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Items: 1 to 20 of 54


Chromosome level assembly and comparative genome analysis confirm lager-brewing yeasts originated from a single hybridization.

Salazar AN, Gorter de Vries AR, van den Broek M, Brouwers N, de la Torre Cortès P, Kuijpers NGA, Daran JG, Abeel T.

BMC Genomics. 2019 Dec 2;20(1):916. doi: 10.1186/s12864-019-6263-3.


Himalayan Saccharomyces eubayanus Genome Sequences Reveal Genetic Markers Explaining Heterotic Maltotriose Consumption by Saccharomyces pastorianus Hybrids.

Brouwers N, Brickwedde A, Gorter de Vries AR, van den Broek M, Weening SM, van den Eijnden L, Diderich JA, Bai FY, Pronk JT, Daran JG.

Appl Environ Microbiol. 2019 Oct 30;85(22). pii: e01516-19. doi: 10.1128/AEM.01516-19. Print 2019 Nov 15.


New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.

Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J.

J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. Epub 2019 Sep 5.


Laboratory Evolution of a Saccharomyces cerevisiae × S. eubayanus Hybrid Under Simulated Lager-Brewing Conditions.

Gorter de Vries AR, Voskamp MA, van Aalst ACA, Kristensen LH, Jansen L, van den Broek M, Salazar AN, Brouwers N, Abeel T, Pronk JT, Daran JG.

Front Genet. 2019 Mar 29;10:242. doi: 10.3389/fgene.2019.00242. eCollection 2019.


In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation.

Brouwers N, Gorter de Vries AR, van den Broek M, Weening SM, Elink Schuurman TD, Kuijpers NGA, Pronk JT, Daran JG.

PLoS Genet. 2019 Apr 4;15(4):e1007853. doi: 10.1371/journal.pgen.1007853. eCollection 2019 Apr.


GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion.

Chiritoiu M, Brouwers N, Turacchio G, Pirozzi M, Malhotra V.

Dev Cell. 2019 Apr 8;49(1):145-155.e4. doi: 10.1016/j.devcel.2019.02.011. Epub 2019 Mar 14.


Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells.

Cantero-Recasens G, Butnaru CM, Brouwers N, Mitrovic S, Valverde MA, Malhotra V.

J Biol Chem. 2019 Jan 18;294(3):816-826. doi: 10.1074/jbc.RA117.000848. Epub 2018 Nov 27.


KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon.

Cantero-Recasens G, Butnaru CM, Valverde MA, Naranjo JR, Brouwers N, Malhotra V.

Elife. 2018 Oct 1;7. pii: e39729. doi: 10.7554/eLife.39729.


Structural, Physiological and Regulatory Analysis of Maltose Transporter Genes in Saccharomyces eubayanus CBS 12357T.

Brickwedde A, Brouwers N, van den Broek M, Gallego Murillo JS, Fraiture JL, Pronk JT, Daran JG.

Front Microbiol. 2018 Aug 10;9:1786. doi: 10.3389/fmicb.2018.01786. eCollection 2018.


Home-based bimanual training based on motor learning principles in children with unilateral cerebral palsy and their parents (the COAD-study): rationale and protocols.

Schnackers M, Beckers L, Janssen-Potten Y, Aarts P, Rameckers E, van der Burg J, de Groot I; COAD Focus Group, Smeets R, Geurts S, Steenbergen B.

BMC Pediatr. 2018 Apr 18;18(1):139. doi: 10.1186/s12887-018-1110-2.


Nanopore sequencing enables near-complete de novo assembly of Saccharomyces cerevisiae reference strain CEN.PK113-7D.

Salazar AN, Gorter de Vries AR, van den Broek M, Wijsman M, de la Torre Cortés P, Brickwedde A, Brouwers N, Daran JG, Abeel T.

FEMS Yeast Res. 2017 Nov 1;17(7). doi: 10.1093/femsyr/fox074.


A diacidic motif determines unconventional secretion of wild-type and ALS-linked mutant SOD1.

Cruz-Garcia D, Brouwers N, Duran JM, Mora G, Curwin AJ, Malhotra V.

J Cell Biol. 2017 Sep 4;216(9):2691-2700. doi: 10.1083/jcb.201704056. Epub 2017 Aug 9.


Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment.

Brouwers N, Mallol Martinez N, Vernos I.

PLoS One. 2017 Apr 26;12(4):e0174819. doi: 10.1371/journal.pone.0174819. eCollection 2017.


ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion.

Curwin AJ, Brouwers N, Alonso Y Adell M, Teis D, Turacchio G, Parashuraman S, Ronchi P, Malhotra V.

Elife. 2016 Apr 26;5. pii: e16299. doi: 10.7554/eLife.16299.


Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin.

Kleinberger G, Capell A, Brouwers N, Fellerer K, Sleegers K, Cruts M, Van Broeckhoven C, Haass C.

Neurobiol Aging. 2016 Mar;39:220.e17-26. doi: 10.1016/j.neurobiolaging.2015.12.014. Epub 2015 Dec 29.


TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export.

Santos AJ, Raote I, Scarpa M, Brouwers N, Malhotra V.

Elife. 2015 Nov 14;4. pii: e10982. doi: 10.7554/eLife.10982.


Climate and landscape drivers of tree decline in a Mediterranean ecoregion.

Brouwers NC, Mercer J, Lyons T, Poot P, Veneklaas E, Hardy G.

Ecol Evol. 2012 Jan;3(1):67-79. doi: 10.1002/ece3.437. Epub 2012 Dec 5.


Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.

Engelborghs S, Sleegers K, Van der Mussele S, Le Bastard N, Brouwers N, Van Broeckhoven C, De Deyn PP.

J Alzheimers Dis. 2013;35(1):67-73. doi: 10.3233/JAD-101305.


Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.

Hazrati LN, Van Cauwenberghe C, Brooks PL, Brouwers N, Ghani M, Sato C, Cruts M, Sleegers K, St George-Hyslop P, Van Broeckhoven C, Rogaeva E.

Neurobiol Aging. 2012 Dec;33(12):2949.e5-2949.e12. doi: 10.1016/j.neurobiolaging.2012.07.001. Epub 2012 Jul 21.


Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.

Bettens K, Brouwers N, Engelborghs S, Lambert JC, Rogaeva E, Vandenberghe R, Le Bastard N, Pasquier F, Vermeulen S, Van Dongen J, Mattheijssens M, Peeters K, Mayeux R, St George-Hyslop P, Amouyel P, De Deyn PP, Sleegers K, Van Broeckhoven C.

Mol Neurodegener. 2012 Jan 16;7:3. doi: 10.1186/1750-1326-7-3.

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