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Items: 1 to 50 of 52

1.

The genome sequences of Himalayan Saccharomyces eubayanus revealed genetic markers explaining heterotic maltotriose consumption by hybrid Saccharomyces pastorianus.

Brouwers N, Brickwedde A, Gorter de Vries AR, van den Broek M, Weening SM, van den Eijnden L, Diderich JA, Bai FY, Pronk JT, Daran JG.

Appl Environ Microbiol. 2019 Sep 13. pii: AEM.01516-19. doi: 10.1128/AEM.01516-19. [Epub ahead of print]

2.

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.

Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J.

J Cell Biol. 2019 Sep 5. pii: jcb.201902028. doi: 10.1083/jcb.201902028. [Epub ahead of print]

PMID:
31488582
3.

Laboratory Evolution of a Saccharomyces cerevisiae × S. eubayanus Hybrid Under Simulated Lager-Brewing Conditions.

Gorter de Vries AR, Voskamp MA, van Aalst ACA, Kristensen LH, Jansen L, van den Broek M, Salazar AN, Brouwers N, Abeel T, Pronk JT, Daran JG.

Front Genet. 2019 Mar 29;10:242. doi: 10.3389/fgene.2019.00242. eCollection 2019.

4.

In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation.

Brouwers N, Gorter de Vries AR, van den Broek M, Weening SM, Elink Schuurman TD, Kuijpers NGA, Pronk JT, Daran JG.

PLoS Genet. 2019 Apr 4;15(4):e1007853. doi: 10.1371/journal.pgen.1007853. eCollection 2019 Apr.

5.

GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion.

Chiritoiu M, Brouwers N, Turacchio G, Pirozzi M, Malhotra V.

Dev Cell. 2019 Apr 8;49(1):145-155.e4. doi: 10.1016/j.devcel.2019.02.011. Epub 2019 Mar 14.

PMID:
30880003
6.

Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells.

Cantero-Recasens G, Butnaru CM, Brouwers N, Mitrovic S, Valverde MA, Malhotra V.

J Biol Chem. 2019 Jan 18;294(3):816-826. doi: 10.1074/jbc.RA117.000848. Epub 2018 Nov 27.

PMID:
30482841
7.

KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon.

Cantero-Recasens G, Butnaru CM, Valverde MA, Naranjo JR, Brouwers N, Malhotra V.

Elife. 2018 Oct 1;7. pii: e39729. doi: 10.7554/eLife.39729.

8.

Structural, Physiological and Regulatory Analysis of Maltose Transporter Genes in Saccharomyces eubayanus CBS 12357T.

Brickwedde A, Brouwers N, van den Broek M, Gallego Murillo JS, Fraiture JL, Pronk JT, Daran JG.

Front Microbiol. 2018 Aug 10;9:1786. doi: 10.3389/fmicb.2018.01786. eCollection 2018.

9.

Nanopore sequencing enables near-complete de novo assembly of Saccharomyces cerevisiae reference strain CEN.PK113-7D.

Salazar AN, Gorter de Vries AR, van den Broek M, Wijsman M, de la Torre Cortés P, Brickwedde A, Brouwers N, Daran JG, Abeel T.

FEMS Yeast Res. 2017 Nov 1;17(7). doi: 10.1093/femsyr/fox074.

10.

A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1.

Cruz-Garcia D, Brouwers N, Duran JM, Mora G, Curwin AJ, Malhotra V.

J Cell Biol. 2017 Aug 9. pii: jcb.201704056. doi: 10.1083/jcb.201704056. [Epub ahead of print]

11.

Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment.

Brouwers N, Mallol Martinez N, Vernos I.

PLoS One. 2017 Apr 26;12(4):e0174819. doi: 10.1371/journal.pone.0174819. eCollection 2017.

12.

ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.

Curwin AJ, Brouwers N, Alonso Y Adell M, Teis D, Turacchio G, Parashuraman S, Ronchi P, Malhotra V.

Elife. 2016 Apr 26;5. pii: e16299. doi: 10.7554/eLife.16299.

13.

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin.

Kleinberger G, Capell A, Brouwers N, Fellerer K, Sleegers K, Cruts M, Van Broeckhoven C, Haass C.

Neurobiol Aging. 2016 Mar;39:220.e17-26. doi: 10.1016/j.neurobiolaging.2015.12.014. Epub 2015 Dec 29.

PMID:
26811050
14.

TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export.

Santos AJ, Raote I, Scarpa M, Brouwers N, Malhotra V.

Elife. 2015 Nov 14;4. pii: e10982. doi: 10.7554/eLife.10982.

15.

Climate and landscape drivers of tree decline in a Mediterranean ecoregion.

Brouwers NC, Mercer J, Lyons T, Poot P, Veneklaas E, Hardy G.

Ecol Evol. 2012 Jan;3(1):67-79. doi: 10.1002/ece3.437. Epub 2012 Dec 5.

16.

Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.

Engelborghs S, Sleegers K, Van der Mussele S, Le Bastard N, Brouwers N, Van Broeckhoven C, De Deyn PP.

J Alzheimers Dis. 2013;35(1):67-73. doi: 10.3233/JAD-101305.

PMID:
23334703
17.

Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.

Hazrati LN, Van Cauwenberghe C, Brooks PL, Brouwers N, Ghani M, Sato C, Cruts M, Sleegers K, St George-Hyslop P, Van Broeckhoven C, Rogaeva E.

Neurobiol Aging. 2012 Dec;33(12):2949.e5-2949.e12. doi: 10.1016/j.neurobiolaging.2012.07.001. Epub 2012 Jul 21.

PMID:
22819390
18.

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.

Bettens K, Brouwers N, Engelborghs S, Lambert JC, Rogaeva E, Vandenberghe R, Le Bastard N, Pasquier F, Vermeulen S, Van Dongen J, Mattheijssens M, Peeters K, Mayeux R, St George-Hyslop P, Amouyel P, De Deyn PP, Sleegers K, Van Broeckhoven C.

Mol Neurodegener. 2012 Jan 16;7:3. doi: 10.1186/1750-1326-7-3.

19.

Potent amyloidogenicity and pathogenicity of Aβ43.

Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC.

Nat Neurosci. 2011 Jul 3;14(8):1023-32. doi: 10.1038/nn.2858.

PMID:
21725313
20.

APOE and Alzheimer disease: a major gene with semi-dominant inheritance.

Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fiévet N, Brouwers N, Bettens K, Arosio B, Coto E, Del Zompo M, Mateo I, Epelbaum J, Frank-Garcia A, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Seripa D, Galimberti D, Licastro F, Soininen H, Dartigues JF, Kamboh MI, Van Broeckhoven C, Lambert JC, Amouyel P, Campion D.

Mol Psychiatry. 2011 Sep;16(9):903-7. doi: 10.1038/mp.2011.52. Epub 2011 May 10.

21.

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.

Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B.

EMBO Mol Med. 2011 May;3(5):291-302. doi: 10.1002/emmm.201100138. Epub 2011 Apr 15.

22.

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.

Brouwers N, Van Cauwenberghe C, Engelborghs S, Lambert JC, Bettens K, Le Bastard N, Pasquier F, Montoya AG, Peeters K, Mattheijssens M, Vandenberghe R, Deyn PP, Cruts M, Amouyel P, Sleegers K, Van Broeckhoven C.

Mol Psychiatry. 2012 Feb;17(2):223-33. doi: 10.1038/mp.2011.24. Epub 2011 Mar 15.

23.

Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C.

J Neurosci. 2011 Feb 2;31(5):1885-94. doi: 10.1523/JNEUROSCI.5757-10.2011.

24.

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.

Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P.

J Alzheimers Dis. 2010;22(1):247-55. doi: 10.3233/JAD-2010-100933.

25.

Reply: Predicted pathogenic missense mutation of PGRN found in a normal control.

Sleegers K, Brouwers N, Van Broeckhoven C.

Ann Neurol. 2010 Jul;68(1):119. doi: 10.1002/ana.22056. No abstract available.

PMID:
20582989
26.

Contribution of TARDBP to Alzheimer's disease genetic etiology.

Brouwers N, Bettens K, Gijselinck I, Engelborghs S, Pickut BA, Van Miegroet H, Montoya AG, Mattheijssens M, Peeters K, De Deyn PP, Cruts M, Sleegers K, Van Broeckhoven C.

J Alzheimers Dis. 2010;21(2):423-30. doi: 10.3233/JAD-2010-100198.

PMID:
20555136
27.

Role of progranulin as a biomarker for Alzheimer's disease.

Sleegers K, Brouwers N, Van Broeckhoven C.

Biomark Med. 2010 Feb;4(1):37-50. Review.

PMID:
20387302
28.

Follow-up study of susceptibility loci for Alzheimer's disease and onset age identified by genome-wide association.

Bettens K, Brouwers N, Van Miegroet H, Gil A, Engelborghs S, De Deyn PP, Vandenberghe R, Van Broeckhoven C, Sleegers K.

J Alzheimers Dis. 2010;19(4):1169-75. doi: 10.3233/JAD-2010-1310.

PMID:
20308783
29.

Movement analyses of wood cricket ( Nemobius sylvestris) (Orthoptera: Gryllidae).

Brouwers NC, Newton AC.

Bull Entomol Res. 2010 Dec;100(6):623-34. doi: 10.1017/S0007485309990332. Epub 2009 Dec 11. Erratum in: Bull Entomol Res. 2011 Apr;101(2):249.

PMID:
20003571
30.

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn PP, Theuns J, Sleegers K, Van Broeckhoven C.

Hum Mutat. 2009 Aug;30(8):1207-13. doi: 10.1002/humu.21027.

PMID:
19462468
31.

Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.

Nuytemans K, Meeus B, Crosiers D, Brouwers N, Goossens D, Engelborghs S, Pals P, Pickut B, Van den Broeck M, Corsmit E, Cras P, De Deyn PP, Del-Favero J, Van Broeckhoven C, Theuns J.

Hum Mutat. 2009 Jul;30(7):1054-61. doi: 10.1002/humu.21007.

PMID:
19405094
32.

Serum biomarker for progranulin-associated frontotemporal lobar degeneration.

Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, Peeters K, Mattheijssens M, Cruts M, Vandenberghe R, De Deyn PP, Robberecht W, Van Broeckhoven C.

Ann Neurol. 2009 May;65(5):603-9. doi: 10.1002/ana.21621.

PMID:
19288468
33.

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.

Sleegers K, Brouwers N, Bettens K, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C.

Hum Mutat. 2009 Apr;30(4):E570-4. doi: 10.1002/humu.20990.

PMID:
19191332
34.

Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.

Sleegers K, Bettens K, Brouwers N, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C.

Hum Mutat. 2009 Feb;30(2):E338-44. doi: 10.1002/humu.20909.

PMID:
18853460
35.

Molecular genetics of Alzheimer's disease: an update.

Brouwers N, Sleegers K, Van Broeckhoven C.

Ann Med. 2008;40(8):562-83. doi: 10.1080/07853890802186905. Review.

PMID:
18608129
36.

Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.

Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, Van Broeckhoven C.

Neurology. 2008 Aug 26;71(9):656-64. doi: 10.1212/01.wnl.0000319688.89790.7a. Epub 2008 Jun 18.

PMID:
18565828
37.

SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.

Bettens K, Brouwers N, Engelborghs S, De Deyn PP, Van Broeckhoven C, Sleegers K.

Hum Mutat. 2008 May;29(5):769-70. doi: 10.1002/humu.20725.

PMID:
18407551
38.

DNMBP is genetically associated with Alzheimer dementia in the Belgian population.

Bettens K, Brouwers N, Engelborghs S, De Pooter T, De Deyn PP, Sleegers K, Van Broeckhoven C.

Neurobiol Aging. 2009 Dec;30(12):2000-9. doi: 10.1016/j.neurobiolaging.2008.02.003. Epub 2008 Mar 24.

PMID:
18359537
39.

Progranulin genetic variability contributes to amyotrophic lateral sclerosis.

Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C.

Neurology. 2008 Jul 22;71(4):253-9. doi: 10.1212/01.wnl.0000289191.54852.75. Epub 2008 Jan 9.

PMID:
18184915
40.

Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.

Brouwers N, Nuytemans K, van der Zee J, Gijselinck I, Engelborghs S, Theuns J, Kumar-Singh S, Pickut BA, Pals P, Dermaut B, Bogaerts V, De Pooter T, Serneels S, Van den Broeck M, Cuijt I, Mattheijssens M, Peeters K, Sciot R, Martin JJ, Cras P, Santens P, Vandenberghe R, De Deyn PP, Cruts M, Van Broeckhoven C, Sleegers K.

Arch Neurol. 2007 Oct;64(10):1436-46.

PMID:
17923627
41.

No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease.

Engelborghs S, Sleegers K, Cras P, Brouwers N, Serneels S, De Leenheir E, Martin JJ, Vanmechelen E, Van Broeckhoven C, De Deyn PP.

Brain. 2007 Sep;130(Pt 9):2320-6. Epub 2007 Jun 22.

PMID:
17586559
42.

Association study of cholesterol-related genes in Alzheimer's disease.

Wollmer MA, Sleegers K, Ingelsson M, Zekanowski C, Brouwers N, Maruszak A, Brunner F, Huynh KD, Kilander L, Brundin RM, Hedlund M, Giedraitis V, Glaser A, Engelborghs S, De Deyn PP, Kapaki E, Tsolaki M, Daniilidou M, Molyva D, Paraskevas GP, Thal DR, Barcikowska M, Kuznicki J, Lannfelt L, Van Broeckhoven C, Nitsch RM, Hock C, Papassotiropoulos A.

Neurogenetics. 2007 Aug;8(3):179-88. Epub 2007 Mar 27.

43.

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.

van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, De Deyn PP, Rousseau F, Brice A, Van Broeckhoven C.

Hum Mutat. 2007 Apr;28(4):416.

PMID:
17345602
44.

Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.

Brouwers N, Sleegers K, Engelborghs S, Bogaerts V, Serneels S, Kamali K, Corsmit E, De Leenheir E, Martin JJ, De Deyn PP, Van Broeckhoven C, Theuns J.

Brain. 2006 Nov;129(Pt 11):2984-91. Epub 2006 Aug 24.

PMID:
16931535
45.

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

Sleegers K, Brouwers N, Gijselinck I, Theuns J, Goossens D, Wauters J, Del-Favero J, Cruts M, van Duijn CM, Van Broeckhoven C.

Brain. 2006 Nov;129(Pt 11):2977-83. Epub 2006 Aug 18.

PMID:
16921174
46.

Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.

Theuns J, Marjaux E, Vandenbulcke M, Van Laere K, Kumar-Singh S, Bormans G, Brouwers N, Van den Broeck M, Vennekens K, Corsmit E, Cruts M, De Strooper B, Van Broeckhoven C, Vandenberghe R.

Hum Mutat. 2006 Sep;27(9):888-96.

PMID:
16917905
47.

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

Theuns J, Brouwers N, Engelborghs S, Sleegers K, Bogaerts V, Corsmit E, De Pooter T, van Duijn CM, De Deyn PP, Van Broeckhoven C.

Am J Hum Genet. 2006 Jun;78(6):936-46. Epub 2006 Apr 10.

48.

The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.

Brouwers N, Sleegers K, Engelborghs S, Bogaerts V, van Duijn CM, De Deyn PP, Van Broeckhoven C, Dermaut B.

Neurosci Lett. 2006 Jan 9;392(1-2):72-4. Epub 2005 Oct 6.

PMID:
16214290
49.
50.

IL-4-dependent IgE switch in membrane IgA-positive human B cells.

Zhang XH, Werner-Favre C, Tang HY, Brouwers N, Bonnefoy JY, Zubler RH.

J Immunol. 1991 Nov 1;147(9):3001-4.

PMID:
1919002

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