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The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells.

Lappano R, Mallet C, Rizzuti B, Grande F, Galli GR, Byrne C, Broutin I, Boudieu L, Eschalier A, Jacquot Y, Maggiolini M.

Cells. 2019 Jun 14;8(6). pii: E590. doi: 10.3390/cells8060590.


VEGF (Vascular Endothelial Growth Factor) Functionalized Magnetic Beads in a Microfluidic Device to Improve the Angiogenic Balance in Preeclampsia.

Trapiella-Alfonso L, Alexandre L, Fraichard C, Pons K, Dumas S, Huart L, Gaucher JF, Hebert-Schuster M, Guibourdenche J, Fournier T, Vidal M, Broutin I, Lecomte-Raclet L, Malaquin L, Descroix S, Tsatsaris V, Gagey-Eilstein N, Lecarpentier E.

Hypertension. 2019 Jul;74(1):145-153. doi: 10.1161/HYPERTENSIONAHA.118.12380. Epub 2019 May 13.


Minimal nanodisc without exogenous lipids for stabilizing membrane proteins in detergent-free buffer.

Salvador D, Glavier M, Schoehn G, Phan G, Taveau JC, Decossas M, Lecomte S, Mongrand S, Garnier C, Broutin I, Daury L, Lambert O.

Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):852-860. doi: 10.1016/j.bbamem.2019.01.013. Epub 2019 Jan 30.


From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

Bonnet AL, Chaussain C, Broutin I, Rochefort GY, Schrewe H, Gaucher C.

Front Med (Lausanne). 2018 Dec 4;5:335. doi: 10.3389/fmed.2018.00335. eCollection 2018. Review.


LC-MS/MS-based quantification of efflux transporter proteins at the BBB.

Gomez-Zepeda D, Taghi M, Smirnova M, Sergent P, Liu WQ, Chhuon C, Vidal M, Picard M, Thioulouse E, Broutin I, Guerrera IC, Scherrmann JM, Parmentier Y, Decleves X, Menet MC.

J Pharm Biomed Anal. 2019 Feb 5;164:496-508. doi: 10.1016/j.jpba.2018.11.013. Epub 2018 Nov 8.


Functional Mechanism of the Efflux Pumps Transcription Regulators From Pseudomonas aeruginosa Based on 3D Structures.

Housseini B Issa K, Phan G, Broutin I.

Front Mol Biosci. 2018 Jun 19;5:57. doi: 10.3389/fmolb.2018.00057. eCollection 2018. Review.


Lysine Succinylation and Acetylation in Pseudomonas aeruginosa.

Gaviard C, Broutin I, Cosette P, Dé E, Jouenne T, Hardouin J.

J Proteome Res. 2018 Jul 6;17(7):2449-2459. doi: 10.1021/acs.jproteome.8b00210. Epub 2018 May 30.


Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa.

Juarez P, Broutin I, Bordi C, Plésiat P, Llanes C.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02445-17. doi: 10.1128/AAC.02445-17. Print 2018 May.


Biochemical Reconstitution and Characterization of Multicomponent Drug Efflux Transporters.

Picard M, Tikhonova EB, Broutin I, Lu S, Verchère A, Zgurskaya HI.

Methods Mol Biol. 2018;1700:113-145. doi: 10.1007/978-1-4939-7454-2_8.


Xenon for tunnelling analysis of the efflux pump component OprN.

Ntsogo Enguéné YV, Phan G, Garnier C, Ducruix A, Prangé T, Broutin I.

PLoS One. 2017 Sep 8;12(9):e0184045. doi: 10.1371/journal.pone.0184045. eCollection 2017.


Reconstitution of Membrane Proteins in Liposomes.

Verchère A, Broutin I, Picard M.

Methods Mol Biol. 2017;1635:259-282. doi: 10.1007/978-1-4939-7151-0_14.


Targeted unlabeled multiple reaction monitoring analysis of cell markers for the study of sample heterogeneity in isolated rat brain cortical microvessels.

Gomez-Zepeda D, Chaves C, Taghi M, Sergent P, Liu WQ, Chhuon C, Vidal M, Picard M, Thioulouse E, Broutin I, Guerrera IC, Scherrmann JM, Parmentier Y, Decleves X, Menet MC.

J Neurochem. 2017 Aug;142(4):597-609. doi: 10.1111/jnc.14095. Epub 2017 Jul 11.


VEGFR1 domain 2 covalent labeling with horseradish peroxidase: Development of a displacement assay on VEGF.

Reille-Seroussi M, Gaucher JF, Cussac LA, Broutin I, Vidal M, Broussy S.

Anal Biochem. 2017 Aug 1;530:107-112. doi: 10.1016/j.ab.2017.05.004. Epub 2017 May 3.


Quantification of Detergents Complexed with Membrane Proteins.

Chaptal V, Delolme F, Kilburg A, Magnard S, Montigny C, Picard M, Prier C, Monticelli L, Bornert O, Agez M, Ravaud S, Orelle C, Wagner R, Jawhari A, Broutin I, Pebay-Peyroula E, Jault JM, Kaback HR, le Maire M, Falson P.

Sci Rep. 2017 Feb 8;7:41751. doi: 10.1038/srep41751.


Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A.

Gaucher JF, Reille-Seroussi M, Gagey-Eilstein N, Broussy S, Coric P, Seijo B, Lascombe MB, Gautier B, Liu WQ, Huguenot F, Inguimbert N, Bouaziz S, Vidal M, Broutin I.

PLoS One. 2016 Dec 12;11(12):e0167755. doi: 10.1371/journal.pone.0167755. eCollection 2016.


Tripartite assembly of RND multidrug efflux pumps.

Daury L, Orange F, Taveau JC, Verchère A, Monlezun L, Gounou C, Marreddy RK, Picard M, Broutin I, Pos KM, Lambert O.

Nat Commun. 2016 Feb 12;7:10731. doi: 10.1038/ncomms10731.


Germline Prolactin Receptor Mutation Is Not a Major Cause of Sporadic Prolactinoma in Humans.

Bernard V, Bouilly J, Beau I, Broutin I, Chanson P, Young J, Binart N.

Neuroendocrinology. 2016;103(6):738-45. doi: 10.1159/000442981. Epub 2015 Dec 8.


Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins.

Berrazeg M, Jeannot K, Ntsogo Enguéné VY, Broutin I, Loeffert S, Fournier D, Plésiat P.

Antimicrob Agents Chemother. 2015 Oct;59(10):6248-55. doi: 10.1128/AAC.00825-15. Epub 2015 Jul 27.


Vascular Endothelial Growth Factor Peptide Ligands Explored by Competition Assay and Isothermal Titration Calorimetry.

Reille-Seroussi M, Gaucher JF, Desole C, Gagey-Eilstein N, Brachet F, Broutin I, Vidal M, Broussy S.

Biochemistry. 2015 Aug 25;54(33):5147-56. doi: 10.1021/acs.biochem.5b00722. Epub 2015 Aug 13.


New OprM structure highlighting the nature of the N-terminal anchor.

Monlezun L, Phan G, Benabdelhak H, Lascombe MB, Enguéné VY, Picard M, Broutin I.

Front Microbiol. 2015 Jul 1;6:667. doi: 10.3389/fmicb.2015.00667. eCollection 2015.


Catch me if you can: a biotinylated proteoliposome affinity assay for the investigation of assembly of the MexA-MexB-OprM efflux pump from Pseudomonas aeruginosa.

Ntsogo Enguéné VY, Verchère A, Phan G, Broutin I, Picard M.

Front Microbiol. 2015 Jun 2;6:541. doi: 10.3389/fmicb.2015.00541. eCollection 2015.


Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells.

Fiorini L, Tribalat MA, Sauvard L, Cazareth J, Lalli E, Broutin I, Thomas OP, Mus-Veteau I.

Oncotarget. 2015 Sep 8;6(26):22282-97.


In vitro transport activity of the fully assembled MexAB-OprM efflux pump from Pseudomonas aeruginosa.

Verchère A, Dezi M, Adrien V, Broutin I, Picard M.

Nat Commun. 2015 Apr 22;6:6890. doi: 10.1038/ncomms7890.


A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling.

Zhang C, Nygaard M, Haxholm GW, Boutillon F, Bernadet M, Hoos S, England P, Broutin I, Kragelund BB, Goffin V.

J Biol Chem. 2015 May 8;290(19):11890-904. doi: 10.1074/jbc.M115.639096. Epub 2015 Mar 17.


Carbapenem resistance in cystic fibrosis strains of Pseudomonas aeruginosa as a result of amino acid substitutions in porin OprD.

Richardot C, Plésiat P, Fournier D, Monlezun L, Broutin I, Llanes C.

Int J Antimicrob Agents. 2015 May;45(5):529-32. doi: 10.1016/j.ijantimicag.2014.12.029. Epub 2015 Feb 12.


Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies.

Phan G, Picard M, Broutin I.

Antibiotics (Basel). 2015 Nov 12;4(4):544-66. doi: 10.3390/antibiotics4040544. Review.


Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis.

Zhang C, Cherifi I, Nygaard M, Haxholm GW, Bogorad RL, Bernadet M, England P, Broutin I, Kragelund BB, Guidotti JE, Goffin V.

Mol Cell Endocrinol. 2015 Feb 5;401:173-88. doi: 10.1016/j.mce.2014.12.006. Epub 2014 Dec 15.


Amphipol-mediated screening of molecular orthoses specific for membrane protein targets.

Ferrandez Y, Dezi M, Bosco M, Urvoas A, Valerio-Lepiniec M, Le Bon C, Giusti F, Broutin I, Durand G, Polidori A, Popot JL, Picard M, Minard P.

J Membr Biol. 2014 Oct;247(9-10):925-40. doi: 10.1007/s00232-014-9707-3. Epub 2014 Aug 3.


In vitro investigation of the MexAB efflux pump from Pseudomonas aeruginosa.

Verchère A, Dezi M, Broutin I, Picard M.

J Vis Exp. 2014 Feb 17;(84):e50894. doi: 10.3791/50894.


Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.

Guénard S, Muller C, Monlezun L, Benas P, Broutin I, Jeannot K, Plésiat P.

Antimicrob Agents Chemother. 2014;58(1):221-8. doi: 10.1128/AAC.01252-13. Epub 2013 Oct 21. Erratum in: Antimicrob Agents Chemother. 2014 Mar;58(3):1833.


Identification of polyproline II regions derived from the proline-rich nuclear receptor coactivators PNRC and PNRC2: new insights for ERα coactivator interactions.

Byrne C, Miclet E, Broutin I, Gallo D, Pelekanou V, Kampa M, Castanas E, Leclercq G, Jacquot Y.

Chirality. 2013 Oct;25(10):628-42. doi: 10.1002/chir.22188. Epub 2013 Aug 8.


Contribution of asparagine 346 residue to the carbapenemase activity of CMY-2 β-lactamase.

Dahyot S, Broutin I, de Champs C, Guillon H, Mammeri H.

FEMS Microbiol Lett. 2013 Aug;345(2):147-53. doi: 10.1111/1574-6968.12199. Epub 2013 Jul 1.


Hoechst likes to play hide and seek...use it with caution!

Verchère A, Broutin I, Picard M.

Anal Biochem. 2013 Sep 15;440(2):117-9. doi: 10.1016/j.ab.2013.05.019. Epub 2013 Jun 3.


Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding.

de Mol NJ, Kruijtzer JA, Moret EE, Broutin I, Liskamp RM.

Biochim Biophys Acta. 2013 Feb;1834(2):524-35. doi: 10.1016/j.bbapap.2012.11.001. Epub 2012 Nov 15.


Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis.

Ferrandez Y, Monlezun L, Phan G, Benabdelhak H, Benas P, Ulryck N, Falson P, Ducruix A, Picard M, Broutin I.

Electrophoresis. 2012 Apr;33(8):1282-7. doi: 10.1002/elps.201100541.


Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps.

Verchère A, Broutin I, Picard M.

Sci Rep. 2012;2:306. doi: 10.1038/srep00306. Epub 2012 Mar 7.


Activity monitoring of functional OprM using a biomimetic microfluidic device.

Wang W, Monlezun L, Picard M, Benas P, Français O, Broutin I, Le Pioufle B.

Analyst. 2012 Feb 21;137(4):847-52. doi: 10.1039/c2an16007b. Epub 2012 Jan 4.


Targeting the proangiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening.

Gautier B, Miteva MA, Goncalves V, Huguenot F, Coric P, Bouaziz S, Seijo B, Gaucher JF, Broutin I, Garbay C, Lesnard A, Rault S, Inguimbert N, Villoutreix BO, Vidal M.

Chem Biol. 2011 Dec 23;18(12):1631-9. doi: 10.1016/j.chembiol.2011.10.016.


INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy.

Boyer O, Nevo F, Plaisier E, Funalot B, Gribouval O, Benoit G, Huynh Cong E, Arrondel C, Tête MJ, Montjean R, Richard L, Karras A, Pouteil-Noble C, Balafrej L, Bonnardeaux A, Canaud G, Charasse C, Dantal J, Deschenes G, Deteix P, Dubourg O, Petiot P, Pouthier D, Leguern E, Guiochon-Mantel A, Broutin I, Gubler MC, Saunier S, Ronco P, Vallat JM, Alonso MA, Antignac C, Mollet G.

N Engl J Med. 2011 Dec 22;365(25):2377-88. doi: 10.1056/NEJMoa1109122.


Monitoring the active transport of efflux pumps after their reconstitution into proteoliposomes: caveats and keys.

Picard M, Verchère A, Broutin I.

Anal Biochem. 2012 Jan 15;420(2):194-6. doi: 10.1016/j.ab.2011.09.025. Epub 2011 Oct 2.


Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.

Bouilly J, Bachelot A, Broutin I, Touraine P, Binart N.

Hum Mutat. 2011 Oct;32(10):1108-13. doi: 10.1002/humu.21543. Epub 2011 Sep 9.


Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis.

Boyer O, Benoit G, Gribouval O, Nevo F, Tête MJ, Dantal J, Gilbert-Dussardier B, Touchard G, Karras A, Presne C, Grunfeld JP, Legendre C, Joly D, Rieu P, Mohsin N, Hannedouche T, Moal V, Gubler MC, Broutin I, Mollet G, Antignac C.

J Am Soc Nephrol. 2011 Feb;22(2):239-45. doi: 10.1681/ASN.2010050518. Epub 2011 Jan 21.


Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.

van Agthoven J, Zhang C, Tallet E, Raynal B, Hoos S, Baron B, England P, Goffin V, Broutin I.

J Mol Biol. 2010 Nov 19;404(1):112-26. doi: 10.1016/j.jmb.2010.09.036. Epub 2010 Sep 25.


Structural and dynamical insights into the opening mechanism of P. aeruginosa OprM channel.

Phan G, Benabdelhak H, Lascombe MB, Benas P, Rety S, Picard M, Ducruix A, Etchebest C, Broutin I.

Structure. 2010 Mar 14;18(4):507-17. doi: 10.1016/j.str.2010.01.018.


Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.

Broutin I, Jomain JB, Tallet E, van Agthoven J, Raynal B, Hoos S, Kragelund BB, Kelly PA, Ducruix A, England P, Goffin V.

J Biol Chem. 2010 Mar 12;285(11):8422-33. doi: 10.1074/jbc.M109.089128. Epub 2010 Jan 6.


NKX2-1 mutations leading to surfactant protein promoter dysregulation cause interstitial lung disease in "Brain-Lung-Thyroid Syndrome".

Guillot L, Carré A, Szinnai G, Castanet M, Tron E, Jaubert F, Broutin I, Counil F, Feldmann D, Clement A, Polak M, Epaud R.

Hum Mutat. 2010 Feb;31(2):E1146-62. doi: 10.1002/humu.21183.


Molecular determinants of Grb14-mediated inhibition of insulin signaling.

Goenaga D, Hampe C, Carré N, Cailliau K, Browaeys-Poly E, Perdereau D, Holt LJ, Daly RJ, Girard J, Broutin I, Issad T, Burnol AF.

Mol Endocrinol. 2009 Jul;23(7):1043-51. doi: 10.1210/me.2008-0360. Epub 2009 Apr 9.


Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance.

Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F.

EMBO Rep. 2008 Apr;9(4):344-9. doi: 10.1038/embor.2008.9. Epub 2008 Feb 22.


A non-canonical Grb2-PLC-gamma1-Sos cascade triggered by lipovitellin 1, an apolipoprotein B homologue.

Browaeys-Poly E, Broutin I, Antoine AF, Marin M, Lescuyer A, Vilain JP, Ducruix A, Cailliau K.

Cell Signal. 2007 Dec;19(12):2540-8. Epub 2007 Aug 15.


Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.

Jomain JB, Tallet E, Broutin I, Hoos S, van Agthoven J, Ducruix A, Kelly PA, Kragelund BB, England P, Goffin V.

J Biol Chem. 2007 Nov 9;282(45):33118-31. Epub 2007 Sep 4.

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