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Items: 1 to 50 of 63

1.

Legal and Ethical Challenges of International Direct-to-Participant Genomic Research: Conclusions and Recommendations.

Rothstein MA, Zawati MH, Beskow LM, Brelsford KM, Brothers KB, Hammack-Aviran CM, Hazel JW, Joly Y, Lang M, Patrinos D, Saltzman A, Knoppers BM.

J Law Med Ethics. 2019 Dec;47(4):705-731. doi: 10.1177/1073110519898297. No abstract available.

PMID:
31957580
2.

Participant Engagement in Translational Genomics Research: Respect for Persons-and Then Some.

Childerhose JE, Finnila CR, Yu JH, Koenig BA, McEwen J, Berg SL, Wilfond BS, Appelbaum PS, Brothers KB.

Ethics Hum Res. 2019 Sep;41(5):2-15. doi: 10.1002/eahr.500029.

PMID:
31541538
3.

Consent for clinical genome sequencing: considerations from the Clinical Sequencing Exploratory Research Consortium.

Yu JH, Appelbaum PS, Brothers KB, Joffe S, Kauffman TL, Koenig BA, Prince AE, Scollon S, Wolf SM, Bernhardt BA, Wilfond BS; Clinical Sequencing Exploratory Research (CSER) Consortium Informed Consent and Governance Working Group.

Per Med. 2019 Jul;16(4):325-333. doi: 10.2217/pme-2018-0076. Epub 2019 Jul 17.

PMID:
31313633
4.

Psychological outcomes related to exome and genome sequencing result disclosure: a meta-analysis of seven Clinical Sequencing Exploratory Research (CSER) Consortium studies.

Robinson JO, Wynn J, Biesecker B, Biesecker LG, Bernhardt B, Brothers KB, Chung WK, Christensen KD, Green RC, McGuire AL, Hart MR, Griesemer I, Patrick DL, Rini C, Veenstra D, Cronin AM, Gray SW.

Genet Med. 2019 Dec;21(12):2781-2790. doi: 10.1038/s41436-019-0565-3. Epub 2019 Jun 13.

PMID:
31189963
5.

Bespoke Babies: Genome Editing in Cystic Fibrosis Embryos.

Brothers KB, Devereaux M, Sade RM.

Ann Thorac Surg. 2019 Oct;108(4):995-999. doi: 10.1016/j.athoracsur.2019.04.030. Epub 2019 May 29. No abstract available.

PMID:
31152729
6.

A Belmont Reboot: Building a Normative Foundation for Human Research in the 21st Century.

Brothers KB, Rivera SM, Cadigan RJ, Sharp RR, Goldenberg AJ.

J Law Med Ethics. 2019 Mar;47(1):165-172. doi: 10.1177/1073110519840497. No abstract available.

7.

The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results.

Bombard Y, Brothers KB, Fitzgerald-Butt S, Garrison NA, Jamal L, James CA, Jarvik GP, McCormick JB, Nelson TN, Ormond KE, Rehm HL, Richer J, Souzeau E, Vassy JL, Wagner JK, Levy HP.

Am J Hum Genet. 2019 Apr 4;104(4):578-595. doi: 10.1016/j.ajhg.2019.02.025. Review.

8.

Genomic Contextualism: Shifting the Rhetoric of Genetic Exceptionalism.

Garrison NA, Brothers KB, Goldenberg AJ, Lynch JA.

Am J Bioeth. 2019 Jan;19(1):51-63. doi: 10.1080/15265161.2018.1544304.

9.

Correction: Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study.

Hart MR, Biesecker BB, Blout CL, Christensen KD, Amendola LM, Bergstrom KL, Biswas S, Bowling KM, Brothers KB, Conlin LK, Cooper GM, Dulik MC, East KM, Everett JN, Finnila CR, Ghazani AA, Gilmore MJ, Goddard KAB, Jarvik GP, Johnston JJ, Kauffman TL, Kelley WV, Krier JB, Lewis KL, McGuire AL, McMullen C, Ou J, Plon SE, Rehm HL, Richards CS, Romasko EJ, Sagardia AM, Spinner NB, Thompson ML, Turbitt E, Vassy JL, Wilfond BS, Veenstra DL, Berg JS, Green RC, Biesecker LG, Hindorff LA.

Genet Med. 2019 May;21(5):1261-1262. doi: 10.1038/s41436-019-0440-2.

PMID:
30670880
10.

Reconciling Opportunistic and Population Screening in Clinical Genomics.

Brothers KB, Vassy JL, Green RC.

Mayo Clin Proc. 2019 Jan;94(1):103-109. doi: 10.1016/j.mayocp.2018.08.028. Review.

11.

Enrichment sampling for a multi-site patient survey using electronic health records and census data.

Mercaldo ND, Brothers KB, Carrell DS, Clayton EW, Connolly JJ, Holm IA, Horowitz CR, Jarvik GP, Kitchner TE, Li R, McCarty CA, McCormick JB, McManus VD, Myers MF, Pankratz JJ, Shrubsole MJ, Smith ME, Stallings SC, Williams JL, Schildcrout JS.

J Am Med Inform Assoc. 2019 Mar 1;26(3):219-227. doi: 10.1093/jamia/ocy164.

12.

Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study.

Hart MR, Biesecker BB, Blout CL, Christensen KD, Amendola LM, Bergstrom KL, Biswas S, Bowling KM, Brothers KB, Conlin LK, Cooper GM, Dulik MC, East KM, Everett JN, Finnila CR, Ghazani AA, Gilmore MJ, Goddard KAB, Jarvik GP, Johnston JJ, Kauffman TL, Kelley WV, Krier JB, Lewis KL, McGuire AL, McMullen C, Ou J, Plon SE, Rehm HL, Richards CS, Romasko EJ, Miren Sagardia A, Spinner NB, Thompson ML, Turbitt E, Vassy JL, Wilfond BS, Veenstra DL, Berg JS, Green RC, Biesecker LG, Hindorff LA.

Genet Med. 2019 May;21(5):1100-1110. doi: 10.1038/s41436-018-0308-x. Epub 2018 Oct 5. Erratum in: Genet Med. 2019 Jan 22;:.

13.

How Should Primary Care Physicians Respond to Direct-to-Consumer Genetic Test Results?

Brothers KB, Knapp EE.

AMA J Ethics. 2018 Sep 1;20(9):E812-818. doi: 10.1001/amajethics.2018.812.

14.

Parents' attitudes toward consent and data sharing in biobanks: A multisite experimental survey.

Antommaria AHM, Brothers KB, Myers JA, Feygin YB, Aufox SA, Brilliant MH, Conway P, Fullerton SM, Garrison NA, Horowitz CR, Jarvik GP, Li R, Ludman EJ, McCarty CA, McCormick JB, Mercaldo ND, Myers MF, Sanderson SC, Shrubsole MJ, Schildcrout JS, Williams JL, Smith ME, Clayton EW, Holm IA.

AJOB Empir Bioeth. 2018 Jul-Sep;9(3):128-142. doi: 10.1080/23294515.2018.1505783. Epub 2018 Sep 21.

15.

Research Consent at the Age of Majority: Preferable but not Obligatory.

Brothers KB, Wilfond BS.

Pediatrics. 2018 Aug;142(2). pii: e20173038. doi: 10.1542/peds.2017-3038. Epub 2018 Jul 6. Review.

16.

Developing a conceptual, reproducible, rubric-based approach to consent and result disclosure for genetic testing by clinicians with minimal genetics background.

Ormond KE, Hallquist MLG, Buchanan AH, Dondanville D, Cho MK, Smith M, Roche M, Brothers KB, Coughlin CR 2nd, Hercher L, Hudgins L, Jamal S, Levy HP, Raskin M, Stosic M, Uhlmann W, Wain KE, Currey E, Faucett WA.

Genet Med. 2019 Mar;21(3):727-735. doi: 10.1038/s41436-018-0093-6. Epub 2018 Jul 6.

17.

Physicians' perspectives on receiving unsolicited genomic results.

Pet DB, Holm IA, Williams JL, Myers MF, Novak LL, Brothers KB, Wiesner GL, Clayton EW.

Genet Med. 2019 Feb;21(2):311-318. doi: 10.1038/s41436-018-0047-z. Epub 2018 Jul 5.

18.

Genomic sequencing identifies secondary findings in a cohort of parent study participants.

Thompson ML, Finnila CR, Bowling KM, Brothers KB, Neu MB, Amaral MD, Hiatt SM, East KM, Gray DE, Lawlor JMJ, Kelley WV, Lose EJ, Rich CA, Simmons S, Levy SE, Myers RM, Barsh GS, Bebin EM, Cooper GM.

Genet Med. 2018 Dec;20(12):1635-1643. doi: 10.1038/gim.2018.53. Epub 2018 Apr 12.

19.

Tensions in ethics and policy created by National Precision Medicine Programs.

Minari J, Brothers KB, Morrison M.

Hum Genomics. 2018 Apr 17;12(1):22. doi: 10.1186/s40246-018-0151-9.

20.

Correction to: PUGS: A novel scale to assess perceptions of uncertainties in genome sequencing.

Biesecker BB, Woolford SW, Klein WMP, Brothers KB, Umstead KL, Lewis KL, Biesecker LG, Han PKJ.

Clin Genet. 2018 May;93(5):1119. doi: 10.1111/cge.13241. No abstract available.

PMID:
29655271
21.

Systematic reanalysis of genomic data improves quality of variant interpretation.

Hiatt SM, Amaral MD, Bowling KM, Finnila CR, Thompson ML, Gray DE, Lawlor JMJ, Cochran JN, Bebin EM, Brothers KB, East KM, Kelley WV, Lamb NE, Levy SE, Lose EJ, Neu MB, Rich CA, Simmons S, Myers RM, Barsh GS, Cooper GM.

Clin Genet. 2018 Jul;94(1):174-178. doi: 10.1111/cge.13259. Epub 2018 May 10.

22.

Ethics and Brain Death in Pediatrics: Recent Controversy and Practical Suggestions.

Bibler TM, Galbraith KL, Brothers KB.

J Pediatr Intensive Care. 2017 Dec;6(4):240-244. doi: 10.1055/s-0037-1604012. Epub 2017 Jun 27. Review.

23.

Modernizing Research Regulations Is Not Enough: It's Time to Think Outside the Regulatory Box.

Rivera SM, Brothers KB, Cadigan RJ, Harrell HL, Rothstein MA, Sharp RR, Goldenberg AJ.

Am J Bioeth. 2017 Jul;17(7):1-3. doi: 10.1080/15265161.2017.1328899. No abstract available.

24.

Genomic diagnosis for children with intellectual disability and/or developmental delay.

Bowling KM, Thompson ML, Amaral MD, Finnila CR, Hiatt SM, Engel KL, Cochran JN, Brothers KB, East KM, Gray DE, Kelley WV, Lamb NE, Lose EJ, Rich CA, Simmons S, Whittle JS, Weaver BT, Nesmith AS, Myers RM, Barsh GS, Bebin EM, Cooper GM.

Genome Med. 2017 May 30;9(1):43. doi: 10.1186/s13073-017-0433-1.

25.

Providers' Behaviors and Beliefs on Prescribing Antipsychotic Medication to Children: A Qualitative Study.

Lohr WD, Brothers KB, Davis DW, Rich CA, Ryan L, Smith M, Stevenson M, Feygin Y, Woods C, Myers J, Liu GC.

Community Ment Health J. 2018 Jan;54(1):17-26. doi: 10.1007/s10597-017-0125-8. Epub 2017 Mar 31.

PMID:
28364300
26.

Public Attitudes toward Consent and Data Sharing in Biobank Research: A Large Multi-site Experimental Survey in the US.

Sanderson SC, Brothers KB, Mercaldo ND, Clayton EW, Antommaria AHM, Aufox SA, Brilliant MH, Campos D, Carrell DS, Connolly J, Conway P, Fullerton SM, Garrison NA, Horowitz CR, Jarvik GP, Kaufman D, Kitchner TE, Li R, Ludman EJ, McCarty CA, McCormick JB, McManus VD, Myers MF, Scrol A, Williams JL, Shrubsole MJ, Schildcrout JS, Smith ME, Holm IA.

Am J Hum Genet. 2017 Mar 2;100(3):414-427. doi: 10.1016/j.ajhg.2017.01.021. Epub 2017 Feb 9.

27.

PUGS: A novel scale to assess perceptions of uncertainties in genome sequencing.

Biesecker BB, Woolford SW, Klein WMP, Brothers KB, Umstead KL, Lewis KL, Biesecker LG, Han PKJ.

Clin Genet. 2017 Aug;92(2):172-179. doi: 10.1111/cge.12949. Epub 2017 Jan 30. Erratum in: Clin Genet. 2018 May;93(5):1119.

28.

Conducting a large, multi-site survey about patients' views on broad consent: challenges and solutions.

Smith ME, Sanderson SC, Brothers KB, Myers MF, McCormick J, Aufox S, Shrubsole MJ, Garrison NA, Mercaldo ND, Schildcrout JS, Clayton EW, Antommaria AH, Basford M, Brilliant M, Connolly JJ, Fullerton SM, Horowitz CR, Jarvik GP, Kaufman D, Kitchner T, Li R, Ludman EJ, McCarty C, McManus V, Stallings S, Williams JL, Holm IA.

BMC Med Res Methodol. 2016 Nov 24;16(1):162.

29.

Ethical and legal considerations for pediatric biobank consent: current and future perspectives.

Brothers KB, Goldenberg AJ.

Per Med. 2016 Nov;13(6):597-607. doi: 10.2217/pme-2016-0028. Epub 2016 Oct 13.

PMID:
29754545
30.

Eliciting preferences on secondary findings: the Preferences Instrument for Genomic Secondary Results.

Brothers KB, East KM, Kelley WV, Wright MF, Westbrook MJ, Rich CA, Bowling KM, Lose EJ, Bebin EM, Simmons S, Myers JA, Barsh G, Myers RM, Cooper GM, Pulley JM, Rothstein MA, Clayton EW.

Genet Med. 2017 Mar;19(3):337-344. doi: 10.1038/gim.2016.110. Epub 2016 Aug 25.

31.

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.

Green RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium.

Am J Hum Genet. 2016 Jul 7;99(1):246. doi: 10.1016/j.ajhg.2016.06.002. No abstract available.

32.

Clinical decision-making and secondary findings in systems medicine.

Fischer T, Brothers KB, Erdmann P, Langanke M.

BMC Med Ethics. 2016 May 21;17(1):32. doi: 10.1186/s12910-016-0113-5.

33.

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.

Green RC, Goddard KAB, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S, Blout CL, Bowling KM, Brothers KB, Burke W, Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K, Evans JP, Fullerton SM, Garraway LA, Garrett JR, Gray SW, Henderson GE, Hindorff LA, Holm IA, Lewis MH, Hutter CM, Janne PA, Joffe S, Kaufman D, Knoppers BM, Koenig BA, Krantz ID, Manolio TA, McCullough L, McEwen J, McGuire A, Muzny D, Myers RM, Nickerson DA, Ou J, Parsons DW, Petersen GM, Plon SE, Rehm HL, Roberts JS, Robinson D, Salama JS, Scollon S, Sharp RR, Shirts B, Spinner NB, Tabor HK, Tarczy-Hornoch P, Veenstra DL, Wagle N, Weck K, Wilfond BS, Wilhelmsen K, Wolf SM, Wynn J, Yu JH; CSER Consortium.

Am J Hum Genet. 2016 Jun 2;98(6):1051-1066. doi: 10.1016/j.ajhg.2016.04.011. Epub 2016 May 12. Erratum in: Am J Hum Genet. 2016 Jul 7;99(1):246.

34.

Factors Associated with Attendance after Referral to a Pediatric Weight Management Program.

Shaffer LA, Brothers KB, Burkhead TA, Yeager R, Myers JA, Sweeney B.

J Pediatr. 2016 May;172:35-9. doi: 10.1016/j.jpeds.2016.02.011. Epub 2016 Mar 2.

PMID:
26947949
35.

Citizen Science on Your Smartphone: An ELSI Research Agenda.

Rothstein MA, Wilbanks JT, Brothers KB.

J Law Med Ethics. 2015 Winter;43(4):897-903. doi: 10.1111/jlme.12327.

PMID:
26711425
36.

When Participants in Genomic Research Grow Up: Contact and Consent at the Age of Majority.

Brothers KB, Holm IA, Childerhose JE, Antommaria AH, Bernhardt BA, Clayton EW, Gelb BD, Joffe S, Lynch JA, McCormick JB, McCullough LB, Parsons DW, Sundaresan AS, Wolf WA, Yu JH, Wilfond BS; Pediatrics Workgroup of the Clinical Sequencing Exploratory Research (CSER) Consortium; Pediatrics Workgroup of the Clinical Sequencing Exploratory Research CSER Consortium.

J Pediatr. 2016 Jan;168:226-31.e1. doi: 10.1016/j.jpeds.2015.09.020. Epub 2015 Oct 23. No abstract available.

37.

Professionally Responsible Disclosure of Genomic Sequencing Results in Pediatric Practice.

McCullough LB, Brothers KB, Chung WK, Joffe S, Koenig BA, Wilfond B, Yu JH; Clinical Sequencing Exploratory Research (CSER) Consortium Pediatrics Working Group.

Pediatrics. 2015 Oct;136(4):e974-82. doi: 10.1542/peds.2015-0624. Epub 2015 Sep 14.

38.

State-offered ethnically targeted reproductive genetic testing.

Clayton EW, Brothers KB.

Genet Med. 2016 Feb;18(2):126-7. doi: 10.1038/gim.2015.74. Epub 2015 Jun 4. No abstract available.

PMID:
26043291
39.

Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy.

Van Driest SL, McGregor TL, Velez Edwards DR, Saville BR, Kitchner TE, Hebbring SJ, Brilliant M, Jouni H, Kullo IJ, Creech CB, Kannankeril PJ, Vear SI, Brothers KB, Bowton EA, Shaffer CM, Patel N, Delaney JT, Bradford Y, Wilson S, Olson LM, Crawford DC, Potts AL, Ho RH, Roden DM, Denny JC.

PLoS One. 2015 Jun 1;10(6):e0127791. doi: 10.1371/journal.pone.0127791. eCollection 2015.

40.
41.

Erratum to: How can psychological science inform research about genetic counseling for clinical genomic sequencing?

Khan CM, Rini C, Bernhardt BA, Roberts JS, Christensen KD, Evans JP, Brothers KB, Roche MI, Berg JS, Henderson GE.

J Genet Couns. 2015 Apr;24(2):372. doi: 10.1007/s10897-014-9814-4.

42.

How can psychological science inform research about genetic counseling for clinical genomic sequencing?

Khan CM, Rini C, Bernhardt BA, Roberts JS, Christensen KD, Evans JP, Brothers KB, Roche MI, Berg JS, Henderson GE.

J Genet Couns. 2015 Apr;24(2):193-204. doi: 10.1007/s10897-014-9804-6. Epub 2014 Dec 9. Erratum in: J Genet Couns. 2015 Apr;24(2):372.

43.

Practical guidance on informed consent for pediatric participants in a biorepository.

Brothers KB, Lynch JA, Aufox SA, Connolly JJ, Gelb BD, Holm IA, Sanderson SC, McCormick JB, Williams JL, Wolf WA, Antommaria AH, Clayton EW.

Mayo Clin Proc. 2014 Nov;89(11):1471-80. doi: 10.1016/j.mayocp.2014.07.006. Epub 2014 Sep 26. No abstract available.

44.

Patient awareness and approval for an opt-out genomic biorepository.

Brothers KB, Westbrook MJ, Wright MF, Myers JA, Morrison DR, Madison JL, Pulley JM, Clayton EW.

Per Med. 2013 Jun;10(4). doi: 10.2217/pme.13.34.

45.

Ethical issues in pediatric pharmacogenomics.

Brothers KB.

J Pediatr Pharmacol Ther. 2013 Jul;18(3):192-8. doi: 10.5863/1551-6776-18.3.192. No abstract available.

46.

Ethical, legal, and social implications of incorporating genomic information into electronic health records.

Hazin R, Brothers KB, Malin BA, Koenig BA, Sanderson SC, Rothstein MA, Williams MS, Clayton EW, Kullo IJ.

Genet Med. 2013 Oct;15(10):810-6. doi: 10.1038/gim.2013.117. Epub 2013 Sep 12. Review.

47.

Implications of the incidentalome for clinical pharmacogenomics.

Brothers KB, Langanke M, Erdmann P.

Pharmacogenomics. 2013 Aug;14(11):1353-62. doi: 10.2217/pgs.13.119.

48.

Ethical and practical challenges to studying patients who opt out of large-scale biorepository research.

Rosenbloom ST, Madison JL, Brothers KB, Bowton EA, Clayton EW, Malin BA, Roden DM, Pulley J.

J Am Med Inform Assoc. 2013 Dec;20(e2):e221-5. doi: 10.1136/amiajnl-2013-001937. Epub 2013 Jul 25.

49.

Informed consent in the era of biobanks.

Brothers KB.

Genome Med. 2013 Jan 25;5(1):4. doi: 10.1186/gm408. eCollection 2013.

50.

Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU.

McGregor TL, Van Driest SL, Brothers KB, Bowton EA, Muglia LJ, Roden DM.

Clin Pharmacol Ther. 2013 Feb;93(2):204-11. doi: 10.1038/clpt.2012.230. Epub 2012 Nov 21.

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