04.013. No abstract available.

PMID:
31051142
2.

An Allosteric Network for Spliceosome Activation Revealed by High-Throughput Suppressor Analysis in Saccharomyces cerevisiae.

Brow DA.

Genetics. 2019 May;212(1):111-124. doi: 10.1534/genetics.119.301922. Epub 2019 Mar 21.

PMID:
30898770
3.

Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA.

Montemayor EJ, Didychuk AL, Yake AD, Sidhu GK, Brow DA, Butcher SE.

Nat Commun. 2018 May 1;9(1):1749. doi: 10.1038/s41467-018-04145-4.

4.

The life of U6 small nuclear RNA, from cradle to grave.

Didychuk AL, Butcher SE, Brow DA.

RNA. 2018 Apr;24(4):437-460. doi: 10.1261/rna.065136.117. Epub 2018 Jan 24. Review.

5.

Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities.

Didychuk AL, Montemayor EJ, Carrocci TJ, DeLaitsch AT, Lucarelli SE, Westler WM, Brow DA, Hoskins AA, Butcher SE.

Nat Commun. 2017 Sep 8;8(1):497. doi: 10.1038/s41467-017-00484-w.

6.

Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome.

Chen X, Poorey K, Carver MN, Müller U, Bekiranov S, Auble DT, Brow DA.

PLoS Genet. 2017 Jun 30;13(6):e1006863. doi: 10.1371/journal.pgen.1006863. eCollection 2017 Jun.

7.

Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.

Montemayor EJ, Didychuk AL, Liao H, Hu P, Brow DA, Butcher SE.

Acta Crystallogr D Struct Biol. 2017 Jan 1;73(Pt 1):1-8. doi: 10.1107/S2059798316018222. Epub 2017 Jan 1.

8.

A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex.

Rodgers ML, Didychuk AL, Butcher SE, Brow DA, Hoskins AA.

Nucleic Acids Res. 2016 Dec 15;44(22):10912-10928. Epub 2016 Aug 2.

9.

Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly.

Didychuk AL, Montemayor EJ, Brow DA, Butcher SE.

Nucleic Acids Res. 2016 Feb 18;44(3):1398-410. doi: 10.1093/nar/gkv1374. Epub 2015 Dec 15.

10.

Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5'- to 3'-Helicase Activity with a Preference for Translocation on DNA Rather than RNA.

Martin-Tumasz S, Brow DA.

J Biol Chem. 2015 Sep 18;290(38):22880-9. doi: 10.1074/jbc.M115.674002. Epub 2015 Jul 20.

11.

An RNA mystery and its denouement.

Brow DA.

RNA. 2015 Apr;21(4):576-7. doi: 10.1261/rna.049668.115. No abstract available.

12.

Spliceosome assembly in the absence of stable U4/U6 RNA pairing.

Burke JE, Butcher SE, Brow DA.

RNA. 2015 May;21(5):923-34. doi: 10.1261/rna.048421.114. Epub 2015 Mar 11.

13.

Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.

Chen X, Müller U, Sundling KE, Brow DA.

Genetics. 2014 Oct;198(2):577-90. doi: 10.1534/genetics.114.167585. Epub 2014 Aug 12.

14.

Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution.

Montemayor EJ, Curran EC, Liao HH, Andrews KL, Treba CN, Butcher SE, Brow DA.

Nat Struct Mol Biol. 2014 Jun;21(6):544-51. doi: 10.1038/nsmb.2832. Epub 2014 May 18.

15.

An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8.

Price AM, Görnemann J, Guthrie C, Brow DA.

RNA. 2014 Jan;20(1):46-60. doi: 10.1261/rna.041970.113. Epub 2013 Nov 14.

16.

Sen-sing RNA terminators.

Brow DA.

Mol Cell. 2011 Jun 24;42(6):717-8. doi: 10.1016/j.molcel.2011.06.002.

17.

A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop.

Martin-Tumasz S, Richie AC, Clos LJ 2nd, Brow DA, Butcher SE.

Nucleic Acids Res. 2011 Sep 1;39(17):7837-47. doi: 10.1093/nar/gkr455. Epub 2011 Jun 7.

18.

Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24.

Martin-Tumasz S, Reiter NJ, Brow DA, Butcher SE.

RNA. 2010 Apr;16(4):792-804. doi: 10.1261/rna.1913310. Epub 2010 Feb 24.

19.

Eye on RNA unwinding.

Brow DA.

Nat Struct Mol Biol. 2009 Jan;16(1):7-8. doi: 10.1038/nsmb0109-7. No abstract available.

PMID:
19125166
20.

Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation.

Kuehner JN, Brow DA.

Mol Cell. 2008 Jul 25;31(2):201-11. doi: 10.1016/j.molcel.2008.05.018. Erratum in: Mol Cell. 2019 May 2;74(3):634.

21.

A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.

McManus CJ, Schwartz ML, Butcher SE, Brow DA.

RNA. 2007 Dec;13(12):2252-65. Epub 2007 Oct 9.

22.

Structure and interactions of the first three RNA recognition motifs of splicing factor prp24.

Bae E, Reiter NJ, Bingman CA, Kwan SS, Lee D, Phillips GN Jr, Butcher SE, Brow DA.

J Mol Biol. 2007 Apr 13;367(5):1447-58. Epub 2007 Feb 7.

23.

Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.

Steinmetz EJ, Warren CL, Kuehner JN, Panbehi B, Ansari AZ, Brow DA.

Mol Cell. 2006 Dec 8;24(5):735-746. doi: 10.1016/j.molcel.2006.10.023.

24.

Quantitative analysis of in vivo initiator selection by yeast RNA polymerase II supports a scanning model.

Kuehner JN, Brow DA.

J Biol Chem. 2006 May 19;281(20):14119-28. Epub 2006 Mar 29.

25.

cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II.

Steinmetz EJ, Ng SB, Cloute JP, Brow DA.

Mol Cell Biol. 2006 Apr;26(7):2688-96.

26.

Towards understanding the catalytic core structure of the spliceosome.

Butcher SE, Brow DA.

Biochem Soc Trans. 2005 Jun;33(Pt 3):447-9. Review.

PMID:
15916538
27.
28.

U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction.

Sashital DG, Cornilescu G, McManus CJ, Brow DA, Butcher SE.

Nat Struct Mol Biol. 2004 Dec;11(12):1237-42. Epub 2004 Nov 14. Erratum in: Nat Struct Mol Biol. 2005 Jan;12(1):99.

PMID:
15543154
29.
30.
31.

Allosteric cascade of spliceosome activation.

Brow DA.

Annu Rev Genet. 2002;36:333-60. Epub 2002 Jun 11. Review.

PMID:
12429696
32.

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.

Kuhn AN, Reichl EM, Brow DA.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9145-9. Epub 2002 Jun 26.

33.

Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure.

Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE.

Nat Struct Biol. 2002 Jun;9(6):431-5.

PMID:
11992125
34.

RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts.

Steinmetz EJ, Conrad NK, Brow DA, Corden JL.

Nature. 2001 Sep 20;413(6853):327-31.

PMID:
11565036
38.

A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II.

Conrad NK, Wilson SM, Steinmetz EJ, Patturajan M, Brow DA, Swanson MS, Corden JL.

Genetics. 2000 Feb;154(2):557-71.

39.

Multiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangements.

Vidaver RM, Fortner DM, Loos-Austin LS, Brow DA.

Genetics. 1999 Nov;153(3):1205-18.

40.
45.
46.
47.

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.

Fortner DM, Troy RG, Brow DA.

Genes Dev. 1994 Jan;8(2):221-33.

48.

A rapid assay for quantitative detection of specific RNAs.

Li Z, Brow DA.

Nucleic Acids Res. 1993 Sep 25;21(19):4645-6. No abstract available.

49.

Architecture of a yeast U6 RNA gene promoter.

Eschenlauer JB, Kaiser MW, Gerlach VL, Brow DA.

Mol Cell Biol. 1993 May;13(5):3015-26.

50.

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