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Items: 1 to 50 of 154

1.

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Green JP, Yu S, Martín-Sánchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, Brough D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9371-E9380. doi: 10.1073/pnas.1812744115. Epub 2018 Sep 19.

PMID:
30232264
2.

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.

Palazón-Riquelme P, Worboys JD, Green J, Valera A, Martín-Sánchez F, Pellegrini C, Brough D, López-Castejón G.

EMBO Rep. 2018 Oct;19(10). pii: e44766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11.

3.

Efficacy of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine in cattle using a direct contact transmission model.

Neilan JG, Schutta C, Barrera J, Pisano M, Zsak L, Hartwig E, Rasmussen MV, Kamicker BJ, Ettyreddy D, Brough DE, Butman BT, Brake DA.

BMC Vet Res. 2018 Aug 29;14(1):254. doi: 10.1186/s12917-018-1582-1.

4.

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

Swanton T, Cook J, Beswick JA, Freeman S, Lawrence CB, Brough D.

SLAS Discov. 2018 Jul 1:2472555218786210. doi: 10.1177/2472555218786210. [Epub ahead of print]

PMID:
29969573
5.

Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.

Strangward P, Haley MJ, Albornoz MG, Barrington J, Shaw T, Dookie R, Zeef L, Baker SM, Winter E, Tzeng TC, Golenbock DT, Cruickshank SM, Allan SM, Craig A, Liew FY, Brough D, Couper KN.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7404-7409. doi: 10.1073/pnas.1801737115. Epub 2018 Jun 28.

PMID:
29954866
6.

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Redondo-Castro E, Faust D, Fox S, Baldwin AG, Osborne S, Haley MJ, Karran E, Nuthall H, Atkinson PJ, Dawson LA, Routledge C, Allan SM, Freeman S, Brownlees J, Brough D.

Sci Rep. 2018 Apr 4;8(1):5667. doi: 10.1038/s41598-018-24029-3.

7.

Redefining the ancestral origins of the interleukin-1 superfamily.

Rivers-Auty J, Daniels MJD, Colliver I, Robertson DL, Brough D.

Nat Commun. 2018 Mar 20;9(1):1156. doi: 10.1038/s41467-018-03362-1.

8.

Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid.

Baldwin AG, Bevan J, Brough D, Ledder R, Freeman S.

Med Chem Res. 2018;27(3):884-889. doi: 10.1007/s00044-017-2110-8. Epub 2017 Nov 13.

9.

Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine.

Barrera J, Schutta C, Pisano M, Grubman MJ, Brake DA, Miller T, Kamicker BJ, Olutunmbi F, Ettyreddy D, Brough DE, Butman BT, Neilan JG.

Vaccine. 2018 Feb 14;36(8):1078-1084. doi: 10.1016/j.vaccine.2018.01.026. Epub 2018 Jan 20.

10.

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Tapia VS, Swanton T, White CS, Beswick JA, Brough D, Freeman S.

ChemMedChem. 2018 Feb 20;13(4):312-320. doi: 10.1002/cmdc.201700731. Epub 2018 Feb 5.

11.

Microglial Priming as Trained Immunity in the Brain.

Haley MJ, Brough D, Quintin J, Allan SM.

Neuroscience. 2017 Dec 29. pii: S0306-4522(17)30929-6. doi: 10.1016/j.neuroscience.2017.12.039. [Epub ahead of print]

PMID:
29292078
12.

CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression.

Daniels MJD, Adamson AD, Humphreys N, Brough D.

Sci Rep. 2017 Dec 6;7(1):17077. doi: 10.1038/s41598-017-17387-x.

13.

Safety profile of a replication-deficient human adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle.

Barrera J, Brake DA, Kamicker BJ, Purcell C, Kaptur R Jr, Schieber T, Lechtenberg K, Miller TD, Ettyreddy D, Brough DE, Butman BT, Colby M, Neilan JG.

Transbound Emerg Dis. 2018 Apr;65(2):447-455. doi: 10.1111/tbed.12724. Epub 2017 Oct 27.

14.

Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI.

Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR.

J Neuroimaging. 2018 Mar;28(2):158-161. doi: 10.1111/jon.12477. Epub 2017 Oct 24.

PMID:
29064155
15.

Profiling the Targets of Protective CD8+ T Cell Responses to Infection.

Bruder JT, Chen P, Ekberg G, Smith EC, Lazarski CA, Myers BA, Bolton J, Sedegah M, Villasante E, Richie TL, King CR, Aguiar JC, Doolan DL, Brough DE.

Mol Ther Methods Clin Dev. 2017 Aug 18;7:20-31. doi: 10.1016/j.omtm.2017.08.003. eCollection 2017 Dec 15.

16.

Boron-Based Inhibitors of the NLRP3 Inflammasome.

Baldwin AG, Rivers-Auty J, Daniels MJD, White CS, Schwalbe CH, Schilling T, Hammadi H, Jaiyong P, Spencer NG, England H, Luheshi NM, Kadirvel M, Lawrence CB, Rothwell NJ, Harte MK, Bryce RA, Allan SM, Eder C, Freeman S, Brough D.

Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5. doi: 10.1016/j.chembiol.2017.08.011. Epub 2017 Sep 21.

17.

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

Brough D, Pelegrin P, Nickel W.

J Cell Sci. 2017 Oct 1;130(19):3197-3202. doi: 10.1242/jcs.204206. Epub 2017 Sep 4. Review.

18.

Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.

Diamond CE, Leong KWK, Vacca M, Rivers-Auty J, Brough D, Mortellaro A.

Sci Rep. 2017 Jul 31;7(1):6861. doi: 10.1038/s41598-017-07081-3.

19.

Materials Knowledge Systems in Python - A Data Science Framework for Accelerated Development of Hierarchical Materials.

Brough DB, Wheeler D, Kalidindi SR.

Integr Mater Manuf Innov. 2017 Mar;6(1):36-53. doi: 10.1007/s40192-017-0089-0. Epub 2017 Mar 15.

20.

New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model.

Limbach K, Stefaniak M, Chen P, Patterson NB, Liao G, Weng S, Krepkiy S, Ekberg G, Torano H, Ettyreddy D, Gowda K, Sonawane S, Belmonte A, Abot E, Sedegah M, Hollingdale MR, Moormann A, Vulule J, Villasante E, Richie TL, Brough DE, Bruder JT.

Malar J. 2017 Jul 3;16(1):263. doi: 10.1186/s12936-017-1911-z.

21.

Rhesus Cochlear and Vestibular Functions Are Preserved After Inner Ear Injection of Saline Volume Sufficient for Gene Therapy Delivery.

Dai C, Lehar M, Sun DQ, Rvt LS, Carey JP, MacLachlan T, Brough D, Staecker H, Della Santina AM, Hullar TE, Della Santina CC.

J Assoc Res Otolaryngol. 2017 Aug;18(4):601-617. doi: 10.1007/s10162-017-0628-6. Epub 2017 Jun 23.

22.

Unconventional Pathways of Secretion Contribute to Inflammation.

Daniels MJ, Brough D.

Int J Mol Sci. 2017 Jan 5;18(1). pii: E102. doi: 10.3390/ijms18010102. Review.

23.

Mini-symposium: Role of the inflammasome in brain pathogenesis: a potential therapeutic target? - introduction.

Boche D, Brough D.

Brain Pathol. 2017 Mar;27(2):190-191. doi: 10.1111/bpa.12481. No abstract available.

PMID:
28009081
24.

Inflammasomes as therapeutic targets for Alzheimer's disease.

White CS, Lawrence CB, Brough D, Rivers-Auty J.

Brain Pathol. 2017 Mar;27(2):223-234. doi: 10.1111/bpa.12478. Review.

PMID:
28009077
25.

P2X7 receptor-dependent tuning of gut epithelial responses to infection.

Huang SW, Walker C, Pennock J, Else K, Muller W, Daniels MJ, Pellegrini C, Brough D, Lopez-Castejon G, Cruickshank SM.

Immunol Cell Biol. 2017 Feb;95(2):178-188. doi: 10.1038/icb.2016.75. Epub 2016 Aug 25.

26.

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.

Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D.

Nat Commun. 2016 Aug 11;7:12504. doi: 10.1038/ncomms12504.

27.

Inflammasomes link vascular disease with neuroinflammation and brain disorders.

Lénárt N, Brough D, Dénes Á.

J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685. Epub 2016 Aug 2. Review.

28.

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

Diamond C, Bagnall J, Spiller DG, White MR, Mortellaro A, Paszek P, Brough D.

Methods Mol Biol. 2016;1417:75-88. doi: 10.1007/978-1-4939-3566-6_4.

PMID:
27221482
29.

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production.

Houlden A, Goldrick M, Brough D, Vizi ES, Lénárt N, Martinecz B, Roberts IS, Denes A.

Brain Behav Immun. 2016 Oct;57:10-20. doi: 10.1016/j.bbi.2016.04.003. Epub 2016 Apr 6.

30.

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation.

Martín-Sánchez F, Diamond C, Zeitler M, Gomez AI, Baroja-Mazo A, Bagnall J, Spiller D, White M, Daniels MJ, Mortellaro A, Peñalver M, Paszek P, Steringer JP, Nickel W, Brough D, Pelegrín P.

Cell Death Differ. 2016 Jul;23(7):1219-31. doi: 10.1038/cdd.2015.176. Epub 2016 Feb 12.

31.

Multiple efficacy studies of an adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle using homologous challenge.

Schutta C, Barrera J, Pisano M, Zsak L, Grubman MJ, Mayr GA, Moraes MP, Kamicker BJ, Brake DA, Ettyreddy D, Brough DE, Butman BT, Neilan JG.

Vaccine. 2016 Jun 8;34(27):3214-3220. doi: 10.1016/j.vaccine.2015.12.018. Epub 2015 Dec 18.

32.

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P.

Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

33.

Inhibiting the Inflammasome: A Chemical Perspective.

Baldwin AG, Brough D, Freeman S.

J Med Chem. 2016 Mar 10;59(5):1691-710. doi: 10.1021/acs.jmedchem.5b01091. Epub 2015 Oct 12. Review.

PMID:
26422006
34.

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways.

Rivers-Auty J, Brough D.

Eur J Immunol. 2015 Oct;45(10):2758-61. doi: 10.1002/eji.201545958. Epub 2015 Sep 21. Review.

35.

Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage.

Edye ME, Brough D, Allan SM.

J Biol Chem. 2015 Oct 16;290(42):25374-81. doi: 10.1074/jbc.M115.667162. Epub 2015 Aug 31.

36.

Interleukin-1 as a pharmacological target in acute brain injury.

Brough D, Rothwell NJ, Allan SM.

Exp Physiol. 2015 Dec;100(12):1488-94. doi: 10.1113/EP085135. Epub 2015 Jul 14. Review.

37.

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Englezou PC, Rothwell SW, Ainscough JS, Brough D, Landsiedel R, Verkhratsky A, Kimber I, Dearman RJ.

Cytokine. 2015 Aug;74(2):293-304. doi: 10.1016/j.cyto.2015.05.013. Epub 2015 Jun 9.

38.

Consensus guidelines for the detection of immunogenic cell death.

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, Faggioni A, Formenti SC, Fučíková J, Gabriele L, Gaipl US, Galon J, Garg A, Ghiringhelli F, Giese NA, Guo ZS, Hemminki A, Herrmann M, Hodge JW, Holdenrieder S, Honeychurch J, Hu HM, Huang X, Illidge TM, Kono K, Korbelik M, Krysko DV, Loi S, Lowenstein PR, Lugli E, Ma Y, Madeo F, Manfredi AA, Martins I, Mavilio D, Menger L, Merendino N, Michaud M, Mignot G, Mossman KL, Multhoff G, Oehler R, Palombo F, Panaretakis T, Pol J, Proietti E, Ricci JE, Riganti C, Rovere-Querini P, Rubartelli A, Sistigu A, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Sukkurwala AQ, Tartour E, Thorburn A, Thorne SH, Vandenabeele P, Velotti F, Workenhe ST, Yang H, Zong WX, Zitvogel L, Kroemer G, Galluzzi L.

Oncoimmunology. 2014 Dec 13;3(9):e955691. eCollection 2014 Oct. Review.

39.

Interleukin-1α and brain inflammation.

Brough D, Denes A.

IUBMB Life. 2015 May;67(5):323-30. doi: 10.1002/iub.1377. Epub 2015 Apr 23. Review.

40.

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

Denes A, Coutts G, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4050-5. doi: 10.1073/pnas.1419090112. Epub 2015 Mar 16.

41.

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.

Compan V, Martín-Sánchez F, Baroja-Mazo A, López-Castejón G, Gomez AI, Verkhratsky A, Brough D, Pelegrín P.

J Immunol. 2015 Feb 1;194(3):1261-73. doi: 10.4049/jimmunol.1301676. Epub 2014 Dec 31.

42.

Novel perspectives on non-canonical inflammasome activation.

Diamond CE, Khameneh HJ, Brough D, Mortellaro A.

Immunotargets Ther. 2015 Jul 24;4:131-41. doi: 10.2147/ITT.S57976. eCollection 2015. Review.

43.

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.

Ainscough JS, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman RJ.

J Biol Chem. 2014 Dec 19;289(51):35582-92. doi: 10.1074/jbc.M114.595686. Epub 2014 Nov 4.

44.

Ocular localization and transduction by adenoviral vectors are serotype-dependent and can be modified by inclusion of RGD fiber modifications.

Ueyama K, Mori K, Shoji T, Omata H, Gehlbach PL, Brough DE, Wei LL, Yoneya S.

PLoS One. 2014 Sep 18;9(9):e108071. doi: 10.1371/journal.pone.0108071. eCollection 2014.

45.

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, Buján S, Couillin I, Brough D, Arostegui JI, Pelegrín P.

Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22.

PMID:
24952504
46.

Optimizing atoh1-induced vestibular hair cell regeneration.

Staecker H, Schlecker C, Kraft S, Praetorius M, Hsu C, Brough DE.

Laryngoscope. 2014 Oct;124 Suppl 5:S1-S12. doi: 10.1002/lary.24775. Epub 2014 Jun 17.

47.

Therapeutic potential of adenovirus-mediated delivery of β-defensin 2 for experimental otitis media.

Woo JI, Kil SH, Brough DE, Lee YJ, Lim DJ, Moon SK.

Innate Immun. 2015 Feb;21(2):215-24. doi: 10.1177/1753425914534002. Epub 2014 May 19.

PMID:
24842664
48.

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death.

England H, Summersgill HR, Edye ME, Rothwell NJ, Brough D.

J Biol Chem. 2014 Jun 6;289(23):15942-50. doi: 10.1074/jbc.M114.557561. Epub 2014 Apr 30.

49.

Zinc depletion regulates the processing and secretion of IL-1β.

Summersgill H, England H, Lopez-Castejon G, Lawrence CB, Luheshi NM, Pahle J, Mendes P, Brough D.

Cell Death Dis. 2014 Jan 30;5:e1040. doi: 10.1038/cddis.2013.547.

50.

The role of inflammation and interleukin-1 in acute cerebrovascular disease.

Galea J, Brough D.

J Inflamm Res. 2013 Aug 20;6:121-8. doi: 10.2147/JIR.S35629. Review.

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