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Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase.

Shao B, Tang C, Sinha A, Mayer PS, Davenport GD, Brot N, Oda MN, Zhao XQ, Heinecke JW.

Circ Res. 2014 May 23;114(11):1733-42. doi: 10.1161/CIRCRESAHA.114.303454. Epub 2014 Mar 19.


Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells.

Dun Y, Vargas J, Brot N, Finnemann SC.

Free Radic Biol Med. 2013 Dec;65:1340-1351. doi: 10.1016/j.freeradbiomed.2013.10.006. Epub 2013 Oct 10.


Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine.

Kadiiska MB, Basu S, Brot N, Cooper C, Saari Csallany A, Davies MJ, George MM, Murray DM, Jackson Roberts L 2nd, Shigenaga MK, Sohal RS, Stocker R, Van Thiel DH, Wiswedel I, Hatch GE, Mason RP.

Free Radic Biol Med. 2013 Aug;61:408-15. doi: 10.1016/j.freeradbiomed.2013.04.023. Epub 2013 Apr 19.


Studies on the metabolism and biological activity of the epimers of sulindac.

Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H.

Drug Metab Dispos. 2011 Jun;39(6):1014-21. doi: 10.1124/dmd.110.037663. Epub 2011 Mar 7.


The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region.

Herrero R, Kajikawa O, Matute-Bello G, Wang Y, Hagimoto N, Mongovin S, Wong V, Park DR, Brot N, Heinecke JW, Rosen H, Goodman RB, Fu X, Martin TR.

J Clin Invest. 2011 Mar;121(3):1174-90. doi: 10.1172/JCI43004.


A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A.

Brunell D, Weissbach H, Hodder P, Brot N.

Assay Drug Dev Technol. 2010 Oct;8(5):615-20. doi: 10.1089/adt.2009.0263. Epub 2010 Jun 1.


Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils.

Rosen H, Klebanoff SJ, Wang Y, Brot N, Heinecke JW, Fu X.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18686-91. doi: 10.1073/pnas.0909464106. Epub 2009 Oct 15.


Protection of vascular smooth muscle cells by over-expressed methionine sulphoxide reductase A: role of intracellular localization and substrate availability.

Haenold R, Wassef R, Brot N, Neugebauer S, Leipold E, Heinemann SH, Hoshi T.

Free Radic Res. 2008 Nov;42(11-12):978-88. doi: 10.1080/10715760802566541.


Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.

Lee WL, Gold B, Darby C, Brot N, Jiang X, de Carvalho LP, Wellner D, St John G, Jacobs WR Jr, Nathan C.

Mol Microbiol. 2009 Feb;71(3):583-93. doi: 10.1111/j.1365-2958.2008.06548.x.


Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I.

Shao B, Cavigiolio G, Brot N, Oda MN, Heinecke JW.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12224-9. doi: 10.1073/pnas.0802025105. Epub 2008 Aug 21.


Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms.

Wassef R, Haenold R, Hansel A, Brot N, Heinemann SH, Hoshi T.

J Neurosci. 2007 Nov 21;27(47):12808-16.


Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function.

Lin Z, Johnson LC, Weissbach H, Brot N, Lively MO, Lowther WT.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9597-602. Epub 2007 May 29.


The thioredoxin domain of Neisseria gonorrhoeae PilB can use electrons from DsbD to reduce downstream methionine sulfoxide reductases.

Brot N, Collet JF, Johnson LC, Jönsson TJ, Weissbach H, Lowther WT.

J Biol Chem. 2006 Oct 27;281(43):32668-75. Epub 2006 Aug 22.


Selenocompounds can serve as oxidoreductants with the methionine sulfoxide reductase enzymes.

Sagher D, Brunell D, Brot N, Vallee BL, Weissbach H.

J Biol Chem. 2006 Oct 20;281(42):31184-7. Epub 2006 Aug 17.


Thionein can serve as a reducing agent for the methionine sulfoxide reductases.

Sagher D, Brunell D, Hejtmancik JF, Kantorow M, Brot N, Weissbach H.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8656-61. Epub 2006 May 30.


Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I.

Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, Oram JF, Heinecke JW.

J Biol Chem. 2006 Apr 7;281(14):9001-4. Epub 2006 Feb 22.


Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells.

Marchetti MA, Pizarro GO, Sagher D, Deamicis C, Brot N, Hejtmancik JF, Weissbach H, Kantorow M.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2107-12.


Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?

Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA, George M, Heinecke JW, Hatch GE, Hensley K, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ 2nd, Rokach J, Shigenaga MK, Sohal RS, Sun J, Tice RR, Van Thiel DH, Wellner D, Walter PB, Tomer KB, Mason RP, Barrett JC.

Free Radic Biol Med. 2005 Mar 15;38(6):698-710.


Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.

Weissbach H, Resnick L, Brot N.

Biochim Biophys Acta. 2005 Jan 17;1703(2):203-12. Epub 2004 Nov 11. Review.


Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation.

Yermolaieva O, Xu R, Schinstock C, Brot N, Weissbach H, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1159-64. Epub 2004 Jan 26.


Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system.

Etienne F, Resnick L, Sagher D, Brot N, Weissbach H.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):1005-10.


Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses.

Kim SJ, Gershov D, Ma X, Brot N, Elkon KB.

Ann N Y Acad Sci. 2003 Apr;987:68-78. Review.


New membrane-associated and soluble peptide methionine sulfoxide reductases in Escherichia coli.

Spector D, Etienne F, Brot N, Weissbach H.

Biochem Biophys Res Commun. 2003 Mar 7;302(2):284-9.


A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide.

Etienne F, Spector D, Brot N, Weissbach H.

Biochem Biophys Res Commun. 2003 Jan 10;300(2):378-82.


The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species.

Skaar EP, Tobiason DM, Quick J, Judd RC, Weissbach H, Etienne F, Brot N, Seifert HS.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10108-13. Epub 2002 Jul 2.


The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB.

Lowther WT, Weissbach H, Etienne F, Brot N, Matthews BW.

Nat Struct Biol. 2002 May;9(5):348-52.


High-quality life extension by the enzyme peptide methionine sulfoxide reductase.

Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2748-53. Epub 2002 Feb 26. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184. Chen, M-L [corrected to Chen, Mai-Lei]; Joiner, MA [corrected to Joiner, Mei-Ling A]; Heinemann, Stephen H [corrected to Heinemann, Stefan H].


Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function.

Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N.

Arch Biochem Biophys. 2002 Jan 15;397(2):172-8. Review.


Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates.

St John G, Brot N, Ruan J, Erdjument-Bromage H, Tempst P, Weissbach H, Nathan C.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9901-6. Epub 2001 Jul 31.


Oxidative regulation of large conductance calcium-activated potassium channels.

Tang XD, Daggett H, Hanner M, Garcia ML, McManus OB, Brot N, Weissbach H, Heinemann SH, Hoshi T.

J Gen Physiol. 2001 Mar;117(3):253-74.


Peptide methionine sulfoxide reductase: biochemistry and physiological role.

Brot N, Weissbach H.

Biopolymers. 2000;55(4):288-96. Review.


Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme.

Lowther WT, Brot N, Weissbach H, Matthews BW.

Biochemistry. 2000 Nov 7;39(44):13307-12.


Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase.

Lowther WT, Brot N, Weissbach H, Honek JF, Matthews BW.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6463-8.


Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling.

Yermolaieva O, Brot N, Weissbach H, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):448-53.


Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).

Kuschel L, Hansel A, Schönherr R, Weissbach H, Brot N, Hoshi T, Heinemann SH.

FEBS Lett. 1999 Jul 30;456(1):17-21.


Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C.

Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T.

FEBS Lett. 1999 Jan 8;442(1):48-52.


Induction of in vitro heart block is not restricted to affinity purified anti-52 kDa Ro/SSA antibody from mothers of children with neonatal lupus.

Viana VS, Garcia S, Nascimento JH, Elkon KB, Brot N, Campos de Carvalho AC, Bonfá E.

Lupus. 1998;7(3):141-7.


Modulation of potassium channel function by methionine oxidation and reduction.

Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9932-7.


Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens.

Wizemann TM, Moskovitz J, Pearce BJ, Cundell D, Arvidson CG, So M, Weissbach H, Brot N, Masure HR.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7985-90.


ATP hydrolysis is not required for the dissociation of a substance P.BiP complex.

Vidal V, Qiu NH, Redfield B, Carlino A, Brot N, Weissbach H.

Arch Biochem Biophys. 1996 Jun 15;330(2):314-8.


Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.

Moskovitz J, Jenkins NA, Gilbert DJ, Copeland NG, Jursky F, Weissbach H, Brot N.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3205-8.


Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.

Moskovitz J, Weissbach H, Brot N.

Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2095-9.


Heat shock-dependent transcriptional activation of the metA gene of Escherichia coli.

Biran D, Brot N, Weissbach H, Ron EZ.

J Bacteriol. 1995 Mar;177(5):1374-9.


Escherichia coli peptide methionine sulfoxide reductase gene: regulation of expression and role in protecting against oxidative damage.

Moskovitz J, Rahman MA, Strassman J, Yancey SO, Kushner SR, Brot N, Weissbach H.

J Bacteriol. 1995 Feb;177(3):502-7.


Interaction of BiP with substance P and nucleotides.

Weissbach H, Redfield B, Qiu N, Chen G, Carlino A, Vidal V, Tsolas O, Brot N.

Cell Mol Biol Res. 1995;41(5):397-403.


Escherichia coli peptide methionine sulfoxide reductase: cloning, high expression, and purification.

Brot N, Rahman MA, Moskovitz J, Weissbach H.

Methods Enzymol. 1995;251:462-70. No abstract available.


Similarity of nucleotide interactions of BiP and GTP-binding proteins.

Brot N, Redfield B, Qiu NH, Chen GJ, Vidal V, Carlino A, Weissbach H.

Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12120-4.


The effect of phosphorylation and site-specific mutations in the immunodominant epitope of the human ribosomal P proteins.

Hasler P, Brot N, Weissbach H, Danho W, Blount Y, Zhou JL, Elkon KB.

Clin Immunol Immunopathol. 1994 Aug;72(2):273-9.


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