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Net-zero emissions energy systems.

Davis SJ, Lewis NS, Shaner M, Aggarwal S, Arent D, Azevedo IL, Benson SM, Bradley T, Brouwer J, Chiang YM, Clack CTM, Cohen A, Doig S, Edmonds J, Fennell P, Field CB, Hannegan B, Hodge BM, Hoffert MI, Ingersoll E, Jaramillo P, Lackner KS, Mach KJ, Mastrandrea M, Ogden J, Peterson PF, Sanchez DL, Sperling D, Stagner J, Trancik JE, Yang CJ, Caldeira K.

Science. 2018 Jun 29;360(6396). pii: eaas9793. doi: 10.1126/science.aas9793. Review.


Need for a marginal methodology in assessing natural gas system methane emissions in response to incremental consumption.

Mac Kinnon M, Heydarzadeh Z, Doan Q, Ngo C, Reed J, Brouwer J.

J Air Waste Manag Assoc. 2018 May 17:1-9. doi: 10.1080/10962247.2018.1476274. [Epub ahead of print]


The importance of contextual, relational and cognitive factors for novice nurses' emotional state and affective commitment to the profession. A multilevel study.

Hoeve YT, Brouwer J, Roodbol PF, Kunnen S.

J Adv Nurs. 2018 May 13. doi: 10.1111/jan.13709. [Epub ahead of print]


The voice of nurses: Novice nurses' first experiences in a clinical setting. A longitudinal diary study.

Ten Hoeve Y, Kunnen S, Brouwer J, Roodbol PF.

J Clin Nurs. 2018 Apr;27(7-8):e1612-e1626. doi: 10.1111/jocn.14307. Epub 2018 Apr 3.


Biodegradation and mechanical behavior of an advanced bioceramic-containing Mg matrix composite synthesized through in-situ solid-state oxidation.

NaddafDezfuli S, Brouwer JC, Mol JMC, van der Helm FCT, Zhou J.

J Mech Behav Biomed Mater. 2018 Apr;80:209-221. doi: 10.1016/j.jmbbm.2018.01.014.


Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.

Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE.

Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001.


Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches.

Karaca Ö, Scalcon V, Meier-Menches SM, Bonsignore R, Brouwer JMJL, Tonolo F, Folda A, Rigobello MP, Kühn FE, Casini A.

Inorg Chem. 2017 Nov 20;56(22):14237-14250. doi: 10.1021/acs.inorgchem.7b02345. Epub 2017 Nov 2.


Inflammatory potential of the diet and colorectal tumor risk in persons with Lynch syndrome.

Brouwer JG, Makama M, van Woudenbergh GJ, Vasen HF, Nagengast FM, Kleibeuker JH, Kampman E, van Duijnhoven FJ.

Am J Clin Nutr. 2017 Nov;106(5):1287-1294. doi: 10.3945/ajcn.117.152900. Epub 2017 Sep 20.


Home closure as a weapon in the Dutch war on drugs: Does judicial review function as a safety net?

Bruijn LM, Vols M, Brouwer JG.

Int J Drug Policy. 2018 Jan;51:137-147. doi: 10.1016/j.drugpo.2017.08.003. Epub 2017 Sep 1.


Practical guidance on heart failure diagnosis and management in primary care: recent EPCCS recommendations.

Taylor CJ, Rutten FH, Brouwer JR, Hobbs FR.

Br J Gen Pract. 2017 Jul;67(660):326-327. doi: 10.3399/bjgp17X691553. No abstract available.


Framing migration and the process of crimmigration: A systematic analysis of the media representation of unauthorized immigrants in the Netherlands.

Brouwer J, van der Woude M, van der Leun J.

Eur J Criminol. 2017 Jan;14(1):100-119. doi: 10.1177/1477370816640136. Epub 2017 Jan 26.


Comparative toxicity of imidacloprid and thiacloprid to different species of soil invertebrates.

de Lima E Silva C, Brennan N, Brouwer JM, Commandeur D, Verweij RA, van Gestel CAM.

Ecotoxicology. 2017 May;26(4):555-564. doi: 10.1007/s10646-017-1790-7. Epub 2017 Mar 23.


Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

Uren RT, O'Hely M, Iyer S, Bartolo R, Shi MX, Brouwer JM, Alsop AE, Dewson G, Kluck RM.

Elife. 2017 Feb 6;6. pii: e19944. doi: 10.7554/eLife.19944.


Serous tubal intraepithelial neoplasia: the concept and its application.

Meserve EEK, Brouwer J, Crum CP.

Mod Pathol. 2017 May;30(5):710-721. doi: 10.1038/modpathol.2016.238. Epub 2017 Jan 20. Review.


Subfertility in Women With Rheumatoid Arthritis and the Outcome of Fertility Assessments.

Brouwer J, Fleurbaaij R, Hazes JMW, Dolhain RJEM, Laven JSE.

Arthritis Care Res (Hoboken). 2017 Aug;69(8):1142-1149. doi: 10.1002/acr.23124. Epub 2017 Jun 26.


How the concept of biochemical response influenced the management of primary biliary cholangitis over time.

Lammers WJ, Leeman M, Ponsioen CI, Boonstra K, van Erpecum KJ, Wolfhagen FH, Kuyvenhoven JP, Vrolijk JM, Drenth JP, Witteman EM, van Nieuwkerk CM, van der Spek BW, Witteman BJ, Erkelens GW, Verhagen MA, van Tuyl SA, Poen AC, Brouwer JT, Ter Borg F, Koek GH, van Ditzhuijsen TJ, Hansen BE; Dutch Multicenter PBC Study Group.

Neth J Med. 2016 Jul;74(6):240-6.


Chemotherapy dose intensity predicted by baseline nutrition assessment in gastrointestinal malignancies: A multicentre analysis.

Klute KA, Brouwer J, Jhawer M, Sachs H, Gangadin A, Ocean A, Popa E, Dai T, Wu G, Christos P, Shah MA.

Eur J Cancer. 2016 Aug;63:189-200. doi: 10.1016/j.ejca.2016.05.011. Epub 2016 Jun 27.


Small RNA sequencing reveals a comprehensive miRNA signature of BRCA1-associated high-grade serous ovarian cancer.

Brouwer J, Kluiver J, de Almeida RC, Modderman R, Terpstra MM, Kok K, Withoff S, Hollema H, Reitsma W, de Bock GH, Mourits MJ, van den Berg A.

J Clin Pathol. 2016 Apr 5. pii: jclinpath-2016-203679. doi: 10.1136/jclinpath-2016-203679. [Epub ahead of print]


Introduction to the annual report 2016: a joint venture in the field of Acute ENT.

Watelet JB, De Brouwer J, Van der Veken P, Idrissil HS.

B-ENT. 2016;Suppl 26(1):7-9. No abstract available.


Interaction of Hereditary Thrombophilia and Traditional Cardiovascular Risk Factors on the Risk of Arterial Thromboembolism: Pooled Analysis of Four Family Cohort Studies.

Mahmoodi BK, Veeger NJ, Middeldorp S, Lijfering WM, Brouwer JL, Ten Berg J, Hamulyák K, Meijer K.

Circ Cardiovasc Genet. 2016 Feb;9(1):79-85. doi: 10.1161/CIRCGENETICS.115.001211. Epub 2015 Dec 17.


Research ethics needs fine tuning, not rigidity: how to promote evidence in neglected patient populations by rethinking informed consent.

Jukema JW, Brouwer JR, Lüscher TF, Engberts DP, Quax PH.

Eur Heart J. 2015 Oct 21;36(40):2681-5. doi: 10.1093/eurheartj/ehv358. Epub 2015 Jul 28. No abstract available.


Letter: scoring models in alcoholic hepatitis.

Wieten E, Brouwer JT, Quispel R, Veldt BJ.

Aliment Pharmacol Ther. 2015 Jul;42(1):126. doi: 10.1111/apt.13224. No abstract available.


The live donor assessment tool: a psychosocial assessment tool for live organ donors.

Iacoviello BM, Shenoy A, Braoude J, Jennings T, Vaidya S, Brouwer J, Haydel B, Arroyo H, Thakur D, Leinwand J, Rudow DL.

Psychosomatics. 2015 May-Jun;56(3):254-61. doi: 10.1016/j.psym.2015.02.001. Epub 2015 Feb 11.


Brief Report: Miscarriages in Female Rheumatoid Arthritis Patients: Associations With Serologic Findings, Disease Activity, and Antirheumatic Drug Treatment.

Brouwer J, Laven JS, Hazes JM, Dolhain RJ.

Arthritis Rheumatol. 2015 Jul;67(7):1738-43. doi: 10.1002/art.39137.


Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM.

Cell Death Dis. 2015 Apr 23;6:e1735. doi: 10.1038/cddis.2015.105.


European Primary Care Cardiovascular Society (EPCCS) consensus guidance on stroke prevention in atrial fibrillation (SPAF) in primary care.

Hobbs FR, Taylor CJ, Jan Geersing G, Rutten FH, Brouwer JR; European Primary Care Cardiovascular Society (EPCCS) SPAF working group.

Eur J Prev Cardiol. 2016 Mar;23(5):460-73. doi: 10.1177/2047487315571890. Epub 2015 Feb 20. Review.


HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1.

van Gerven NM, de Boer YS, Zwiers A, Verwer BJ, Drenth JP, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, Coenraad MJ, Kraal G, Mulder CJ, van Nieuwkerk CM, Bloemena E, Verspaget HW, Kumar V, Zhernakova A, Wijmenga C, Franke L, Bouma G; Dutch Autoimmune Hepatitis Study Group.

Genes Immun. 2015 Jun;16(4):247-52. doi: 10.1038/gene.2014.82. Epub 2015 Jan 22.


Long-term follow-up of second-generation everolimus-eluting stents versus first-generation sirolimus-eluting stents in acute myocardial infarction: three-year results of the XAMI trial.

Hofma SH, Smits PC, Brouwer J, Velders MA, van 't Hof AW, Queré M, de Vries CJ, van Boven AJ.

EuroIntervention. 2015 Mar;10(11):1280-3. doi: 10.4244/EIJY15M01_03.


Dutch guidance for the treatment of chronic hepatitis C virus infection in a new therapeutic era.

Berden FA, Kievit W, Baak LC, Bakker CM, Beuers U, Boucher CA, Brouwer JT, Burger DM, van Erpecum KJ, van Hoek B, Hoepelman AI, Honkoop P, Kerbert-Dreteler MJ, de Knegt RJ, Koek GH, van Nieuwkerk CM, van Soest H, Tan AC, Vrolijk JM, Drenth JP.

Neth J Med. 2014 Oct;72(8):388-400. Review.


Eutrophication threatens Caribbean seagrasses - An example from Curaçao and Bonaire.

Govers LL, Lamers LPM, Bouma TJ, de Brouwer JHF, van Katwijk MM.

Mar Pollut Bull. 2014 Dec 15;89(1-2):481-486. doi: 10.1016/j.marpolbul.2014.09.003. Epub 2014 Sep 23.


Seagrasses as indicators for coastal trace metal pollution: a global meta-analysis serving as a benchmark, and a Caribbean case study.

Govers LL, Lamers LP, Bouma TJ, Eygensteyn J, de Brouwer JH, Hendriks AJ, Huijbers CM, van Katwijk MM.

Environ Pollut. 2014 Dec;195:210-7. doi: 10.1016/j.envpol.2014.08.028. Epub 2014 Sep 21.


Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Brouwer JM, Westphal D, Dewson G, Robin AY, Uren RT, Bartolo R, Thompson GV, Colman PM, Kluck RM, Czabotar PE.

Mol Cell. 2014 Sep 18;55(6):938-946. doi: 10.1016/j.molcel.2014.07.016. Epub 2014 Aug 28.


Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands.

van Gerven NM, Verwer BJ, Witte BI, van Erpecum KJ, van Buuren HR, Maijers I, Visscher AP, Verschuren EC, van Hoek B, Coenraad MJ, Beuers UH, de Man RA, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, Mulder CJ, van Nieuwkerk CM, Bouma G; Dutch Autoimmune hepatitis STUDY group.

Scand J Gastroenterol. 2014 Oct;49(10):1245-54. doi: 10.3109/00365521.2014.946083. Epub 2014 Aug 15.


Toxic effects of increased sediment nutrient and organic matter loading on the seagrass Zostera noltii.

Govers LL, de Brouwer JH, Suykerbuyk W, Bouma TJ, Lamers LP, Smolders AJ, van Katwijk MM.

Aquat Toxicol. 2014 Oct;155:253-60. doi: 10.1016/j.aquatox.2014.07.005. Epub 2014 Jul 12.


The clinical impact of different coagulometers on patient outcomes.

Brouwer JL, Stoevelaar H, Sucker C.

Adv Ther. 2014 Jun;31(6):639-56. doi: 10.1007/s12325-014-0124-x. Epub 2014 Jun 4.


Fertility in women with rheumatoid arthritis: influence of disease activity and medication.

Brouwer J, Hazes JM, Laven JS, Dolhain RJ.

Ann Rheum Dis. 2015 Oct;74(10):1836-41. doi: 10.1136/annrheumdis-2014-205383. Epub 2014 May 15.


Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.

de Boer YS, van Gerven NM, Zwiers A, Verwer BJ, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, Kraal G, Mulder CJ, van Nieuwkerk CM, Fischer J, Berg T, Stickel F, Sarrazin C, Schramm C, Lohse AW, Weiler-Normann C, Lerch MM, Nauck M, Völzke H, Homuth G, Bloemena E, Verspaget HW, Kumar V, Zhernakova A, Wijmenga C, Franke L, Bouma G; Dutch Autoimmune Hepatitis Study Group; LifeLines Cohort Study; Study of Health in Pomerania.

Gastroenterology. 2014 Aug;147(2):443-52.e5. doi: 10.1053/j.gastro.2014.04.022. Epub 2014 Apr 23.


Everolimus- and sirolimus-eluting stents in patients with and without ST-segment elevation myocardial infarction.

Velders MA, van Boven AJ, Brouwer J, Smits PC, van 't Hof AW, de Vries CJ, Queré M, Hofma SH.

Neth Heart J. 2014 Apr;22(4):167-73. doi: 10.1007/s12471-014-0525-0.


Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus.

Brouwer JR, Huguet A, Nicole A, Munnich A, Gourdon G.

J Nucleic Acids. 2013;2013:567435. doi: 10.1155/2013/567435. Epub 2013 Dec 23.


Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain.

Baggelaar MP, Janssen FJ, van Esbroeck AC, den Dulk H, Allarà M, Hoogendoorn S, McGuire R, Florea BI, Meeuwenoord N, van den Elst H, van der Marel GA, Brouwer J, Di Marzo V, Overkleeft HS, van der Stelt M.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12081-5. doi: 10.1002/anie.201306295. Epub 2013 Oct 31. No abstract available.


Treatment of hepatitis C monoinfection in adults--Dutch national guidelines.

Lamers MH, Broekman MM, Boucher CA, Brouwer JT, Burger DM, van Hoek B, Hoepelman AI, de Knegt RJ, Reesink HW, Drenth JP; Netherlands Association of Hepato-gastroenterologists; Netherlands Association of Internal Medicine; Dutch Association for the Study of Liver Disease.

Neth J Med. 2013 Sep;71(7):377-85.


Comparing quality, safety, and costs of colonoscopies performed by nurse vs physician trainees.

Massl R, van Putten PG, Steyerberg EW, van Tilburg AJ, Lai JY, de Ridder RJ, Brouwer JT, Verburg RJ, Alderliesten J, Schoon EJ, van Leerdam ME, Kuipers EJ.

Clin Gastroenterol Hepatol. 2014 Mar;12(3):470-7. doi: 10.1016/j.cgh.2013.08.049. Epub 2013 Sep 10.


More cells, bigger cells or simply reorganization? Alternative mechanisms leading to changed internode architecture under contrasting stress regimes.

Huber H, de Brouwer J, von Wettberg EJ, During HJ, Anten NP.

New Phytol. 2014 Jan;201(1):193-204. doi: 10.1111/nph.12474. Epub 2013 Sep 13.


Utilization of a benchmarking database to inform NICHE implementation.

Capezuti E, Boltz MP, Shuluk J, Denysyk L, Brouwer JP, Roberts MC, Dickson VV, Cline DD, Wagner LM, Fairchild S, Kim H, Secic M.

Res Gerontol Nurs. 2013 Jul;6(3):198-208. doi: 10.3928/19404921-20130607-01. Epub 2013 Jun 13.


Two-year results of an open-label randomized comparison of everolimus-eluting stents and sirolimus-eluting stents.

Velders MA, Hofma SH, Brouwer J, de Vries CJ, Queré M, van Boven AJ.

PLoS One. 2013 Jun 3;8(6):e64424. doi: 10.1371/journal.pone.0064424. Print 2014. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/ba8e169c-a2bc-4423-b664-0de7496e453a. de Vries, Cees Jan [corrected to Vries, Cornelis Jan].


Cell recovery from DM1 transgenic mouse tissue to study (CTG) n instability and DM1 pathogenesis.

Brouwer JR, Foiry L, Gourdon G.

Methods Mol Biol. 2013;1010:253-64. doi: 10.1007/978-1-62703-411-1_16.


Implementation of geriatric acute care best practices: initial results of the NICHE SITE self-evaluation.

Boltz M, Capezuti E, Shuluk J, Brouwer J, Carolan D, Conway S, DeRosa S, LaReau R, Lyons D, Nickoley S, Smith T, Galvin JE.

Nurs Health Sci. 2013 Dec;15(4):518-24. doi: 10.1111/nhs.12067. Epub 2013 May 9.


Levels of serum anti-Müllerian hormone, a marker for ovarian reserve, in women with rheumatoid arthritis.

Brouwer J, Laven JS, Hazes JM, Schipper I, Dolhain RJ.

Arthritis Care Res (Hoboken). 2013 Sep;65(9):1534-8. doi: 10.1002/acr.22013.


Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis.

van Gerven NM, de Boer YS, Zwiers A, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, Kraal G, Mulder CJ, van Nieuwkerk CM, Bouma G; Dutch Autoimmune Hepatitis Study group.

Liver Int. 2013 Aug;33(7):1039-43. doi: 10.1111/liv.12157. Epub 2013 Mar 31.


Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin.

Lanz HL, Zimmerman RM, Brouwer J, Noteborn MH, Backendorf C.

Cell Death Dis. 2013 Feb 7;4:e487. doi: 10.1038/cddis.2013.2.

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