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Items: 1 to 50 of 77

1.

Lipid Analysis of the 6-Hydroxydopamine-Treated SH-SY5Y Cell Model for Parkinson's Disease.

Xicoy H, Brouwers JF, Kalnytska O, Wieringa B, Martens GJM.

Mol Neurobiol. 2019 Sep 6. doi: 10.1007/s12035-019-01733-3. [Epub ahead of print]

PMID:
31493240
2.

Liver phosphorus content and liver function in states of phosphorus deficiency in transition dairy cows.

Grünberg W, Witte S, Cohrs I, Golbeck L, Brouwers JF, Müller AE, Schmicke M.

PLoS One. 2019 Jul 22;14(7):e0219546. doi: 10.1371/journal.pone.0219546. eCollection 2019.

3.

BODIPY-cholesterol can be reliably used to monitor cholesterol efflux from capacitating mammalian spermatozoa.

Bernecic NC, Zhang M, Gadella BM, Brouwers JFHM, Jansen JWA, Arkesteijn GJA, de Graaf SP, Leahy T.

Sci Rep. 2019 Jul 8;9(1):9804. doi: 10.1038/s41598-019-45831-7.

4.

Schistosoma mansoni does not and cannot oxidise fatty acids, but these are used for biosynthetic purposes instead.

Bexkens ML, Mebius MM, Houweling M, Brouwers JF, Tielens AGM, van Hellemond JJ.

Int J Parasitol. 2019 Jul;49(8):647-656. doi: 10.1016/j.ijpara.2019.03.005. Epub 2019 Jun 3.

PMID:
31170410
5.

LION/web: a web-based ontology enrichment tool for lipidomic data analysis.

Molenaar MR, Jeucken A, Wassenaar TA, van de Lest CHA, Brouwers JF, Helms JB.

Gigascience. 2019 Jun 1;8(6). pii: giz061. doi: 10.1093/gigascience/giz061.

6.

A Comprehensive Functional Characterization of Escherichia coli Lipid Genes.

Jeucken A, Molenaar MR, van de Lest CHA, Jansen JWA, Helms JB, Brouwers JF.

Cell Rep. 2019 Apr 30;27(5):1597-1606.e2. doi: 10.1016/j.celrep.2019.04.018.

7.

Comparison of the systemic phospholipid profile in dogs diagnosed with idiopathic inflammatory bowel disease or food-responsive diarrhea before and after treatment.

Kalenyak K, Heilmann RM, van de Lest CHA, Brouwers JF, Burgener IA.

PLoS One. 2019 Apr 16;14(4):e0215435. doi: 10.1371/journal.pone.0215435. eCollection 2019.

8.

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.

van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB.

Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24.

9.

High-Throughput Screening of Lipidomic Adaptations in Cultured Cells.

Jeucken A, Brouwers JF.

Biomolecules. 2019 Jan 24;9(2). pii: E42. doi: 10.3390/biom9020042.

10.

Chronic dietary changes in n-6/n-3 polyunsaturated fatty acid ratios cause developmental delay and reduce social interest in mice.

van Elst K, Brouwers JF, Merkens JE, Broekhoven MH, Birtoli B, Helms JB, Kas MJH.

Eur Neuropsychopharmacol. 2019 Jan;29(1):16-31. doi: 10.1016/j.euroneuro.2018.11.1106. Epub 2018 Dec 15.

PMID:
30563719
11.

The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast.

Anaokar S, Kodali R, Jonik B, Renne MF, Brouwers JFHM, Lager I, de Kroon AIPM, Patton-Vogt J.

J Biol Chem. 2019 Jan 25;294(4):1189-1201. doi: 10.1074/jbc.RA118.005232. Epub 2018 Dec 4.

PMID:
30514764
12.

Lipids Are the Preferred Substrate of the Protist Naegleria gruberi, Relative of a Human Brain Pathogen.

Bexkens ML, Zimorski V, Sarink MJ, Wienk H, Brouwers JF, De Jonckheere JF, Martin WF, Opperdoes FR, van Hellemond JJ, Tielens AGM.

Cell Rep. 2018 Oct 16;25(3):537-543.e3. doi: 10.1016/j.celrep.2018.09.055.

13.

Structural and functional characterization of protein-lipid interactions of the Salmonella typhimurium melibiose transporter MelB.

Hariharan P, Tikhonova E, Medeiros-Silva J, Jeucken A, Bogdanov MV, Dowhan W, Brouwers JF, Weingarth M, Guan L.

BMC Biol. 2018 Aug 3;16(1):85. doi: 10.1186/s12915-018-0553-0.

14.

Cardiolipin synthases of Escherichia coli have phospholipid class specific phospholipase D activity dependent on endogenous and foreign phospholipids.

Jeucken A, Helms JB, Brouwers JF.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1345-1353. doi: 10.1016/j.bbalip.2018.06.017. Epub 2018 Jun 19.

15.

Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers.

de Almeida Monteiro Melo Ferraz M, Henning HHW, Ferreira da Costa P, Malda J, Le Gac S, Bray F, van Duursen MBM, Brouwers JF, van de Lest CHA, Bertijn I, Kraneburg L, Vos PLAM, Stout TAE, Gadella BM.

Environ Sci Technol Lett. 2018 Feb 13;5(2):80-85. doi: 10.1021/acs.estlett.7b00495. Epub 2018 Jan 5.

16.

Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle.

Kong P, Lehmann MJ, Helms JB, Brouwers JF, Gupta N.

Cell Discov. 2018 May 22;4:24. doi: 10.1038/s41421-018-0023-4. eCollection 2018.

17.

Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts.

Van den Bossche L, Schoonenberg VAC, Burgener IA, Penning LC, Schrall IM, Kruitwagen HS, van Wolferen ME, Grinwis GCM, Kummeling A, Rothuizen J, van Velzen JF, Stathonikos N, Molenaar MR, Helms BJ, Brouwers JFHM, Spee B, van Steenbeek FG.

PLoS One. 2017 Oct 19;12(10):e0186491. doi: 10.1371/journal.pone.0186491. eCollection 2017.

18.

Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Wubbolts R, Houweling M, Yan C, Du H, VanderVen BC, Vaandrager AB, Helms JB.

J Biol Chem. 2017 Jul 28;292(30):12436-12448. doi: 10.1074/jbc.M117.778472. Epub 2017 Jun 14.

19.

Oligodendroglial myelination requires astrocyte-derived lipids.

Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MHG.

PLoS Biol. 2017 May 26;15(5):e1002605. doi: 10.1371/journal.pbio.1002605. eCollection 2017 May.

20.

Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress.

Aardema H, van Tol HTA, Wubbolts RW, Brouwers JFHM, Gadella BM, Roelen BAJ.

Biol Reprod. 2017 May 1;96(5):982-992. doi: 10.1095/biolreprod.116.146159.

21.

Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii.

Kong P, Ufermann CM, Zimmermann DLM, Yin Q, Suo X, Helms JB, Brouwers JF, Gupta N.

J Biol Chem. 2017 Apr 28;292(17):7145-7159. doi: 10.1074/jbc.M116.765487. Epub 2017 Mar 17.

22.

Astrocyte lipid metabolism is critical for synapse development and function in vivo.

van Deijk AF, Camargo N, Timmerman J, Heistek T, Brouwers JF, Mogavero F, Mansvelder HD, Smit AB, Verheijen MH.

Glia. 2017 Apr;65(4):670-682. doi: 10.1002/glia.23120. Epub 2017 Feb 7.

PMID:
28168742
23.

Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT.

Ajat M, Molenaar M, Brouwers JFHM, Vaandrager AB, Houweling M, Helms JB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Feb;1862(2):176-187. doi: 10.1016/j.bbalip.2016.10.013. Epub 2016 Nov 1.

PMID:
27815220
24.

ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Houweling M, Vaandrager AB, Helms JB.

J Lipid Res. 2016 Jul;57(7):1162-74. doi: 10.1194/jlr.M066415. Epub 2016 May 14.

25.

Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.

Arroyo-Olarte RD, Brouwers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N.

PLoS Biol. 2015 Nov 13;13(11):e1002288. doi: 10.1371/journal.pbio.1002288. eCollection 2015.

26.

Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells.

van Gestel RA, Brouwers JF, Ultee A, Helms JB, Gadella BM.

Cell Tissue Res. 2016 Jan;363(1):129-145. doi: 10.1007/s00441-015-2272-y. Epub 2015 Sep 16.

27.

The tegumental surface membranes of Schistosoma mansoni are enriched in parasite-specific phospholipid species.

Retra K, deWalick S, Schmitz M, Yazdanbakhsh M, Tielens AG, Brouwers JF, van Hellemond JJ.

Int J Parasitol. 2015 Aug;45(9-10):629-36. doi: 10.1016/j.ijpara.2015.03.011. Epub 2015 May 11.

PMID:
25975668
28.

Targeting of the hydrophobic metabolome by pathogens.

Helms JB, Kaloyanova DV, Strating JR, van Hellemond JJ, van der Schaar HM, Tielens AG, van Kuppeveld FJ, Brouwers JF.

Traffic. 2015 May;16(5):439-60. doi: 10.1111/tra.12280. Review.

29.

LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery.

Brachet A, Norwood S, Brouwers JF, Palomer E, Helms JB, Dotti CG, Esteban JA.

J Cell Biol. 2015 Mar 16;208(6):791-806. doi: 10.1083/jcb.201407122. Epub 2015 Mar 9.

30.

Free fatty acid levels in fluid of dominant follicles at the preferred insemination time in dairy cows are not affected by early postpartum fatty acid stress.

Aardema H, Gadella BM, van de Lest CH, Brouwers JF, Stout TA, Roelen BA, Vos PL.

J Dairy Sci. 2015 Apr;98(4):2322-36. doi: 10.3168/jds.2014-7970. Epub 2015 Jan 31.

31.

Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells.

Tuohetahuntila M, Spee B, Kruitwagen HS, Wubbolts R, Brouwers JF, van de Lest CH, Molenaar MR, Houweling M, Helms JB, Vaandrager AB.

Biochim Biophys Acta. 2015 Feb;1851(2):220-30. doi: 10.1016/j.bbalip.2014.12.003. Epub 2014 Dec 9.

PMID:
25500141
32.

The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity.

Lolicato F, Brouwers JF, de Lest CH, Wubbolts R, Aardema H, Priore P, Roelen BA, Helms JB, Gadella BM.

Biol Reprod. 2015 Jan;92(1):16. doi: 10.1095/biolreprod.114.120634. Epub 2014 Oct 8.

PMID:
25297544
33.

A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells.

Zenker J, Stettner M, Ruskamo S, Domènech-Estévez E, Baloui H, Médard JJ, Verheijen MH, Brouwers JF, Kursula P, Kieseier BC, Chrast R.

Glia. 2014 Sep;62(9):1502-12. doi: 10.1002/glia.22696. Epub 2014 May 21.

PMID:
24849898
34.

Bovine cumulus cells protect maturing oocytes from increased fatty acid levels by massive intracellular lipid storage.

Aardema H, Lolicato F, van de Lest CH, Brouwers JF, Vaandrager AB, van Tol HT, Roelen BA, Vos PL, Helms JB, Gadella BM.

Biol Reprod. 2013 Jun 27;88(6):164. doi: 10.1095/biolreprod.112.106062. Print 2013 Jun.

PMID:
23616596
35.

Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p.

De Smet CH, Cox R, Brouwers JF, de Kroon AI.

Biochim Biophys Acta. 2013 Jun;1831(6):1167-76. doi: 10.1016/j.bbalip.2013.03.002. Epub 2013 Mar 13.

PMID:
23501167
36.

Distinct lipid compositions of two types of human prostasomes.

Brouwers JF, Aalberts M, Jansen JW, van Niel G, Wauben MH, Stout TA, Helms JB, Stoorvogel W.

Proteomics. 2013 May;13(10-11):1660-6. doi: 10.1002/pmic.201200348. Epub 2013 Apr 2.

PMID:
23404715
37.

Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization.

Boerke A, Brouwers JF, Olkkonen VM, van de Lest CH, Sostaric E, Schoevers EJ, Helms JB, Gadella BM.

Biol Reprod. 2013 Jan 25;88(1):21. doi: 10.1095/biolreprod.112.101253. Print 2013 Jan.

PMID:
23115269
38.

High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism.

Camargo N, Brouwers JF, Loos M, Gutmann DH, Smit AB, Verheijen MH.

FASEB J. 2012 Oct;26(10):4302-15. doi: 10.1096/fj.12-205807. Epub 2012 Jul 2.

PMID:
22751013
39.

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation.

Testerink N, Ajat M, Houweling M, Brouwers JF, Pully VV, van Manen HJ, Otto C, Helms JB, Vaandrager AB.

PLoS One. 2012;7(4):e34945. doi: 10.1371/journal.pone.0034945. Epub 2012 Apr 20.

40.

Cholesterol loss during glutamate-mediated excitotoxicity.

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoè-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG.

EMBO J. 2012 Apr 4;31(7):1764-73. doi: 10.1038/emboj.2012.31. Epub 2012 Feb 17.

41.

The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p.

De Smet CH, Vittone E, Scherer M, Houweling M, Liebisch G, Brouwers JF, de Kroon AI.

Mol Biol Cell. 2012 Apr;23(7):1146-56. doi: 10.1091/mbc.E11-07-0624. Epub 2012 Feb 9.

42.

Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays.

Krumpochova P, Sapthu S, Brouwers JF, de Haas M, de Vos R, Borst P, van de Wetering K.

FASEB J. 2012 Feb;26(2):738-47. doi: 10.1096/fj.11-195743. Epub 2011 Oct 27.

43.

Liquid chromatographic-mass spectrometric analysis of phospholipids. Chromatography, ionization and quantification.

Brouwers JF.

Biochim Biophys Acta. 2011 Nov;1811(11):763-75. doi: 10.1016/j.bbalip.2011.08.001. Epub 2011 Aug 7. Review.

PMID:
21851861
44.

A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.

Mul JD, Nadra K, Jagalur NB, Nijman IJ, Toonen PW, Médard JJ, Grès S, de Bruin A, Han GS, Brouwers JF, Carman GM, Saulnier-Blache JS, Meijer D, Chrast R, Cuppen E.

J Biol Chem. 2011 Jul 29;286(30):26781-93. doi: 10.1074/jbc.M110.197947. Epub 2011 Jun 1.

45.

Mass spectrometric detection of cholesterol oxidation in bovine sperm.

Brouwers JF, Boerke A, Silva PF, Garcia-Gil N, van Gestel RA, Helms JB, van de Lest CH, Gadella BM.

Biol Reprod. 2011 Jul;85(1):128-36. doi: 10.1095/biolreprod.111.091207. Epub 2011 Mar 17.

PMID:
21415139
46.

SCAP is required for timely and proper myelin membrane synthesis.

Verheijen MH, Camargo N, Verdier V, Nadra K, de Preux Charles AS, Médard JJ, Luoma A, Crowther M, Inouye H, Shimano H, Chen S, Brouwers JF, Helms JB, Feltri ML, Wrabetz L, Kirschner D, Chrast R, Smit AB.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21383-8. doi: 10.1073/pnas.0905633106. Epub 2009 Nov 30.

47.

Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin.

Rijken PJ, Houtkooper RH, Akbari H, Brouwers JF, Koorengevel MC, de Kruijff B, Frentzen M, Vaz FM, de Kroon AI.

J Biol Chem. 2009 Oct 2;284(40):27609-19. doi: 10.1074/jbc.M109.016311. Epub 2009 Aug 5.

48.

Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.

van de Wetering K, Feddema W, Helms JB, Brouwers JF, Borst P.

Gastroenterology. 2009 Nov;137(5):1725-35. doi: 10.1053/j.gastro.2009.06.052. Epub 2009 Jul 3.

PMID:
19577570
49.

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.

Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC.

J Cell Biol. 2009 Jun 15;185(6):1013-27. doi: 10.1083/jcb.200903152. Epub 2009 Jun 8.

50.

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase.

Ternes P, Brouwers JF, van den Dikkenberg J, Holthuis JC.

J Lipid Res. 2009 Nov;50(11):2270-7. doi: 10.1194/jlr.M900230-JLR200. Epub 2009 May 19.

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