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Items: 1 to 50 of 141

1.

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.

Cresto N, Gaillard MC, Gardier C, Gubinelli F, Diguet E, Bellet D, Legroux L, Mitja J, Auregan G, Guillermier M, Josephine C, Jan C, Dufour N, Joliot A, Hantraye P, Bonvento G, Déglon N, Bemelmans AP, Cambon K, Liot G, Brouillet E.

Neurobiol Dis. 2019 Oct 9;134:104614. doi: 10.1016/j.nbd.2019.104614. [Epub ahead of print]

2.

What is gained or 'lost in translation' in Huntington's disease.

Brouillet E, Merienne K.

Brain. 2019 Oct 1;142(10):2900-2902. doi: 10.1093/brain/awz274. No abstract available.

PMID:
31560061
3.

Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.

Gary C, Lam S, Hérard AS, Koch JE, Petit F, Gipchtein P, Sawiak SJ, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys JP; French Neuropathology Network, Brouillet E, Buée L, Comoy EE, Pifferi F, Picq JL, Dhenain M.

Acta Neuropathol Commun. 2019 Sep 4;7(1):126. doi: 10.1186/s40478-019-0771-x.

4.

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo.

Ligneul C, Palombo M, Hernández-Garzón E, Carrillo-de Sauvage MA, Flament J, Hantraye P, Brouillet E, Bonvento G, Escartin C, Valette J.

Neuroimage. 2019 May 1;191:457-469. doi: 10.1016/j.neuroimage.2019.02.046. Epub 2019 Feb 25.

PMID:
30818026
5.

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease.

Ceyzériat K, Ben Haim L, Denizot A, Pommier D, Matos M, Guillemaud O, Palomares MA, Abjean L, Petit F, Gipchtein P, Gaillard MC, Guillermier M, Bernier S, Gaudin M, Aurégan G, Joséphine C, Déchamps N, Veran J, Langlais V, Cambon K, Bemelmans AP, Baijer J, Bonvento G, Dhenain M, Deleuze JF, Oliet SHR, Brouillet E, Hantraye P, Carrillo-de Sauvage MA, Olaso R, Panatier A, Escartin C.

Acta Neuropathol Commun. 2018 Oct 16;6(1):104. doi: 10.1186/s40478-018-0606-1.

6.

The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease.

Cresto N, Gardier C, Gubinelli F, Gaillard MC, Liot G, West AB, Brouillet E.

Eur J Neurosci. 2019 Feb;49(3):339-363. doi: 10.1111/ejn.14182. Epub 2018 Oct 24.

PMID:
30269383
7.

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E.

Brain. 2018 May 1;141(5):1434-1454. doi: 10.1093/brain/awy057.

8.

Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates.

Senova S, Poupon C, Dauguet J, Stewart HJ, Dugué GP, Jan C, Hosomi K, Ralph GS, Barnes L, Drouot X, Pouzat C, Mangin JF, Pain F, Doignon I, Aron-Badin R, Brouillet E, Boyden ES, Mitrophanous KA, Hantraye P, Palfi S.

Sci Rep. 2018 Feb 20;8(1):3362. doi: 10.1038/s41598-018-21486-8.

9.

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

d'Orange M, Aurégan G, Cheramy D, Gaudin-Guérif M, Lieger S, Guillermier M, Stimmer L, Joséphine C, Hérard AS, Gaillard MC, Petit F, Kiessling MC, Schmitz C, Colin M, Buée L, Panayi F, Diguet E, Brouillet E, Hantraye P, Bemelmans AP, Cambon K.

Brain. 2018 Feb 1;141(2):535-549. doi: 10.1093/brain/awx342.

10.

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes.

Merienne N, Vachey G, de Longprez L, Meunier C, Zimmer V, Perriard G, Canales M, Mathias A, Herrgott L, Beltraminelli T, Maulet A, Dequesne T, Pythoud C, Rey M, Pellerin L, Brouillet E, Perrier AL, du Pasquier R, Déglon N.

Cell Rep. 2017 Sep 19;20(12):2980-2991. doi: 10.1016/j.celrep.2017.08.075.

11.

Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases.

Bonvento G, Valette J, Flament J, Mochel F, Brouillet E.

J Cereb Blood Flow Metab. 2017 Jun;37(6):1927-1943. doi: 10.1177/0271678X17697989. Epub 2017 Mar 9. Review.

12.

Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature.

Le Gras S, Keime C, Anthony A, Lotz C, De Longprez L, Brouillet E, Cassel JC, Boutillier AL, Merienne K.

Sci Rep. 2017 Feb 22;7:42875. doi: 10.1038/srep42875.

13.

Contribution of Neuroepigenetics to Huntington's Disease.

Francelle L, Lotz C, Outeiro T, Brouillet E, Merienne K.

Front Hum Neurosci. 2017 Jan 30;11:17. doi: 10.3389/fnhum.2017.00017. eCollection 2017. Review.

14.

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin.

Galan-Rodriguez B, Martin E, Brouillet E, Déglon N, Betuing S, Caboche J.

Eur J Neurosci. 2017 Jan;45(1):198-206. doi: 10.1111/ejn.13415. Epub 2016 Oct 24.

PMID:
27717053
15.

Energy defects in Huntington's disease: Why "in vivo" evidence matters.

Liot G, Valette J, Pépin J, Flament J, Brouillet E.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1084-1095. doi: 10.1016/j.bbrc.2016.09.065. Epub 2016 Sep 14. Review.

PMID:
27639641
16.
17.

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.

Pépin J, Francelle L, Carrillo-de Sauvage MA, de Longprez L, Gipchtein P, Cambon K, Valette J, Brouillet E, Flament J.

Neuroimage. 2016 Oct 1;139:53-64. doi: 10.1016/j.neuroimage.2016.06.023. Epub 2016 Jun 16.

18.

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo.

Palombo M, Ligneul C, Najac C, Le Douce J, Flament J, Escartin C, Hantraye P, Brouillet E, Bonvento G, Valette J.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6671-6. doi: 10.1073/pnas.1504327113. Epub 2016 May 25.

19.

Exposing elusive cationic magnesium-chloro aggregates in aluminate complexes through donor control.

Brouillet EV, Kennedy AR, Koszinowski K, McLellan R, Mulvey RE, Robertson SD.

Dalton Trans. 2016 Apr 7;45(13):5590-7. doi: 10.1039/c6dt00531d. Epub 2016 Feb 26.

20.

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

Rocher AB, Gubellini P, Merienne N, Boussicault L, Petit F, Gipchtein P, Jan C, Hantraye P, Brouillet E, Bonvento G.

Neurobiol Dis. 2016 Feb;86:131-9. doi: 10.1016/j.nbd.2015.10.016. Epub 2015 Nov 25.

PMID:
26626081
21.

The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study.

Carrillo-de Sauvage MA, Flament J, Bramoulle Y, Ben Haim L, Guillermier M, Berniard A, Aurégan G, Houitte D, Brouillet E, Bonvento G, Hantraye P, Valette J, Escartin C.

J Cereb Blood Flow Metab. 2015 Jun;35(6):917-21. doi: 10.1038/jcbfm.2015.48. Epub 2015 Apr 1.

22.

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

Ben Haim L, Ceyzériat K, Carrillo-de Sauvage MA, Aubry F, Auregan G, Guillermier M, Ruiz M, Petit F, Houitte D, Faivre E, Vandesquille M, Aron-Badin R, Dhenain M, Déglon N, Hantraye P, Brouillet E, Bonvento G, Escartin C.

J Neurosci. 2015 Feb 11;35(6):2817-29. doi: 10.1523/JNEUROSCI.3516-14.2015.

23.

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.

Francelle L, Galvan L, Gaillard MC, Petit F, Bernay B, Guillermier M, Bonvento G, Dufour N, Elalouf JM, Hantraye P, Déglon N, de Chaldée M, Brouillet E.

Neurobiol Aging. 2015 Mar;36(3):1601.e7-16. doi: 10.1016/j.neurobiolaging.2014.11.014. Epub 2014 Dec 18.

24.

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.

Francelle L, Galvan L, Gaillard MC, Guillermier M, Houitte D, Bonvento G, Petit F, Jan C, Dufour N, Hantraye P, Elalouf JM, De Chaldée M, Déglon N, Brouillet E.

Hum Mol Genet. 2015 Mar 15;24(6):1563-73. doi: 10.1093/hmg/ddu571. Epub 2014 Nov 14.

25.

Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease.

Francelle L, Galvan L, Brouillet E.

Front Cell Neurosci. 2014 Sep 26;8:295. doi: 10.3389/fncel.2014.00295. eCollection 2014. Review.

26.

Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF.

Hum Mol Genet. 2015 Jan 1;24(1):76-85. doi: 10.1093/hmg/ddu421. Epub 2014 Aug 20.

PMID:
25143394
27.

Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.

Roy M, Cardoso C, Dorieux O, Malgorn C, Epelbaum S, Petit F, Kraska A, Brouillet E, Delatour B, Perret M, Aujard F, Dhenain M.

Neurobiol Aging. 2015 Jan;36(1):149-56. doi: 10.1016/j.neurobiolaging.2014.07.017. Epub 2014 Jul 18.

28.

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.

29.

Donor-activated alkali metal dipyridylamides: co-complexation reactions with zinc alkyls and reactivity studies with benzophenone.

Armstrong DR, Brouillet EV, Kennedy AR, Garden JA, Granitzka M, Mulvey RE, Trivett JJ.

Dalton Trans. 2014 Oct 14;43(38):14409-23. doi: 10.1039/c4dt00914b.

PMID:
24968199
30.

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.

Boussicault L, Hérard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, Brouillet E, Véga C, Bonvento G.

J Cereb Blood Flow Metab. 2014 Sep;34(9):1500-10. doi: 10.1038/jcbfm.2014.110. Epub 2014 Jun 18.

31.

The 3-NP Model of Striatal Neurodegeneration.

Brouillet E.

Curr Protoc Neurosci. 2014 Apr 10;67:9.48.1-14. doi: 10.1002/0471142301.ns0948s67.

PMID:
24723322
32.

Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy.

Najac C, Marchadour C, Guillermier M, Houitte D, Slavov V, Brouillet E, Hantraye P, Lebon V, Valette J.

Neuroimage. 2014 Apr 15;90:374-80. doi: 10.1016/j.neuroimage.2013.12.045. Epub 2013 Dec 29.

PMID:
24382523
33.

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.

Facchinetti P, Dorard E, Contremoulins V, Gaillard MC, Déglon N, Sazdovitch V, Guihenneuc-Jouyaux C, Brouillet E, Duyckaerts C, Allinquant B.

Neurobiol Aging. 2014 May;35(5):958-68. doi: 10.1016/j.neurobiolaging.2013.08.039. Epub 2013 Nov 5.

PMID:
24262202
34.

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.

Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, Beal MF, Brouillet E.

Hum Mol Genet. 2013 Oct 1;22(19):3869-82. doi: 10.1093/hmg/ddt242. Epub 2013 May 29.

35.

High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.

Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Aurégan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL.

Stem Cells. 2013 Sep;31(9):1816-28. doi: 10.1002/stem.1430.

36.

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.

Aron Badin R, Spinnewyn B, Gaillard MC, Jan C, Malgorn C, Van Camp N, Dollé F, Guillermier M, Boulet S, Bertrand A, Savasta M, Auguet M, Brouillet E, Chabrier PE, Hantraye P.

PLoS One. 2013;8(1):e52680. doi: 10.1371/journal.pone.0052680. Epub 2013 Jan 3.

37.

Restricted transgene expression in the brain with cell-type specific neuronal promoters.

Delzor A, Dufour N, Petit F, Guillermier M, Houitte D, Auregan G, Brouillet E, Hantraye P, Déglon N.

Hum Gene Ther Methods. 2012 Aug;23(4):242-54. doi: 10.1089/hgtb.2012.073. Epub 2012 Aug 30.

38.

Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo.

Marchadour C, Brouillet E, Hantraye P, Lebon V, Valette J.

J Cereb Blood Flow Metab. 2012 Dec;32(12):2153-60. doi: 10.1038/jcbfm.2012.119. Epub 2012 Aug 29.

39.

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.

Chaumeil MM, Valette J, Baligand C, Brouillet E, Hantraye P, Bloch G, Gaura V, Rialland A, Krystkowiak P, Verny C, Damier P, Remy P, Bachoud-Levi AC, Carlier P, Lebon V.

J Cereb Blood Flow Metab. 2012 May;32(5):771-9. doi: 10.1038/jcbfm.2012.15. Epub 2012 Feb 29.

40.

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo.

Galvan L, Lepejová N, Gaillard MC, Malgorn C, Guillermier M, Houitte D, Bonvento G, Petit F, Dufour N, Héry P, Gérard M, Elalouf JM, Déglon N, Brouillet E, de Chaldée M.

Neurobiol Aging. 2012 Aug;33(8):1845.e5-6. doi: 10.1016/j.neurobiolaging.2012.01.009. Epub 2012 Feb 24.

PMID:
22365050
41.

Early alterations of brain cellular energy homeostasis in Huntington disease models.

Mochel F, Durant B, Meng X, O'Callaghan J, Yu H, Brouillet E, Wheeler VC, Humbert S, Schiffmann R, Durr A.

J Biol Chem. 2012 Jan 6;287(2):1361-70. doi: 10.1074/jbc.M111.309849. Epub 2011 Nov 28.

42.

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.

Faideau M, Kim J, Cormier K, Gilmore R, Welch M, Auregan G, Dufour N, Guillermier M, Brouillet E, Hantraye P, Déglon N, Ferrante RJ, Bonvento G.

Hum Mol Genet. 2010 Aug 1;19(15):3053-67. doi: 10.1093/hmg/ddq212. Epub 2010 May 21.

43.
44.

Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.

Jarraya B, Boulet S, Ralph GS, Jan C, Bonvento G, Azzouz M, Miskin JE, Shin M, Delzescaux T, Drouot X, Hérard AS, Day DM, Brouillet E, Kingsman SM, Hantraye P, Mitrophanous KA, Mazarakis ND, Palfi S.

Sci Transl Med. 2009 Oct 14;1(2):2ra4. doi: 10.1126/scitranslmed.3000130.

45.

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

Alves S, Nascimento-Ferreira I, Dufour N, Hassig R, Auregan G, Nóbrega C, Brouillet E, Hantraye P, Pedroso de Lima MC, Déglon N, de Almeida LP.

Hum Mol Genet. 2010 Jun 15;19(12):2380-94. doi: 10.1093/hmg/ddq111. Epub 2010 Mar 22.

PMID:
20308049
46.

Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.

Shin M, Jan C, Jacquard C, Jarraya B, Callebert J, Launay JM, Hantraye P, Remy P, Palfi S, Brouillet E.

Neurobiol Aging. 2011 Nov;32(11):2100-2. doi: 10.1016/j.neurobiolaging.2009.11.015. Epub 2009 Dec 16.

PMID:
20018410
47.

Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.

Cleren C, Calingasan NY, Starkov A, Jacquard C, Chen J, Brouillet E, Beal MF.

Neurochem Int. 2010 Jan;56(2):208-12. doi: 10.1016/j.neuint.2009.10.006. Epub 2009 Oct 21.

48.

Mitochondria in Huntington's disease.

Damiano M, Galvan L, Déglon N, Brouillet E.

Biochim Biophys Acta. 2010 Jan;1802(1):52-61. doi: 10.1016/j.bbadis.2009.07.012. Epub 2009 Aug 11. Review.

49.

Sustained effects of nonallele-specific Huntingtin silencing.

Drouet V, Perrin V, Hassig R, Dufour N, Auregan G, Alves S, Bonvento G, Brouillet E, Luthi-Carter R, Hantraye P, Déglon N.

Ann Neurol. 2009 Mar;65(3):276-85. doi: 10.1002/ana.21569.

PMID:
19334076
50.

Normal aging modulates the neurotoxicity of mutant huntingtin.

Diguet E, Petit F, Escartin C, Cambon K, Bizat N, Dufour N, Hantraye P, Déglon N, Brouillet E.

PLoS One. 2009;4(2):e4637. doi: 10.1371/journal.pone.0004637. Epub 2009 Feb 27.

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