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The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study.

Foreman YD, Brouwers MCGJ, Berendschot TTJM, van Dongen MCJM, Eussen SJPM, van Greevenbroek MMJ, Henry RMA, Houben AJHM, van der Kallen CJH, Kroon AA, Reesink KD, Schram MT, Schaper NC, Stehouwer CDA.

Cardiovasc Diabetol. 2019 Nov 14;18(1):152. doi: 10.1186/s12933-019-0950-x.


Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.

Buziau AM, Schalkwijk CG, Stehouwer CDA, Tolan DR, Brouwers MCGJ.

Cell Mol Life Sci. 2019 Nov 12. doi: 10.1007/s00018-019-03348-2. [Epub ahead of print] Review.


Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality.

Brouwers MCGJ, Simons N, Stehouwer CDA, Isaacs A.

Diabetologia. 2019 Nov 11. doi: 10.1007/s00125-019-05024-3. [Epub ahead of print] Review.


Lessons learned from a cancer knowledge translation grants program: results of an evaluation.

O'Brien MA, Makuwaza T, Graham ID, Barbera L, Earle CC, Brouwers MC, Grunfeld E.

Curr Oncol. 2019 Aug;26(4):272-284. doi: 10.3747/co.26.5531. Epub 2019 Aug 1.


Relevant patient characteristics for estimating healthcare needs according to healthcare providers and people with type 2 diabetes: a Delphi survey.

Hertroijs DFL, Brouwers MCGJ, Elissen AMJ, Schaper NC, Ruwaard D.

BMC Health Serv Res. 2019 Aug 16;19(1):575. doi: 10.1186/s12913-019-4371-z.


Assessment of health systems guidance using the Appraisal of Guidelines for Research and Evaluation - Health Systems (AGREE-HS) instrument.

Brouwers MC, Lavis JN, Spithoff K, Vukmirovic M, Florez ID, Velez M, Kibria M, Sekercioglu N, Kamler E, Halladay J, Sandhu J, Ali A, Jaffer A, Kiflen R, Pemberton J.

Health Policy. 2019 Jul;123(7):646-651. doi: 10.1016/j.healthpol.2019.05.004. Epub 2019 May 14.


Preferences of people with Type 2 diabetes for diabetes care: a discrete choice experiment.

Hertroijs DFL, Elissen AMJ, Brouwers MCGJ, Hiligsmann M, Schaper NC, Ruwaard D.

Diabet Med. 2019 Apr 18. doi: 10.1111/dme.13969. [Epub ahead of print]


Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease.

Brouwers MCGJ, Simons N, Stehouwer CDA, Koek GH, Schaper NC, Isaacs A.

Hepatol Commun. 2019 Feb 11;3(4):587-596. doi: 10.1002/hep4.1319. eCollection 2019 Apr.


Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content.

Simons N, Debray FG, Schaper NC, Kooi ME, Feskens EJM, Hollak CEM, Lindeboom L, Koek GH, Bons JAP, Lefeber DJ, Hodson L, Schalkwijk CG, Stehouwer CDA, Cassiman D, Brouwers MCGJ.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5056-5064. doi: 10.1210/jc.2018-02795.


Clinical Practice Guidelines: Tools to Support High Quality Patient Care.

Brouwers MC, Florez ID, McNair SA, Vella ET, Yao X.

Semin Nucl Med. 2019 Mar;49(2):145-152. doi: 10.1053/j.semnuclmed.2018.11.001. Epub 2019 Jan 10. Review.


Movement disorders and nonmotor neuropsychological symptoms in children and adults with classical galactosemia.

Kuiper A, Grünewald S, Murphy E, Coenen MA, Eggink H, Zutt R, Rubio-Gozalbo ME, Bosch AM, Williams M, Derks TGJ, Lachmann RHL, Brouwers MCGJ, Janssen MCH, Tijssen MA, de Koning TJ.

J Inherit Metab Dis. 2019 May;42(3):451-458. doi: 10.1002/jimd.12054. Epub 2019 Feb 27.


Contribution of Liver Fat to Weight Loss-Induced Changes in Serum Hepatokines: A Randomized Controlled Trial.

Telgenkamp I, Kusters YHAM, Schalkwijk CG, Houben AJHM, Kooi ME, Lindeboom L, Bons JAP, Schaper NC, Joris PJ, Plat J, Mensink RP, Stehouwer CDA, Brouwers MCGJ.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2719-2727. doi: 10.1210/jc.2018-02378.


Variable participation of knowledge users in cancer health services research: results of a multiple case study.

O'Brien MA, Carson A, Barbera L, Brouwers MC, Earle CC, Graham ID, Mittmann N, Grunfeld E.

BMC Med Res Methodol. 2018 Nov 22;18(1):150. doi: 10.1186/s12874-018-0593-8.


Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study.

Luijten J, van Greevenbroek MMJ, Schaper NC, Meex SJR, van der Steen C, Meijer LJ, de Boer D, de Graaf J, Stehouwer CDA, Brouwers MCGJ.

Atherosclerosis. 2019 Jan;280:1-6. doi: 10.1016/j.atherosclerosis.2018.11.013. Epub 2018 Nov 8.


Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.

Simons PIHG, Simons N, Stehouwer CDA, Schalkwijk CG, Schaper NC, Brouwers MCGJ.

PLoS One. 2018 Oct 23;13(10):e0206174. doi: 10.1371/journal.pone.0206174. eCollection 2018.


Guideline Assessment Project: Filling the GAP in Surgical Guidelines: Quality Improvement Initiative by an International Working Group.

Antoniou SA, Tsokani S, Mavridis D, López-Cano M, Antoniou GA, Stefanidis D, Francis NK, Smart N, Muysoms FE, Morales-Conde S, Bonjer HJ, Brouwers MC.

Ann Surg. 2019 Apr;269(4):642-651. doi: 10.1097/SLA.0000000000003036.


Non-alcoholic fatty liver disease concerns with glucokinase activators.

Hodson L, Brouwers MCGJ.

Lancet Diabetes Endocrinol. 2018 Sep;6(9):684-685. doi: 10.1016/S2213-8587(18)30196-7. No abstract available.


Engaging cancer patients in clinical practice guideline development: a pilot study.

Brouwers MC, Vukmirovic M, Spithoff K, Zwaal C, McNair S, Peek N.

Curr Oncol. 2018 Aug;25(4):250-256. doi: 10.3747/co.25.3943. Epub 2018 Aug 14.


The impact of metabolic control and tetrahydrobiopterin treatment on health related quality of life of patients with early-treated phenylketonuria: A PKU-COBESO study.

Huijbregts SCJ, Bosch AM, Simons QA, Jahja R, Brouwers MCGJ, De Sonneville LMJ, De Vries MC, Hofstede FC, Hollak CEM, Janssen MCH, Langendonk JG, Rubio-Gozalbo ME, Van der Meere JJ, Van der Ploeg AT, Van Spronsen FJ.

Mol Genet Metab. 2018 Sep;125(1-2):96-103. doi: 10.1016/j.ymgme.2018.07.002. Epub 2018 Jul 7.


Validity and usability testing of a health systems guidance appraisal tool, the AGREE-HS.

Brouwers MC, Ako-Arrey D, Spithoff K, Vukmirovic M, Florez ID, Lavis JN, Cluzeau F, Permanand G, Bosch-Capblanch X, Chen Y; AGREE-HS Research Team.

Health Res Policy Syst. 2018 Jun 20;16(1):51. doi: 10.1186/s12961-018-0334-9.


Uncertain times: A survey of Canadian women's perspectives toward mammography screening.

Abelson J, Tripp L, Brouwers MC, Pond G, Sussman J.

Prev Med. 2018 Jul;112:209-215. doi: 10.1016/j.ypmed.2018.04.021. Epub 2018 Apr 18.


Relevant patient characteristics for guiding tailored integrated diabetes primary care: a systematic review.

Hertroijs DFL, Elissen AMJ, Brouwers MCGJ, Schaper NC, Ruwaard D.

Prim Health Care Res Dev. 2018 Sep;19(5):424-447. doi: 10.1017/S146342361800004X. Epub 2018 Feb 6.


Risk of a first-ever acute myocardial infarction and all-cause mortality with sulphonylurea treatment: A population-based cohort study.

van Dalem J, Brouwers MCGJ, Stehouwer CDA, Krings A, Klungel OH, Driessen JHM, de Vries F, Burden AM.

Diabetes Obes Metab. 2018 Apr;20(4):1056-1060. doi: 10.1111/dom.13168. Epub 2017 Dec 27.


A risk score including body mass index, glycated haemoglobin and triglycerides predicts future glycaemic control in people with type 2 diabetes.

Hertroijs DFL, Elissen AMJ, Brouwers MCGJ, Schaper NC, Köhler S, Popa MC, Asteriadis S, Hendriks SH, Bilo HJ, Ruwaard D.

Diabetes Obes Metab. 2018 Mar;20(3):681-688. doi: 10.1111/dom.13148. Epub 2017 Nov 24.


Propionic acidemia as a cause of adult-onset dilated cardiomyopathy.

Riemersma M, Hazebroek MR, Helderman-van den Enden ATJM, Salomons GS, Ferdinandusse S, Brouwers MCGJ, van der Ploeg L, Heymans S, Glatz JFC, van den Wijngaard A, Krapels IPC, Bierau J, Brunner HG.

Eur J Hum Genet. 2017 Nov;25(11):1195-1201. doi: 10.1038/ejhg.2017.127. Epub 2017 Aug 30.


Long-Term Follow-Up of Cognition and Mental Health in Adult Phenylketonuria: A PKU-COBESO Study.

Jahja R, van Spronsen FJ, de Sonneville LMJ, van der Meere JJ, Bosch AM, Hollak CEM, Rubio-Gozalbo ME, Brouwers MCGJ, Hofstede FC, de Vries MC, Janssen MCH, van der Ploeg AT, Langendonk JG, Huijbregts SCJ.

Behav Genet. 2017 Sep;47(5):486-497. doi: 10.1007/s10519-017-9863-1. Epub 2017 Aug 3.


Guidelines to Limit Added Sugar Intake.

Brouwers MC, Qaseem A, Spithoff K, Florez ID.

Ann Intern Med. 2017 Aug 1;167(3):219-220. doi: 10.7326/L17-0256. No abstract available.


How do the characteristics of breast cancer diagnostic assessment programmes influence service delivery: A mixed methods study.

Gagliardi AR, Honein-AbouHaidar G, Stuart-McEwan T, Smylie J, Arnaout A, Seely J, Wright FC, Dobrow MJ, Brouwers MC, Bukhanov K, McCready DR.

Eur J Cancer Care (Engl). 2018 Mar;27(2):e12727. doi: 10.1111/ecc.12727. Epub 2017 Jun 21.


Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial.

Petrie JR, Chaturvedi N, Ford I, Brouwers MCGJ, Greenlaw N, Tillin T, Hramiak I, Hughes AD, Jenkins AJ, Klein BEK, Klein R, Ooi TC, Rossing P, Stehouwer CDA, Sattar N, Colhoun HM; REMOVAL Study Group.

Lancet Diabetes Endocrinol. 2017 Aug;5(8):597-609. doi: 10.1016/S2213-8587(17)30194-8. Epub 2017 Jun 11. Erratum in: Lancet Diabetes Endocrinol. 2017 Aug;5(8):e5. Lancet Diabetes Endocrinol. 2017 Nov;5(11):e7.


Challenges and insights in implementing coordinated care between oncology and primary care providers: a Canadian perspective.

Tomasone JR, Vukmirovic M, Brouwers MC, Grunfeld E, Urquhart R, O'Brien MA, Walker M, Webster F, Fitch M.

Curr Oncol. 2017 Apr;24(2):120-123. doi: 10.3747/co.24.3426. Epub 2017 Apr 27.


Cognitive profile and mental health in adult phenylketonuria: A PKU-COBESO study.

Jahja R, Huijbregts SCJ, de Sonneville LMJ, van der Meere JJ, Legemaat AM, Bosch AM, Hollak CEM, Rubio-Gozalbo ME, Brouwers MCGJ, Hofstede FC, de Vries MC, Janssen MCH, van der Ploeg AT, Langendonk JG, van Spronsen FJ.

Neuropsychology. 2017 May;31(4):437-447. doi: 10.1037/neu0000358. Epub 2017 Mar 20.


Understanding optimal approaches to patient and caregiver engagement in the development of cancer practice guidelines: a mixed methods study.

Brouwers MC, Vukmirovic M, Spithoff K, Makarski J.

BMC Health Serv Res. 2017 Mar 9;17(1):186. doi: 10.1186/s12913-017-2107-5.


Use of theory to plan or evaluate guideline implementation among physicians: a scoping review.

Liang L, Bernhardsson S, Vernooij RW, Armstrong MJ, Bussières A, Brouwers MC, Gagliardi AR; Members of the Guidelines International Network Implementation Working Group.

Implement Sci. 2017 Feb 27;12(1):26. doi: 10.1186/s13012-017-0557-0. Review.


How do organisational characteristics influence teamwork and service delivery in lung cancer diagnostic assessment programmes? A mixed-methods study.

Honein-AbouHaidar GN, Stuart-McEwan T, Waddell T, Salvarrey A, Smylie J, Dobrow MJ, Brouwers MC, Gagliardi AR.

BMJ Open. 2017 Feb 23;7(2):e013965. doi: 10.1136/bmjopen-2016-013965.


PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease.

Simons N, Isaacs A, Koek GH, Kuč S, Schaper NC, Brouwers MCGJ.

Gastroenterology. 2017 Mar;152(4):912-913. doi: 10.1053/j.gastro.2016.12.020. Epub 2017 Feb 1. No abstract available.


Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department.

van den Nouland DP, Brouwers MC, Stassen PM.

BMJ Open. 2017 Jan 30;7(1):e011450. doi: 10.1136/bmjopen-2016-011450.


Obstetrical brachial plexus injury (OBPI): Canada's national clinical practice guideline.

Coroneos CJ, Voineskos SH, Christakis MK, Thoma A, Bain JR, Brouwers MC; Canadian OBPI Working Group.

BMJ Open. 2017 Jan 27;7(1):e014141. doi: 10.1136/bmjopen-2016-014141.


Barriers, beliefs and practice patterns for breast cancer reconstruction: A provincial survey.

Coroneos CJ, Roth-Albin K, Rai AS, Rai AS, Voineskos SH, Brouwers MC, Avram R, Heller B.

Breast. 2017 Apr;32:60-65. doi: 10.1016/j.breast.2016.12.012. Epub 2016 Dec 28.


Interventions to improve care coordination between primary healthcare and oncology care providers: a systematic review.

Tomasone JR, Brouwers MC, Vukmirovic M, Grunfeld E, O'Brien MA, Urquhart R, Walker M, Webster F, Fitch M.

ESMO Open. 2016 Sep 6;1(5):e000077. eCollection 2016. Review.


Documenting coordination of cancer care between primary care providers and oncology specialists in Canada.

Brouwers MC, Vukmirovic M, Tomasone JR, Grunfeld E, Urquhart R, O'Brien MA, Walker M, Webster F, Fitch M.

Can Fam Physician. 2016 Oct;62(10):e616-e625.


A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.

Simons N, Dekker JM, van Greevenbroek MM, Nijpels G, 't Hart LM, van der Kallen CJ, Schalkwijk CG, Schaper NC, Stehouwer CD, Brouwers MC.

Diabetes Care. 2016 Oct;39(10):1811-7. doi: 10.2337/dc16-0153.


Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study.

van Dalem J, Brouwers MC, Stehouwer CD, Krings A, Leufkens HG, Driessen JH, de Vries F, Burden AM.

BMJ. 2016 Jul 13;354:i3625. doi: 10.1136/bmj.i3625.


Optimizing the language and format of guidelines to improve guideline uptake.

Gupta S, Rai N, Bhattacharrya O, Cheng AYY, Connelly KA, Boulet LP, Kaplan A, Brouwers MC, Kastner M.

CMAJ. 2016 Oct 4;188(14):E362-E368. doi: 10.1503/cmaj.151102. Epub 2016 Apr 18. No abstract available.


The AGREE Reporting Checklist: a tool to improve reporting of clinical practice guidelines.

Brouwers MC, Kerkvliet K, Spithoff K; AGREE Next Steps Consortium.

BMJ. 2016 Mar 8;352:i1152. doi: 10.1136/bmj.i1152. No abstract available. Erratum in: BMJ. 2016 Sep 06;354:i4852.


Patient-mediated knowledge translation (PKT) interventions for clinical encounters: a systematic review.

Gagliardi AR, Légaré F, Brouwers MC, Webster F, Badley E, Straus S.

Implement Sci. 2016 Feb 29;11:26. doi: 10.1186/s13012-016-0389-3. Review.


Social-cognitive functioning and social skills in patients with early treated phenylketonuria: a PKU-COBESO study.

Jahja R, van Spronsen FJ, de Sonneville LMJ, van der Meere JJ, Bosch AM, Hollak CEM, Rubio-Gozalbo ME, Brouwers MCGJ, Hofstede FC, de Vries MC, Janssen MCH, van der Ploeg AT, Langendonk JG, Huijbregts SCJ.

J Inherit Metab Dis. 2016 May;39(3):355-362. doi: 10.1007/s10545-016-9918-0. Epub 2016 Feb 25.


Health systems guidance appraisal--a critical interpretive synthesis.

Ako-Arrey DE, Brouwers MC, Lavis JN, Giacomini MK; AGREE-HS Team.

Implement Sci. 2016 Jan 22;11:9. doi: 10.1186/s13012-016-0373-y. Review.


Health system guidance appraisal--concept evaluation and usability testing.

Ako-Arrey DE, Brouwers MC, Lavis JN, Giacomini MK; AGREE HS Team.

Implement Sci. 2016 Jan 5;11:3. doi: 10.1186/s13012-015-0365-3.


Electrolyte and Acid-Base Disturbances in Diabetes Mellitus.

Brouwers MC.

N Engl J Med. 2015 Dec 17;373(25):2482. doi: 10.1056/NEJMc1511638. No abstract available.


Obstetrical brachial plexus injury: burden in a publicly funded, universal healthcare system.

Coroneos CJ, Voineskos SH, Coroneos MK, Alolabi N, Goekjian SR, Willoughby LI, Farrokhyar F, Thoma A, Bain JR, Brouwers MC; Canadian OBPI Working Group.

J Neurosurg Pediatr. 2016 Feb;17(2):222-229. doi: 10.3171/2015.6.PEDS14703. Epub 2015 Oct 23.


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