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Items: 1 to 50 of 171

1.

A new gorilla adenoviral vector with natural lung tropism avoids liver toxicity and is amenable for capsid engineering and vector retargeting.

Lu ZH, Dmitriev IP, Brough DE, Kashentseva EA, Li J, Curiel DT.

J Virol. 2020 Feb 26. pii: JVI.00265-20. doi: 10.1128/JVI.00265-20. [Epub ahead of print]

2.

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA.

Parker H, Ellison SM, Holley RJ, O'Leary C, Liao A, Asadi J, Glover E, Ghosh A, Jones S, Wilkinson FL, Brough D, Pinteaux E, Boutin H, Bigger BW.

EMBO Mol Med. 2020 Mar 6;12(3):e11185. doi: 10.15252/emmm.201911185. Epub 2020 Feb 14.

3.

A screening-level assessment of the pollinator-attractiveness of ornamental nursery stock using a honey bee foraging assay.

Sponsler DB, Grozinger CM, Richardson RT, Nurse A, Brough D, Patch HM, Stoner KA.

Sci Rep. 2020 Jan 21;10(1):831. doi: 10.1038/s41598-020-57858-2.

4.

Hearing Preservation Following Repeated Adenovector Delivery.

Pfannenstiel SC, Praetorius M, Brough DE, Staecker H.

Anat Rec (Hoboken). 2020 Mar;303(3):600-607. doi: 10.1002/ar.24347. Epub 2020 Jan 8.

PMID:
31916371
5.

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung.

Chenery AL, Alhallaf R, Agha Z, Ajendra J, Parkinson JE, Cooper MM, Chan BHK, Eichenberger RM, Dent LA, Robertson AAB, Kupz A, Brough D, Loukas A, Sutherland TE, Allen JE, Giacomin PR.

J Immunol. 2019 Nov 15;203(10):2724-2734. doi: 10.4049/jimmunol.1900640. Epub 2019 Oct 4.

6.

Stoichiometric control on riparian wetland carbon and nutrient dynamics under different land uses.

Yao L, Rashti MR, Brough DM, Burford MA, Liu W, Liu G, Chen C.

Sci Total Environ. 2019 Dec 20;697:134127. doi: 10.1016/j.scitotenv.2019.134127. Epub 2019 Aug 29.

PMID:
31491632
7.

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy.

Hassan AO, Dmitriev IP, Kashentseva EA, Zhao H, Brough DE, Fremont DH, Curiel DT, Diamond MS.

Cell Rep. 2019 Sep 3;28(10):2634-2646.e4. doi: 10.1016/j.celrep.2019.08.005.

8.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G.

Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2.

9.

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease.

Almari B, Brough D, Harte M, Tirella A.

J Vis Exp. 2019 Jul 6;(149). doi: 10.3791/59597.

PMID:
31329175
10.

Primary aortoenteric fistula: a case of delayed diagnosis.

Brough D, Quinn S, Bartley PB, Cavallucci D, O'Rourke N.

ANZ J Surg. 2020 Mar;90(3):383-384. doi: 10.1111/ans.15159. Epub 2019 May 8. No abstract available.

PMID:
31069930
11.

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Lemarchand E, Barrington J, Chenery A, Haley M, Coutts G, Allen JE, Allan SM, Brough D.

Stroke. 2019 May;50(5):1232-1239. doi: 10.1161/STROKEAHA.118.023620.

12.

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

McHugh BJ, Wang R, Li HN, Beaumont PE, Kells R, Stevens H, Young L, Rossi AG, Gray RD, Dorin JR, Gwyer Findlay EL, Brough D, Davidson DJ.

PLoS Pathog. 2019 Apr 12;15(4):e1007694. doi: 10.1371/journal.ppat.1007694. eCollection 2019 Apr.

13.

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

Tapia VS, Daniels MJD, Palazón-Riquelme P, Dewhurst M, Luheshi NM, Rivers-Auty J, Green J, Redondo-Castro E, Kaldis P, Lopez-Castejon G, Brough D.

J Biol Chem. 2019 May 24;294(21):8325-8335. doi: 10.1074/jbc.RA119.008009. Epub 2019 Apr 2.

14.

Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data.

Kramarz B, Roncaglia P, Meldal BHM, Huntley RP, Martin MJ, Orchard S, Parkinson H, Brough D, Bandopadhyay R, Hooper NM, Lovering RC.

Genes (Basel). 2018 Nov 29;9(12). pii: E593. doi: 10.3390/genes9120593.

15.

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming.

Hoyle C, Rivers-Auty J, Lemarchand E, Vranic S, Wang E, Buggio M, Rothwell NJ, Allan SM, Kostarelos K, Brough D.

ACS Nano. 2018 Dec 26;12(12):11949-11962. doi: 10.1021/acsnano.8b03642. Epub 2018 Nov 20.

PMID:
30444603
16.

Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine.

Barrera J, Brake DA, Schutta C, Ettyreddy D, Kamicker BJ, Rasmussen MV, Bravo de Rueda C, Zurita M, Pisano M, Hurtle W, Brough DE, Butman BT, Harper BG, Neilan JG.

Vaccine. 2018 Nov 19;36(48):7345-7352. doi: 10.1016/j.vaccine.2018.10.031. Epub 2018 Oct 13.

17.

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Green JP, Yu S, Martín-Sánchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, Brough D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9371-E9380. doi: 10.1073/pnas.1812744115. Epub 2018 Sep 19.

18.

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.

Palazón-Riquelme P, Worboys JD, Green J, Valera A, Martín-Sánchez F, Pellegrini C, Brough D, López-Castejón G.

EMBO Rep. 2018 Oct;19(10). pii: e44766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11.

19.

Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model.

Neilan JG, Schutta C, Barrera J, Pisano M, Zsak L, Hartwig E, Rasmussen MV, Kamicker BJ, Ettyreddy D, Brough DE, Butman BT, Brake DA.

BMC Vet Res. 2018 Aug 29;14(1):254. doi: 10.1186/s12917-018-1582-1.

20.

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Swanton T, Cook J, Beswick JA, Freeman S, Lawrence CB, Brough D.

SLAS Discov. 2018 Dec;23(10):991-1017. doi: 10.1177/2472555218786210. Epub 2018 Jul 3. Review.

PMID:
29969573
21.

Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.

Strangward P, Haley MJ, Albornoz MG, Barrington J, Shaw T, Dookie R, Zeef L, Baker SM, Winter E, Tzeng TC, Golenbock DT, Cruickshank SM, Allan SM, Craig A, Liew FY, Brough D, Couper KN.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7404-7409. doi: 10.1073/pnas.1801737115. Epub 2018 Jun 28.

22.

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Redondo-Castro E, Faust D, Fox S, Baldwin AG, Osborne S, Haley MJ, Karran E, Nuthall H, Atkinson PJ, Dawson LA, Routledge C, Allan SM, Freeman S, Brownlees J, Brough D.

Sci Rep. 2018 Apr 4;8(1):5667. doi: 10.1038/s41598-018-24029-3.

23.

Redefining the ancestral origins of the interleukin-1 superfamily.

Rivers-Auty J, Daniels MJD, Colliver I, Robertson DL, Brough D.

Nat Commun. 2018 Mar 20;9(1):1156. doi: 10.1038/s41467-018-03362-1.

24.

Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid.

Baldwin AG, Bevan J, Brough D, Ledder R, Freeman S.

Med Chem Res. 2018;27(3):884-889. doi: 10.1007/s00044-017-2110-8. Epub 2017 Nov 13.

25.

Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine.

Barrera J, Schutta C, Pisano M, Grubman MJ, Brake DA, Miller T, Kamicker BJ, Olutunmbi F, Ettyreddy D, Brough DE, Butman BT, Neilan JG.

Vaccine. 2018 Feb 14;36(8):1078-1084. doi: 10.1016/j.vaccine.2018.01.026. Epub 2018 Jan 20.

26.

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Tapia VS, Swanton T, White CS, Beswick JA, Brough D, Freeman S.

ChemMedChem. 2018 Feb 20;13(4):312-320. doi: 10.1002/cmdc.201700731. Epub 2018 Feb 5.

27.

Microglial Priming as Trained Immunity in the Brain.

Haley MJ, Brough D, Quintin J, Allan SM.

Neuroscience. 2019 May 1;405:47-54. doi: 10.1016/j.neuroscience.2017.12.039. Epub 2017 Dec 29. Review.

PMID:
29292078
28.

CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression.

Daniels MJD, Adamson AD, Humphreys N, Brough D.

Sci Rep. 2017 Dec 6;7(1):17077. doi: 10.1038/s41598-017-17387-x.

29.

Safety profile of a replication-deficient human adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle.

Barrera J, Brake DA, Kamicker BJ, Purcell C, Kaptur R Jr, Schieber T, Lechtenberg K, Miller TD, Ettyreddy D, Brough DE, Butman BT, Colby M, Neilan JG.

Transbound Emerg Dis. 2018 Apr;65(2):447-455. doi: 10.1111/tbed.12724. Epub 2017 Oct 27.

30.

Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI.

Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR.

J Neuroimaging. 2018 Mar;28(2):158-161. doi: 10.1111/jon.12477. Epub 2017 Oct 24.

PMID:
29064155
31.

Profiling the Targets of Protective CD8+ T Cell Responses to Infection.

Bruder JT, Chen P, Ekberg G, Smith EC, Lazarski CA, Myers BA, Bolton J, Sedegah M, Villasante E, Richie TL, King CR, Aguiar JC, Doolan DL, Brough DE.

Mol Ther Methods Clin Dev. 2017 Aug 18;7:20-31. doi: 10.1016/j.omtm.2017.08.003. eCollection 2017 Dec 15.

32.

Boron-Based Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Rivers-Auty J, Daniels MJD, White CS, Schwalbe CH, Schilling T, Hammadi H, Jaiyong P, Spencer NG, England H, Luheshi NM, Kadirvel M, Lawrence CB, Rothwell NJ, Harte MK, Bryce RA, Allan SM, Eder C, Freeman S, Brough D.

Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5. doi: 10.1016/j.chembiol.2017.08.011. Epub 2017 Sep 21.

33.

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

Brough D, Pelegrin P, Nickel W.

J Cell Sci. 2017 Oct 1;130(19):3197-3202. doi: 10.1242/jcs.204206. Epub 2017 Sep 4. Review.

34.

Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.

Diamond CE, Leong KWK, Vacca M, Rivers-Auty J, Brough D, Mortellaro A.

Sci Rep. 2017 Jul 31;7(1):6861. doi: 10.1038/s41598-017-07081-3.

35.

Materials Knowledge Systems in Python - A Data Science Framework for Accelerated Development of Hierarchical Materials.

Brough DB, Wheeler D, Kalidindi SR.

Integr Mater Manuf Innov. 2017 Mar;6(1):36-53. doi: 10.1007/s40192-017-0089-0. Epub 2017 Mar 15.

36.

New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model.

Limbach K, Stefaniak M, Chen P, Patterson NB, Liao G, Weng S, Krepkiy S, Ekberg G, Torano H, Ettyreddy D, Gowda K, Sonawane S, Belmonte A, Abot E, Sedegah M, Hollingdale MR, Moormann A, Vulule J, Villasante E, Richie TL, Brough DE, Bruder JT.

Malar J. 2017 Jul 3;16(1):263. doi: 10.1186/s12936-017-1911-z.

37.

Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery.

Dai C, Lehar M, Sun DQ, Rvt LS, Carey JP, MacLachlan T, Brough D, Staecker H, Della Santina AM, Hullar TE, Della Santina CC.

J Assoc Res Otolaryngol. 2017 Aug;18(4):601-617. doi: 10.1007/s10162-017-0628-6. Epub 2017 Jun 23.

38.

Unconventional Pathways of Secretion Contribute to Inflammation.

Daniels MJ, Brough D.

Int J Mol Sci. 2017 Jan 5;18(1). pii: E102. doi: 10.3390/ijms18010102. Review.

39.

Extraction of Process-Structure Evolution Linkages from X-ray Scattering Measurements Using Dimensionality Reduction and Time Series Analysis.

Brough DB, Kannan A, Haaland B, Bucknall DG, Kalidindi SR.

Integr Mater Manuf Innov. 2017;6(2):147-159. doi: 10.1007/s40192-017-0093-4. Epub 2017 Mar 10.

40.

Mini-symposium: Role of the inflammasome in brain pathogenesis: a potential therapeutic target? - introduction.

Boche D, Brough D.

Brain Pathol. 2017 Mar;27(2):190-191. doi: 10.1111/bpa.12481. No abstract available.

PMID:
28009081
41.

Inflammasomes as therapeutic targets for Alzheimer's disease.

White CS, Lawrence CB, Brough D, Rivers-Auty J.

Brain Pathol. 2017 Mar;27(2):223-234. doi: 10.1111/bpa.12478. Review.

PMID:
28009077
42.

P2X7 receptor-dependent tuning of gut epithelial responses to infection.

Huang SW, Walker C, Pennock J, Else K, Muller W, Daniels MJ, Pellegrini C, Brough D, Lopez-Castejon G, Cruickshank SM.

Immunol Cell Biol. 2017 Feb;95(2):178-188. doi: 10.1038/icb.2016.75. Epub 2016 Aug 25.

43.

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.

Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D.

Nat Commun. 2016 Aug 11;7:12504. doi: 10.1038/ncomms12504.

44.

Inflammasomes link vascular disease with neuroinflammation and brain disorders.

Lénárt N, Brough D, Dénes Á.

J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685. Epub 2016 Aug 2. Review.

45.

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

Diamond C, Bagnall J, Spiller DG, White MR, Mortellaro A, Paszek P, Brough D.

Methods Mol Biol. 2016;1417:75-88. doi: 10.1007/978-1-4939-3566-6_4.

PMID:
27221482
46.

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production.

Houlden A, Goldrick M, Brough D, Vizi ES, Lénárt N, Martinecz B, Roberts IS, Denes A.

Brain Behav Immun. 2016 Oct;57:10-20. doi: 10.1016/j.bbi.2016.04.003. Epub 2016 Apr 6.

47.

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation.

Martín-Sánchez F, Diamond C, Zeitler M, Gomez AI, Baroja-Mazo A, Bagnall J, Spiller D, White M, Daniels MJ, Mortellaro A, Peñalver M, Paszek P, Steringer JP, Nickel W, Brough D, Pelegrín P.

Cell Death Differ. 2016 Jul;23(7):1219-31. doi: 10.1038/cdd.2015.176. Epub 2016 Feb 12.

48.

Multiple efficacy studies of an adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle using homologous challenge.

Schutta C, Barrera J, Pisano M, Zsak L, Grubman MJ, Mayr GA, Moraes MP, Kamicker BJ, Brake DA, Ettyreddy D, Brough DE, Butman BT, Neilan JG.

Vaccine. 2016 Jun 8;34(27):3214-3220. doi: 10.1016/j.vaccine.2015.12.018. Epub 2015 Dec 18.

49.

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P.

Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

50.

Inhibiting the Inflammasome: A Chemical Perspective.

Baldwin AG, Brough D, Freeman S.

J Med Chem. 2016 Mar 10;59(5):1691-710. doi: 10.1021/acs.jmedchem.5b01091. Epub 2015 Oct 12. Review.

PMID:
26422006

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