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Items: 41


TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life.

Eschenbrenner E, Jouannet S, Clay D, Chaker J, Boucheix C, Brou C, Tomlinson MG, Charrin S, Rubinstein E.

Life Sci Alliance. 2019 Dec 2;3(1). pii: e201900444. doi: 10.26508/lsa.201900444. Print 2020 Jan.


Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.

Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M.

Cell Rep. 2018 Dec 26;25(13):3811-3827.e7. doi: 10.1016/j.celrep.2018.11.078.


Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing.

Chastagner P, Rubinstein E, Brou C.

Sci Signal. 2017 Jun 13;10(483). pii: eaag2989. doi: 10.1126/scisignal.aag2989.


TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.

Jouannet S, Saint-Pol J, Fernandez L, Nguyen V, Charrin S, Boucheix C, Brou C, Milhiet PE, Rubinstein E.

Cell Mol Life Sci. 2016 May;73(9):1895-915. doi: 10.1007/s00018-015-2111-z. Epub 2015 Dec 19.


Tracking trafficking of Notch and its ligands in mammalian cells.

Chastagner P, Brou C.

Methods Mol Biol. 2014;1187:87-100. doi: 10.1007/978-1-4939-1139-4_7.


Α-arrestins - new players in Notch and GPCR signaling pathways in mammals.

Puca L, Brou C.

J Cell Sci. 2014 Apr 1;127(Pt 7):1359-67. doi: 10.1242/jcs.142539.


Infusion of docosahexaenoic acid protects against myocardial infarction.

Richard D, Oszust F, Guillaume C, Millart H, Laurent-Maquin D, Brou C, Bausero P, Visioli F.

Prostaglandins Leukot Essent Fatty Acids. 2014 Apr;90(4):139-43. doi: 10.1016/j.plefa.2014.01.001. Epub 2014 Jan 15.


Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.

Puca L, Chastagner P, Meas-Yedid V, Israël A, Brou C.

J Cell Sci. 2013 Oct 1;126(Pt 19):4457-68. doi: 10.1242/jcs.130500. Epub 2013 Jul 25.


Ubiquitinations in the notch signaling pathway.

Moretti J, Brou C.

Int J Mol Sci. 2013 Mar 19;14(3):6359-81. doi: 10.3390/ijms14036359.


The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.

Moretti J, Chastagner P, Liang CC, Cohn MA, Israël A, Brou C.

J Biol Chem. 2012 Aug 24;287(35):29429-41. doi: 10.1074/jbc.M112.366807. Epub 2012 Jul 9.


The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.

Moretti J, Chastagner P, Gastaldello S, Heuss SF, Dirac AM, Bernards R, Masucci MG, Israël A, Brou C.

PLoS Biol. 2010 Nov 23;8(11):e1000545. doi: 10.1371/journal.pbio.1000545.


Drosophila Ndfip is a novel regulator of Notch signaling.

Dalton HE, Denton D, Foot NJ, Ho K, Mills K, Brou C, Kumar S.

Cell Death Differ. 2011 Jul;18(7):1150-60. doi: 10.1038/cdd.2010.130. Epub 2010 Oct 22.


Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage.

Blaise R, Mahjoub M, Salvat C, Barbe U, Brou C, Corvol MT, Savouret JF, Rannou F, Berenbaum F, Bausero P.

Arthritis Rheum. 2009 Feb;60(2):428-39. doi: 10.1002/art.24250.


Intracellular trafficking of Notch receptors and ligands.

Brou C.

Exp Cell Res. 2009 May 15;315(9):1549-55. doi: 10.1016/j.yexcr.2008.09.010. Epub 2008 Sep 25. Review.


AIP4/Itch regulates Notch receptor degradation in the absence of ligand.

Chastagner P, Israël A, Brou C.

PLoS One. 2008 Jul 16;3(7):e2735. doi: 10.1371/journal.pone.0002735.


Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk.

Clément N, Gueguen M, Glorian M, Blaise R, Andréani M, Brou C, Bausero P, Limon I.

J Cell Sci. 2007 Oct 1;120(Pt 19):3352-61.


Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.

Chastagner P, Israël A, Brou C.

EMBO Rep. 2006 Nov;7(11):1147-53. Epub 2006 Oct 6.


[Endocytosis and Notch signalling].

Brou C, Logeat F.

Med Sci (Paris). 2006 Aug-Sep;22(8-9):685-8. French. No abstract available.


Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein.

Olry A, Chastagner P, Israël A, Brou C.

J Biol Chem. 2005 Aug 5;280(31):28564-71. Epub 2005 Jun 15.


The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration.

Six EM, Ndiaye D, Sauer G, Laâbi Y, Athman R, Cumano A, Brou C, Israël A, Logeat F.

J Biol Chem. 2004 Dec 31;279(53):55818-26. Epub 2004 Oct 14.


Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor.

Gupta-Rossi N, Six E, LeBail O, Logeat F, Chastagner P, Olry A, Israël A, Brou C.

J Cell Biol. 2004 Jul 5;166(1):73-83. Erratum in: J Cell Biol. 2004 Nov 8;167(3):following 562.


The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.

Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7638-43. Epub 2003 Jun 6.



Brou C, Israël A.

Curr Biol. 2001 Jul 24;11(14):R543. No abstract available.


Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.

Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israël A.

J Biol Chem. 2001 Sep 14;276(37):34371-8. Epub 2001 Jun 25.


A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israël A.

Mol Cell. 2000 Feb;5(2):207-16.


Limited contributions of serotonin to long-term hyperexcitability of Aplysia sensory neurons.

Liao X, Brou CG, Walters ET.

J Neurophysiol. 1999 Dec;82(6):3223-35.


Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

Jarriault S, Le Bail O, Hirsinger E, Pourquié O, Logeat F, Strong CF, Brou C, Seidah NG, Isra l A.

Mol Cell Biol. 1998 Dec;18(12):7423-31.


The Notch1 receptor is cleaved constitutively by a furin-like convertase.

Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israël A.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8108-12.


Signalling downstream of activated mammalian Notch.

Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A.

Nature. 1995 Sep 28;377(6547):355-8.


Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.

Brou C, Logeat F, Lecourtois M, Vandekerckhove J, Kourilsky P, Schweisguth F, Israël A.

Genes Dev. 1994 Oct 15;8(20):2491-503.


Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.

Jacq X, Brou C, Lutz Y, Davidson I, Chambon P, Tora L.

Cell. 1994 Oct 7;79(1):107-17.


A cell-specific factor represses stimulation of transcription in vitro by transcriptional enhancer factor 1.

Chaudhary S, Brou C, Valentin ME, Burton N, Tora L, Chambon P, Davidson I.

Mol Cell Biol. 1994 Aug;14(8):5290-9.


Sequence-specific transactivators counteract topoisomerase II-mediated inhibition of in vitro transcription by RNA polymerases I and II.

Brou C, Kuhn A, Staub A, Chaudhary S, Grummt I, Davidson I, Tora L.

Nucleic Acids Res. 1993 Aug 25;21(17):4011-8.


Distinct TFIID complexes mediate the effect of different transcriptional activators.

Brou C, Chaudhary S, Davidson I, Lutz Y, Wu J, Egly JM, Tora L, Chambon P.

EMBO J. 1993 Feb;12(2):489-99.


The acidic transcriptional activator GAL-VP16 acts on preformed template-committed complexes.

White J, Brou C, Wu J, Lutz Y, Moncollin V, Chambon P.

EMBO J. 1992 Jun;11(6):2229-40.


In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors.

Shemshedini L, Ji JW, Brou C, Chambon P, Gronemeyer H.

J Biol Chem. 1992 Jan 25;267(3):1834-9.


Evidence for a factor required for transcriptional stimulation by the chimeric acidic activator GAL-VP16 in HeLa cell extracts.

White JH, Brou C, Wu J, Burton N, Egly JM, Chambon P.

Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7674-8.


The human estrogen receptor has two independent nonacidic transcriptional activation functions.

Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P.

Cell. 1989 Nov 3;59(3):477-87.


Characterization of a bovine acidic FGF cDNA clone and its expression in brain and retina.

Alterio J, Halley C, Brou C, Soussi T, Courtois Y, Laurent M.

FEBS Lett. 1988 Dec 19;242(1):41-6.

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