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Items: 34


Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay.

Li J, Ji H, Porter DC, Broude EV, Roninson IB, Chen M.

Cells. 2019 Oct 6;8(10). pii: E1208. doi: 10.3390/cells8101208.


Identifying Cancers Impacted by CDK8/19.

Roninson IB, Győrffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV.

Cells. 2019 Aug 3;8(8). pii: E821. doi: 10.3390/cells8080821.


Role of transcription-regulating kinase CDK8 in colon cancer metastasis.

Liang J, Chen M, Broude EV, Roninson IB.

Oncotarget. 2019 Jan 18;10(6):622-623. doi: 10.18632/oncotarget.26593. eCollection 2019 Jan 18. No abstract available.


Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.

Alam A, Kowal J, Broude E, Roninson I, Locher KP.

Science. 2019 Feb 15;363(6428):753-756. doi: 10.1126/science.aav7102.


CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases.

Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB.

Cancer Res. 2018 Dec 1;78(23):6594-6606. doi: 10.1158/0008-5472.CAN-18-1583. Epub 2018 Sep 5.


Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.

Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K.

Oncogene. 2018 Aug;37(35):4792-4808. doi: 10.1038/s41388-018-0316-y. Epub 2018 May 21.


Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis.

Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K.

Cancer Res. 2018 Jun 1;78(11):2978-2989. doi: 10.1158/0008-5472.CAN-17-2316. Epub 2018 Mar 13.


Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.

Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E1973-E1982. doi: 10.1073/pnas.1717044115. Epub 2018 Feb 13.


CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10208-10213. doi: 10.1073/pnas.1710467114. Epub 2017 Aug 30.


Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.

Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M.

Sci Rep. 2017 Feb 22;7:43023. doi: 10.1038/srep43023.


Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.

McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV.

Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894.


Cellular Model of p21-Induced Senescence.

Shtutman M, Chang BD, Schools GP, Broude EV.

Methods Mol Biol. 2017;1534:31-39.


Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.

Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB.

Curr Cancer Drug Targets. 2015;15(8):739-49. Review.


Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells.

Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M.

Oncotarget. 2015 May 30;6(15):13088-104.


Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS, Gyorffy B, Wentland MP, Broude EV, Kiaris H, Roninson IB.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804. doi: 10.1073/pnas.1206906109. Epub 2012 Aug 6.


Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells.

Gonzalez RE, Lim CU, Cole K, Bianchini CH, Schools GP, Davis BE, Wada I, Roninson IB, Broude EV.

Cell Cycle. 2011 Oct 15;10(20):3505-14. doi: 10.4161/cc.10.20.17778.


Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1.

Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12449-54. doi: 10.1073/pnas.1103842108. Epub 2011 Jul 11.


Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing.

Shtutman M, Maliyekkel A, Shao Y, Carmack CS, Baig M, Warholic N, Cole K, Broude EV, Harkins TT, Ding Y, Roninson IB.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7377-82. doi: 10.1073/pnas.1003055107. Epub 2010 Apr 5.


Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis.

Demidenko ZN, Kalurupalle S, Hanko C, Lim CU, Broude E, Blagosklonny MV.

Oncogene. 2008 Jul 24;27(32):4402-10. doi: 10.1038/onc.2008.82. Epub 2008 May 12.


Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling.

Curry CL, Reed LL, Broude E, Golde TE, Miele L, Foreman KE.

Mol Cancer Ther. 2007 Jul;6(7):1983-92. Epub 2007 Jun 29.


p21 (CDKN1A) is a negative regulator of p53 stability.

Broude EV, Demidenko ZN, Vivo C, Swift ME, Davis BM, Blagosklonny MV, Roninson IB.

Cell Cycle. 2007 Jun 15;6(12):1468-71. Epub 2007 Apr 12.


p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.

Broude EV, Swift ME, Vivo C, Chang BD, Davis BM, Kalurupalle S, Blagosklonny MV, Roninson IB.

Oncogene. 2007 Oct 18;26(48):6954-8. Epub 2007 May 7.


Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.

Demidenko ZN, Vivo C, Halicka HD, Li CJ, Bhalla K, Broude EV, Blagosklonny MV.

Cell Death Differ. 2006 Sep;13(9):1434-41. Epub 2005 Nov 25.


If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.

Roninson IB, Broude EV, Chang BD.

Drug Resist Updat. 2001 Oct;4(5):303-13. Review.


Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent.

Chang BD, Swift ME, Shen M, Fang J, Broude EV, Roninson IB.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):389-94. Epub 2001 Dec 18.


A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication.

Levenson VV, Lausch E, Kirschling DJ, Broude EV, Davidovich IA, Libants S, Fedosova V, Roninson IB.

Somat Cell Mol Genet. 1999 Jan;25(1):9-26.


p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells.

Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB.

Oncogene. 2000 Apr 20;19(17):2165-70.


Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases.

Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, Roninson IB.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4291-6.


Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs.

Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J, Roninson IB.

Oncogene. 1999 Aug 26;18(34):4808-18.


A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB.

Cancer Res. 1999 Aug 1;59(15):3761-7.


Transplants and neurotrophic factors prevent atrophy of mature CNS neurons after spinal cord injury.

Bregman BS, Broude E, McAtee M, Kelley MS.

Exp Neurol. 1998 Jan;149(1):13-27.


c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy.

Broude E, McAtee M, Kelley MS, Bregman BS.

Exp Neurol. 1997 Nov;148(1):367-77.


Down-regulation of cyclin F levels during nerve growth factor-induced differentiation of PC12 cells.

Movsesyan V, Whalin M, Shibutani M, Katagiri Y, Broude E, Guroff G.

Exp Cell Res. 1996 Sep 15;227(2):203-7.


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